The integration of prosodic speech in high functioning autism: a preliminary FMRI study
Open accessAbstract
BACKGROUND: Autism is a neurodevelopmental disorder characterized by a specific triad of symptoms such as abnormalities in social interaction, abnormalities in communication and restricted activities and interests. While verbal autistic subjects may present a correct mastery of the formal aspects of speech, they have difficulties in prosody (music of speech), leading to communication disorders. Few behavioural studies have revealed a prosodic impairment in children with autism, and among the few fMRI studies aiming at assessing the neural network involved in language, none has specifically studied prosodic speech. The aim of the present study was to characterize specific prosodic components such as linguistic prosody (intonation, rhythm and emphasis) and emotional prosody and to correlate them with the neural network underlying them. METHODOLOGY/PRINCIPAL FINDINGS: We used a behavioural test (Profiling Elements of the Prosodic System, PEPS) and fMRI to characterize prosodic deficits and investigate the neural network underlying prosodic processing. Results revealed the existence of a link between perceptive and productive prosodic deficits for some prosodic components (rhythm, emphasis and affect) in HFA and also revealed that the neural network involved in prosodic speech perception exhibits abnormal activation in the left SMG as compared to controls (activation positively correlated with intonation and emphasis) and an absence of deactivation patterns in regions involved in the default mode. CONCLUSIONS/SIGNIFICANCE: These prosodic impairments could not only result from activation patterns abnormalities but also from an inability to adequately use the strategy of the default network inhibition, both mechanisms that have to be considered for decreasing task performance in High Functioning Autism.
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Individuals with ASD fail to fully deactivate the default mode network during speech processing.
“individuals with ASD fail to fully deactivate the DMN, a sign of weak neural coherence between disparate brain regions, during speech processing (Hesling et al., 2010)”
From Behavioral, Perceptual, and Neural Alterations in Sensory and Multisensory Function in Autism Spectrum Disorder (2015) · cites this paper as Hesling et al., 2010
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“Further evidence of altered neural responses to prosody comes from studies of irony (Wang et al., 2006), prosody perception (Hesling et al., 2010), and word-level affective prosody (Korpilahti et al., 2007).”
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- Authors
- Hesling, I., Dilharreguy, B., Peppé, S., Amirault, M., Bouvard, M., & Allard, M.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Queen Margaret University (GB)
- Corresponding author
- Hesling, Isabelle
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2010-07-13
- Volume
- 5
- Issue
- 7
- Pages
- e11571
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC2903486
- OpenAlex
- W2001012387
- Cited by
- 67
- References
- 63
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 7 · 2019: 2 · 2018: 5 · 2017: 8 · 2016: 5 · 2015: 7 · 2014: 3 · 2013: 8 · 2012: 4
- FWCI
- 3.10
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Queen Margaret University Publications Repository (Queen Margaret University) (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Queen Margaret University Publications Repository (Queen Margaret University) (submittedVersion)
- Funders
- Fondation de France
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Social Sciences › Psychology › Developmental and Educational Psychology › Language Development and Disorders
- Keywords
- high-functioning autism, linguistic prosody, emotional prosody, intonation, prosodic rhythm, emphasis, default mode network
- MeSH terms
- Adult, Autistic Disorder, Humans, Magnetic Resonance Imaging, Male, Speech, Case-Control Studies, Young Adult
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