Cited by 78Cancer-related molecular mechanisms researchCancer-related Molecular PathwaysMicroRNA in disease regulation

Expanding the p53 regulatory network: LncRNAs take up the challenge

Grossi, Elena, Sánchez, Yolanda, Huarte, Maite·2016·Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms

Abstract

Long noncoding RNAs (lncRNAs) are rapidly emerging as important regulators of gene expression in a wide variety of physiological and pathological cellular processes. In particular, a number of studies revealed that some lncRNAs participate in the p53 pathway, the unquestioned protagonist of tumor suppressor response. Indeed, several lncRNAs are not only part of the large pool of genes coordinated by p53 transcription factor, but are also required by p53 to fine-tune its response and to fully accomplish its tumor suppressor program. In this review we will discuss the current and fast growing knowledge about the contribution of lncRNAs to the complexity of the p53 network, the different mechanisms by which they affect gene regulation in this context, and their involvement in cancer. The incipient impact of lncRNAs in the p53 biological response may encourage the development of therapies and diagnostic methods focused on these noncoding molecules. This article is part of a Special Issue entitled: Clues to long noncoding RNA taxonomy1, edited by Dr. Tetsuro Hirose and Dr. Shinichi Nakagawa.

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Crossref · 10.1016/j.bbagrm.2015.07.011

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  • Several noncoding RNAs, including microRNAs and long noncoding RNAs such as TUG1, miR-34, lincRNA-p21, PANDA and PINT, were reported to mediate p53-dependent gene regulation.

    “Several noncoding RNAs were reported to mediate p53-dependent gene regulation—these include microRNAs120 and long noncoding RNAs,121 such as TUG1,122, 123 miR-34,124 lincRNA-p21,125 PANDA126 and PINT.127”

    From Census and evaluation of p53 target genes (2017) · cites this paper as [121]

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Authors
Grossi, E., Sánchez, Y., & Huarte, M.
Affiliations
Navarre Institute of Health Research (ES)
Corresponding author
Huarte, Maite
Venue
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
Publisher
Elsevier BV
Published
2016-01
Volume
1859
Issue
1
Pages
200-208
ISSN
1874-9399 (ISSN-L)
OpenAlex
W863742587
Cited by
78
References
130
Citations by year
2026: 2 · 2025: 1 · 2024: 4 · 2022: 7 · 2021: 11 · 2020: 9 · 2019: 9 · 2018: 11 · 2017: 11 · 2016: 12 · 2015: 1
FWCI
1.13
Type
journal article
Language
en
Open access
closed
Locations
  • Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Keywords
long non-coding RNA, p53, tumor suppression, gene expression regulation, cancer, p53 pathway
MeSH terms
Humans, Neoplasms, Signal Transduction, Gene Expression Regulation, Neoplastic, Tumor Suppressor Protein p53, Gene Regulatory Networks, RNA, Long Noncoding

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