The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Prevalence and management of severe asthma in primary care: an observational cohort study in Sweden (PACEHR)
Open accessAbstract
BACKGROUND: Severe and uncontrolled asthma is associated with increased risk of exacerbations and death. A substantial proportion of asthma patients have poor asthma control, and a concurrent COPD diagnosis often increases disease burden. The objective of the study was to describe the prevalence and managemant of severe asthma in a Swedish asthma popuöation. METHODS: In this observational cohort study, primary care medical records data (2006-2013) from 36 primary health care centers were linked to data from national mandatory Swedish health registries. The studied population (>18 years) had a record of drug collection for obstructive pulmonary disease (ATC code R03) during 2011-2012, and a physician diagnosed asthma (ICD-10 code J45-J46) prior to drug collection. Severe asthma was classified as collection of high dose inhaled steroid (> 800 budesonide or equivalent per day) and leukotriene receptor antagonist and/or long-acting beta-agonist. Poor asthma control was defined as either collection of ≥600 doses of short-acting beta-agonists, and/or ≥1 exacerbation(s) during the year post index date. RESULTS: A total of 18,724 asthma patients (mean 49 years, 62.8% women) were included, of whom 17,934 (95.8%) had mild to moderate and 790 (4.2%) had severe asthma. Exacerbations were more prevalent in severe asthma (2.59 [2.41-2.79], Relative Risk [95% confidence interval]; p < 0.001). Poor asthma control was observed for 28.2% of the patients with mild to moderate asthma and for more than half (53.6%) of the patients with severe asthma (<0.001). Prior to index, one in five severe asthma patients had had a contact with secondary care and one third with primary care. A concurrent COPD diagnosis increased disease burden. CONCLUSION: Severe asthma was found in 4.2% of asthma patients in Sweden, more than half of them had poor asthma control, and most patients had no regular health care contacts.
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“For example, in has been reported that 4.2% of Swedish adult asthmatic patients in primary care settings have severe disease (36).”
From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [36]
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Citations
Cites
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“2%, which is somewhat lower than the commonly reported prevalence of 5–-10% [15, 16].”
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“The mean age in our study was approximately 50 years and it has been shown that adherence to treatment increases with age [26, 27] indicating that the adherence to therapy may have been high among those who actually did collect their medication.”
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BackgroundRisks of Pneumonia in Patients with Asthma Taking Inhaled Corticosteroids
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“Severe asthma was classified as collection of high dosage inhaled steroid (ICS, >800 budesonide or equivalent per day) and LTRA and/or LABA collected at the same time or within a 3 months’ period before or after the ICS.”
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“2%, which is somewhat lower than the commonly reported prevalence of 5–-10% [15, 16].”
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MethodAutomated data extraction—A feasible way to construct patient registers of primary care utilization
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“The mean age in our study was approximately 50 years and it has been shown that adherence to treatment increases with age [26, 27] indicating that the adherence to therapy may have been high among those who actually did collect their medication.”
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Cited by
Sorted by citations
Epidemiology of Asthma in Children and Adults
Dharmage, S. C., Perret, J. L., & Custovic, A. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00246 · Cited by 1,200
“2% of Swedish adult asthmatic patients in primary care settings have severe disease (36).”
BackgroundNwaru, B. I., Ekström, M. P., Hasvold, P., Wiklund, F., Telg, G., & Janson, C. (2020) · European Respiratory Journal · doi:10.1183/13993003.01872-2019 · Cited by 472
Canonica, G. W., Colombo, G. L., Bruno, G. M., Matteo, S. D., Martinotti, C., Blasi, F., Bucca, C. B., Crimi, N., Paggiaro, P., Pelaia, G., et al. (2019) · World Allergy Organization Journal · doi:10.1016/j.waojou.2018.12.001 · Cited by 120
Severe Asthma in a General Population Study: Prevalence and Clinical Characteristics
Rönnebjerg, L., Axelsson, M., Kankaanranta, H., Bäckman, H., Rådinger, M., Lundbäck, B., & Ekerljung, L. (2021) · Journal of Asthma and Allergy · doi:10.2147/jaa.s327659 · Cited by 110
“This finding is supported by another Swedish study of severe asthma, showing even fewer had annual follow-ups.(14) Among asthmatics in Finland, the follow-ups occurred generally every third year.”
ResultLee, H. J., Ryu, J., Nam, E., Chung, S. J., Yeo, Y., Park, D. W., Park, T. S., Moon, J., Kim, T., Sohn, J. W., et al. (2019) · European Respiratory Journal · doi:10.1183/13993003.00804-2019 · Cited by 100
Metadata
- Authors
- Larsson, K., Ställberg, B., Lisspers, K., Telg, G., Johansson, G., Thuresson, M., & Janson, C.
- Affiliations
- Karolinska Institutet (SE)
- Uppsala University (SE)
- AstraZeneca (Sweden) (SE)
- Statisticon (Sweden) (SE)
- Corresponding author
- Larsson, Kjell
- ORCID
- Venue
- Respiratory Research
- Published
- 2018-01-18
- Volume
- 19
- Issue
- 1
- Pages
- 12-12
- ISSN
- 1465-9921 (ISSN-L)
- 1465-993X
- PMC
- PMC5774144
- OpenAlex
- W2794020024
- Cited by
- 100
- References
- 27
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 8 · 2023: 8 · 2022: 13 · 2021: 13 · 2020: 26 · 2019: 12 · 2018: 4
- FWCI
- 9.60
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Respiratory Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- AstraZeneca
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
- Keywords
- severe asthma, asthma prevalence, asthma control, asthma exacerbations, COPD comorbidities, primary care, asthma management, inhaled corticosteroids, leukotriene receptor antagonists, long-acting beta2-agonists, short-acting beta2-agonists, health care utilization, disease burden
- MeSH terms
- Adult, Aged, Aged, 80 and over, Asthma, Female, Humans, Male, Middle Aged, Primary Health Care, Registries, Severity of Illness Index, Sweden, Cohort Studies, Prevalence, Anti-Asthmatic Agents, Disease Management
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