Expanding the p53 regulatory network: LncRNAs take up the challenge
Abstract
Long noncoding RNAs (lncRNAs) are rapidly emerging as important regulators of gene expression in a wide variety of physiological and pathological cellular processes. In particular, a number of studies revealed that some lncRNAs participate in the p53 pathway, the unquestioned protagonist of tumor suppressor response. Indeed, several lncRNAs are not only part of the large pool of genes coordinated by p53 transcription factor, but are also required by p53 to fine-tune its response and to fully accomplish its tumor suppressor program. In this review we will discuss the current and fast growing knowledge about the contribution of lncRNAs to the complexity of the p53 network, the different mechanisms by which they affect gene regulation in this context, and their involvement in cancer. The incipient impact of lncRNAs in the p53 biological response may encourage the development of therapies and diagnostic methods focused on these noncoding molecules. This article is part of a Special Issue entitled: Clues to long noncoding RNA taxonomy1, edited by Dr. Tetsuro Hirose and Dr. Shinichi Nakagawa.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Several noncoding RNAs, including microRNAs and long noncoding RNAs such as TUG1, miR-34, lincRNA-p21, PANDA and PINT, were reported to mediate p53-dependent gene regulation.
“Several noncoding RNAs were reported to mediate p53-dependent gene regulation—these include microRNAs120 and long noncoding RNAs,121 such as TUG1,122, 123 miR-34,124 lincRNA-p21,125 PANDA126 and PINT.127”
From Census and evaluation of p53 target genes (2017) · cites this paper as [121]
Cites
Landscape of transcription in human cells
Djebali, S., Davis, C. A., Merkel, A., Dobin, A., Lassmann, T., Mortazavi, A., Tanzer, A., Lagarde, J., Lin, W., Schlesinger, F., et al. (2012) · Nature · doi:10.1038/nature11233 · Cited by 5,187 · see citing works
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,178 · see citing works
Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
Guttman, M., Amit, I., Garber, M., French, C., Lin, M. F., Feldser, D., Huarte, M., Zuk, O., Carey, B. W., Cassady, J. P., et al. (2009) · Nature · doi:10.1038/nature07672 · Cited by 4,098 · see citing works
Self-citationGenome Regulation by Long Noncoding RNAs
Rinn, J. L., & Chang, H. Y. (2012) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-051410-092902 · Cited by 4,011 · see citing works
Cabili, M. N., Trapnell, C., Goff, L. A., Koziol, M. J., Tazón‐Vega, B., Regev, A., & Rinn, J. L. (2011) · Genes & Development · doi:10.1101/gad.17446611 · Cited by 3,473 · see citing works
Blinded by the Light: The Growing Complexity of p53
Vousden, K. H., & Prives, C. (2009) · Cell · doi:10.1016/j.cell.2009.04.037 · Cited by 3,163 · see citing works
Momand, J., Zambetti, G. P., Olson, D. C., George, D., & Levine, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90644-r · Cited by 3,113 · see citing works
Long non-coding RNAs: new players in cell differentiation and development
Fatica, A., & Bozzoni, I. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3606 · Cited by 2,980 · see citing works
Khalil, A. M., Guttman, M., Huarte, M., Garber, M., Raj, A., Rivea Morales, D., Thomas, K., Presser, A., Bernstein, B. E., van Oudenaarden, A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904715106 · Cited by 2,872 · see citing works
Self-citationThe landscape of long noncoding RNAs in the human transcriptome
Iyer, M. K., Niknafs, Y. S., Malik, R., Singhal, U., Sahu, A., Hosono, Y., Barrette, T. R., Prensner, J. R., Evans, J. R., Zhao, S., et al. (2015) · Nature Genetics · doi:10.1038/ng.3192 · Cited by 2,738 · see citing works
lincRNAs: Genomics, Evolution, and Mechanisms
Ulitsky, I., & Bartel, D. P. (2013) · Cell · doi:10.1016/j.cell.2013.06.020 · Cited by 2,596 · see citing works
Ji, P., Diederichs, S., Wang, W., Böing, S., Metzger, R., Schneider, P. M., Tidow, N., Brandt, B., Buerger, H., Bulk, E., et al. (2003) · Oncogene · doi:10.1038/sj.onc.1206928 · Cited by 2,191 · see citing works
A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response
Huarte, M., Guttman, M., Feldser, D., Garber, M., Koziol, M. J., Kenzelmann-Broz, D., Khalil, A. M., Zuk, O., Amit, I., Rabani, M., et al. (2010) · Cell · doi:10.1016/j.cell.2010.06.040 · Cited by 2,053 · see citing works
Self-citationNascent RNA Sequencing Reveals Widespread Pausing and Divergent Initiation at Human Promoters
Core, L. J., Waterfall, J. J., & Lis, J. T. (2008) · Science · doi:10.1126/science.1162228 · Cited by 1,986 · see citing works
Transcriptional control of human p53-regulated genes
Riley, T., Sontag, E., Chen, P., & Levine, A. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2395 · Cited by 1,921 · see citing works
lincRNAs act in the circuitry controlling pluripotency and differentiation
Guttman, M., Donaghey, J., Carey, B. W., Garber, M. G., Grenier, J. K., Munson, G., Young, G., Lucas, A. B., Ach, R. A., Bruhn, L., et al. (2011) · Nature · doi:10.1038/nature10398 · Cited by 1,845 · see citing works
Antisense Transcription in the Mammalian Transcriptome
Katayama, S., Tomaru, Y., Kasukawa, T., Waki, K., Nakanishi, M., Nakamura, M., Nishida, H., Yap, C.-S., Suzuki, M., Kawai, J., et al. (2005) · Science · doi:10.1126/science.1112009 · Cited by 1,664 · see citing works
Suppression of induced pluripotent stem cell generation by the p53–p21 pathway
Hong, H., Takahashi, K., Ichisaka, T., Aoi, T., Kanagawa, O., Nakagawa, M., Okita, K., & Yamanaka, S. (2009) · Nature · doi:10.1038/nature08235 · Cited by 1,301 · see citing works
Post-translational modification of p53 in tumorigenesis
Bode, A. M., & Dong, Z. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1455 · Cited by 1,270 · see citing works
Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters
