Omega-3 polyunsaturated fatty acids in critically ill patients with acute respiratory distress syndrome: A systematic review and meta-analysis
Open accessAbstract
Objective Acute respiratory distress syndrome (ARDS) is characterized by an acute inflammatory response in the lung parenchyma leading to severe hypoxemia. Because of its anti-inflammatory and immunomodulatory properties, omega-3 polyunsaturated fatty acids (ω-3 PUFA) have been administered to ARDS patients, mostly by the enteral route, as immune-enhancing diets with eicosapentaenoic acid, γ-linolenic acid, and antioxidants. However, clinical benefits of ω-3 PUFAs in ARDS patients remain unclear because clinical trials have found conflicting results. Considering the most recent randomized controlled trials (RCTs) and recent change in administration strategies, the aim of this updated systematic review and meta-analysis was to evaluate clinical benefits of ω-3 PUFA administration on gas exchange and clinical outcomes in ARDS patients. Methods We searched for RCTs conducted in intensive care unit (ICU) patients with ARDS comparing the administration of ω-3 PUFAs to placebo. The outcomes assessed were PaO 2-to-FiO 2 ratio evaluated early (3-4 d) and later (7-8 d), mortality, ICU and hospital length of stay (LOS), length of mechanical ventilation (MV), and infectious complications. Two independent reviewers assessed eligibility, risk of bias, and abstracted data. Data were pooled using a random effect model to estimate the relative risk or weighted mean difference (WMD). Results Twelve RCTs (n = 1280 patients) met our inclusion criteria. Omega-3 PUFAs administration was associated with a significant improvement in early PaO 2-to-FiO 2 ratio (WMD = 49.33; 95% confidence interval [CI] 20.88-77.78; P = 0.0007; I 2 = 69%), which persisted at days 7 to 8 (WMD = 27.87; 95% CI 0.75-54.99; P = 0.04; I 2 = 57%). There was a trend in those receiving ω-3 PUFA toward reduced ICU LOS (P = 0.08) and duration of MV (P = 0.06), whereas mortality, hospital LOS, and infectious complications remained unchanged. Continuous enteral infusion was associated with reduced mortality (P = 0.02), whereas analysis restricted to enteral administration either with or without bolus found improved early PaO 2 and FiO 2 (P = 0.001) and MV duration (P = 0.03). Trials at higher risk of bias had a significant reduction in mortality (P = 0.04), and improvement in late PaO 2-to-FiO 2 ratio (P = 0.003). Conclusions In critically ill patients with ARDS, ω-3 PUFAs in enteral immunomodulatory diets may be associated with an improvement in early and late PaO 2-to-FiO 2 ratio, and statistical trends exist for an improved ICU LOS and MV duration. Considering these results, administering ω-3 PUFAs appears a reasonable strategy in ARDS.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the Langlois review, infectious complications remained unchanged.
“Infectious complications remained unchanged.”
From Nutrition in Sepsis: A Bench-to-Bedside Review. (2020) · cites this paper as [70]
Langlois et al. reviewed 12 RCTs (n = 1280 patients) and found that ω-3 PUFA administration, particularly when given as a continuous infusion in combination with γ-linolenic acid and antioxidants, was associated with significant early and late improvement of oxygenation in critically ill patients with ARDS.
“ω-3 PUFA administration, particularly when given as a continuous infusion in combination with γ-linolenic acid and antioxidants, was associated with significant early and late improvement of oxygenation.”
From Nutrition in Sepsis: A Bench-to-Bedside Review. (2020) · cites this paper as [70]
Only trials published before 2011 showed a significant reduction in mortality, which might not relate to feeding but to a change in therapeutic approach of ARDS.
“Only trials published before 2011 showed a significant reduction in mortality, which might not relate to feeding but to a change in therapeutic approach of ARDS [70].”
From Nutrition in Sepsis: A Bench-to-Bedside Review. (2020) · cites this paper as [70]
In the Langlois review, patients who received ω-3 PUFAs tended to have a reduced duration of mechanical ventilation and ICU stay.
“Patients who received ω-3 PUFAs tended to have a reduced duration of mechanical ventilation and ICU stay.”
From Nutrition in Sepsis: A Bench-to-Bedside Review. (2020) · cites this paper as [70]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823 · see citing works
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & The PRISMA Group (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000097 · Cited by 64,042 · see citing works
Measuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139 · see citing works
Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722 · see citing works
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.
