The ubiquitin–proteasome system in regulation of the skeletal muscle homeostasis and atrophy: from basic science to disorders

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

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Induction of the Vitamin D Receptor Attenuates Autophagy Dysfunction-Mediated Cell Death Following Traumatic Brain Injury

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p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy

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The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction

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Autophagy regulates lipid metabolism

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Identification of ubiquitin ligases required for skeletal muscle atrophy.

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Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.

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The role of autophagy during the early neonatal starvation period

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Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules.

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Function and regulation of cullin–RING ubiquitin ligases

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In Vivo Analysis of Autophagy in Response to Nutrient Starvation Using Transgenic Mice Expressing a Fluorescent Autophagosome Marker

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Protein degradation and protection against misfolded or damaged proteins.

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Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

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The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors.

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FoxO3 Controls Autophagy in Skeletal Muscle In Vivo

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Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy

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The 26S Proteasome: A Molecular Machine Designed for Controlled Proteolysis

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Cancer cachexia: understanding the molecular basis

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The Proteasome: Paradigm of a Self-Compartmentalizing Protease

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FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells.

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IKKβ/NF-κB Activation Causes Severe Muscle Wasting in Mice

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Autophagy is required to maintain muscle mass.

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Satellite cells, connective tissue fibroblasts and their interactions are crucial for muscle regeneration

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HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS.

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Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia

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Correlation of Terminal Cell Cycle Arrest of Skeletal Muscle with Induction of p21 by MyoD

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PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription

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The proteasome: overview of structure and functions

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A 26 S protease subunit that binds ubiquitin conjugates.

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Prognostic importance of weight loss in chronic heart failure and the effect of treatment with angiotensin-converting-enzyme inhibitors: an observational study

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Back to the Future with Ubiquitin

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HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin.

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Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy

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<emph type="ital">SQSTM1</emph> Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

Fecto, F. (2011) · Archives of Neurology · doi:10.1001/archneurol.2011.250 · Cited by 650

During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation

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Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85

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BMP signaling controls muscle mass

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Atrogin-1/muscle atrophy F-box inhibits calcineurin-dependent cardiac hypertrophy by participating in an SCF ubiquitin ligase complex

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Classification and management of adult inflammatory myopathies

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Autophagy revisited: A conversation with Christian de Duve

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RPN-6 determines C. elegans longevity under proteotoxic stress conditions

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The Multiubiquitin-Chain-Binding Protein Mcb1 Is a Component of the 26S Proteasome in Saccharomyces cerevisiae and Plays a Nonessential, Substrate-Specific Role in Protein Turnover

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Therapeutic developments for Duchenne muscular dystrophy

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The role and regulation of MAFbx/atrogin-1 and MuRF1 in skeletal muscle atrophy

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Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I

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Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction

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Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production

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Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1

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Limb-girdle muscular dystrophy type 2G is caused by mutations in the gene encoding the sarcomeric protein telethonin

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PSMB8 Encoding the β5i Proteasome Subunit Is Mutated in Joint Contractures, Muscle Atrophy, Microcytic Anemia, and Panniculitis-Induced Lipodystrophy Syndrome

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Proteasome assembly defect due to a proteasome subunit beta type 8 (PSMB8) mutation causes the autoinflammatory disorder, Nakajo-Nishimura syndrome

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Sustained Activation of mTORC1 in Skeletal Muscle Inhibits Constitutive and Starvation-Induced Autophagy and Causes a Severe, Late-Onset Myopathy

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Genetic Evidence Linking Age-Dependent Attenuation of the 26S Proteasome with the Aging Process

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Proteasome Active Sites Allosterically Regulate Each Other, Suggesting a Cyclical Bite-Chew Mechanism for Protein Breakdown

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Effects of food deprivation on protein synthesis and degradation in rat skeletal muscles

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Inclusion body myositis: clinical features and pathogenesis

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Myosin accumulation and striated muscle myopathy result from the loss of muscle RING finger 1 and 3

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Proteasomal inhibition by misfolded mutant superoxide dismutase 1 induces selective motor neuron death in familial amyotrophic lateral sclerosis

Urushitani, M., Kurisu, J., Tsukita, K., & Takahashi, R. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01211.x · Cited by 278

Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1

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Contribution of Proteasomal β-Subunits to the Cleavage of Peptide Substrates Analyzed with Yeast Mutants

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Altered proteasome structure, function, and oxidation in aged muscle.

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A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes

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Age-Dependent Declines in Proteasome Activity in the Heart

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Targeted ablation of TRAF6 inhibits skeletal muscle wasting in mice

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Diaphragm Muscle Fiber Weakness and Ubiquitin–Proteasome Activation in Critically Ill Patients

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CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia

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Cul3-KLHL20 Ubiquitin Ligase Governs the Turnover of ULK1 and VPS34 Complexes to Control Autophagy Termination

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Skeletal muscle gene expression in space-flown rats

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Ubiquitylation by Trim32 causes coupled loss of desmin, Z-bands, and thin filaments in muscle atrophy

Cohen, S., Zhai, B., Gygi, S. P., & Goldberg, A. L. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201110067 · Cited by 205

Biomaterials for skeletal muscle tissue engineering

Kwee, B. J., & Mooney, D. J. (2017) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2017.05.003 · Cited by 204

K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking

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SQSTM1Mutations in French Patients With Frontotemporal Dementia or Frontotemporal Dementia With Amyotrophic Lateral Sclerosis

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Ubiquitin Ligase Cbl-b Is a Negative Regulator for Insulin-Like Growth Factor 1 Signaling during Muscle Atrophy Caused by Unloading

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Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis.

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The ubiquitin proteasome system in atrophying skeletal muscle: roles and regulation

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CHIP promotes proteasomal degradation of familial ALS‐linked mutant SOD1 by ubiquitinating Hsp/Hsc70

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Decreased Proteasomal Activity Causes Age-Related Phenotypes and Promotes the Development of Metabolic Abnormalities

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Misregulation of autophagy and protein degradation systems in myopathies and muscular dystrophies.

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Runx1 prevents wasting, myofibrillar disorganization, and autophagy of skeletal muscle

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Identification of KLHL41 Mutations Implicates BTB-Kelch-Mediated Ubiquitination as an Alternate Pathway to Myofibrillar Disruption in Nemaline Myopathy

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Untitled work

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Dominant Mutations in KBTBD13, a Member of the BTB/Kelch Family, Cause Nemaline Myopathy with Cores

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Kelch proteins: emerging roles in skeletal muscle development and diseases

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The MCK enhancer contains a p53 responsive element.

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The E3 Ubiquitin Ligase TRAF6 Intercedes in Starvation-Induced Skeletal Muscle Atrophy through Multiple Mechanisms

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Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals

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