The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Long non-coding RNA XIST regulates gastric cancer progression by acting as a molecular sponge of miR-101 to modulate EZH2 expression
Open accessAbstract
Background: Long non-coding RNAs (lncRNAs) have emerged as critical regulators of tumor progression. However, the role and molecular mechanism of lncRNA XIST in gastric cancer is still unknown. Methods: Real-time PCR analysis was performed to measure the expression levels of lncRNA XIST in gastric cancer tissues and cell lines, the correlation between lncRNA XIST expression and clinicopathological characteristics and prognosis was analyzed in gastric cancer patients. The biological function of lncRNA XIST on gastric cancer cells were determined both in vitro and in vivo. The regulating relationship between lncRNA XIST and miR-101 was investigated in gastric cancer cells. Results: lncRNA XIST was significantly up-regulated in gastric cancer tissues and cell lines. Overexpression of lncRNA XIST was markedly associated with larger tumor size, lymph node invasion, distant metastasis and TNM stage in gastric cancer patients. Functionally, knockdown of lncRNA XIST exerted tumor-suppressive effects by inhibiting cell proliferation, migration and invasion in vitro and tumor growth and metastasis in vivo. Furthermore, an inverse relationship between lncRNA XIST and miR-101 was found. Polycomb group protein enhancer of zeste homolog 2 (EZH2), a direct target of miR-101, could mediated the biological effects that lncRNA XIST exerted. Conclusions: lncRNA XIST is up-regulated and is associated with aggressive tumor phenotypes and patient survival in gastric cancer, and the newly identified lncRNA XIST/miR-101/EZH2 axis could be a potential biomarkers or therapeutic targets for gastric cancer patients.
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Cites
Non-coding RNAs in human disease
Esteller, M. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3074 · Cited by 4,825
Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes
Tsai, M.-C., Manor, O., Wan, Y., Mosammaparast, N., Wang, J. K., Lan, F., Shi, Y., Segal, E., & Chang, H. Y. (2010) · Science · doi:10.1126/science.1192002 · Cited by 3,290
The polycomb group protein EZH2 is involved in progression of prostate cancer
Varambally, S., Dhanasekaran, S. M., Zhou, M., Barrette, T. R., Kumar-Sinha, C., Sanda, M. G., Ghosh, D., Pienta, K. J., Sewalt, R. G. A. B., Otte, A. P., et al. (2002) · Nature · doi:10.1038/nature01075 · Cited by 2,717
Cited by
Chen, J., Yu, Y., Li, H., Hu, Q., Chen, X., He, Y., Xue, C., Ren, F., Ren, Z., Li, J., et al. (2019) · Molecular Cancer · doi:10.1186/s12943-019-0947-9 · Cited by 389
RetractedBiological Function of Long Non-coding RNA (LncRNA) Xist
Wang, W., Min, L., Qiu, X., Wu, X., Liu, C., Ma, J., Zhang, D., & Zhu, L. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.645647 · Cited by 248
Self-citationRecent advances of nucleic acid-based cancer biomarkers and biosensors
Zhao, J., Xia, K., He, P., Wei, G., Zhou, X., & Zhang, X. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2023.215456 · Cited by 44
Long noncoding RNAs expression in gastric cancer
Esfandi, F., Taheri, M., Kholghi Oskooei, V., & Ghafouri‐Fard, S. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28653 · Cited by 21
Prognostic Implication of Plasma Metabolites in Gastric Cancer
Cao, K., Lyu, Y., Chen, J., He, C., Lyu, X., Zhang, Y., Chen, L., Jiang, Y., Xiang, J., Liu, B., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612774 · Cited by 16
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Metadata
- Authors
- Chen, D.-L., Ju, H.-Q., Lu, Y.-X., Chen, L.-Z., Zeng, Z.-L., Zhang, D.-S., Luo, H.-Y., Wang, F., Qiu, M.-Z., Wang, D.-S., Xu, D.-Z., Zhou, Z.-W., Pelicano, H., Huang, P., Xie, D., Wang, F.-H., Li, Y.-H., & Xu, R.-H.
- Venue
- Journal of Experimental & Clinical Cancer Research
- Published
- 2016-09-13
- Volume
- 35
- Issue
- 1
- Pages
- 142-142
- ISSN
- 0392-9078 (ISSN-L)
- 1756-9966
- OpenAlex
- W2520931866
- Cited by
- 262
- References
- 3
- FWCI
- 15.41
- Type
- journal article
- Language
- en
- Open access
- gold
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- Chen, D.-L., Ju, H.-Q., Lu, Y.-X., Chen, L.-Z., Zeng, Z.-L., Zhang, D.-S., Luo, H.-Y., Wang, F., Qiu, M.-Z., Wang, D.-S., Xu, D.-Z., Zhou, Z.-W., Pelicano, H., Huang, P., Xie, D., Wang, F.-H., Li, Y.-H., & Xu, R.-H. (2016). Long non-coding RNA XIST regulates gastric cancer progression by acting as a molecular sponge of miR-101 to modulate EZH2 expression. Journal of Experimental & Clinical Cancer Research. https://doi.org/10.1186/s13046-016-0420-1
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