(2009) · PubMed Central · Cited by 44,859 · see citing works
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552 · see citing works
Wang, G., Ma, R., Qiao, G., Wada, K., Aizawa, Y., & Satoh, T. (2015) · Integrative Medicine International · doi:10.1159/000368408 · Cited by 18,759 · see citing works
Chen, Y., Wang, L., Kang, Q., Zhang, X., Yu, G., Wan, X., Wang, J., & Zhu, K. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000477308 · Cited by 10,730 · see citing works
Acute Respiratory Distress Syndrome
Ards Definition Task Force (2012) · JAMA · doi:10.1001/jama.2012.5669 · Cited by 8,806 · see citing works
McClave, S. A., Taylor, B. E., Martindale, R. G., Warren, M. M., Johnson, D. R., Braunschweig, C., McCarthy, M. S., Davanos, E., Rice, T. W., Cresci, G. A., et al. (2016) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607115621863 · Cited by 3,982 · see citing works
Lewis (1990) · doi:10.1056/nejm199009063231006 · Cited by 1,200 · see citing works
Polyunsaturated fatty acids, inflammation, and immunity
Calder, P. C. (2001) · Lipids · doi:10.1007/s11745-001-0812-7 · Cited by 784 · see citing works
Gadek, J. E., DeMichele, S. J., Karlstad, M. D., Pacht, E. R., Donahoe, M., Albertson, T. E., Van Hoozen, C., Wennberg, A. K., Nelson, J. L., & Noursalehi, M. (1999) · Critical Care Medicine · doi:10.1097/00003246-199908000-00001 · Cited by 757 · see citing works
Enteral Omega-3 Fatty Acid, γ-Linolenic Acid, and Antioxidant Supplementation in Acute Lung Injury
Rice, T. W. (2011) · JAMA · doi:10.1001/jama.2011.1435 · Cited by 552 · see citing works
Pontes-Arruda, A., Aragão, A. M. A., & Albuquerque, J. D. (2006) · Critical Care Medicine · doi:10.1097/01.ccm.0000234033.65657.b6 · Cited by 423 · see citing works
Singer, P., Theilla, M., Fisher, H., Gibstein, L., Grozovski, E., & Cohen, J. (2006) · Critical Care Medicine · doi:10.1097/01.ccm.0000206111.23629.0a · Cited by 393 · see citing works
Singer, P., Shapiro, H., Theilla, M., Anbar, R., Singer, J., & Cohen, J. D. (2008) · Intensive Care Medicine · doi:10.1007/s00134-008-1142-4 · Cited by 232 · see citing works
Stapleton, R. D., Martin, T. R., Weiss, N. S., Crowley, J. J., Gundel, S. J., Nathens, A. B., Akhtar, S. R., Ruzinski, J. T., Caldwell, E., Curtis, J. R., et al. (2011) · Critical Care Medicine · doi:10.1097/ccm.0b013e318218669d · Cited by 173 · see citing works
Lipids in the intensive care unit: Recommendations from the ESPEN Expert Group
Calder, P. C., Adolph, M., Deutz, N. E., Grau, T., Innes, J. K., Klek, S., Lev, S., Mayer, K., Michael-Titus, A. T., Pradelli, L., et al. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2017.08.032 · Cited by 158 · see citing works
Barham, J. B., Edens, M. B., Fonteh, A. N., Johnson, M. M., Easter, L. H., & Chilton, F. H. (2000) · Journal of Nutrition · doi:10.1093/jn/130.8.1925 · Cited by 127 · see citing works
