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Cited by 53Clinical Nutrition and GastroenterologySepsis Diagnosis and TreatmentFatty Acid Research and Health

Correlation analysis of omega-3 fatty acids and mortality of sepsis and sepsis-induced ARDS in adults: data from previous randomized controlled trials

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Chen, HuaiSheng, Wang, Su, Zhao, Ying, Luo, YuTian, Tong, HuaSheng, Su, Lei·2018·Nutrition Journal
DOI 10.1186/s12937-018-0356-8PMC PMC5984323
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Abstract

OBJECTIVE: This study aimed to investigate the possible effect of omega-3 fatty acids on reducing the mortality of sepsis and sepsis-induced acute respiratory distress syndrome (ARDS) in adults. METHODS: Medline, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI) database, WangFang database, and Chinese BioMedical Literature Database from their inception to March 6, 2017, were searched using systematic review researching methods. Five factors were analyzed to investigate the correlation between omega-3 fatty acids (either parenteral or enteral supplementation) and mortality rate. RESULTS: Forty randomized controlled trials (RCTs) were initially included, but only 25 of them assessed mortality. Of these RCTs, nine used enteral nutrition (EN) and 16 used parenteral nutrition (PN). The total mortality rate in the omega-3 fatty acid group was lower than that in the control group. However, the odds ratio (OR) value was not significantly different in the EN or PN subgroup. Eighteen RCTs including 1790 patients with similar severity of sepsis and ARDS were also analyzed. The OR value was not significantly different in the EN or PN subgroup. Omega-3 fatty acids did not show positive effect on improving mortality of sepsis-induced ARDS (p = 0.39). But in EN subgroup, omega-3 fatty acids treatment seemed to have some benefits in reducing mortality rate (p = 0.04). In the RCTs including similar baseline patients, partial correlation analysis found that the concentration ratio of n-6 to n-3 fatty acids had positive correlation with reduction of mortality (RM) (γ = 0.60, P = 0.02), whereas the total number of each RCT had negative correlation with RM (γ = - 0.54, P = 0.05). CONCLUSIONS: This review found that omega-3 fatty acid supplementation could reduce the mortality rate of sepsis and sepsis-induced ARDS. However, further investigation based on suitable concentrations and indications is needed to support the findings.

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  • Correlation analysis of 18 RCTs of enteral and parenteral ω-3 PUFA administration in 1790 patients with similar severity of sepsis and sepsis-induced ARDS underscored that ω-3 fatty acids had no positive effect on mortality.

    “Correlation analysis of 18 RCTs of enteral and parenteral ω-3 PUFA administration in 1790 patients with similar severity of sepsis and sepsis-induced ARDS further underscored that ω-3 fatty acids had no positive effect on mortality [66].”

    From Nutrition in Sepsis: A Bench-to-Bedside Review. (2020) · cites this paper as [66]

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Sorted by citations

Authors
Chen, H., Wang, S., Zhao, Y., Luo, Y., Tong, H., & Su, L.
Affiliations
  • Jinan University (CN)
  • Southern Medical University (CN)
Corresponding author
  • Tong, HuaSheng
  • Su, Lei
ORCID
Venue
Nutrition Journal
Publisher
Springer Science and Business Media LLC
Published
2018-05-31
Volume
17
Issue
1
Pages
57-57
ISSN
1475-2891 (ISSN-L)
DOI
10.1186/s12937-018-0356-8
PMC
PMC5984323
OpenAlex
W2805745038
Cited by
53
References
2
Citations by year
2026: 5 · 2025: 3 · 2024: 7 · 2023: 3 · 2022: 5 · 2021: 16 · 2020: 12 · 2019: 1 · 2018: 1
FWCI
0.96
Type
journal article
Language
en
Open access
Licence
Locations
  • Nutrition Journal (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
  • Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords
omega-3 fatty acids, sepsis, sepsis-induced acute respiratory distress syndrome, mortality, enteral nutrition, parenteral nutrition, fatty acid supplementation, adults
MeSH terms
Adult, Humans, Respiratory Distress Syndrome, Fatty Acids, Omega-3, Odds Ratio, Randomized Controlled Trials as Topic, MEDLINE, Sepsis, Dietary Supplements

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