Adherence therapy versus routine psychiatric care for people with schizophrenia spectrum disorders: a randomised controlled trial
Open accessAbstract
BACKGROUND: Current practice guidelines for schizophrenia care recommend that antipsychotic medication is essential for patients' long-term maintenance treatment but their non-adherence to this medication is still a main obstacle to relapse prevention. This study evaluated the effects of a motivational-interviewing-based adherence therapy for people with schizophrenia spectrum disorders. METHODS: This randomised controlled trial was conducted with 134 outpatients with schizophrenia spectrum disorders; 67 of them received a six-session adherence therapy (in addition to usual care) and 67 received usual psychiatric care alone. Participants' outcome measures included symptom severity, medication adherence, hospitalisation rates, insight into illness/treatment, and functioning. RESULTS: The adherence therapy group reported significantly greater improvements in symptom severity (p < 0.003), insight into illness/treatment (p < 0.001), functioning (p < 0.005), duration of re-hospitalisations (p < 0.005), and medication adherence (p < 0.005) over 18 months follow-up, when compared with usual care alone. CONCLUSIONS: Motivational-interviewing-based adherence therapy can be an effective approach to treatment for people with early stage of schizophrenia who poorly adhere to medication regimen. TRIAL REGISTRATION: ClinicalTrials.gov NCT01780116, registration date January 29, 2013.
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Motivational interviewing is linked to improved insight relative to treatment as usual.
“Motivational interviewing 165,166 and mindfulness based interventions [167][168][169] have also been linked to improved insight relative to treatment as usual.”
From Insight in schizophrenia spectrum disorders: relationship with behavior, mood and perceived quality of life, underlying causes and emerging treatments (2018) · cites this paper as [166]
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“Acceptance-based psychoeducation involving mindfulness and problem-solving skills has been shown to induce positive changes in insight into one ’ s illness and ambivalence toward medication adherence (Gray et al., 2010; Chien et al., 2016).”
InfluentialSelf-citation
- Authors
- Chien, W. T., Mui, J., Gray, R., & Cheung, E.
- Affiliations
- Hong Kong Polytechnic University (HK)
- Castle Peak Hospital (CN)
- Hamad Medical Corporation (QA)
- Corresponding author
- Chien, Wai Tong
- Venue
- BMC Psychiatry
- Published
- 2016-02-25
- Volume
- 16
- Issue
- 1
- Pages
- 42-42
- ISSN
- 1471-244X (ISSN-L)
- PMC
- PMC4766670
- OpenAlex
- W2287987347
- Cited by
- 48
- References
- 39
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 6 · 2023: 4 · 2022: 9 · 2021: 6 · 2020: 5 · 2019: 1 · 2018: 6 · 2017: 1 · 2016: 1
- FWCI
- 3.66
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- BMC Psychiatry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- PolyU Institutional Research Archive (Hong Kong Polytechnic University) (submittedVersion, cc-by)
- Funders
- Health and Medical Research Fund (10111671)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Keywords
- schizophrenia spectrum disorders, medication adherence, motivational interviewing, adherence therapy, antipsychotic drugs, relapse prevention, hospitalization, insight into illness, functioning, early schizophrenia
- MeSH terms
- Adult, Female, Humans, Male, Middle Aged, Patient Education as Topic, Psychotherapy, Psychotherapy, Group, Schizophrenia, Schizophrenic Psychology, Antipsychotic Agents, Cognitive Behavioral Therapy, Treatment Outcome, Drug Monitoring, Motivational Interviewing
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