The DOI matches its Crossref record; 116 of the 116 references it cites were found in a registry or an index.
Mesenchymal stem cells: key players in cancer progression
Open accessAbstract
Tumour progression is dependent on the interaction between tumour cells and cells of the surrounding microenvironment. The tumour is a dynamic milieu consisting of various cell types such as endothelial cells, fibroblasts, cells of the immune system and mesenchymal stem cells (MSCs). MSCs are multipotent stromal cells that are known to reside in various areas such as the bone marrow, fat and dental pulp. MSCs have been found to migrate towards inflammatory sites and studies have shown that they also migrate towards and incorporate into the tumour. The key question is how they interact there. MSCs may interact with tumour cells through paracrine signalling. On the other hand, MSCs have the capacity to differentiate to various cell types such as osteocytes, chondrocytes and adipocytes and it is possible that MSCs differentiate at the site of the tumour. More recently it has been shown that cross-talk between tumour cells and MSCs has been shown to increase metastatic potential and promote epithelial-to-mesenchymal transition. This review will focus on the role of MSCs in tumour development at various stages of progression from growth of the primary tumour to the establishment of distant metastasis.
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Cited by
Samsonraj, R. M., Raghunath, M., Nurcombe, V., Hui, J. H., van Wijnen, A. J., & Cool, S. M. (2017) · Stem Cells Translational Medicine · doi:10.1002/sctm.17-0129 · Cited by 729
Inflammatory Response Mechanisms of the Dentine–Pulp Complex and the Periapical Tissues
Galler, K. M., Weber, M., Korkmaz, Y., Widbiller, M., & Feuerer, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031480 · Cited by 455
Brain malignancies: Glioblastoma and brain metastases
Lah, T. T., Novak, M., & Breznik, B. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.10.010 · Cited by 438
Mesenchymal stem/stromal cells in cancer therapy
Lan, T., Luo, M., & Wei, X. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01208-w · Cited by 374
Exosome and mesenchymal stem cell cross-talk in the tumor microenvironment
Whiteside, T. L. (2018) · Seminars in Immunology · doi:10.1016/j.smim.2017.12.003 · Cited by 308
Metadata
- Authors
- Ridge, S. M., Sullivan, F. J., & Glynn, S. A.
- Venue
- Molecular Cancer
- Published
- 2017-02-01
- Volume
- 16
- Issue
- 1
- Pages
- 31-31
- ISSN
- 1476-4598 (ISSN-L)
- OpenAlex
- W2584286435
- Cited by
- 526
- References
- 116
- FWCI
- 26.76
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