Hung, T., Wang, Y., Lin, M. F., Koegel, A. K., Kotake, Y., Grant, G. D., Horlings, H. M., Shah, N., Umbricht, C. B., Wang, P., et al. (2011) · Nature Genetics · doi:10.1038/ng.848 · Cited by 1,165 · see citing works
Oda, K., Arakawa, H., Tanaka, T., Matsuda, K., Tanikawa, C., Mori, T., Nishimori, H., Tamai, K., Tokino, T., Nakamura, Y., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)00073-8 · Cited by 1,162 · see citing works
Post‐translational modifications and activation of p53 by genotoxic stresses
Appella, E., & Anderson, C. W. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2001.02225.x · Cited by 1,071 · see citing works
Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells
Loewer, S., Cabili, M. N., Guttman, M., Loh, Y., Thomas, K., Park, I. H., Garber, M. G., Curran, M. S., Önder, T. T., Agarwal, S., et al. (2010) · Nature Genetics · doi:10.1038/ng.710 · Cited by 971 · see citing works
LincRNA-p21 Suppresses Target mRNA Translation
Yoon, J., Abdelmohsen, K., Srikantan, S., Yang, X., Martindale, J. L., De, S., Huarte, M., Zhan, M., Becker, K. G., & Gorospe, M. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.06.027 · Cited by 962 · see citing works
Self-citationWild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.Preprint
Debbas, M. E., & White, E. (1993) · Genes & Development · doi:10.1101/gad.7.4.546 · Cited by 871 · see citing works
Functional and Mechanistic Diversity of Distal Transcription Enhancers
Bulger, M., & Groudine, M. (2011) · Cell · doi:10.1016/j.cell.2011.01.024 · Cited by 803 · see citing works
Tripathi, V., Shen, Z., Chakraborty, A., Giri, S., Freier, S. M., Wu, X., Zhang, Y., Gorospe, M., Prasanth, S. G., Lal, A., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003368 · Cited by 753 · see citing works
Mediation of c-Myc-Induced Apoptosis by p53
Hermeking, H., & Eick, D. (1994) · Science · doi:10.1126/science.8091232 · Cited by 738 · see citing works
A long nuclear‐retained non‐coding RNA regulates synaptogenesis by modulating gene expression
Bernard, D., Prasanth, K. V., Tripathi, V., Colasse, S., Nakamura, T., Xuan, Z., Zhang, M. Q., Sedel, F., Jourdren, L., Coulpier, F., et al. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.199 · Cited by 738 · see citing works
Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiationPreprint
Dinger, M. E., Amaral, P., Mercer, T. R., Pang, K. C., Bruce, S. J., Gardiner, B., Askarian-Amiri, M., Ru, K., Soldà, G., Simons, C., et al. (2008) · Genome Research · doi:10.1101/gr.078378.108 · Cited by 729 · see citing works
PVT1 dependence in cancer with MYC copy-number increase
Tseng, Y., Moriarity, B. S., Gong, W., Akiyama, R., Tiwari, A., Kawakami, H., Ronning, P., REULAND, B. D., Guenther, K. L., Beadnell, T. C., et al. (2014) · Nature · doi:10.1038/nature13311 · Cited by 724 · see citing works
MEG3 noncoding RNA: a tumor suppressor
Zhou, Y., Zhang, X., & Klibanski, A. (2012) · Journal of Molecular Endocrinology · doi:10.1530/jme-12-0008 · Cited by 717 · see citing works
Bulavin, D. V., Saito, S., Hollander, M. C., Sakaguchi, K., Anderson, C. W., Appella, E., & Fornace, A. J. (1999) · The EMBO Journal · doi:10.1093/emboj/18.23.6845 · Cited by 704 · see citing works
Activation of p53 by MEG3 Non-coding RNA
Zhou, Y., Zhong, Y., Wang, Y., Zhang, X., Batista, D. L., Gejman, R., Ansell, P. J., Zhao, J. C., Weng, C., & Klibanski, A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702029200 · Cited by 654 · see citing works
Posttranscriptional Gene Regulation by Long Noncoding RNA
Yoon, J., Abdelmohsen, K., & Gorospe, M. (2012) · Journal of Molecular Biology · doi:10.1016/j.jmb.2012.11.024 · Cited by 628 · see citing works
Yang, L., Lin, C., Liu, W., Zhang, J., Ohgi, K. A., Grinstein, J. D., Dorrestein, P. C., & Rosenfeld, M. G. (2011) · Cell · doi:10.1016/j.cell.2011.08.054 · Cited by 612 · see citing works
Transcriptional Regulation by P53
Beckerman, R., & Prives, C. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000935 · Cited by 569 · see citing works
The expanding universe of p53 targets
Menendez, D., Inga, A., & Resnick, M. A. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2730 · Cited by 568 · see citing works
eRNAs Are Required for p53-Dependent Enhancer Activity and Gene Transcription
Melo, C. A., Drost, J., Wijchers, P. J., van de Werken, H., de Wit, E., Vrielink, J. A. F. O., Elkon, R., Melo, S. A., Léveillé, N., Kalluri, R., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.11.021 · Cited by 544 · see citing works
MicroRNAs in the p53 network: micromanagement of tumour suppression
Hermeking, H. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3318 · Cited by 518 · see citing works
The Noncoding RNA Taurine Upregulated Gene 1 Is Required for Differentiation of the Murine Retina
Young‐Pearse, T. L., Matsuda, T., & Cepko, C. L. (2005) · Current Biology · doi:10.1016/j.cub.2005.02.027 · Cited by 500 · see citing works
Targeting long non-coding RNAs in cancers: Progress and prospects
Li, C. H., & Chen, Y. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.05.030 · Cited by 473 · see citing works
Up‐regulated long non‐coding RNA H19 contributes to proliferation of gastric cancer cells
Yang, F., Bi, J., Xue, X., Zheng, L., Zhi, K., Hua, J.-D., & Fang, G. (2012) · FEBS Journal · doi:10.1111/j.1742-4658.2012.08694.x · Cited by 466 · see citing works
p53 regulates maternal reproduction through LIF
Hu, W., Feng, Z., Teresky, A. K., & Levine, A. J. (2007) · Nature · doi:10.1038/nature05993 · Cited by 446 · see citing works
Dimitrova, N., Zamudio, J. R., Jong, R. M., Soukup, D., Resnick, R., Sarma, K., Ward, A. J., Raj, A., Lee, J. T., Sharp, P. A., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.04.025 · Cited by 445 · see citing works
p53 Transcriptional Activation Mediated by Coactivators TAF II 40 and TAF II 60
