The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
EIF4A3-induced circular RNA MMP9 (circMMP9) acts as a sponge of miR-124 and promotes glioblastoma multiforme cell tumorigenesis
Open accessAbstract
Background: Circular RNAs (circRNAs) have been found to play critical roles in the development and progression of various cancers. However, little is known about the effects of the circular RNA network on glioblastoma multiforme (GBM). Methods: A microarray was used to screen circRNA expression in GBM. Quantitative real-time PCR was used to detect the expression of circMMP9. GBM cells were transfected with a circMMP9 overexpression vector or siRNA, and cell proliferation, migration and invasion, as well as tumorigenesis in nude mice, were assessed to examine the effect of circMMP9 in GBM. Biotin-coupled miRNA capture, fluorescence in situ hybridization and luciferase reporter assays were conducted to confirm the relationship between circMMP9 and miR-124. Results: In this study, we screened differentially expressed circRNAs and identified circMMP9 in GBM. We found that circMMP9 acted as an oncogene, was upregulated in GBM and promoted the proliferation, migration and invasion abilities of GBM cells. Next, we verified that circMMP9 served as a sponge that directly targeted miR-124; circMMP9 accelerated GBM cell proliferation, migration and invasion by targeting miR-124. Furthermore, we found that cyclin-dependent kinase 4 (CDK4) and aurora kinase A (AURKA) were involved in circMMP9/miR-124 axis-induced GBM tumorigenesis. Finally, we found that eukaryotic initiation factor 4A3 (eIF4A3), which binds to the MMP9 mRNA transcript, induced circMMP9 cyclization and increased circMMP9 expression in GBM. Conclusions: Our findings indicate that eIF4A3-induced circMMP9 is an important underlying mechanism in GBM cell proliferation, invasion and metastasis through modulation of the miR-124 signaling pathway, which could provide pivotal potential therapeutic targets for the treatment of GBM. Graphical abstract:
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Cited by
Ding, L., Zhao, Y., Dang, S., Wang, Y., Li, X., Yu, X., Li, Z., Wei, J., Liu, M., & Li, G. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1006-2 · Cited by 298
Role of circular RNAs in brain development and CNS diseases
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Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression
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Zhou, J., Zhang, S., Chen, Z., He, Z., Xu, Y., & Li, Z. (2019) · Cell Death & Disease · doi:10.1038/s41419-019-2127-7 · Cited by 265
Self-citationmiR-124: A Promising Therapeutic Target for Central Nervous System Injuries and Diseases
Xu, J., Zheng, Y., Wang, L., Liu, Y., Wang, X., Li, Y., & Chi, G. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-021-01091-6 · Cited by 55
Metadata
- Authors
- Wang, R., Zhang, S., Chen, X., Li, N., Li, J., Jia, R., Pan, Y., & Liang, H.
- Venue
- Molecular Cancer
- Published
- 2018-11-23
- Volume
- 17
- Issue
- 1
- Pages
- 166-166
- ISSN
- 1476-4598 (ISSN-L)
- OpenAlex
- W2901528543
- Cited by
- 369
- References
- 31
- FWCI
- 14.60
- Type
- journal article
- Language
- en
- Open access
- gold
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- Wang, R., Zhang, S., Chen, X., Li, N., Li, J., Jia, R., Pan, Y., & Liang, H. (2018). EIF4A3-induced circular RNA MMP9 (circMMP9) acts as a sponge of miR-124 and promotes glioblastoma multiforme cell tumorigenesis. Molecular Cancer. https://doi.org/10.1186/s12943-018-0911-0
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