Small‐molecule‐mediated chemical knock‐down of MuRF1/MuRF2 and attenuation of diaphragm dysfunction in chronic heart failure
Open accessAbstract
Background: Chronic heart failure (CHF) leads to diaphragm myopathy that significantly impairs quality of life and worsens prognosis. In this study, we aimed to assess the efficacy of a recently discovered small‐molecule inhibitor of MuRF1 in treating CHF‐induced diaphragm myopathy and loss of contractile function. Methods: Myocardial infarction was induced in mice by ligation of the left anterior descending coronary artery. Sham‐operated animals (sham) served as controls. One week post‐left anterior descending coronary artery ligation animals were randomized into two groups—one group was fed control rodent chow, whereas the other group was fed a diet containing 0.1% of the compound ID#704946—a recently described MuRF1‐interfering small molecule. Echocardiography confirmed development of CHF after 10 weeks. Functional and molecular analysis of the diaphragm was subsequently performed. Results: Chronic heart failure induced diaphragm fibre atrophy and contractile dysfunction by ~20%, as well as decreased activity of enzymes involved in mitochondrial energy production (P < 0.05). Treatment with compound ID#704946 in CHF mice had beneficial effects on the diaphragm: contractile function was protected, while mitochondrial enzyme activity and up‐regulation of the MuRF1 and MuRF2 was attenuated after infarct. Conclusions: Our murine CHF model presented with diaphragm fibre atrophy, impaired contractile function, and reduced mitochondrial enzyme activities. Compound ID#704946 rescued from this partially, possibly by targeting MuRF1/MuRF2. However, at this stage of our study, we refrain to claim specific mechanism(s) and targets of compound ID#704946, because the nature of changes after 12 weeks of feeding is likely to be complex and is not necessarily caused by direct mechanistic effects.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A specific inhibitor of MuRF1 was developed and a protective effect in atrophying muscles of mice with heart failure was found.
“Interestingly, a specific inhibitor of the muscle-specific ubiquitin ligase MuRF1 was developed and a protective effect in atrophying muscles of mice with heart failure was found100.”
From Mechanisms of muscle atrophy and hypertrophy: implications in health and disease (2021) · cites this paper as [100]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · see citing works
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709 · see citing works
HTSeq—a Python framework to work with high-throughput sequencing data
Anders, S., Pyl, P. T., & Huber, W. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btu638 · Cited by 21,464 · see citing works
Cox, J., & Mann, M. (2008) · Nature Biotechnology · doi:10.1038/nbt.1511 · Cited by 14,855 · see citing works
Elias, J. E., & Gygi, S. P. (2007) · Nature Methods · doi:10.1038/nmeth1019 · Cited by 3,925 · see citing works
Identification of ubiquitin ligases required for skeletal muscle atrophy.
Bodine, S. C., Latres, E., Baumhueter, S., Lai, V. K.-M., Nunez, L., Clarke, B. A., Poueymirou, W. T., Panaro, F. J., Na, E., Dharmarajan, K., et al. (2001) · Science · doi:10.1126/science.1065874 · Cited by 3,521 · see citing works
Martin, L., Birdsell, L., Macdonald, N., Reiman, T., Clandinin, M. T., McCargar, L. J., Murphy, R. A., Ghosh, S., Sawyer, M. B., & Baracos, V. E. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.45.2722 · Cited by 2,698 · see citing works
Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression
Lecker, S. H., Jagoe, R. T., Gilbert, A., Gomes, M., Baracos, V., Bailey, J., Price, S. R., Mitch, W. E., & Goldberg, A. L. (2004) · The FASEB Journal · doi:10.1096/fj.03-0610com · Cited by 1,539 · see citing works
Multiplex peptide stable isotope dimethyl labeling for quantitative proteomics
Boersema, P. J., Raijmakers, R., Lemeer, S., Mohammed, S., & Heck, A. J. R. (2009) · Nature Protocols · doi:10.1038/nprot.2009.21 · Cited by 1,359 · see citing works
Cellular and molecular mechanisms of muscle atrophy
Bonaldo, P., & Sandri, M. (2013) · Disease Models & Mechanisms · doi:10.1242/dmm.010389 · Cited by 1,284 · see citing works
Muscle wasting in disease: molecular mechanisms and promising therapies
