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Short-chain perfluoroalkyl acids: environmental concerns and a regulatory strategy under REACH

Open access
Brendel, Stephan, Fetter, Éva, Staude, Claudia, Vierke, Lena, Biegel-Engler, Annegret·2018·Environmental Sciences Europe

Abstract

BACKGROUND: Short-chain PFASs (per- and polyfluoroalkyl substances) are widely used as alternatives to long-chain PFASs. Long-chain PFASs become gradually regulated under REACH (EC No. 1907/2006) and other international regulations, due to having persistent, bioaccumulative and toxic properties and/or being toxic for reproduction. The increasingly used short-chain PFASs are assumed to have a lower bioaccumulation potential. Nonetheless, they have other properties of concern and are already widely distributed in the environment, also in remote regions. The REACH Regulation does not directly address these emerging properties of concern, complicating the implementation of regulatory measures. Therefore, this study illustrates these environmental concerns and provides a strategy for a regulation of short-chain PFASs within REACH. RESULTS: Short-chain PFASs have a high mobility in soil and water, and final degradation products are extremely persistent. This results in a fast distribution to water resources, and consequently, also to a contamination of drinking water resources. Once emitted, short-chain PFASs remain in the environment. A lack of appropriate water treatment technologies results in everlasting background concentrations in the environment, and thus, organisms are permanently and poorly reversibly exposed. Considering such permanent exposure, it is very difficult to estimate long-term adverse effects in organisms. Short-chain PFASs enrich in edible parts of plants and the accumulation in food chains is unknown. Regarding these concerns and uncertainties, especially with respect to the precautionary principle, short-chain PFASs are of equivalent concern to PBT substances. Therefore, they should be identified as substances of very high concern (SVHC) under REACH. The SVHC identification should be followed by a restriction under REACH, which is the most efficient way to minimize the environmental and human exposure of short-chain PFASs in the European Union. CONCLUSION: Due to an increasing use of short-chain PFASs, an effective regulation is urgently needed. The concerns of short-chain PFASs do not match the "classical" concerns as defined under REACH, but are not of minor concern. Therefore, it is of advantage to clearly define the concerns of short-chain PFASs. This might facilitate the following restriction process under REACH.

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Research works printed but not linked: 43