Thut, C. J., Chen, J.-L., Klemm, R. D., & Tjian, R. (1995) · Science · doi:10.1126/science.7809597 · Cited by 439 · see citing works
A Pituitary-Derived MEG3 Isoform Functions as a Growth Suppressor in Tumor Cells
Zhang, X., Zhou, Y., Mehta, K. R., Danila, D. C., Scolavino, S., Johnson, S. R., & Klibanski, A. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030222 · Cited by 436 · see citing works
Zhang, E.-B., Yin, D.-D., Sun, M., Kong, R., Liu, X.-H., You, L.-H., Han, L., Xia, R., Wang, K.-M., Yang, J.-S., et al. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.201 · Cited by 427 · see citing works
p53 suppresses the self-renewal of adult neural stem cells
Meletis, K., Wirta, V., Hede, S., Nistér, M., Lundeberg, J., & Frisén, J. (2005) · Development · doi:10.1242/dev.02208 · Cited by 414 · see citing works
TGF-β–Induced Upregulation of malat1 Promotes Bladder Cancer Metastasis by Associating with suz12
Fan, Y., Shen, B., Tan, M., Mu, X., Qin, Y., Zhang, F., & Liu, Y. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-1455 · Cited by 410 · see citing works
Noncoding Transcription at Enhancers: General Principles and Functional Models
Natoli, G., & Andrau, J. (2012) · Annual Review of Genetics · doi:10.1146/annurev-genet-110711-155459 · Cited by 395 · see citing works
LncRNA loc285194 is a p53-regulated tumor suppressor
Liu, Q., Huang, J., Zhou, N., Zhang, Z., Zhang, A., Lu, Z., Wu, F., & Mo, Y. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt182 · Cited by 384 · see citing works
Human Cancer Long Non-Coding RNA Transcriptomes
Gibb, E. A., Vucic, E. A., Enfield, K. S. S., Stewart, G. L., Lonergan, K. M., Kennett, J. Y., Becker‐Santos, D. D., MacAulay, C. E., Lam, S. C., Brown, C. J., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025915 · Cited by 365 · see citing works
Considerations when investigating lncRNA function in vivo
Bassett, A. R., Akhtar, A., Barlow, D. P., Bird, A. P., Brockdorff, N., Duboule, D., Ephrussi, A., Ferguson‐Smith, A. C., Gingeras, T., Haerty, W., et al. (2014) · eLife · doi:10.7554/elife.03058 · Cited by 348 · see citing works
Amplification of PVT1 Contributes to the Pathophysiology of Ovarian and Breast Cancer
Guan, Y., Kuo, W.-L., Stilwell, J. L., Takano, H., Lapuk, A. V., Fridlyand, J., Mao, J., Yu, M., Miller, M. A., Santos, J. L., et al. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2882 · Cited by 347 · see citing works
Hou, P., Zhao, Y., Li, Z., Yao, R., Ma, M., Gao, Y., Zhao, L., Zhang, Y., Huang, B., & Lü, J. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.249 · Cited by 341 · see citing works
Transcriptomic and genomic analysis of human hepatocellular carcinomas and hepatoblastomas†
Luo, J., Ren, B., Keryanov, S., Tseng, G. C., Rao, U. N. M., Monga, S. P., Strom, S. C., Demetris, A. J., Nalesnik, M. A., Yu, Y. P., et al. (2006) · Hepatology · doi:10.1002/hep.21328 · Cited by 339 · see citing works
Li, Z. (2011) · International Journal of Oncology · doi:10.3892/ijo.2011.1007 · Cited by 325 · see citing works
Kong, R., Zhang, E., Yin, D., You, L., Xu, T., Chen, W., Xia, R., Wan, L., Sun, M., Wang, Z.-X., et al. (2015) · Molecular Cancer · doi:10.1186/s12943-015-0355-8 · Cited by 314 · see citing works
Neighboring Gene Regulation by Antisense Long Non-Coding RNAs
Villegas, V. E., & Zaphiropoulos, P. G. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16023251 · Cited by 309 · see citing works
The human long non-coding RNA-RoR is a p53 repressor in response to DNA damage
Zhang, A., Zhou, N., Huang, J., Liu, Q., Fukuda, K., Ma, D., Lü, Z., Bai, C., Watabe, K., & Mo, Y. (2012) · Cell Research · doi:10.1038/cr.2012.164 · Cited by 301 · see citing works
Downregulated MEG3 activates autophagy and increases cell proliferation in bladder cancer
Ying, L., Huang, Y., Chen, H., Wang, Y., Xia, L., Chen, Y., Liu, Y., & Qiu, F. (2012) · Molecular BioSystems · doi:10.1039/c2mb25386k · Cited by 299 · see citing works
Loss of H19 imprinting in esophageal cancer.
Hibi, K., Nakamura, H., Hirai, A., Fujikake, Y., Kasai, Y., Akiyama, S., Ito, K., & Takagi, H. (1996) · PubMed · Cited by 267 · see citing works
PintlincRNA connects the p53 pathway with epigenetic silencing by the Polycomb repressive complex 2
Marín-Béjar, O., Marchese, F. P., Athie, A., Sánchez, Y., González, J., Segura, V., Huang, L., Moreno, I., Navarro, A., Monzó, M., et al. (2013) · Genome biology · doi:10.1186/gb-2013-14-9-r104 · Cited by 265 · see citing works
Self-citationWrap53, a Natural p53 Antisense Transcript Required for p53 Induction upon DNA Damage
Mahmoudi, S., Henriksson, S., Corcoran, M., Méndez‐Vidal, C., Wiman, K. G., & Farnebo, M. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.11.027 · Cited by 250 · see citing works
Wrap53, a Natural p53 Antisense Transcript Required for p53 Induction upon DNA Damage
Mahmoudi, S., Henriksson, S., Corcoran, M., Méndez‐Vidal, C., Wiman, K. G., & Farnebo, M. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.01.028 · Cited by 248 · see citing works
A transcriptional sketch of a primary human breast cancer by 454 deep sequencing
Guffanti, A., Iacono, M., Pelucchi, P., Kim, N., Soldà, G., Croft, L., Taft, R. J., Rizzi, E., Askarian-Amiri, M., Bonnal, R. J. P., et al. (2009) · BMC Genomics · doi:10.1186/1471-2164-10-163 · Cited by 229 · see citing works
Saldaña-Meyer, R., González-Buendía, E., Guerrero, G., Narendra, V., Bonasio, R., Recillas-Targa, F., & Reinberg, D. (2014) · Genes & Development · doi:10.1101/gad.236869.113 · Cited by 217 · see citing works
Zhang, H., Yang, F., Shao-jun, C., Che, J., & Zheng, J. (2014) · Tumor Biology · doi:10.1007/s13277-014-2925-6 · Cited by 214 · see citing works
Prives, C. L., & Manley, J. L. (2001) · Cell · doi:10.1016/s0092-8674(01)00619-5 · Cited by 210 · see citing works
PVT1: A Rising Star among Oncogenic Long Noncoding RNAs