Cohen, S., Nathan, J. A., & Goldberg, A. L. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4467 · Cited by 1,089 · see citing works
Mitonuclear protein imbalance as a conserved longevity mechanism
Houtkooper, R. H., Mouchiroud, L., Ryu, D., Moullan, N., Katsyuba, E., Knott, G., Williams, R. W., & Auwerx, J. (2013) · Nature · doi:10.1038/nature12188 · Cited by 1,035 · see citing works
Lecker, S. H., Solomon, V., Mitch, W. E., & Goldberg, A. L. (1999) · Journal of Nutrition · doi:10.1093/jn/129.1.227s · Cited by 732 · see citing works
Protein breakdown in muscle wasting: Role of autophagy-lysosome and ubiquitin-proteasome
Sandri, M. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.04.023 · Cited by 689 · see citing works
The E3 Ligase MuRF1 Degrades Myosin Heavy Chain Protein in Dexamethasone-Treated Skeletal Muscle
Clarke, B. A., Drujan, D., Willis, M. S., Murphy, L. O., Corpina, R. A., Burova, E., Rakhilin, S. V., Stitt, T. N., Patterson, C., Latres, E., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.09.009 · Cited by 683 · see citing works
Fulster, S., Tacke, M., Sandek, A., Ebner, N., Tschope, C., Doehner, W., Anker, S. D., & von Haehling, S. (2013) · European Heart Journal · doi:10.1093/eurheartj/ehs381 · Cited by 658 · see citing works
Muscle strength and body mass index as long-term predictors of mortality in initially healthy men
Rantanen, T., Harris, T., Leveille, S. G., Visser, M., Foley, D., Masaki, K., & Guralnik, J. M. (2000) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/55.3.m168 · Cited by 647 · see citing works
Cohen, S., Brault, J. J., Gygi, S. P., Glass, D. J., Valenzuela, D. M., Gartner, C. A., Latres, E., & Goldberg, A. L. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200901052 · Cited by 584 · see citing works
Lenk, K., Schuler, G. C., & Adams, V. (2010) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1007/s13539-010-0007-1 · Cited by 492 · see citing works
Self-citationDemoule, A., Jung, B., Prodanovic, H., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201209-1668oc · Cited by 459 · see citing works
Bowen, T. S., Schuler, G. C., & Adams, V. (2015) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12043 · Cited by 429 · see citing works
Self-citationEthical guidelines for publishing in the journal of cachexia, sarcopenia and muscle: update 2017
von Haehling, S., Morley, J. E., Coats, A. J. S., & Anker, S. D. (2017) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12261 · Cited by 351 · see citing works
Li, Y.-P., Chen, Y., Li, A. S., & Reid, M. B. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00129.2003 · Cited by 313 · see citing works
Witt, S. H., Granzier, H. L. M., Witt, C. C., & Labeit, S. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.05.021 · Cited by 310 · see citing works
Self-citationWannamethee, S. G., Shaper, A. G., Lennon, L., & Whincup, P. H. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1339 · Cited by 307 · see citing works
The ubiquitin–proteasome system and skeletal muscle wasting
Attaix, D., Ventadour, S., Codran, A., Béchet, D., Taillandier, D., & Combaret, L. (2005) · Essays in Biochemistry · doi:10.1042/eb0410173 · Cited by 253 · see citing works
Muscle sparing in muscle RING finger 1 null mice: response to synthetic glucocorticoids
Baehr, L. M., Furlow, J. D., & Bodine, S. C. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.212845 · Cited by 234 · see citing works
Diaphragm Muscle Fiber Weakness and Ubiquitin–Proteasome Activation in Critically Ill Patients
Hooijman, P. E., Beishuizen, A., Witt, C. C., de Waard, M. C., Girbes, A. R. J., de Man, A., Niessen, H. W. M., Manders, E., van Hees, H. W. H., van den Brom, C. E., et al. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201412-2214oc · Cited by 230 · see citing works
Self-citationGielen, S., Sandri, M., Kozarez, I., Kratzsch, J., Teupser, D., Thiery, J., Erbs, S., Mangner, N., Lenk, K., Hambrecht, R., et al. (2012) · Circulation · doi:10.1161/circulationaha.111.047381 · Cited by 203 · see citing works
Self-citationMuscle Ring Finger 1, but not Muscle Ring Finger 2, Regulates Cardiac Hypertrophy In Vivo
Willis, M. S., Ike, C., Li, L., Wang, D.-Z., Glass, D. J., & Patterson, C. (2007) · Circulation Research · doi:10.1161/01.res.0000259559.48597.32 · Cited by 174 · see citing works
