Cited by 39Autism Spectrum Disorder ResearchNeuroscience and Music PerceptionGenetics and Neurodevelopmental Disorders

Emotional prosodic change detection in autism Spectrum disorder: an electrophysiological investigation in children and adults

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Charpentier, J., Kovarski, K., Houy-Durand, E., Malvy, J., Saby, A., Bonnet-Brilhault, F., Latinus, M., Gomot, M.·2018·Journal of Neurodevelopmental Disorders

Abstract

BACKGROUND: Autism spectrum disorder (ASD) is characterized by atypical behaviors in social environments and in reaction to changing events. While this dyad of symptoms is at the core of the pathology along with atypical sensory behaviors, most studies have investigated only one dimension. A focus on the sameness dimension has shown that intolerance to change is related to an atypical pre-attentional detection of irregularity. In the present study, we addressed the same process in response to emotional change in order to evaluate the interplay between alterations of change detection and socio-emotional processing in children and adults with autism. METHODS: Brain responses to neutral and emotional prosodic deviancies (mismatch negativity (MMN) and P3a, reflecting change detection and orientation of attention toward change, respectively) were recorded in children and adults with autism and in controls. Comparison of neutral and emotional conditions allowed distinguishing between general deviancy and emotional deviancy effects. Moreover, brain responses to the same neutral and emotional stimuli were recorded when they were not deviants to evaluate the sensory processing of these vocal stimuli. RESULTS: In controls, change detection was modulated by prosody: in children, this was characterized by a lateralization of emotional MMN to the right hemisphere, and in adults, by an earlier MMN for emotional deviancy than for neutral deviancy. In ASD, an overall atypical change detection was observed with an earlier MMN and a larger P3a compared to controls suggesting an unusual pre-attentional orientation toward any changes in the auditory environment. Moreover, in children with autism, deviancy detection depicted reduced MMN amplitude. In addition in children with autism, contrary to adults with autism, no modulation of the MMN by prosody was present and sensory processing of both neutral and emotional vocal stimuli appeared atypical. CONCLUSIONS: Overall, change detection remains altered in people with autism. However, differences between children and adults with ASD evidence a trend toward normalization of vocal processing and of the automatic detection of emotion deviancy with age.

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Authors
Charpentier, J., Kovarski, K., Houy-Durand, E., Malvy, J., Saby, A., Bonnet-Brilhault, F., Latinus, M., & Gomot, M.
Affiliations
  • Université de Tours (FR)
  • Centre Hospitalier Universitaire de Tours (FR)
Corresponding author
Gomot, M.
Venue
Journal of Neurodevelopmental Disorders
Published
2018-09-18
Volume
10
Issue
1
Pages
28-28
ISSN
  • 1866-1947 (ISSN-L)
  • 1866-1955
OpenAlex
W2891125374
Cited by
39
References
3
Citations by year
2026: 4 · 2025: 5 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 9 · 2020: 5 · 2019: 5
FWCI
2.83
Type
journal article
Language
en
Open access
Locations
  • Journal of Neurodevelopmental Disorders (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • Agence Nationale de la Recherche (ANR-12-JSH2-0001-01-AUTATTEN)
  • INSERM- Région Centre
  • John Bost Foundation
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
autism spectrum disorder, emotional prosody, change detection, mismatch negativity, P3a, auditory deviance, socio-emotional processing, auditory sensory processing, hemispheric lateralization, age differences, children and adults
MeSH terms
Autism Spectrum Disorder, Acoustic Stimulation, Adolescent, Adult, Attention, Brain, Child, Electroencephalography, Emotions, Evoked Potentials, Female, Humans, Male, Speech Perception, Young Adult

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