Grau-Carmona, T., Morán-García, V., García-de-Lorenzo, A., Heras-de-la-Calle, G., Quesada-Bellver, B., López-Martínez, J., González-Fernández, C., Montejo-González, J. C., Blesa-Malpica, A., Albert-Bonamusa, I., et al. (2011) · Clinical Nutrition · doi:10.1016/j.clnu.2011.03.004 · Cited by 121 · see citing works
Lipid mediators in the pathophysiology of critical illness
Bulger, E. M., & Maier, R. V. (2000) · Critical Care Medicine · doi:10.1097/00003246-200004001-00004 · Cited by 110 · see citing works
Oxidant stress and essential fatty acids in patients with risk and established ARDS
Kutala, V. K., Rao, S. M., Gayani, R., Mohan, I. K., & Naidu, M. U. R. (2000) · Clinica Chimica Acta · doi:10.1016/s0009-8981(00)00264-3 · Cited by 63 · see citing works
Efficacy and safety of parenteral omega 3 fatty acids in ventilated patients with acute lung injury
Patel, S., Gupta, A., Bhatnagar, S., Goyal, J., & Baweja, H. (2011) · Indian Journal of Critical Care Medicine · doi:10.4103/0972-5229.83019 · Cited by 56 · see citing works
Chen, H., Wang, S., Zhao, Y., Luo, Y., Tong, H., & Su, L. (2018) · Nutrition Journal · doi:10.1186/s12937-018-0356-8 · Cited by 53 · see citing works
Kagan, I., Cohen, J. D., Stein, M., Bendavid, I., Pinsker, D., Silva, V., Theilla, M., Anbar, R., Lev, S., Grinev, M., et al. (2015) · Intensive Care Medicine · doi:10.1007/s00134-015-3646-z · Cited by 52 · see citing works
Shirai, K., Yoshida, S., Matsumaru, N., Toyoda, I., & Ogura, S. (2015) · Journal of Intensive Care · doi:10.1186/s40560-015-0087-2 · Cited by 47 · see citing works
Elamin, E. M. (2012) · Journal of Nutritional Disorders & Therapy · doi:10.4172/2161-0509.1000109 · Cited by 43 · see citing works
Palombo, J. D., Lydon, E. E., Chen, P., Bistrian, B. R., & Forse, R. A. (1994) · Lipids · doi:10.1007/bf02536099 · Cited by 37 · see citing works
The Effect of Omega-3 Fatty Acids on ARDS: A Randomized Double-Blind Study
Parish, M., Valiyi, F., Hamishehkar, H., Sanaie, S., Jafarabadi, M. A., Golzari, S. E., & Mahmoodpoor, A. (2014) · Europe PMC (PubMed Central) · doi:10.5681/apb.2014.082 · Cited by 28 · see citing works
Theilla, M., Schwartz, B., Zimra, Y., Shapiro, H., Anbar, R., Rabizadeh, E., Cohen, J. D., & Singer, P. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511004004 · Cited by 22 · see citing works
Pharmaconutrition in Acute Lung Injury
Cook, D. J., & Heyland, D. K. (2011) · JAMA · doi:10.1001/jama.2011.1470 · Cited by 9 · see citing works
Flagged first, then by citations
1 of the 33 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Berlana, D. (2022) · Nutrients · doi:10.3390/nu14214480 · Cited by 165 · see citing works
The Role of Nutrition in COVID-19 Susceptibility and Severity of Disease: A Systematic Review
James, P. T., Ali, Z., Armitage, A. E., Bonell, A., Cerami, C., Drakesmith, H., Jobe, M., Jones, K. S., Liew, Z., Moore, S. E., et al. (2021) · The Journal of Nutrition · doi:10.1093/jn/nxab059 · Cited by 147 · see citing works
Nutrition in Sepsis: A Bench-to-Bedside Review.