Bowen, T. S., Rolim, N. P. L., Fischer, T., Bækkerud, F. H., Medeiros, A., Werner, S., Brønstad, E., Rognmo, O., Mangner, N., Linke, A., et al. (2015) · European Journal of Heart Failure · doi:10.1002/ejhf.239 · Cited by 165 · see citing works
Self-citationInspiratory Muscle Weakness and Dyspnea in Chronic Heart Failure
McParland, C., Krishnan, B., Wang, Y., et al. (1992) · American Review of Respiratory Disease · doi:10.1164/ajrccm/146.2.467 · Cited by 164 · see citing works
Increased Proteolysis, Myosin Depletion, and Atrophic AKT-FOXO Signaling in Human Diaphragm Disuse
Levine, S., Biswas, C., Dierov, J. K., Barsotti, R., Shrager, J. B., Nguyen, T., Sonnad, S. S., Kucharchzuk, J. C., Kaiser, L. R., Singhal, S. K., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200910-1487oc · Cited by 157 · see citing works
Respiratory muscle function and exercise intolerance in heart failure
Ribeiro, J. P., Chiappa, G. R., Neder, J. A., & Frankenstein, L. (2009) · Current Heart Failure Reports · doi:10.1007/s11897-009-0015-7 · Cited by 125 · see citing works
Diaphragm Strength In Chronic Heart Failure
Hughes, P. D., Polkey, M. I., HARRIS, M. L., et al. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.160.2.9810081 · Cited by 119 · see citing works
Bowen, T. S., Adams, V., Werner, S., Fischer, T., Vinke, P., Brögger, M. N., Mangner, N., Linke, A. H.-P., Sehr, P. A., Lewis, J., et al. (2017) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12233 · Cited by 107 · see citing works
Self-citationInduction of MuRF1 Is Essential for TNF-α-Induced Loss of Muscle Function in Mice
Adams, V., Mangner, N., Gasch, A., Krohne, C., Gielen, S., Hirner, S., Thierse, H., Witt, C. C., Linke, A., Schuler, G. C., et al. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.08.087 · Cited by 104 · see citing works
Self-citationMeasurement of total lactate dehydrogenase activity.
VANDERLINDE, R. E. (1985) · PubMed · Cited by 103 · see citing works
Molecular determinants for the recruitment of the ubiquitin‐ligase MuRF‐1 onto M‐line titin
Mrosek, M., Labeit, D., Witt, S. H., et al. (2007) · The FASEB Journal · doi:10.1096/fj.06-7644com · Cited by 97 · see citing works
Self-citationSuppression of atrogin-1 and MuRF1 prevents dexamethasone-induced atrophy of cultured myotubes
Castillero, E., Alamdari, N., Lecker, S. H., & Hasselgren, P.-O. (2013) · Metabolism · doi:10.1016/j.metabol.2013.05.018 · Cited by 88 · see citing works
Hirner, S., Krohne, C., Schuster, A., Hoffmann, S., Witt, S. H., Erber, R., Sticht, C., Gasch, A., Labeit, S., & Labeit, D. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.03.049 · Cited by 85 · see citing works
Self-citationDiaphragm Atrophy and Weakness in the Absence of Mitochondrial Dysfunction in the Critically Ill
van den Berg, M., Hooijman, P. E., Beishuizen, A., de Waard, M. C., Paul, M. A., Hartemink, K. J., van Hees, H. W. H., Lawlor, M. W., Brocca, L., Bottinelli, R., et al. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201703-0501oc · Cited by 85 · see citing works
The proteasome inhibitor MG132 reduces immobilization-induced skeletal muscle atrophy in mice
Caron, A. Z., Haroun, S., Leblanc, É., Trensz, F., Guindi, C., Amrani, A., & Grenier, G. (2011) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-12-185 · Cited by 80 · see citing works
Seiler, M., Bowen, T. S., Rolim, N. P. L., Dieterlen, M., Werner, S., Hoshi, T., Fischer, T., Mangner, N., Linke, A. H.-P., Schuler, G. C., et al. (2016) · Circulation Heart Failure · doi:10.1161/circheartfailure.116.003027 · Cited by 75 · see citing works
Self-citationYakabe, M., Ogawa, S., Ota, H., Iijima, K., Eto, M., Ouchi, Y., & Akishita, M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0191318 · Cited by 74 · see citing works
Mangner, N., Weikert, B., Bowen, T. S., Sandri, M., Höllriegel, R., Erbs, S., Hambrecht, R., Schuler, G. C., Linke, A., Gielen, S., et al. (2015) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12034 · Cited by 72 · see citing works
Self-citationMG132-mediated inhibition of the ubiquitin–proteasome pathway ameliorates cancer cachexia
Zhang, L., Tang, H., Kou, Y., Li, R., Zheng, Y., Wang, Q., Zhou, X., & Jin, L. (2013) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-013-1412-6 · Cited by 72 · see citing works
Ubiquitin-protein ligases in muscle wasting: multiple parallel pathways?
