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Cited by 28Cancer-related molecular mechanisms researchGlioma Diagnosis and TreatmentCytokine Signaling Pathways and Interactions

Noncoding RNAs involved in the STAT3 pathway in glioma

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Bian, Zheng, Ji, Wei, Xu, Bin, Huo, Zhengyuan, Huang, Hui, Huang, Jin, Jiao, Jiantong, Shao, Junfei +1 more·2021·Cancer Cell International
DOI 10.1186/s12935-021-02144-yPMC PMC8381529
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Abstract

Glioma is the most common malignant primary brain tumour in adults. Despite improvements in neurosurgery and radiotherapy, the prognosis of glioma patients remains poor. One of the main limitations is that there are no proper clinical therapeutic targets for glioma. Therefore, it is crucial to find one or more effective targets. Signal transducer and activator of transcription 3 (STAT3) is a member of the STAT family of genes. Abnormal expression of STAT3 is involved in the process of cell proliferation, migration, invasion, immunosuppression, angiogenesis, dryness maintenance, and resistance to radiotherapy and chemotherapy in glioma. Therefore, STAT3 has been considered an ideal therapeutic target in glioma. Noncoding RNAs (ncRNAs) are a group of genes with limited or no protein-coding capacity that can regulate gene expression at the epigenetic, transcriptional and posttranscriptional level. In this review, we summarized the ncRNAs that are correlated with the ectopic expression of STAT3 in glioma.

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Cited by

Sorted by citations

Authors
Bian, Z., Ji, W., Xu, B., Huo, Z., Huang, H., Huang, J., Jiao, J., Shao, J., & Zhang, X.
Affiliations
Wuxi People's Hospital (CN)
Corresponding author
  • Shao, Junfei
  • Zhang, Xiaolu
ORCID
Venue
Cancer Cell International
Publisher
Springer Science and Business Media LLC
Published
2021-08-23
Volume
21
Issue
1
Pages
445-445
ISSN
1475-2867 (ISSN-L)
DOI
10.1186/s12935-021-02144-y
PMC
PMC8381529
OpenAlex
W3194035584
Cited by
28
References
2
Citations by year
2026: 2 · 2025: 4 · 2024: 6 · 2023: 9 · 2022: 6 · 2021: 1
FWCI
0.66
Type
journal article
Language
en
Open access
Licence
Locations
  • Cancer Cell International (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Innovative Research Group Project of the National Natural Science Foundation of China (81672487)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
  • Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
  • Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
Keywords
glioma, STAT3 signaling, non-coding RNA, therapeutic target, epigenetic regulation, post-transcriptional regulation, radiotherapy resistance, chemoresistance, tumor immunosuppression, tumor angiogenesis, cell proliferation and invasion

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