The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Long noncoding RNA PVT1 indicates a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically regulating p15 and p16
Open accessAbstract
BACKGROUND: Mounting evidence indicates that long noncoding RNAs (lncRNAs) could play a pivotal role in cancer biology. However, the overall biological role and clinical significance of PVT1 in gastric carcinogenesis remains largely unknown. METHODS: Expression of PVT1 was analyzed in 80 GC tissues and cell lines by qRT-PCR. The effect of PVT1 on proliferation was evaluated by MTT and colony formation assays, and cell apoptosis was evaluated by Flow-cytometric analysis. GC cells transfected with shPVT1 were injected into nude mice to study the effect of PVT1 on tumorigenesis in vivo. RIP was performed to confirm the interaction between PVT1 and EZH2. ChIP was used to study the promoter region of related genes. RESULTS: The higher expression of PVT1 was significantly correlated with deeper invasion depth and advanced TNM stage. Multivariate analyses revealed that PVT1 expression served as an independent predictor for overall survival (p = 0.031). Further experiments demonstrated that PVT1 knockdown significantly inhibited the proliferation both in vitro and in vivo. Importantly, we also showed that PVT1 played a key role in G1 arrest. Moreover, we further confirmed that PVT1 was associated with enhancer of zeste homolog 2 (EZH2) and that this association was required for the repression of p15 and p16. To our knowledge, this is the first report showed that the role and the mechanism of PVT1 in the progression of gastric cancer. CONCLUSIONS: Together, these results suggest that lncRNA PVT1 may serve as a candidate prognostic biomarker and target for new therapies in human gastric cancer.
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Long non-coding RNAs: insights into functions
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Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
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Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
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The role of non-coding RNAs in oncology
Slack, F. J., & Chinnaiyan, A. M. (2019) · Cell · doi:10.1016/j.cell.2019.10.017 · Cited by 1,619
Chen, J., Yu, Y., Li, H., Hu, Q., Chen, X., He, Y., Xue, C., Ren, F., Ren, Z., Li, J., et al. (2019) · Molecular Cancer · doi:10.1186/s12943-019-0947-9 · Cited by 389
RetractedLong Noncoding RNAs as Biomarkers in Cancer
Bolha, L., Ravnik-Glavač, M., & Glavač, D. (2017) · Disease Markers · doi:10.1155/2017/7243968 · Cited by 365
Expanding the p53 regulatory network: LncRNAs take up the challenge
Grossi, E., Sánchez, Y., & Huarte, M. (2016) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2015.07.011 · Cited by 78
Metadata
- Authors
- Kong, R., Zhang, E.-B., Yin, D.-D., You, L.-H., Xu, T.-P., Chen, W.-M., Xia, R., Wan, L., Sun, M., Wang, Z.-X., De, W., & Zhang, Z.-H.
- Venue
- Molecular Cancer
- Published
- 2015-04-12
- Volume
- 14
- Issue
- 1
- Pages
- 82-82
- ISSN
- 1476-4598 (ISSN-L)
- OpenAlex
- W2124996418
- Cited by
- 314
- References
- 6
- FWCI
- 14.52
- Type
- journal article
- Language
- en
- Open access
- gold
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- Kong, R., Zhang, E.-B., Yin, D.-D., You, L.-H., Xu, T.-P., Chen, W.-M., Xia, R., Wan, L., Sun, M., Wang, Z.-X., De, W., & Zhang, Z.-H. (2015). Long noncoding RNA PVT1 indicates a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically regulating p15 and p16. Molecular Cancer. https://doi.org/10.1186/s12943-015-0355-8
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