Lecker, S. H. (2003) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/01.mco.0000068963.34812.e5 · Cited by 71 · see citing works
Schwarzer, M., Osterholt, M., Lunkenbein, A., Schrepper, A., Amorim, P., & Doenst, T. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.274704 · Cited by 68 · see citing works
Effect of proteasome inhibitors on endotoxin-induced diaphragm dysfunction
Supinski, G. S., Vanags, J., & Callahan, L. A. (2009) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.90404.2008 · Cited by 68 · see citing works
Mitochondrial biogenesis and fragmentation as regulators of protein degradation in striated muscles
Romanello, V., & Sandri, M. (2012) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2012.08.001 · Cited by 67 · see citing works
Targeting the Ubiquitin E3 Ligase MuRF1 to Inhibit Muscle Atrophy
Eddins, M. J., Marblestone, J. G., Kumar, S., Leach, C. A., Sterner, D. E., Mattern, M. R., & Nicholson, B. (2011) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-011-9175-7 · Cited by 58 · see citing works
Carvalho, R. F., Castan, E. P., Coelho, C. A. O., Pacagnelli, F. L., de Almeida, F. L. A., Michelin, A. C., de Souza, R. W. A., Araújo, J. P., Cicogna, A. C., & Dal‐Pai‐Silva, M. (2010) · Journal of Molecular Histology · doi:10.1007/s10735-010-9262-x · Cited by 53 · see citing works
Liu, J., Peng, Y., Cui, Z., Wu, Z., Qian, A., Shang, P., Qu, L., Li, Y., Liu, J., & Long, J. (2012) · IUBMB Life · doi:10.1002/iub.1087 · Cited by 53 · see citing works
Noh, K. K., Chung, K. W., Choi, Y. J., Park, M. H., Jang, E. J., Park, C. H., Yoon, C., Kim, N. D., Kim, M. K., & Chung, H. Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102947 · Cited by 52 · see citing works
Polge, C., Cabantous, S., Deval, C., Claustre, A., Hauvette, A., Bouchenot, C., Aniort, J., Béchet, D., Combaret, L., Attaix, D., et al. (2017) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12249 · Cited by 51 · see citing works
Dzeja, P. P., Pucar, D., Redfield, M. M., et al. (1999) · Molecular and Cellular Biochemistry · doi:10.1023/a:1007016703229 · Cited by 50 · see citing works
Occurrence of two 3-Hydroxyacyl-CoA dehydrogenases in rat liver
Osumi, T., & Takashi, H. (1979) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(79)90007-9 · Cited by 48 · see citing works
Prevention of muscle disuse atrophy by MG132 proteasome inhibitor
Jamart, C., Raymackers, J., An, G.-L., Deldicque, L., & Francaux, M. (2011) · Muscle & Nerve · doi:10.1002/mus.21949 · Cited by 46 · see citing works
Titin and diaphragm dysfunction in mechanically ventilated rats
van Hees, H. W. H., Schellekens, W. M., Acuňa, G. L. A., Linkels, M., Hafmans, T. G. M., Ottenheijm, C. A. C., Granzier, H. L. M., Scheffer, G., van der Hoeven, J. G., Dekhuijzen, P. N. R., et al. (2012) · Intensive Care Medicine · doi:10.1007/s00134-012-2504-5 · Cited by 43 · see citing works
Bowen, T. S., Mangner, N., Werner, S., Glaser, S., Kullnick, Y., Schrepper, A., Doenst, T., Oberbach, A., Linke, A., Steil, L., et al. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00756.2014 · Cited by 41 · see citing works
Self-citationDiaphragm Atrophy and Contractile Dysfunction in a Murine Model of Pulmonary Hypertension
Ahn, B., Empinado, H. M., Al‐Rajhi, M., Judge, A. R., & Ferreira, L. F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062702 · Cited by 41 · see citing works
Laitano, O., Ahn, B., Patel, N. N., Coblentz, P. D., Smuder, A. J., Yoo, J., Christou, D. D., Adhihetty, P. J., & Ferreira, L. F. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00822.2015 · Cited by 39 · see citing works