Colombo, T., Farina, L., Macino, G., & Paci, P. (2015) · BioMed Research International · doi:10.1155/2015/304208 · Cited by 208 · see citing works
Long noncoding RNA PANDA and scaffold-attachment-factor SAFA control senescence entry and exit
Pavan Kumar, P., Desetty, R. D., Pineau, P., Marchio, A., Moon, A., Dejean, A., & Bischof, O. (2014) · Nature Communications · doi:10.1038/ncomms6323 · Cited by 200 · see citing works
Long intergenic non‐coding RNA TUG1 is overexpressed in urothelial carcinoma of the bladder
Han, Y., Liu, Y., Gui, Y., & Cai, Z. (2012) · Journal of Surgical Oncology · doi:10.1002/jso.23264 · Cited by 195 · see citing works
Sánchez, Y., Segura, V., Marín-Béjar, O., Athie, A., Marchese, F. P., González, J., Bujanda, L., Guo, S., Matheu, A., & Huarte, M. (2014) · Nature Communications · doi:10.1038/ncomms6812 · Cited by 192 · see citing works
Self-citationLong Non-Coding RNAs: Challenges for Diagnosis and Therapies
Sánchez, Y., & Huarte, M. (2013) · Nucleic Acid Therapeutics · doi:10.1089/nat.2012.0414 · Cited by 187 · see citing works
Self-citationZhang, Q., Geng, P., Yin, P., Wang, X., Jia, J.-P., & Yao, J. (2013) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2013.14.4.2311 · Cited by 187 · see citing works
p53-dependent Induction of PVT1 and miR-1204
Barsotti, A. M., Beckerman, R., Laptenko, O., Huppi, K. E., Caplen, N. J., & Prives, C. L. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.322875 · Cited by 186 · see citing works
Bao, X., Wu, H., Zhu, X., Guo, X., Hutchins, A. P., Luo, Z., Song, H., Chen, Y., Lai, K., Yin, M., et al. (2014) · Cell Research · doi:10.1038/cr.2014.165 · Cited by 186 · see citing works
Léveillé, N., Melo, C. A., Rooijers, K., Díaz-Lagares, A., Melo, S. A., Korkmaz, G., Lopes, R., Moqadam, F. A., Maia, A. R., Wijchers, P. J., et al. (2015) · Nature Communications · doi:10.1038/ncomms7520 · Cited by 183 · see citing works
Wang, F., Ren, S., Chen, R., Lu, J., Shi, X., Zhu, Y., Zhang, W., Jing, T., Zhang, C., Shen, J. G., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2691 · Cited by 181 · see citing works
Long non-coding RNAs and chromatin modifiers
Marchese, F. P., & Huarte, M. (2013) · Epigenetics · doi:10.4161/epi.27472 · Cited by 179 · see citing works
Self-citationMelanoma cell invasiveness is regulated by miR‐211 suppression of the BRN2 transcription factor
Boyle, G. M., Woods, S. L., Bonazzi, V., Stark, M. S., Hacker, E., Aoude, L. G., Dutton‐Regester, K., Cook, A. L., Sturm, R. A., & Hayward, N. K. (2011) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2011.00849.x · Cited by 177 · see citing works
SnapShot: p53 Posttranslational Modifications
Kruse, J.-P., & Gu, W. J. (2008) · Cell · doi:10.1016/j.cell.2008.05.020 · Cited by 170 · see citing works
Pašić, I., Shlien, A., Durbin, A. D., Stavropoulos, D. J., Baskin, B., Ray, P. N., Novokmet, A., & Malkin, D. M. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-1902 · Cited by 170 · see citing works
Zhou, X., Gao, Q. F., Wang, J., Zhang, X., Liu, K., & Duan, Z. (2014) · Gynecologic Oncology · doi:10.1016/j.ygyno.2014.02.033 · Cited by 168 · see citing works
Investigation of circulating lncRNAs in B-cell neoplasms
Işın, M., Özgür, E., Çetin, G., Erten, N., Aktan, M., Deligezer, U., & Dalay, N. (2014) · Clinica Chimica Acta · doi:10.1016/j.cca.2014.02.010 · Cited by 163 · see citing works
Han, L., Zhang, E.-B., Yin, D.-D., Kong, R., Xu, T.-P., Chen, W.-M., Xia, R., Shu, Y.-Q., & De, W. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.30 · Cited by 161 · see citing works
Benetatos, L., Hatzimichael, E. C., Dasoula, A., Dranitsaris, G., Tsiara, S., Syrrou, M., Georgiou, I. A., & Bourantas, K. L. (2009) · Leukemia Research · doi:10.1016/j.leukres.2009.06.019 · Cited by 153 · see citing works
Xu, Y., Wang, J., Qiu, M., Xu, L., Li, M., Jiang, F., Yin, R. H., & Xu, L. (2014) · Tumor Biology · doi:10.1007/s13277-014-2763-6 · Cited by 149 · see citing works
The imprinted H19 gene is a marker of early recurrence in human bladder carcinoma
Ariel, I. (2000) · Molecular Pathology · doi:10.1136/mp.53.6.320 · Cited by 146 · see citing works
Low expression of LOC285194 is associated with poor prognosis in colorectal cancer
Qi, P., Xu, M., Ni, S., Huang, D., Wei, P., Tan, C., Zhou, X.-Y., & Du, X. (2013) · Journal of Translational Medicine · doi:10.1186/1479-5876-11-122 · Cited by 138 · see citing works
Wang, G., Li, Z., Zhao, Q., Zhu, Y., Zhao, C., LI, X., Ma, Z., Li, X., & Zhang, Y. (2014) · Oncology Reports · doi:10.3892/or.2014.3047 · Cited by 137 · see citing works
A perspective of promoter architecture from the CCAAT box
Dolfini, D., Zambelli, F., Pavesi, G., & Mantovani, R. (2009) · Cell Cycle · doi:10.4161/cc.8.24.10240 · Cited by 136 · see citing works
Mahmoudi, S., Henriksson, S., Weibrecht, I., Smith, S., Söderberg, O., Strömblad, S., Wiman, K. G., & Farnebo, M. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000521 · Cited by 135 · see citing works
Yang, D.-Q., Halaby, M. J., & Zhang, Y. (2006) · Oncogene · doi:10.1038/sj.onc.1209483 · Cited by 134 · see citing works
Prognostic significance of drug-regulated genes in high-grade osteosarcoma
Fellenberg, J., Bernd, L., Delling, G., Witte, D., & Zahlten‐Hinguranage, A. (2007) · Modern Pathology · doi:10.1038/modpathol.3800937 · Cited by 131 · see citing works
Adriaenssens, É., Dumont, L., Lottin, S., Bolle, D., Alain Leprêtre, A., Delobelle, A., Bouali, F., Dugimont, T., Coll, J., & Curgy, J. (1998) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65748-3 · Cited by 127 · see citing works
Phenotypic characterization of endometrial stromal sarcoma of the uterus
Yamada, K., Kano, J., Tsunoda, H., Yoshikawa, H., Okubo, C., Ishiyama, T., & Noguchi, M. (2006) · Cancer Science · doi:10.1111/j.1349-7006.2006.00147.x · Cited by 127 · see citing works
Imprinted H19 oncofetal RNA is a candidate tumour marker for hepatocellular carcinoma.