De Waele, E., Malbrain, M. L. N. G., & Spapen, H. (2020) · Nutrients · doi:10.3390/nu12020395 · Cited by 140 · see citing works
Weill, P., Plissonneau, C., Legrand, P., Rioux, V., & Thibault, R. (2020) · Biochimie · doi:10.1016/j.biochi.2020.09.003 · Cited by 124 · see citing works
Blood omega-3 fatty acids and death from COVID-19: A pilot study
Asher, A., Tintle, N. L., Myers, M., Lockshon, L., Bacareza, H., & Harris, W. S. (2021) · Prostaglandins, Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2021.102250 · Cited by 118 · see citing works
Risk Factors of Severe COVID-19: A Review of Host, Viral and Environmental Factors
Zsichla, L., & Müller, V. (2023) · Viruses · doi:10.3390/v15010175 · Cited by 113 · see citing works
Nutrients in prevention, treatment, and management of viral infections; special focus on Coronavirus
Bourbour, F., Dahka, S. M., Gholamalizadeh, M., Akbari, M. E., Shadnoush, M., Haghighi, M., Masoumi, H. T., Ashoori, N., & Doaei, S. (2020) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2020.1791188 · Cited by 104 · see citing works
van Vuren, E. J., Steyn, S. F., Brink, C. B., Möller, M., Viljoen, F. P., & Harvey, B. H. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.111200 · Cited by 105 · see citing works
Arnardottir, H. H., Pawelzik, S., Öhlund‐Wistbacka, U., Artiach, G., Hofmann, R., Reinholdsson, I., Braunschweig, F., Tornvall, P., Religa, D., & Bäck, M. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2020.624657 · Cited by 75 · see citing works
Davinelli, S., Medoro, A., Intrieri, M., Saso, L., Scapagnini, G., & Kang, J. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.11.017 · Cited by 65 · see citing works
Darwesh, A. M., Bassiouni, W., Sosnowski, D. K., & Seubert, J. M. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107703 · Cited by 66 · see citing works
Alterations of Lipid Profile in COVID-19: A Narrative Review
Rezaei, A., Neshat, S., & Heshmat‐Ghahdarijani, K. (2021) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2021.100907 · Cited by 61 · see citing works
Plasma Linoleate Diols Are Potential Biomarkers for Severe COVID-19 Infections
McReynolds, C. B., Cortés‐Puch, I., Ravindran, R. K., Khan, I. H., Hammock, B. G., Shih, P.-A. B., Hammock, B. D., & Yang, J. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.663869 · Cited by 60 · see citing works
Parenteral fish oil: An adjuvant pharmacotherapy for coronavirus disease 2019?
Torrinhas, R. S., Calder, P. C., Lemos, G., & Waitzberg, D. L. (2020) · Nutrition · doi:10.1016/j.nut.2020.110900 · Cited by 57 · see citing works
COVID-19 Outbreak: Pathogenesis, Current Therapies, and Potentials for Future Management
Hossain, M. F., Hasana, S., Mamun, A. A., Uddin, M. S., Wahed, M. I. I., Sarker, S., Behl, T., Ullah, I., Begum, Y., Bulbul, I. J., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.563478 · Cited by 55 · see citing works
Yu, B. S., Sung, Y. J., Choi, H. I., Sirohi, R., & Sim, S. J. (2021) · Bioresource Technology · doi:10.1016/j.biortech.2021.125720 · Cited by 44 · see citing works
Yu, B. S., Lee, S. Y., & Sim, S. J. (2021) · Bioresource Technology · doi:10.1016/j.biortech.2021.126289 · Cited by 38 · see citing works
Potential benefits of dietary seaweeds as protection against COVID-19
Tamama, K. (2020) · Nutrition Reviews · doi:10.1093/nutrit/nuaa126 · Cited by 37 · see citing works
Mazidimoradi, A., Alemzadeh, E., Alemzadeh, E., & Salehiniya, H. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120489 · Cited by 37 · see citing works
Owumi, S. E., Olayiwola, Y., Alao, G. E., Gbadegesin, M. A., & Odunola, O. A. (2019) · Environmental Toxicology · doi:10.1002/tox.22860 · Cited by 35 · see citing works
Yu, H., Su, X., Lei, T., Zhang, C., Zhang, M., Wang, Y., Zhu, L., & Liu, J. (2021) · International Journal of COPD · doi:10.2147/copd.s331154 · Cited by 35 · see citing works