  1. Siegemund G, Schwertfeger W, Feiring A, Smart B, Behr F, Vogel H, McKusick B, Kirsch P (2000) Fluorine compounds, organic. Ullmann’s encyclopedia of industrial chemistry. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
  2. Gremmel C, Frömel T, Knepper TP (2016) Systematic determination of perfluoroalkyl and polyfluoroalkyl substances (PFASs) in outdoor jackets. Chemosphere 160:173–180 · DOI
  3. Wang Z, Cousins IT, Scheringer M, Buck RC, Hungerbühler K (2014) Global emission inventories for C4–C14 perfluoroalkyl carboxylic acid (PFCA) homologues from 1951 to 2030, Part I: production and emissions from quantifiable sources. Environ Int 70:62–75 · DOI · Paper page
  4. Fischer S, Lilja K, Ahrens L, Wiberg K (2016) Poly- and perfluoroalkyl substances on the market and in the Swedish environment. Norman Bull 5:6–9
  5. Houde M, Martin JW, Letcher RJ, Solomon KR, Muir DC (2006) Biological monitoring of polyfluoroalkyl substances: a review. Environ Sci Technol 40:3463–3473 · DOI · Paper page
  6. Cousins IT, Kong D, Vestergren R (2011) Reconciling measurement and modelling studies of the sources and fate of perfluorinated carboxylates. Environ Chem 8(4):339–354 · DOI
  7. Scheringer M, Trier X, Cousins IT, de Voogt P, Fletcher T, Wang Z, Webster TF (2014) Helsingør statement on poly-and perfluorinated alkyl substances (PFASs). Chemosphere 114:337–339 · DOI · Paper page
  8. Bowman JS (2015) Fluorotechnology is critical to modern life: the FluoroCouncil counterpoint to the Madrid Statement. Environ Health Perspect 123:A112
  9. Schwanz TG, Llorca M, Farré M, Barceló D (2016) Perfluoroalkyl substances assessment in drinking waters from Brazil, France and Spain. Sci Total Environ 539:143–152 · DOI · Paper page
  10. Gellrich V, Brunn H, Stahl T (2013) Perfluoroalkyl and polyfluoroalkyl substances (PFASs) in mineral water and tap water. J Environ Sci Health A Tox Hazard Subst Environ Eng 48:129–135 · DOI
  11. Shafique U, Schulze S, Slawik C, Böhme A, Paschke A, Schüürmann G (2017) Perfluoroalkyl acids in aqueous samples from Germany and Kenya. Environ Sci Pollut Res 24:11031–11043 · DOI
  12. Kirchgeorg T, Dreyer A, Gabrieli J, Kehrwald N, Sigl M, Schwikowski M, Boutron C, Gambaro A, Barbante C, Ebinghaus R (2013) Temporal variations of perfluoroalkyl substances and polybrominated diphenyl ethers in alpine snow. Environ Pollut 178:367–374 · DOI · Paper page
  13. Gebbink WA, Bignert A, Berger U (2016) Perfluoroalkyl Acids (PFAAs) and selected precursors in the Baltic Sea environment: do precursors play a role in food web accumulation of PFAAs? Environ Sci Technol 50:6354–6362 · DOI
  14. Li L, Liu J, Hu J, Wania F (2017) Degradation of fluorotelomer-based polymers contributes to the global occurrence of fluorotelomer alcohol and perfluoroalkyl carboxylates: A combined dynamic substance flow and environmental fate modeling analysis. Environ Sci Technol 51(8):4461–4470 · DOI · Paper page
  15. Kjølholt J, Jensen A, Warming M (2015) Short-chain Polyfluoroalkyl Substances (PFAS): a literature review of information on human health effects and environmental fate and effect aspects of short-chain PFAS. Danish Ministry of the Environment. Project no. 1707. https://www2.mst.dk/Udgiv/publications/2015/05/978-87-93352-15-5.pdf . Accessed 15 Jan 2018
  16. Hagenaars A, Meyer I, Herzke D, Pardo B, Martinez P, Pabon M, De Coen W, Knapen D (2011) The search for alternative aqueous film forming foams (AFFF) with a low environmental impact: physiological and transcriptomic effects of two Forafac® fluorosurfactants in turbot. Aquat Toxicol 104(3):168–176 · DOI · Paper page
  17. Herzke D, Olsson E, Posner S (2012) Perfluoroalkyl and polyfluoroalkyl substances (PFASs) in consumer products in Norway: a pilot study. Chemosphere 88:980–987 · DOI · Paper page
  18. Fujii Y, Harada KH, Koizumi A (2013) Occurrence of perfluorinated carboxylic acids (PFCAs) in personal care products and compounding agents. Chemosphere 93:538–544 · DOI · Paper page
  19. Parsons JR, Sáez M, Dolfing J, de Voogt P (2008) Biodegradation of perfluorinated compounds. Rev Environ Contam Toxicol 196:53–71
  20. D’Agostino LA, Mabury SA (2017) Aerobic biodegradation of two fluorotelomer sulfonamide-based aqueous film forming foam components produces perfluoroalkyl carboxylates. Environ Toxicol Chem 36:2012–2021 · DOI
  21. Wang Z, MacLeod M, Cousins IT, Scheringer M, Hungerbühler K (2011) Using COSMOtherm to predict physicochemical properties of poly-and perfluorinated alkyl substances (PFASs). Environ Chem 8:389–398 · DOI · Paper page
  22. Vierke L, Möller A, Klitzke S (2014) Transport of perfluoroalkyl acids in a water-saturated sediment column investigated under near-natural conditions. Environ Pollut 186:7–13 · DOI · Paper page
  23. Boiteux V, Dauchy X, Bach C, Colin A, Hemard J, Sagres V, Rosin C, Munoz J-F (2017) Concentrations and patterns of perfluoroalkyl and polyfluoroalkyl substances in a river and three drinking water treatment plants near and far from a major production source. Sci Total Environ 583:393–400 · DOI · Paper page
  24. Lundgren S (2014) Evaluation of the efficiency of treatment techniques in removing perfluoroalkyl substances from water. Dissertation, Uppsala University. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-231195
