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Cited by 39Algal biology and biofuel productionMicrobial Metabolic Engineering and BioproductionPlant biochemistry and biosynthesis

Algal glycobiotechnology: omics approaches for strain improvement

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Sirohi, Ranjna, Joun, Jaemin, Choi, Hong II, Gaur, Vivek Kumar, Sim, Sang Jun·2021·Microbial Cell Factories
DOI 10.1186/s12934-021-01656-6PMC PMC8379821
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Abstract

Microalgae has the capability to replace petroleum-based fuels and is a promising option as an energy feedstock because of its fast growth, high photosynthetic capacity and remarkable ability to store energy reserve molecules in the form of lipids and starch. But the commercialization of microalgae based product is difficult due to its high processing cost and low productivity. Higher accumulation of these molecules may help to cut the processing cost. There are several reports on the use of various omics techniques to improve the strains of microalgae for increasing the productivity of desired products. To effectively use these techniques, it is important that the glycobiology of microalgae is associated to omics approaches to essentially give rise to the field of algal glycobiotechnology. In the past few decades, lot of work has been done to improve the strain of various microalgae such as Chlorella, Chlamydomonas reinhardtii, Botryococcus braunii etc., through genome sequencing and metabolic engineering with major focus on significantly increasing the productivity of biofuels, biopolymers, pigments and other products. The advancements in algae glycobiotechnology have highly significant role to play in innovation and new developments for the production algae-derived products as above. It would be highly desirable to understand the basic biology of the products derived using -omics technology together with biochemistry and biotechnology. This review discusses the potential of different omic techniques (genomics, transcriptomics, proteomics, metabolomics) to improve the yield of desired products through algal strain manipulation.

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  • Recombinant Canola seeds were produced by over-expressing the Δ15 desaturase from Brassica napus to synthesize omega 3 fatty acids.

    “Recombinant Canola seeds were produced by over-expressing the Δ15 desaturase from Brassica napus to synthesize omega 3 fatty acids (Oliver et al. 2020; Sirohi et al. 2021a).”

    From Production of microalgae with high lipid content and their potential as sources of nutraceuticals (2023) · cites this paper as Sirohi et al. 2021a

    The Proteomics and Transcriptomics sections discuss fatty-acid production and lipid engineering in microalgae, not recombinant canola seeds. Searches for Brassica napus, Δ15 desaturase, and omega-3 production found no passage addressing the attributed claim; page numbers were unavailable in our copy. (LLM, conf=0.76)

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Sorted by citations

Authors
Sirohi, R., Joun, J., Choi, H. I., Gaur, V. K., & Sim, S. J.
Affiliations
  • Korea University (KR)
  • Amity University (IN)
Corresponding author
Sim, Sang Jun
ORCID
Venue
Microbial Cell Factories
Publisher
Springer Science and Business Media LLC
Published
2021-08-21
Volume
20
Issue
1
Pages
163-163
ISSN
1475-2859 (ISSN-L)
DOI
10.1186/s12934-021-01656-6
PMC
PMC8379821
OpenAlex
W3193822833
Cited by
39
References
0
Citations by year
2026: 5 · 2025: 8 · 2024: 7 · 2023: 9 · 2022: 7 · 2021: 3
FWCI
0.32
Type
journal article
Language
en
Open access
Licence
Locations
  • Microbial Cell Factories (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Korea Carbon to the X R&D Center (2020 M3H7A1098295)
  • National Research Foundation (NRF-2019R1A2C3009821, NRF-2020R1A5A1018052)
Topics
  • Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
Keywords
microalgae, strain improvement, omics technologies, biofuels, lipid accumulation, starch accumulation, Chlorella, Chlamydomonas reinhardtii, Botryococcus braunii, metabolic engineering, transcriptomics, proteomics, metabolomics, genomics, biopolymers, pigments
MeSH terms
Biotechnology, Genomics, Proteomics, Metabolomics, Biofuels, Microalgae, Transcriptome, Metabolic Engineering

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