Vitamin D supplementation improves SIRT1, Irisin, and glucose indices in overweight or obese type 2 diabetic patients: a double-blind randomized placebo-controlled clinical trial
Open accessAbstract
Background: Vitamin D (VD) may increase sirtuin 1 (SIRT1) and subsequently PPAR-γ coactivator 1α (PGC-1α) and irisin levels and these improvements may reduce insulin resistance (IR). The aim was to assess the effects of vitamin D supplementation on SIRT1, irisin, and IR in overweight/obese type 2 diabetes (T2D) patients. Methods: Ninety T2D males and females were recruited as a clinical trial study (mean of age and body mass index (BMI) of intervention and placebo groups were 50.05 ± 10.17 and 50.36 ± 10.2 yrs. and 31.37 ± 3.4 and 30.43 ± 3.2 kg/m 2, respectively). The inclusion criteria were T2D, VD deficient, BMI > 25 kg/m 2, and serum HbA1c < 8.5%. The exclusion criteria were using vitamin and mineral supplements, having any acute disease, recent modifying dose or type of drugs. The supplementation was 50,000 IU/week VD or placebo for 8 weeks. The demographic characteristics, anthropometrics, dietary intakes and physical activity status, sun exposure status, fasting blood sugar (FBS) and insulin, glycosylated hemoglobin (HbA1c), irisin, SIRT1, 25-hydroxy D3 (25(OH)VD), homeostasis model assessment of insulin resistance (HOMA-IR), and quantitative insulin sensitivity check index (QUICKI) were determined. The significant P-value was ≤0.05. Results: The increase of serum VD, SIRT1, and irisin in the intervention group was significant (p < 0.001). HbA1c was decreased significantly by 1%. The changes in the other glucose indices (FBS, insulin, and IR) were non-significant. Conclusions: VD supplementation may improve T2D by decreasing HbA1c and increasing SIRT1 and irisin in VD deficient T2D patients. Further trials are suggested. Trial registration: Iranian Registry of Clinical Trials, IRCT201604202365N11. Registered 21/08/2016,http://en.irct.ir/trial/2019.
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Traditional exogenous antioxidants and compounds with antioxidant properties reduce oxidative stress but have limited cellular uptake and do not accumulate where needed.
“Traditional exogenous antioxidants (for example, vitamins E, C and D), as well as chemical compounds with described antioxidants properties (for example, coenzyme Q, α-lipoic acid and N-acetylcysteine), have been used to reduce oxidative stress279,280, but their cellular uptake is limited and they do not accumulate where needed281.”
From Mitochondrial and metabolic dysfunction in ageing and age-related diseases (2022) · cites this paper as [279]
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- Authors
- Safarpour, P., Daneshi-Maskooni, M., Vafa, M., Nourbakhsh, M., Janani, L., Maddah, M., Amiri, F.-S., Mohammadi, F., & Sadeghi, H.
- Affiliations
- Iran University of Medical Sciences (IR)
- Guilan University of Medical Sciences (IR)
- University of Massachusetts Lowell (US)
- Corresponding author
- Vafa, Mohammadreza
- Venue
- BMC Family Practice
- Published
- 2020-02-07
- Volume
- 21
- Issue
- 1
- Pages
- 26-26
- ISSN
- 1471-2296 (ISSN-L)
- PMC
- PMC7007689
- OpenAlex
- W3009201497
- Cited by
- 100
- References
- 56
- Citations by year
- 2026: 10 · 2025: 9 · 2024: 20 · 2023: 20 · 2022: 24 · 2021: 12 · 2020: 4
- FWCI
- 9.83
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- BMC Family Practice (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Research Information System of Ardabil University of Medical Sciences (Ardabil University of Medical Sciences) (submittedVersion)
- Funders
- Iran University of Medical Sciences (1395.9223475201)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- vitamin D supplementation, type 2 diabetes, SIRT1, irisin, insulin resistance, obesity, overweight, HbA1c, 25-hydroxyvitamin D, PGC-1α, glucose metabolism, vitamin D deficiency, glycemic control, QUICKI, HOMA-IR, fasting insulin, fasting blood glucose, sun exposure, physical activity, dietary intake
- MeSH terms
- Adult, Blood Glucose, Calcifediol, Diabetes Mellitus, Type 2, Double-Blind Method, Female, Fibronectins, Glyburide, Glycated Hemoglobin, Humans, Hypoglycemic Agents, Insulin, Insulin Resistance, Iran, Male, Metformin, Middle Aged, Obesity, Vitamin D Deficiency, Treatment Outcome, Overweight, Sirtuin 1
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