Rebalancing the unbalanced aged immune system – A special focus on zinc
Baarz, B. R., & Rink, L. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101541 · Cited by 35 · see citing works
Rousseau, A., & Martindale, R. G. (2024) · Annals of Intensive Care · doi:10.1186/s13613-024-01350-x · Cited by 32 · see citing works
Specialized pro-resolving mediators in respiratory diseases
Cagnina, R. E., Duvall, M. G., Nijmeh, J., & Levy, B. D. (2021) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000805 · Cited by 30 · see citing works
Serum lipid mediator profiles in COVID-19 patients and lung disease severity: a pilot study
Irún, P., Gracia, R., Piazuelo, E., Pardo, J., Morte-Romea, E., Paño, J. R., Bozá, J., Carrera‐Lasfuentes, P., Higuera, G. A., & Lanas, Á. (2023) · Scientific Reports · doi:10.1038/s41598-023-33682-2 · Cited by 27 · see citing works
Gut microbiota in antiviral strategy from bats to humans: a missing link in COVID-19
Luo, J., Shan, L., & Jin, F. (2021) · Science China Life Sciences · doi:10.1007/s11427-020-1847-7 · Cited by 30 · see citing works
Review: Obesity and COVID-19: A Detrimental Intersection
Gammone, M. A., & D’Orazio, N. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.652639 · Cited by 27 · see citing works
Karu, N., Kindt, A. S. D., Lamont, L., van Gammeren, A. J., Ermens, A. A. M., Harms, A. C., Portengen, L., Vermeulen, R. C. H., Dik, W. A., Langerak, A. W., et al. (2022) · Metabolites · doi:10.3390/metabo12070619 · Cited by 27 · see citing works
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies
Rueda, F. R., Nieves‐Alonso, J., Villabona, E. G., Vallejo, C., Kattan, E., & Méndez, R. (2024) · Journal of Personalized Medicine · doi:10.3390/jpm14020176 · Cited by 24 · see citing works
Fekete, M., Szarvas, Z., Fazekas‐Pongor, V., Lehoczki, A., Tarantini, S., & Varga, J. T. (2022) · Annals of Palliative Medicine · doi:10.21037/apm-22-254 · Cited by 24 · see citing works
Taha, A. M., Shaarawy, A. S., Omar, M. M., Abouelmagd, K., Shalma, N. M., Alhashemi, M., Ahmed, H., Allam, A. H., & Abd‐ElGawad, M. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03604-3 · Cited by 24 · see citing works
Lipidomic and metabolomic changes in community-acquired and COVID-19 pneumonia
Saballs, M., Parra, S., Martínez, N., Amigó, N., Cabau, L., Iftimie, S. M., Pavón, R., Gabaldó-Barrios, X., Correig, X., Paredes, S., et al. (2024) · Journal of Lipid Research · doi:10.1016/j.jlr.2024.100622 · Cited by 23 · see citing works
Santos, H. O., Tinsley, G. M., da Silva, G. A. R., & Bueno, A. A. (2020) · Journal of Personalized Medicine · doi:10.3390/jpm10040145 · Cited by 23 · see citing works
Maresin-1 and its receptors RORα/LGR6 as potential therapeutic target for respiratory diseases
Zhao, M., Li, C., Zhang, J., Yin, Z., Zheng, Z., Wan, J., & Wang, M. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106337 · Cited by 24 · see citing works
The Role of an Anti-Inflammatory Diet in Conjunction to COVID-19
Ling, V., & Zabetakis, I. (2021) · Diseases · doi:10.3390/diseases9040076 · Cited by 21 · see citing works
Investigational pharmacological agents for the treatment of ARDS
Aribindi, K., Lim, M., Lakshminrusimha, S., & Albertson, T. E. (2024) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2024.2315128 · Cited by 22 · see citing works
Velotti, F., Costantini, L., & Merendino, N. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm12010304 · Cited by 20 · see citing works
Nutraceuticals and herbal extracts: A ray of hope for COVID‑19 and related infections (Review)
Tahir, A. H., Javed, M. M., & Hussain, Z. (2020) · International Journal of Functional Nutrition · doi:10.3892/ijfn.2020.6 · Cited by 19 · see citing works
The role of omega-3 polyunsaturated fatty acids in the intensive care unit
Singer, P., & Calder, P. C. (2023) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000896 · Cited by 19 · see citing works
