The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
RETRACTED ARTICLE: Long non-coding RNA PVT1 promotes tumor progression by regulating the miR-143/HK2 axis in gallbladder cancer
Open accessAbstract
Background: The long non-coding RNA PVT1 (lncRNA PVT1) has been reported to act as an oncogenic regulator of several cancers. However, its expression and function in gallbladder cancer (GBC) remain largely unknown. Methods: In situ hybridization (ISH) and quantitative real-time PCR (qPCR) were performed to detect the expression of PVT1 and miR-143 in GBC tissues and cell lines. Immunohistochemistry (IHC) assays were performed to assess the expression of the hexokinase 2 (HK2) protein. The relationships among PVT1, miR-143 and HK2 were evaluated using dual-luciferase reporter, RNA immunoprecipitation (RIP) and biotin pull-down assays. The biological functions of PVT1, miR-143 and HK2 in GBC cells were explored with cell counting kit 8 (CCK-8), 5-ethynyl-20-deoxyuridine (EdU), colony formation, transwell, wound healing and glucose metabolism assays in vitro. For in vivo experiments, a xenograft model was used to investigate the effects of PVT1 and HK2 on GBC. Results: PVT1 was upregulated in GBC tissues and cells and was positively associated with malignancies and worse overall survival. PVT1 knockdown inhibited cell proliferation, migration, and invasion in vitro and restrained tumor growth in vivo. Further studies demonstrated that PVT1 positively regulated HK2 expression via its competing endogenous RNA (ceRNA) activity on miR-143. Additionally, HK2 expression and function were positively correlated with PVT1. Furthermore, we observed that the PVT1/miR-143/HK2 axis promoted cell proliferation and metastasis by regulating aerobic glucose metabolism in GBC cells. Conclusions: The results of our study reveal a potential ceRNA regulatory pathway in which PVT1 modulates HK2 expression by competitively binding to endogenous miR-143 in GBC cells, which may provide new insights into novel molecular therapeutic targets for GBC.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Long non-coding RNAs: insights into functions
Mercer, T. R., Dinger, M. E., & Mattick, J. S. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2521 · Cited by 5,654
Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
Guttman, M., Amit, I., Garber, M., French, C., Lin, M. F., Feldser, D., Huarte, M., Zuk, O., Carey, B. W., Cassady, J. P., et al. (2009) · Nature · doi:10.1038/nature07672 · Cited by 4,098
Mathupala, S. P., Ko, Y. H., & Pedersen, P. L. (2006) · Oncogene · doi:10.1038/sj.onc.1209603 · Cited by 765
PVT1 dependence in cancer with MYC copy-number increase
Tseng, Y.-Y., Moriarity, B. S., Gong, W., Akiyama, R., Tiwari, A., Kawakami, H., Ronning, P., Reuland, B., Guenther, K., Beadnell, T. C., et al. (2014) · Nature · doi:10.1038/nature13311 · Cited by 722
Kong, R., Zhang, E.-B., Yin, D.-D., You, L.-H., Xu, T.-P., Chen, W.-M., Xia, R., Wan, L., Sun, M., Wang, Z.-X., et al. (2015) · Molecular Cancer · doi:10.1186/s12943-015-0355-8 · Cited by 314
Amplification of PVT-1 is involved in poor prognosis via apoptosis inhibition in colorectal cancers
Takahashi, Y., Sawada, G., Kurashige, J., Uchi, R., Matsumura, T., Ueo, H., Takano, Y., Eguchi, H., Sudo, T., Sugimachi, K., et al. (2014) · British Journal of Cancer · doi:10.1038/bjc.2013.698 · Cited by 287
Chen, D.-L., Ju, H.-Q., Lu, Y.-X., Chen, L.-Z., Zeng, Z.-L., Zhang, D.-S., Luo, H.-Y., Wang, F., Qiu, M.-Z., Wang, D.-S., et al. (2016) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-016-0420-1 · Cited by 262
Guo, W., Qiu, Z., Wang, Z., Wang, Q., Tan, N., Chen, T., Chen, Z., Huang, S., Gu, J., Li, J., et al. (2015) · Hepatology · doi:10.1002/hep.27929 · Cited by 250
Self-citationLnc RNA ‐ PAGBC acts as a micro RNA sponge and promotes gallbladder tumorigenesis
Wu, X., Wang, F., Li, H., Hu, Y., Jiang, L., Zhang, F., Li, M., Wang, X., Jin, Y., Zhang, Y., et al. (2017) · EMBO reports · doi:10.15252/embr.201744147 · Cited by 245
Self-citationXu, B., Niu, X., Zhang, X., Tao, J., Wu, D., Wang, Z., Li, P., Zhang, W., Wu, H., Feng, N., et al. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-010-0700-6 · Cited by 227
Cited by
Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches
de la Cruz-López, K. G., Castro-Muñoz, L. J., Reyes-Hernández, D. O., García-Carrancá, A., & Manzo-Merino, J. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01143 · Cited by 940
TGF-β signaling in the tumor metabolic microenvironment and targeted therapies
Shi, X., Yang, J., Deng, S., Xu, H., Wu, D., Zeng, Q., Wang, S., Hu, T., Wu, F., & Zhou, H. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01349-6 · Cited by 262
Zhao, W., Qin, P., Zhang, D., Cui, X., Gao, J., Yu, Z., Chai, Y., Wang, J., & Li, J. (2019) · Aging · doi:10.18632/aging.102406 · Cited by 115
Self-citation
Metadata
- Authors
- Chen, J., Yu, Y., Li, H., Hu, Q., Chen, X., He, Y., Xue, C., Ren, F., Ren, Z., Li, J., Liu, L., Duan, Z., Cui, G., & Sun, R.
- Venue
- Molecular Cancer
- Published
- 2019-03-02
- Volume
- 18
- Issue
- 1
- Pages
- 33-33
- ISSN
- 1476-4598 (ISSN-L)
- OpenAlex
- W2930633744
- Cited by
- 389
- References
- 30
- FWCI
- 20.32
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: RETRACTED ARTICLE: Long non-coding RNA PVT1 promotes tumor progression by regulating the miR-143/HK2 axis in gallbladder cancer. https://app.cochat.ai/papers/10.1186/s12943-019-0947-9
- The paper
- Chen, J., Yu, Y., Li, H., Hu, Q., Chen, X., He, Y., Xue, C., Ren, F., Ren, Z., Li, J., Liu, L., Duan, Z., Cui, G., & Sun, R. (2019). RETRACTED ARTICLE: Long non-coding RNA PVT1 promotes tumor progression by regulating the miR-143/HK2 axis in gallbladder cancer. Molecular Cancer. https://doi.org/10.1186/s12943-019-0947-9
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
