Extraction and purification of high‐value metabolites from microalgae: essential lipids, astaxanthin and phycobiliproteins
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The marked trend and consumers growing interest in natural and healthy products have forced researches and industry to develop novel products with functional ingredients. Microalgae have been recognized as source of functional ingredients with positive health effects since these microorganisms produce polyunsaturated fatty acids, polysaccharides, natural pigments, essential minerals, vitamins, enzymes and bioactive peptides. For this reason, the manuscript reviews two of the main high-value metabolites which can be obtained from microalgae: pigments and essential lipids. Therefore, the extraction and purification methods for polyunsaturated fatty acids, astaxanthin, phycoerythrin and phycocyanin are described. Also, the effect that environmental growth conditions have in the production of these metabolites is described. This review summarizes the existing methods to extract and purify such metabolites in order to develop a feasible and sustainable algae industry.
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Photosynthetic pigments in microalgae exhibit beneficial biological activities such as anti-carcinogenic, anti-inflammatory, antioxidant, anti-obesity, anti-angiogenic and neuroprotective.
“These pigments have received great attention since they exhibit several beneficial biological activities such as anti-carcinogenic, anti-inflammatory, antioxidant, anti-obesity, anti-angiogenic and neuroprotective [122].”
From Challenges and Opportunities to Increase Economic Feasibility and Sustainability of Mixotrophic Cultivation of Green Microalgae of the Genus Chlorella (2022) · cites this paper as [122]
Numerous studies suggest coating bioactive compounds with a biopolymer layer can significantly increase stability of bioactive compounds under different conditions.
“To deal with the poor physicochemical stability of microalgae bioactive extracts, especially carotenoid, astaxanthin, and free fatty acids, numerous studies have suggested the coating of these bioactive compounds with biopolymer layer. This can significantly increase the stability of bioactive compounds under different conditions [152].”
From Challenges in Functional Food Products with the Incorporation of Some Microalgae (2024) · cites this paper as [152]
Microalgae produce vitamins, which elevates their importance as a nutritional food for people and animals.
“They produce vitamins, which elevates their importance as a nutritional food for people and animals [136, 142].”
From The promising future of microalgae: Current status, challenges, and optimization of a sustainable and renewable industry for biofuels, feed, and other products (2018) · cites this paper as [142]
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Flagged first, then by citations
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- Kantz PT Bold HC Morphological and Taxonomic Investigations of Nostoc and Anabaena in Culture 1969 Austin, TX, USA University of Texas Press pp. 67
- Richmond A Handbook of Microalgal Culture 2004 Oxford, UK Blackwell Publishing Ltd pp. 83–90
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- Authors
- Cuellar‐Bermudez, S. P., Aguilar‐Hernandez, I., Cardenas‐Chavez, D. L., Ornelas‐Soto, N., Romero‐Ogawa, M. A., & Parra‐Saldivar, R.
- Affiliations
- Cátedra de Bioprocesos Ambientales Centro del Agua Para América Latina y el Caribe Instituto Tecnológico y de Estudios Superiores de Monterrey Monterrey Nuevo Leon 64849 Mexico
- Tecnológico de Monterrey (MX)
- ORCID
- Ornelas‐Soto, Nancy
- Venue
- Microbial Biotechnology
- Publisher
- Wiley
- Published
- 2014-09-15
- Volume
- 8
- Issue
- 2
- Pages
- 190-209
- ISSN
- 1751-7915 (ISSN-L)
- PMC
- PMC4353334
- OpenAlex
- W1541955874
- Cited by
- 486
- References
- 131
- Citations by year
- 2026: 27 · 2025: 36 · 2024: 38 · 2023: 51 · 2022: 50 · 2021: 43 · 2020: 54 · 2019: 54 · 2018: 60 · 2017: 42 · 2016: 26 · 2015: 5
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Microbial Biotechnology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
- Keywords
- microalgae, high-value metabolites, polyunsaturated fatty acids, astaxanthin, phycobiliproteins, phycoerythrin, phycocyanin, pigment extraction, growth conditions, functional food ingredients
- MeSH terms
- Biological Factors, Lipids, Pigments, Biological, Xanthophylls, Lipid Metabolism, Phycobiliproteins, Microalgae
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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