The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.
Emerging roles of lipid metabolism in cancer metastasis
Open accessAbstract
Cancer cells frequently display fundamentally altered cellular metabolism, which provides the biochemical foundation and directly contributes to tumorigenicity and malignancy. Rewiring of metabolic programmes, such as aerobic glycolysis and increased glutamine metabolism, are crucial for cancer cells to shed from a primary tumor, overcome the nutrient and energy deficit, and eventually survive and form metastases. However, the role of lipid metabolism that confers the aggressive properties of malignant cancers remains obscure. The present review is focused on key enzymes in lipid metabolism associated with metastatic disease pathogenesis. We also address the function of an important membrane structure-lipid raft in mediating tumor aggressive progression. We enumerate and integrate these recent findings into our current understanding of lipid metabolic reprogramming in cancer metastasis accompanied by new and exciting therapeutic implications.
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Cites
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Erin, N., Grahovac, J., Brozovic, A., & Efferth, T. (2020) · Drug Resistance Updates · doi:10.1016/j.drup.2020.100715 · Cited by 527
Chen, B., Yu, P., Chan, W. N., Xie, F., Zhang, Y., Liang, L., Leung, K. T., Lo, K. W., Yu, J., Tse, G. M. K., et al. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01679-y · Cited by 420
Liu, W., Chakraborty, B., Safi, R., Kazmin, D., Chang, C.-Y., & McDonnell, D. P. (2021) · Nature Communications · doi:10.1038/s41467-021-25354-4 · Cited by 341
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Metadata
- Authors
- Luo, X., Cheng, C., Tan, Z., Li, N., Tang, M., Yang, L., & Cao, Y.
- Venue
- Molecular Cancer
- Published
- 2017-04-11
- Volume
- 16
- Issue
- 1
- Pages
- 76-76
- ISSN
- 1476-4598 (ISSN-L)
- OpenAlex
- W2606111706
- Cited by
- 677
- References
- 110
- FWCI
- 13.43
- Type
- journal article
- Language
- en
- Open access
- gold
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- Luo, X., Cheng, C., Tan, Z., Li, N., Tang, M., Yang, L., & Cao, Y. (2017). Emerging roles of lipid metabolism in cancer metastasis. Molecular Cancer. https://doi.org/10.1186/s12943-017-0646-3
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
