An ingestible bacterial-electronic system to monitor gastrointestinal health
Open accessAbstract
Using bugs in the gut to detect blood: Bacteria are environmentally resilient and can be engineered to sense various biomolecules. Mimee et al. combined biosensor bacteria with a miniaturized wireless readout capsule to produce a minimally invasive device capable of in vivo biosensing in harsh, difficult-to-access environments (see the Perspective by Gibson and Burgell). The device successfully measured gastrointestinal bleeding in pigs. Science , this issue p. 915 ; see also p. 856
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Genetically engineered bacterial strains that assess the gut environment, release metabolites at specific GI locations, and optimize drug metabolism appear to be on the horizon.
“The use of genetically engineered bacterial strains to assess the gut environment, release metabolites of interest at specific locations within the GI tract, and optimize drug metabolism appears to be on the horizon190, 191.”
From The gut Microbiome in adult and pediatric functional gastrointestinal disorders (2019) · cites this paper as [191]
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Self-citation
- Authors
- Mimee, M., Nadeau, P., Hayward, A., Carim, S., Flanagan, S., Jerger, L., Collins, J., McDonnell, S., Swartwout, R., Citorik, R. J., Bulović, V., Langer, R., Traverso, G., Chandrakasan, A. P., & Lu, T. K.
- Affiliations
- Massachusetts Institute of Technology (US)
- Koch Institute for Integrative Cancer Research At MIT (US)
- Harvard University (US)
- Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA.
- Brigham and Women's Hospital (US)
- Corresponding author
- Mimee, Mark
- Nadeau, Phillip
- Chandrakasan, Anantha P.
- Lu, Timothy K.
- ORCID
- Venue
- Science
- Published
- 2018-05-25
- Volume
- 360
- Issue
- 6391
- Pages
- 915-918
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC6430580
- OpenAlex
- W2803662842
- Cited by
- 606
- References
- 35
- Citations by year
- 2026: 58 · 2025: 106 · 2024: 75 · 2023: 81 · 2022: 76 · 2021: 84 · 2020: 67 · 2019: 42 · 2018: 17
- FWCI
- 20.97
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-sa)
- PMC
- Funders
- National Institutes of Health (EB-000244)
- Office of Naval Research Global (N00014-13-1-0424)
- National Science Foundation (1522074)
- Hong Kong Innovation and Technology Fund (ITS/195/14FP)
- Center for Microbiome Informatics and Therapeutics (15127713)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Biosensors and Analytical Detection
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › bioluminescence and chemiluminescence research
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Keywords
- gastrointestinal bleeding diagnosis, gastrointestinal disease diagnosis, porcine model, implantable electronics
- MeSH terms
- Animals, Gastrointestinal Diseases, Heme, Gastrointestinal Hemorrhage, Monitoring, Physiologic, Swine, Biosensing Techniques, Probiotics, Gastrointestinal Tract, Electrical Equipment and Supplies
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