Ariel, I. M., Miao, H., Ji, X., Schneider, T., Roll, D., de Groot, N., Hochberg, A., & Ayesh, S. K. (1998) · Molecular Pathology · doi:10.1136/mp.51.1.21 · Cited by 125 · see citing works
Hall, J. R., Messenger, Z. J., Tam, H. W., Phillips, S., Recio, L., & Smart, R. C. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.67 · Cited by 123 · see citing works
Emerging epigenetic mechanisms of long non-coding RNAs
Schaukowitch, K., & Kim, T.-K. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.12.009 · Cited by 122 · see citing works
Kim, K., Choi, J., Heo, K., Kim, H., Levens, D., Kohno, K., Johnson, E. M., Brock, H. W., & An, W. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708205200 · Cited by 116 · see citing works
Gong, Z., Zhang, S., Zeng, Z., Wu, H., Yang, Q., Xiong, F., Shi, L., Yang, J., Zhang, W., Zhou, Y., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110674 · Cited by 110 · see citing works
Clinical Significance of Long Intergenic Noncoding RNA-p21 in Colorectal Cancer
Zhai, H., Fesler, A. T., Schee, K., Fodstad, Ø., Flatmark, K., & Ju, J. (2013) · Clinical Colorectal Cancer · doi:10.1016/j.clcc.2013.06.003 · Cited by 110 · see citing works
Cai, C., Ashktorab, H., Pang, X., Zhao, Y., Sha, W., Liu, Y., & Gu, X. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029750 · Cited by 108 · see citing works
Polypyrimidine tract binding protein regulates IRES-mediated translation of p53 isoforms
Grover, R., Ray, P. S., & Das, S. (2008) · Cell Cycle · doi:10.4161/cc.7.14.6271 · Cited by 104 · see citing works
Intergenic lncRNAs and the evolution of gene expression
Marques, A. C., & Ponting, C. P. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2014.03.009 · Cited by 102 · see citing works
Integrative genomic analysis reveals widespread enhancer regulation by p53 in response to DNA damage
Younger, S. T., Kenzelmann-Broz, D., Jung, H., Attardi, L. D., & Rinn, J. L. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv284 · Cited by 99 · see citing works
Soto‐Reyes, E., & Targa, F. R. (2010) · Oncogene · doi:10.1038/onc.2009.509 · Cited by 95 · see citing works
Tong, Y., Zhou, X., Wang, X., Wu, Q., Yang, T., Lv, J., Yang, J., Zhu, B., & Cao, X. (2014) · Journal of Translational Medicine · doi:10.1186/s12967-014-0233-y · Cited by 94 · see citing works
p53 tumour suppressor gene polymorphism is associated with recurrent implantation failure
Kay, C., Jeyendran, R., & Coulam, C. B. (2006) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)60635-9 · Cited by 92 · see citing works
Expression and Functional Role of Reprogramming-Related Long Noncoding RNA (lincRNA-ROR) in Glioma
Feng, S., Yao, J., Chen, Y., Geng, P., Zhang, H., Ma, X., Zhao, J., & Yu, X. (2015) · Journal of Molecular Neuroscience · doi:10.1007/s12031-014-0488-z · Cited by 91 · see citing works
The Regulation of Aging and Longevity: A New and Complex Role of p53
Feng, Z., Lin, M., & Wu, R. (2011) · Genes & Cancer · doi:10.1177/1947601911410223 · Cited by 87 · see citing works
H19 expression in hepatic metastases from a range of human carcinomas
Fellig, Y., Ariel, I., Ohana, P., Schachter, P., Синельников, И. Е., Birman, T., Ayesh, S. K., Schneider, T., de Groot, N., Czerniak, A., et al. (2005) · Journal of Clinical Pathology · doi:10.1136/jcp.2004.023648 · Cited by 86 · see citing works
Vousden, K. H., & Woude, G. F. V. (2000) · Nature Cell Biology · doi:10.1038/35036427 · Cited by 83 · see citing works
Reduced Expression of the Caenorhabditis elegans p53 Ortholog cep-1 Results in Increased Longevity
Arum, O., & Johnson, T. E. (2007) · The Journals of Gerontology Series A · doi:10.1093/gerona/62.9.951 · Cited by 77 · see citing works
The p53 tumor suppressor protein is a critical regulator of hematopoietic stem cell behavior
Liu, Y., Elf, S., Asai, T., Miyata, Y., Liu, Y., Sashida, G., Huang, G., Giandomenico, S. D., Koff, A., & Nimer, S. D. (2009) · Cell Cycle · doi:10.4161/cc.8.19.9627 · Cited by 65 · see citing works
Getting p53 Out of the Nucleus
Gottifredi, V., & Prives, C. L. (2001) · Science · doi:10.1126/science.1062238 · Cited by 62 · see citing works
hGTSE-1 Expression Stimulates Cytoplasmic Localization of p53
Monte, M., Benetti, R., Collavin, L., Marchionni, L., Sal, G. D., & Schneider, C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311123200 · Cited by 62 · see citing works
Гарипов, А. Р., Li, H., Bitler, B. G., Thapa, R. J., Balachandran, S., & Zhang, R. (2013) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-12-0661 · Cited by 59 · see citing works
Jiao, Y., Liu, C., Cui, F., Xu, J., Tong, J., Qi, X., Wang, L., & Zhu, W. (2014) · Oncology Letters · doi:10.3892/ol.2014.2622 · Cited by 39 · see citing works
Ding, Y., Yu, W., Ma, C., Wang, Q., Huang, C., & Huang, T. (2014) · Europe PMC (PubMed Central) · Cited by 36 · see citing works
Lottin, S., Adriaenssens, É., Berteaux, N., Alain Leprêtre, A., Vilain, M. O., Denhez, E., Coll, J., Dugimont, T., & Curgy, J. (2004) · European Journal of Cancer · doi:10.1016/j.ejca.2004.09.025 · Cited by 36 · see citing works
Idogawa, M., Ohashi, T., Sasaki, Y., Maruyama, R., Kashima, L., Suzuki, H., & Tokino, T. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddt673 · Cited by 36 · see citing works
Shibayama, Y., Fanucchi, S., Magagula, L., & Mhlanga, M. M. (2014) · Transcription · doi:10.4161/trns.28658 · Cited by 34 · see citing works
Functional Characterization of Long Noncoding RNA Lnc_bc060912 in Human Lung Carcinoma Cells
Luo, H., Sun, Y., Wei, G., Luo, J., Yang, X., Liu, W., Guo, M., & Chen, R. (2015) · Biochemistry · doi:10.1021/acs.biochem.5b00259 · Cited by 30 · see citing works
LincRNA-p21 acts as a mediator of ING1b-induced apoptosis