Attari, V. E., Panahi, G., Hébert, J. R., Ostadrahimi, A., Saghafi‐Asl, M., Yagin, N. L., & Baradaran, B. (2021) · Health Promotion Perspectives · doi:10.34172/hpp.2021.17 · Cited by 18 · see citing works
The Role of Innate Immunity and Bioactive Lipid Mediators in COVID-19 and Influenza
Sahanic, S., Löffler‐Ragg, J., Tymoszuk, P., Hilbe, R., Demetz, E., Masanetz, R. K., Theurl, M., Holfeld, J., Gollmann‐Tepeköylü, C., Tzankov, A., et al. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.688946 · Cited by 18 · see citing works
Mahluji, S., Jalili, M., Ostadrahimi, A., Hallajzadeh, J., Attari, V. E., & Saghafi‐Asl, M. (2021) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-021-00784-5 · Cited by 16 · see citing works
Nanotechnology-based Approaches and Investigational Therapeutics against COVID-19
Rahman, M. M., Ahmed, M., Islam, M. T., Khan, M. R., Sultana, S., Maeesa, S. K., Hasan, S., Hossain, M. A., Ferdous, K. S., Mathew, B., et al. (2021) · Current Pharmaceutical Design · doi:10.2174/1381612827666210701150315 · Cited by 16 · see citing works
Siritientong, T., Thet, D., Buangbon, M., Nokehoon, P., Leelakanok, N., Methaneethorn, J., Angspatt, A., & Meevassana, J. (2022) · Nutrients · doi:10.3390/nu14142874 · Cited by 16 · see citing works
The Complex Interplay between Immunonutrition, Mast Cells, and Histamine Signaling in COVID-19
Kakavas, S., Karayiannis, D., & Mastora, Z. (2021) · Nutrients · doi:10.3390/nu13103458 · Cited by 12 · see citing works
N-3 polyunsaturated fatty acids may affect the course of COVID-19
Lampová, B., Doskočil, I., Kouřimská, L., & Kopeć, A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.957518 · Cited by 14 · see citing works
Elajaili, H. B., Dee, N. M., Dikalov, S., Kao, J. P. Y., & Nozik‐Grayck, E. (2023) · Molecular Imaging and Biology · doi:10.1007/s11307-023-01826-5 · Cited by 11 · see citing works
Rust, P., & Ekmekçioğlu, C. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20075400 · Cited by 11 · see citing works
Overview of dietary lipids and human health
Li, D. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823914-8.00008-2 · Cited by 11 · see citing works
Immunmodulation durch Ernährung bei kritisch kranken Patienten
Hirschberger, S., Schmid, A., & Kreth, S. (2023) · Die Anaesthesiologie · doi:10.1007/s00101-023-01258-4 · Cited by 8 · see citing works
Jeyakumar, S. M., & Vajreswari, A. (2021) · World Journal of Clinical Cases · doi:10.12998/wjcc.v9.i31.9333 · Cited by 8 · see citing works
Miyoshi, T., Naoe, S., Wakabayashi, H., Yano, T., Mori, T., Kanda, S., Arita, M., & Ito, H. (2023) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.64135 · Cited by 7 · see citing works
Recomendaciones para la terapia nutricional de pacientes con COVID-19
Matos, A. A., Nava, V. M. S., Villarreal, A. Q., Méndez, C., Petterson, K., Vergara, J., Castillo, J. C., & Arroyo, M. (2021) · Acta Colombiana de Cuidado Intensivo · doi:10.1016/j.acci.2021.01.002 · Cited by 6 · see citing works
Black, L. P., Hopson, C., Barker, G., Munson, T., Henson, M., Bertrand, A. H., Daly-Crews, K., Reddy, S. T., & Guirgis, F. W. (2023) · Shock · doi:10.1097/shk.0000000000002295 · Cited by 5 · see citing works
Wahyuni, D., Taslim, N. A., Syam, N., & Virani, D. (2021) · Gaceta Sanitaria · doi:10.1016/j.gaceta.2021.10.083 · Cited by 4 · see citing works
Could Immunonutrition Help in the Fight against COVID-19 in Cancer Patient?
Tang, G., Zhang, L., Huang, W., & Wei, Z. (2021) · Nutrition and Cancer · doi:10.1080/01635581.2021.1957128 · Cited by 4 · see citing works
Medical Nutrition Therapy In Enterocutaneous Fistula: A Step-By-Step Approach
Nathania, M., & Andayani, D. E. (2021) · World Nutrition Journal · doi:10.25220/wnj.v05.i1.0002 · Cited by 3 · see citing works
Can Nutritional Supports Beneficial in Other Viral Diseases Be Favorable for COVID-19?