  25. Rahman MF, Peldszus S, Anderson WB (2014) Behaviour and fate of perfluoroalkyl and polyfluoroalkyl substances (PFASs) in drinking water treatment: a review. Water Res 50:318–340 · DOI · Paper page
  26. Soriano Á, Gorri D, Urtiaga A (2017) Efficient treatment of perfluorohexanoic acid by nanofiltration followed by electrochemical degradation of the NF concentrate. Water Res 112:147–156 · DOI · Paper page
  27. Llorca M, Farré M, Tavano MS, Alonso B, Koremblit G, Barceló D (2012) Fate of a broad spectrum of perfluorinated compounds in soils and biota from Tierra del Fuego and Antarctica. Environ Pollut 163:158–166 · DOI
  28. Kirchgeorg T, Dreyer A, Gabrielli P, Gabrieli J, Thompson L, Barbante C, Ebinghaus R (2016) Seasonal accumulation of persistent organic pollutants on a high altitude glacier in the Eastern Alps. Environ Pollut 218:804–812 · DOI
  29. Lam JC, Lyu J, Kwok KY, Lam PK (2016) Perfluoroalkyl Substances (PFASs) in marine mammals from the South China Sea and their temporal changes 2002–2014: Concern for alternatives of PFOS? Environ Sci Technol 50:6728–6736 · DOI · Paper page
  30. Shiwaku Y, Lee P, Thepaksorn P, Zheng B, Koizumi A, Harada KH (2016) Spatial and temporal trends in perfluorooctanoic and perfluorohexanoic acid in well, surface, and tap water around a fluoropolymer plant in Osaka, Japan. Chemosphere 164:603–610 · DOI
  31. Land M, de Wit CA, Cousins IT, Herzke D, Johansson J, Martin JW (2017) What is the effect of phasing out long-chain per-and polyfluoroalkyl substances on the concentrations of perfluoroalkyl acids and their precursors in the environment? A systematic review protocol. Environ Evid 4(1):3 · DOI
  32. Renner R (2006) The long and the short of perfluorinated replacements. Environ Sci Technol 40:12–13 · DOI · Paper page
  33. Chengelis CP, Kirkpatrick JB, Myers NR, Shinohara M, Stetson PL, Sved DW (2009) Comparison of the toxicokinetic behavior of perfluorohexanoic acid (PFHxA) and nonafluorobutane-1-sulfonic acid (PFBS) in cynomolgus monkeys and rats. Reprod Toxicol 27:400–406 · DOI
  34. Gannon SA, Johnson T, Nabb DL, Serex TL, Buck RC, Loveless SE (2011) Absorption, distribution, metabolism, and excretion of [1–14 C]-perfluorohexanoate ([14 C]-PFHx) in rats and mice. Toxicology 283:55–62 · DOI
  35. Nilsson H, Kärrman A, Westberg H, Rotander A, Van Bavel B, Lindström G (2010) A time trend study of significantly elevated perfluorocarboxylate levels in humans after using fluorinated ski wax. Environ Sci Technol 44:2150–2155 · DOI
  36. Chen Y-M, Guo L-H (2009) Fluorescence study on site-specific binding of perfluoroalkyl acids to human serum albumin. Arch Toxicol 83:255 · DOI · Paper page
  37. Bogdanska J, Sundström M, Bergström U, Borg D, Abedi-Valugerdi M, Bergman Å, DePierre J, Nobel S (2014) Tissue distribution of 35S-labelled perfluorobutanesulfonic acid in adult mice following dietary exposure for 1–5 days. Chemosphere 98:28–36 · DOI
  38. Burkemper JL, Aweda TA, Rosenberg AJ, Lunderberg D, Peaslee GF, Lapi SE (2017) Radiosynthesis and biological distribution of [18F]-labeled perfluorinated alkyl substances. Environ Sci Technol Lett 4:211–215 · DOI
  39. Lilienthal H, Dieter HH, Hölzer J, Wilhelm M (2017) Recent experimental results of effects of perfluoroalkyl substances in laboratory animals—relation to current regulations and guidance values. Int J Hyg Environ Health 220:766–775 · DOI · Paper page
  40. Felizeter S, McLachlan MS, de Voogt P (2012) Uptake of perfluorinated alkyl acids by hydroponically grown lettuce (Lactuca sativa). Environ Sci Technol 46:11735–11743 · DOI · Paper page
  41. Müller CE, De Silva AO, Small J, Williamson M, Wang X, Morris A, Katz S, Gamberg M, Muir DC (2011) Biomagnification of perfluorinated compounds in a remote terrestrial food chain: lichen–caribou–wolf. Environ Sci Technol 45:8665–8673 · DOI · Paper page
  42. Navarro I, de la Torre A, Sanz P, Pro J, Carbonell G, de los Ángeles Martínez M (2016) Bioaccumulation of emerging organic compounds (perfluoroalkyl substances and halogenated flame retardants) by earthworm in biosolid amended soils. Environ Res 149:32–39 · DOI · Paper page
  43. German Environment Agency (2017) Fortschreibung der vorläufigen Bewertung von per-und polyfluorierten Chemikalien (PFC) im Trinkwasser (in German). Bundesgesundheitsblatt 60:350–352 · DOI

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Metadata

Authors
Brendel, S., Fetter, É., Staude, C., Vierke, L., & Biegel-Engler, A.
Venue
Environmental Sciences Europe
Published
2018-02-27
Volume
30
Issue
1
Pages
9-9
ISSN
  • 2190-4715 (ISSN-L)
  • 2190-4707
OpenAlex
W2791402978
Cited by
751
References
23
FWCI
19.05
Type
journal article
Language
en
Open access
gold
Licence
creativecommons.org/licenses/by/4.0 (tdm)

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Brendel, S., Fetter, É., Staude, C., Vierke, L., & Biegel-Engler, A. (2018). Short-chain perfluoroalkyl acids: environmental concerns and a regulatory strategy under REACH. Environmental Sciences Europe. https://doi.org/10.1186/s12302-018-0134-4

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