Tran, U., Rajarajacholan, U. K., Soh, J., Ts, K., Thalappilly, S., Sensen, C. W., & Riabowol, K. T. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.15 · Cited by 30 · see citing works
Jeffers, L. K., Duan, K., Ellies, L. G., Seaman, W. T., Binder, R. A., Diatchenko, L. B., & Webster-Cyriaque, J. Y. (2013) · Journal of Cancer Therapy · doi:10.4236/jct.2013.43094 · Cited by 25 · see citing works
Flagged first, then by citations
2 of the 130 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Census and evaluation of p53 target genes
Fischer, M. (2017) · Oncogene · doi:10.1038/onc.2016.502 · Cited by 971 · see citing works
Non-Coding RNAs and their Integrated Networks
Zhang, P., Wu, W., Chen, Q., & Chen, M. (2019) · Berichte aus der medizinischen Informatik und Bioinformatik/Journal of integrative bioinformatics · doi:10.1515/jib-2019-0027 · Cited by 691 · see citing works
Non-coding RNA regulatory networks
Panni, S., Lovering, R. C., Porras, P., & Orchard, S. (2020) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2019.194417 · Cited by 479 · see citing works
Long noncoding RNAs in cancer: mechanisms of action and technological advancements
Bartoniček, N., Mååg, J. L. V., & Dinger, M. E. (2016) · Molecular Cancer · doi:10.1186/s12943-016-0530-6 · Cited by 461 · see citing works
Fischer, M., Grossmann, P., Padi, M., & DeCaprio, J. A. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw523 · Cited by 330 · see citing works
Circulating long non-coding RNAs in cancer: current status and future perspectives
Qi, P., Zhou, X.-Y., & Du, X. (2016) · Molecular Cancer · doi:10.1186/s12943-016-0524-4 · Cited by 313 · see citing works
Jain, A. K., Xi, Y., McCarthy, R. L., Allton, K. L., Akdemir, K. C., Patel, L. R., Aronow, B. J., Lin, C., Li, W., Yang, L., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.10.039 · Cited by 243 · see citing works
Emerging role of non‐coding RNA in health and disease
Bhatti, G. K., Khullar, N., Sidhu, I. S., Navik, U. S., Reddy, A. P., Reddy, P. H., & Bhatti, J. S. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-021-00739-y · Cited by 183 · see citing works
Li, X. L., Subramanian, M., Jones, M. F., Chaudhary, R., Singh, D. K., Zong, X., Gryder, B. E., Sindri, S., Mo, M., Schetter, A. J., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.08.041 · Cited by 160 · see citing works
Self-citationZhang, P., Cao, L., Fan, P., Mei, Y., & Wu, M. (2016) · EMBO Reports · doi:10.15252/embr.201642067 · Cited by 125 · see citing works
Li, X. L., Pongor, L. S., Tang, W., Das, S., Muys, B. R., Jones, M. F., Lazar, S. B., Dangelmaier, E. A., Hartford, C. C. R., Grammatikakis, I., et al. (2020) · eLife · doi:10.7554/elife.53734 · Cited by 105 · see citing works
Revealing a human p53 universe
Nguyen, T., Grimm, S. A., Bushel, P. R., Li, J., Li, Y., Bennett, B. D., Lavender, C. A., Ward, J. M., Fargo, D. C., Anderson, C. W., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky720 · Cited by 94 · see citing works
de Jong, J. J., Liu, Y., Robertson, A. G., Seiler, R., Groeneveld, C. S., van der Heijden, M. S., Wright, J. L., Douglas, J., Dall’Era, M., Crabb, S. J., et al. (2019) · Genome Medicine · doi:10.1186/s13073-019-0669-z · Cited by 90 · see citing works
Nohata, N., Abba, M. C., & Gutkind, J. S. (2016) · Oral Oncology · doi:10.1016/j.oraloncology.2016.05.014 · Cited by 83 · see citing works
Goyal, A., Fiškin, E., Gutschner, T., Polycarpou‐Schwarz, M., Groß, M., Neugebauer, J. K., Gandhi, M., Caudron‐Herger, M., Beneš, V., & Diederichs, S. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx952 · Cited by 77 · see citing works
Tumor suppressor p53: from engaging DNA to target gene regulation
Sammons, M. A., Nguyen, T., McDade, S. S., & Fischer, M. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa666 · Cited by 77 · see citing works
Fattah, Y. K. A. E., Abulsoud, A. I., AbdelHamid, S. G., & Hamdy, N. Μ. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.09.209 · Cited by 70 · see citing works
Emerging roles of lnc RNA s in senescence
Montes, M., & Lund, A. H. (2016) · FEBS Journal · doi:10.1111/febs.13679 · Cited by 64 · see citing works
Long non-coding RNAs in hepatocellular carcinoma: Potential roles and clinical implications
Niu, Z.-S., Niu, X.-J., & Wang, W. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i32.5860 · Cited by 64 · see citing works
Radiation-Induced Long Noncoding RNAs in a Mouse Model after Whole-Body Irradiation
Aryankalayil, M. J., Chopra, S., LEVIN, J. M., Eke, I., Makinde, A. Y., Das, S., Shankavaram, U. T., Vanpouille‐Box, C., Demaria, S., & Coleman, C. N. (2018) · Radiation Research · doi:10.1667/rr14891.1 · Cited by 62 · see citing works
Mutant p53 in cell-cell interactionsPreprint
Pilley, S. E., Rodríguez, T. A., & Vousden, K. H. (2021) · Genes & Development · doi:10.1101/gad.347542.120 · Cited by 54 · see citing works
Meza‐Sosa, K. F., Miao, R., Navarro, F., Zhang, Z., Zhang, Y., Hu, J. J., Hartford, C. C. R., Li, X. L., Pedraza‐Alva, G., Pérez‐Martínez, L., et al. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.01.001 · Cited by 52 · see citing works
Long non-coding RNAs: crucial regulators of gastrointestinal cancer cell proliferation
Chen, J., Liu, S., & Hu, X. (2018) · Cell Death Discovery · doi:10.1038/s41420-018-0051-8 · Cited by 48 · see citing works
Yang, Y., Wang, C., Zhao, K., Zhang, G., Wang, D., & Mei, Y. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0884-3 · Cited by 43 · see citing works
Long Noncoding RNAs at the Crossroads of Cell Cycle and Genome Integrity
Guiducci, G., & Stojic, L. (2021) · Trends in Genetics · doi:10.1016/j.tig.2021.01.006 · Cited by 42 · see citing works
Emerging roles of long non-coding RNAs in the p53 network
Jain, A. K. (2020) · RNA Biology · doi:10.1080/15476286.2020.1770981 · Cited by 35 · see citing works