Zelka, F. Z., Kocatürk, R. R., Özcan, Ö. Ö., & Karahan, M. (2022) · Korean Journal of Family Medicine · doi:10.4082/kjfm.20.0134 · Cited by 3 · see citing works
Huang, Y., Li, P., & Lew, C. C. H. (2023) · Nutrition in Clinical Practice · doi:10.1002/ncp.10982 · Cited by 3 · see citing works
Nutrition Management in Diabetes Patients during COVID-19: The Role of Nutrients in Immunity
Ahn, H. J. (2021) · Journal of Korean Diabetes · doi:10.4093/jkd.2021.22.4.284 · Cited by 3 · see citing works
Nutritional support for intensive care patients: the role of lipid component
Пасечник, И. Н., Talyzin, P. A., & Skobelev, E. I. (2024) · Russian Journal of Anesthesiology and Reanimatology · doi:10.17116/anaesthesiology202403158 · Cited by 2 · see citing works
Wu, M., Wang, X., Cai, J.-Z., Liu, T., Wang, Y.-Y., Wang, Y. H. A., & Xu, C.-X. (2026) · Journal of Nutrition · doi:10.1016/j.tjnut.2025.101351 · Cited by 2 · see citing works
Leuenberger, L. A., Bednash, J. S., Schott, E., Mikacenic, C. R., Morrell, E. D., Richardson, C., Fussner, L. A., Horowitz, J. C., Mallampalli, R. K., Shaikh, S. R., et al. (2026) · The FASEB Journal · doi:10.1096/fj.202504787rr · Cited by 2 · see citing works
Polyunsaturated Fatty Acid-Derived Lipid Mediators as Biomarkers in Critical Care
Khan, B., O’Laughlin, A., Perelas, A., Thatcher, T. H., & Jackson, P. (2023) · Biomarkers in disease · doi:10.1007/978-3-031-07395-3_77 · Cited by 2 · see citing works
Expert suggestions on nutrition therapy for severe COVID-19 patients
Zhang, K., Xu, H. A., XinYing, W. A. N. G., Min, W. E. N. G., Li, T., HUANG, D., ChangHui, W. A. N. G., Sheng, W. A. N. G., null Chinese Society for Parenteral and Enteral Nutrition, Yu, Z., et al. (2020) · Scientia Sinica Vitae · doi:10.1360/ssv-2020-0055 · Cited by 1 · see citing works
Abbasi, E., Rezayat, S., & Saneei, P. (2021) · Nutrition · doi:10.1016/j.nut.2021.111421 · Cited by 2 · see citing works
Pengaruh Nutritional Support terhadap Luaran Klinis pada Pasien Intensive Care Unit
Harti, L. B., Dini, C. Y., & Fatoni, A. Z. (2024) · Amerta Nutrition · doi:10.20473/amnt.v8i2.2024.328-334 · Cited by 1 · see citing works
Dorchin, M., Jounaghani, M. N., Hashemi-Javaheri, F.-S., Safarian, M., Moghaddam, A. B., Norouzy, A., Khadem‐Rezaiyan, M., Hejazi, S., & Arabi, M. (2025) · Scientific Reports · doi:10.1038/s41598-025-09391-3 · Cited by 1 · see citing works
Electron paramagnetic resonance detection of superoxide in a murine model of acute lung injury
Elajaili, H. B., Dee, N. M., Hovey, T. A., Canny, A., Amassah, G., Posey, J. N., Rinard, G. A., Kao, J. P. Y., Eaton, S. S., Eaton, G. R., et al. (2025) · Discover Imaging. · doi:10.1007/s44352-025-00014-1 · Cited by 1 · see citing works
Antimicrobial and Synergistic Activity of Metformin Against Helicobacter pylori
Rajab, W. H., Jaradat, N. A., Abdo, Q., Aljouda, N., & Qadi, M. (2026) · Canadian Journal of Infectious Diseases and Medical Microbiology · doi:10.1155/cjid/3542284 · Cited by 1 · see citing works
Covid-19, la piste de l’alimentation barrière
Lecerf, J., & Weill, P. (2021) · Pratiques en nutrition · doi:10.1016/j.pranut.2021.06.008 · Cited by 1 · see citing works
Nutrition in the ICU: Foreword from the Editors
Manzanares, W., & Singer, P. (2018) · Nutrition · doi:10.1016/j.nut.2018.12.010
Self-citationNektarios, S., Eftychios, A., & Nikoleta, G. (2021) · Journal of Biosciences and Medicines · doi:10.4236/jbm.2021.97015
Manzanares, W., Hardy, G., & Langlois, P. L. (2021) · Nutrition · doi:10.1016/j.nut.2021.111432
Self-citationДмитриев, А. В., Machulina, I. A., & Шестопалов, А. Е. (2021) · Medical alphabet · doi:10.33667/2078-5631-2021-17-63-70