Smuder, A. J., Nelson, W. B., Hudson, M. B., Kavazis, A. N., & Powers, S. K. (2014) · Anesthesiology · doi:10.1097/aln.0000000000000245 · Cited by 34 · see citing works
Mukherjee, A., Srere, P. A., & Frenkel, E. P. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33669-4 · Cited by 33 · see citing works
Bowen, T. S., Eisenkolb, S., Drobner, J., Fischer, T., Werner, S., Linke, A., Mangner, N., Schuler, G. C., & Adams, V. (2016) · The FASEB Journal · doi:10.1096/fj.201600672r · Cited by 26 · see citing works
Self-citationLoss of Sox9 in cardiomyocytes delays the onset of cardiac hypertrophy and fibrosis
Schauer, A., Adams, V., Poitz, D. M., Barthel, P., Joachim, D., Friedrich, J., Linke, A., & Augstein, A. (2019) · International Journal of Cardiology · doi:10.1016/j.ijcard.2019.01.078 · Cited by 26 · see citing works
Self-citationExercise Training Prevents Diaphragm Contractile Dysfunction in Heart Failure
Mangner, N., Bowen, T. S., Werner, S., FISCHER, T., Kullnick, Y., Oberbach, A., Linke, A., Steil, L., Schuler, G. C., & Adams, V. (2016) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001016 · Cited by 24 · see citing works
Self-citationProlonged mechanical ventilation worsens sepsis-induced diaphragmatic dysfunction in the rat
Dinh, M. L., Carreira, S., Obert, J., Gayan‐Ramirez, G., Riou, B., Beuvin, M., Similowski, T., Coirault, C., & Demoule, A. (2018) · PLoS ONE · doi:10.1371/journal.pone.0200429 · Cited by 20 · see citing works
Belova, S. P., Shenkman, B. S., Kostrominova, T. Y., & Nemirovskaya, T. L. (2017) · Physiological Reports · doi:10.14814/phy2.13291 · Cited by 16 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Mechanisms of muscle atrophy and hypertrophy: implications in health and disease
Sartori, R., Romanello, V., & Sandri, M. (2021) · Nature Communications · doi:10.1038/s41467-020-20123-1 · Cited by 940 · see citing works
Kitajima, Y., Yoshioka, K., & Suzuki, N. (2020) · The Journal of Physiological Sciences · doi:10.1186/s12576-020-00768-9 · Cited by 171 · see citing works
- Authors
- Adams, V., Bowen, T. S., Werner, S., Barthel, P., Amberger, C., Konzer, A., Graumann, J., Sehr, P., Lewis, J., Provaznik, J., Benes, V., Büttner, P., Gasch, A., Mangner, N., Witt, C. C., Labeit, D., Linke, A., & Labeit, S.
- Affiliations
- Herzzentrum Dresden Universitätsklinik (DE)
- University of Leeds (GB)
- Leipzig Heart Institute (DE)
- Max Planck Institute for Heart and Lung Research (DE)
- European Molecular Biology Laboratory (DE)
- European Molecular Biology Laboratory Heidelberg Germany
- University Clinic of Cardiology Heart Center Leipzig Leipzig Germany
- Heidelberg University (DE)
- Corresponding author
- Adams, Volker
- ORCID
- Venue
- Journal of Cachexia, Sarcopenia and Muscle
- Publisher
- Wiley
- Published
- 2019-05-29
- Volume
- 10
- Issue
- 5
- Pages
- 1102-1115
- ISSN
- 2190-5991 (ISSN-L)
- 2190-6009
- PMC
- PMC6818456
- OpenAlex
- W2947692027
- Cited by
- 51
- References
- 70
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 6 · 2023: 8 · 2022: 7 · 2021: 11 · 2020: 9
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Cachexia Sarcopenia and Muscle (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Horizon 2020 (645648)
- Fondation Leducq (13CVD04)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- chronic heart failure, MuRF1, MuRF2, small molecule inhibitors, contractile dysfunction, mitochondrial bioenergetics, myocardial infarction
- MeSH terms
- Tripartite Motif Proteins, Animals, Cell Line, Chronic Disease, Diaphragm, Echocardiography, Female, Heart Failure, Humans, Mitochondria, Muscle Contraction, Muscle Proteins, Proteomics, Ubiquitin-Protein Ligases, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