Sharma, S. K., & Münger, K. (2020) · mBio · doi:10.1128/mbio.01190-20 · Cited by 34 · see citing works
Anti-Transcription Factor RNA Aptamers as Potential Therapeutics
Mondragón, E., & Maher, L. J. (2015) · Nucleic Acid Therapeutics · doi:10.1089/nat.2015.0566 · Cited by 33 · see citing works
The crosstalk between long non-coding RNAs and PI3K in cancer
Benetatos, L., Voulgaris, E., & Vartholomatos, G. (2017) · Medical Oncology · doi:10.1007/s12032-017-0897-2 · Cited by 33 · see citing works
A novel lncRNA, GASL1, inhibits cell proliferation and restricts E2F1 activity
Gasri-Plotnitsky, L., Ovadia, A., Shamalov, K., Nizri-Megnaji, T., Meir, S., Zurer, I., Cohen, C. J., & Ginsberg, D. (2017) · Oncotarget · doi:10.18632/oncotarget.15864 · Cited by 32 · see citing works
Long Non-Coding RNAs: Tools for Understanding and Targeting Cancer Pathways
Pandey, G. K., & Kanduri, C. (2022) · Cancers · doi:10.3390/cancers14194760 · Cited by 31 · see citing works
miRNA–miRNA crosstalk: from genomics to phenomics
Xu, J., Shao, T., Ding, N., Li, Y., & Li, X. (2016) · Briefings in Bioinformatics · doi:10.1093/bib/bbw073 · Cited by 31 · see citing works
Xu, W., Liu, C., Deng, B., Lin, P., Sun, Z., Liu, A., Xuan, J., Li, Y., Zhou, K., Zhang, X., et al. (2022) · Genome Research · doi:10.1101/gr.275831.121 · Cited by 30 · see citing works
The role of long non‐coding RNAs in multiple myeloma
Cui, Y., Song, Y., & Fang, B. (2019) · European Journal Of Haematology · doi:10.1111/ejh.13237 · Cited by 30 · see citing works
Novel isatin-derived molecules activate p53 via interference with Mdm2 to promote apoptosis
Fedorova, O., Daks, A. A., Petrova, V., Petukhov, A., Lezina, L., Shuvalov, O. Y., Davidovich, P. B., Kriger, D. V., Lomert, E. V., Tentler, D., et al. (2018) · Cell Cycle · doi:10.1080/15384101.2018.1506664 · Cited by 30 · see citing works
Zhihua, Z., Wang, W., Lihua, N., Jianying, Z., & Guozhong, J. (2019) · IUBMB Life · doi:10.1002/iub.2069 · Cited by 28 · see citing works
Melo, C. A., Léveillé, N., Rooijers, K., Wijchers, P. J., Geeven, G., Tal, A., Melo, S. A., de Laat, W. L., & Agami, R. (2016) · Oncogene · doi:10.1038/onc.2015.502 · Cited by 28 · see citing works
RETRACTED: lncRNA TRMP-S directs dual mechanisms to regulate p27-mediated cellular senescence
Tian, S., Khan, M. R., Zhang, X. D., Li, J., Thorne, R. F., Wu, M., & Shao, F. (2021) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2021.04.004 · Cited by 27 · see citing works
RetractedChen, G., Xue, H., Zhang, X., Ding, D., & Zhang, S. (2022) · Renal Failure · doi:10.1080/0886022x.2022.2039195 · Cited by 26 · see citing works
Long non-coding RNA profiling of pediatric Medulloblastoma
Kesherwani, V., Shukla, M., Coulter, D. W., Sharp, J. G., Joshi, S. S., & Chaturvedi, N. K. (2020) · BMC Medical Genomics · doi:10.1186/s12920-020-00744-7 · Cited by 25 · see citing works
Loss of p53-inducible long non-coding RNA LINC01021 increases chemosensitivity
Kaller, M., Götz, U., & Hermeking, H. (2017) · Oncotarget · doi:10.18632/oncotarget.22245 · Cited by 24 · see citing works
Shining the Light on Senescence Associated LncRNAs
Ghanam, A. R., Xu, Q., Ke, S., Azhar, M., Cheng, Q., & Song, X. (2017) · Aging and Disease · doi:10.14336/ad.2016.0810 · Cited by 23 · see citing works
Tesfaye, E., Martínez‐Terroba, E., Bendor, J., Winkler, L., Olivero, C. E., Chen, K., Feldser, D. M., Zamudio, J. R., & Dimitrova, N. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2025539118 · Cited by 21 · see citing works
Long non-coding RNA HOTAIR polymorphism and susceptibility to cancer: an updated meta-analysis
Li, J., Cui, Z., Li, H., Lv, X., Gao, M., Yang, Z., Bi, Y., Zhou, B., & Yin, Z. (2018) · Environmental Health and Preventive Medicine · doi:10.1186/s12199-018-0697-0 · Cited by 20 · see citing works
Clinical relevance of circulating molecules in cancer: focus on gastrointestinal stromal tumors
Ravegnini, G., Sammarini, G., Serrano, C., Nannini, M., Pantaleo, M. A., Hrelia, P., & Angelini, S. (2019) · Therapeutic Advances in Medical Oncology · doi:10.1177/1758835919831902 · Cited by 18 · see citing works
Toraih, E. A., El-Wazir, A., Hussein, M. H., Khashana, M. S., Matter, A., Fawzy, M. S., & Hosny, S. (2019) · The International Journal of Biological Markers · doi:10.1177/1724600818814459 · Cited by 17 · see citing works
p53 partners with RNA in the DNA damage response
Huarte, M. (2016) · Nature Genetics · doi:10.1038/ng.3702 · Cited by 16 · see citing works
Self-citationP53 long noncoding RNA regulatory network in cancer development
Surendar, A., Younus, L. A., Lafta, M. H., Markov, A. A., Enina, Y. I., Yushchenko, N., Thangavelu, L. P., Mostafavi, S. M., Pokrovskii, M. V., & Ahmadi, M. (2021) · Cell Biology International · doi:10.1002/cbin.11600 · Cited by 15 · see citing works
LncRNAs are regulated by chromatin states and affect the skeletal muscle cell differentiation
Qi, X., Hu, M., Xiang, Y., Wang, D., Xu, Y., Hou, Y., Zhou, H., Luan, Y., Wang, Z., Zhang, W., et al. (2020) · Cell Proliferation · doi:10.1111/cpr.12879 · Cited by 14 · see citing works
Regulation of Age-related Decline by Transcription Factors and Their Crosstalk with the Epigenome
Zhou, X., Sen, I., Lin, X.-X., & Riedel, C. G. (2018) · Current Genomics · doi:10.2174/1389202919666180503125850 · Cited by 14 · see citing works
p21 governs p53's repressive side
Fischer, M. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1205393 · Cited by 12 · see citing works
Tumor Suppressors in Chronic Lymphocytic Leukemia: From Lost Partners to Active Targets
Andreani, G., Carrà, G., Lingua, M. F., Maffeo, B., Brancaccio, M., Taulli, R., & Morotti, A. (2020) · Cancers · doi:10.3390/cancers12030629 · Cited by 11 · see citing works