Koçan, S., Kazancıoğlu, L., DEMİREL, Y., & Altınsoy, C. (2021) · Sakarya Medical Journal · doi:10.31832/smj.927439
Clinical Features, Diagnostic Evaluation, and Management of COVID-19 Patients
Mallick, R., & Duttaroy, A. K. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-85113-2_1
Niţă, & Lestari, W. (2022) · IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN) · doi:10.54773/ijcnp.v5i1.82
Nutritional management against severe acute respiratory syndrome coronavirus-2 infection
Aslam, M., Azam, M. B., & Egbuna, C. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-95574-4.00014-7
Polyunsaturated Fatty Acid-Derived Lipid Mediators as Biomarkers in Critical Care
Khan, B., O’Laughlin, A. E., Perelas, A., Thatcher, T. H., & Jackson, P. (2022) · Biomarkers in disease · doi:10.1007/978-3-030-87302-8_77-1
Souza, Y. D. D. E. S., Moreira, J. S. B., Lobato, T. A. A., Costa, R. L. V., & Teixeira, L. M. D. A. (2023) · DEMETRA Alimentação Nutrição & Saúde · doi:10.12957/demetra.2023.77540
Lembke, P. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-29114-2.00008-8
Pharmaconutrition in Critical Care
Cotoia, A., Mariotti, P. S., Edel, A., & Schaller, S. J. (2024) · Springer eBooks · doi:10.1007/978-3-031-66541-7_17
Preoperative management in octogenarian patients with rectal cancer
Damasceno, A. M., Kesley, R., Valadão, M., Braga, F., D’Almeida, C. A., & Pitombo, M. B. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e41469
Taha, A. M., Shaarawy, A. S., Omar, M. M., Abouelmagd, K., Shalma, N. M., Alhashemi, M., Ahmed, H., Allam, A. H., & Abd‐ElGawad, M. (2022) · Figshare · doi:10.6084/m9.figshare.20968296
Taha, A. M., Shaarawy, A. S., Omar, M. M., Abouelmagd, K., Shalma, N. M., Alhashemi, M., Ahmed, H., Allam, A. H., & Abd‐ElGawad, M. (2022) · Figshare · doi:10.6084/m9.figshare.20968299
Serum lipidome remodeling in viral pneumonia: from pathophysiology to therapeutics
Wang, Y., & Xiao, Q. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1836315 · Cited by 1 · see citing works
Lee, J. G., Sohn, Y. M., Lee, S. H., Jung, Y. T., Lee, H., Park, J. Y., Choi, N.-J., Song, J. M., Lee, J. Y., Kim, M., et al. (2026) · 한국정맥경장영양학회지 · doi:10.15747/acnm.26.0059
Lituma-González, W. D., Casella, C., & Ballaz, S. (2026) · Lipids · doi:10.1002/lipd.70077
- Authors
- Langlois, P. L., D'Aragon, F., Hardy, G., & Manzanares, W.
- Affiliations
- Université de Sherbrooke (CA)
- Universidad de la República de Uruguay (UY)
- Corresponding author
- Langlois, Pascal L.
- Venue
- Nutrition
- Publisher
- Elsevier BV
- Published
- 2019-05
- Volume
- 61
- Pages
- 84-92
- ISSN
- 0899-9007 (ISSN-L)
- PMC
- PMC10019281
- OpenAlex
- W2900137047
- Cited by
- 91
- References
- 33
- Citations by year
- 2026: 7 · 2025: 2 · 2024: 9 · 2023: 11 · 2022: 17 · 2021: 32 · 2020: 11 · 2019: 1 · 2018: 1
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nutrition (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- omega-3 polyunsaturated fatty acids, acute respiratory distress syndrome, eicosapentaenoic acid, gamma-linolenic acid, oxygenation, mechanical ventilation duration, ICU length of stay, mortality, infectious complications, critically ill patients, anti-inflammatory therapy, immune-enhancing diet
- MeSH terms
- Antioxidants, Enteral Nutrition, Humans, Length of Stay, Respiration, Artificial, Respiratory Distress Syndrome, Eicosapentaenoic Acid, Fatty Acids, Omega-3, Randomized Controlled Trials as Topic, Critical Illness, Treatment Outcome, gamma-Linolenic Acid, Immunomodulation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