Noncoding RNAs Regulating p53 and c-Myc Signaling
Mei, Y., & Wu, M. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-1498-7_13 · Cited by 10 · see citing works
Lai, L., Wang, Y., Peng, S., Guo, W., Li, F., & Xu, S. (2022) · Bioengineered · doi:10.1080/21655979.2022.2048985 · Cited by 10 · see citing works
Assessment of Expression of lncRNAs in Autistic Patients
Sane, S., Ebrahimi, V., Shirvani-Farsani, Z., & Ghafouri‐Fard, S. (2024) · Journal of Molecular Neuroscience · doi:10.1007/s12031-024-02258-8 · Cited by 9 · see citing works
TP53LNC-DB, the database of lncRNAs in the p53 signalling network
Khan, M. R., Bukhari, I., Khan, R., Hussain, H. M. J., Wu, M., Thorne, R. F., Li, J., & Liu, G. (2018) · Database · doi:10.1093/database/bay136 · Cited by 8 · see citing works
lncRNA ZEB1‑AS1 is downregulated in diabetic lung and regulates lung cell apoptosis
Gu, L.-Z., Sun, H., & Yan, Z. (2020) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2020.9355 · Cited by 9 · see citing works
Modulation of Colorectal Tumor Behavior via lncRNA TP53TG1-Lipidic Nanosystem
Masoumi, F., Saraiva, S. M., Bouzo, B. L., López‐López, R., Esteller, M., Díaz‐Lagares, Á., & de la Fuente, M. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13091507 · Cited by 9 · see citing works
The potential value of lncRNA-BC050642 in osteosarcoma origination and outcomes
Yang, Y., Fei, M., Zhou, X., Li, Y., & Jin, D. (2019) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2019.1611593 · Cited by 7 · see citing works
Marney, C. B., Anderson, E. S., Baum, R., & Schmitt, A. M. (2022) · Cells · doi:10.3390/cells11111818 · Cited by 7 · see citing works
Cheng, Y., Zhu, Y., & Ma, L. (2021) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s298185 · Cited by 7 · see citing works
Interferon‐stimulated gene 15 enters posttranslational modifications of p53
Wang, Y., Ding, Q., Lu, Y., Cao, S., Liu, Q., & Zhang, L. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27347 · Cited by 6 · see citing works
Trujillo-Uscanga, A., & Gutiérrez‐Escolano, A. L. (2020) · Virology · doi:10.1016/j.virol.2020.08.008 · Cited by 6 · see citing works
Computationally Modeling ncRNA-ncRNA Crosstalk
Xu, J., Bai, J., & Xiao, J. Y. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-0719-5_8 · Cited by 6 · see citing works
Vf, M., Шуленина, Л. В., Раева, Н. Ф., Vasilieva, I. M., Салеева, Д. В., Незнанова, М. В., & Засухина, Г. Д. (2019) · Cell and Tissue Biology · doi:10.1134/s1990519x19060063 · Cited by 6 · see citing works
Lalruatfela, A., Biswal, P., Behera, S. K., Biswal, S., Behera, D. K., Dash, J. J., & Mallick, B. (2026) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2026.110756 · Cited by 5 · see citing works
A lncRNA GUARDINg genome integrity
Grossi, E., & Huarte, M. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0075-6 · Cited by 3 · see citing works
Self-citationLong non‐coding RNAs and microorganism‐associated cancers
Ranjbar, R., Behjatfar, M., Teimouri, A., Fard, A. A., Maniati, M., & Taheri‐Anganeh, M. (2021) · Cell Biochemistry and Function · doi:10.1002/cbf.3657 · Cited by 3 · see citing works
A novel E2F1-regulated lncRNA, LAPAS1, is required for S phase progression and cell proliferation
Baruch, E., Nizri-Megnaji, T., Berkowitz, O., & Ginsberg, D. (2021) · Oncotarget · doi:10.18632/oncotarget.27962 · Cited by 2 · see citing works
Tissue-Specific Functions of p53 During Kidney Development
Saifudeen, Z. R. (2017) · Results and problems in cell differentiation · doi:10.1007/978-3-319-51436-9_5 · Cited by 2 · see citing works
Regunath, K., Fomin, V., Liu, Z., Wang, P., Hoque, M., Tian, B., Rabadán, R., & Prives, C. L. (2024) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-23-0295 · Cited by 2 · see citing works
LINC01021 Attenuates Expression and Affects Alternative Splicing of a Subset of p53-Regulated Genes
Kaller, M., Forné, I., Imhof, A., & Hermeking, H. (2024) · Cancers · doi:10.3390/cancers16091639 · Cited by 1 · see citing works
New insights into the role of non-coding RNAs as transcriptional targets of p53
Cătană, C.-S., Gulei, D., & Berindan‐Neagoe, I. (2017) · Endogenous locus-driven H-Ras G12V expression induces senescence-like phenotype in primary fibroblasts of the Costello syndrome mouse model · doi:10.26600/mollife.1.1.5.2017 · Cited by 1 · see citing works
Effect of Linc-00475 Regulation of p53 on Glycolysis and Survival in Gastric CancerPreprint
Zhang, C., Zhao, S., & Wang, X. (2021) · Research Square · doi:10.21203/rs.3.rs-1136189/v1
Zhang, C., Li, X., Chen, X., Liu, W., Zhao, X., & Wang, X. (2024) · Research Square · doi:10.21203/rs.3.rs-3978496/v1
Nasiri-Varzeghani, M., Boldaji, S. A. H., & Maddah, S. M. (2025) · Semina Ciências Biológicas e da Saúde · doi:10.5433/1679-0367.2025v46n1p23
Li, H., Ju, R., Zhang, P., Jia, C., Xue, T., Wang, S., Zhu, X., Zhu, R., Luo, J., Jing, X., et al. (2026) · APOPTOSIS · doi:10.1007/s10495-026-02337-8
- Authors
- Grossi, E., Sánchez, Y., & Huarte, M.
- Affiliations
- Navarre Institute of Health Research (ES)
- Corresponding author
- Huarte, Maite
- Venue
- Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 1859
- Issue
- 1
- Pages
- 200-208
- ISSN
- 1874-9399 (ISSN-L)
- OpenAlex
- W863742587
- Cited by
- 78
- References
- 130
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 4 · 2022: 7 · 2021: 11 · 2020: 9 · 2019: 9 · 2018: 11 · 2017: 11 · 2016: 12 · 2015: 1
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Keywords
- long non-coding RNA, p53, tumor suppression, gene expression regulation, cancer, p53 pathway
- MeSH terms
- Humans, Neoplasms, Signal Transduction, Gene Expression Regulation, Neoplastic, Tumor Suppressor Protein p53, Gene Regulatory Networks, RNA, Long Noncoding
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review