The DOI matches its Crossref record; 96 of the 97 references it cites were found in a registry or an index.
The clinical relevance of omega-3 fatty acids in the management of hypertriglyceridemia
Open accessAbstract
Hypertriglyceridemia (triglycerides > 150 mg/dL) affects ~25 % of the United States (US) population and is associated with increased cardiovascular risk. Severe hypertriglyceridemia (≥ 500 mg/dL) is also a risk factor for pancreatitis. Three omega-3 fatty acid (OM3FA) prescription formulations are approved in the US for the treatment of adults with severe hypertriglyceridemia: (1) OM3FA ethyl esters (OM3EE), a mixture of OM3FA ethyl esters, primarily eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (Lovaza®, Omtryg™, and generics); (2) icosapent ethyl (IPE), EPA ethyl esters (Vascepa®); and (3) omega-3 carboxylic acids (OM3CA), a mixture of OM3FAs in free fatty acid form, primarily EPA, DHA, and docosapentaenoic acid (Epanova®). At approved doses, all formulations substantially reduce triglyceride and very-low-density lipoprotein levels. DHA-containing formulations may also increase low-density lipoprotein cholesterol. However, this is not accompanied by increased non-high-density lipoprotein cholesterol, which is thought to provide a better indication of cardiovascular risk in this patient population. Proposed mechanisms of action of OM3FAs include inhibition of diacylglycerol acyltransferase, increased plasma lipoprotein lipase activity, decreased hepatic lipogenesis, and increased hepatic β-oxidation. OM3CA bioavailability (area under the plasma concentration-time curve from zero to the last measurable concentration) is up to 4-fold greater than that of OM3FA ethyl esters, and unlike ethyl esters, the absorption of OM3CA is not dependent on pancreatic lipase hydrolysis. All three formulations are well tolerated (the most common adverse events are gastrointestinal) and demonstrate a lack of drug-drug interactions with other lipid-lowering drugs, such as statins and fibrates. OM3FAs appear to be an effective treatment option for patients with severe hypertriglyceridemia.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Figures
![Fig. 2 TG reduction observed with varying doses of omega-3 carboxylic acids, omega-3 ethyl esters, and icosapent ethyl in (a) patients with severe hypertriglyceridemia (TG ≥ 500 mg/dL) [14, 16, 17] and (b) statin-treated patients with high baseline TG levels (TG level ≥ 200 mg/dL and < 500 mg/dL) [20, 21, 24] Data not available for OM3EE at 2 g/day. OM3CA = Percentage change from baseline expressed as least-squares geometric mean; OM3EE = percentage change from baseline expressed as geometric mean; IPE = percentage change from baseline expressed as median. †Placebo used = olive oil; ‡Placebo used = vegetable oil; §Placebo used = mineral oil; ǁPlacebo used = corn oil; ¶Placebo not specified. IPE icosapent ethyl, OM3CA omega-3 carboxylic acids, OM3EE omega-3 ethyl esters, TG triglyceride](/paper-figures/d233ddfca28e42378bc78600998e583a/the-clinical-relevance-of-omega-3-fatty-acids-in-the-management-of-figure-2.jpg)
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Combined EPA + DHA formulations, such as omega-3 carboxylic acids and ethyl esters, effectively lower TG levels by reducing hepatic VLDL synthesis and enhancing fatty acid oxidation [87].”
From Targeting triglycerides for cardiovascular risk reduction (2026) · cites this paper as [87]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)
Grundy, S. M., Becker, D. M., Clark, L. T., Cooper, R., Denke, M. A., Howard, J. L., Hunninghake, D. B., Illingworth, D. R., Luepker, R. V., McBride, P. E., et al. (2002) · Civil War Book Review · Cited by 12,198
Standards of Medical Care in Diabetes
Power, D. V. (2006) · Diabetes Care · doi:10.2337/diacare.29.02.06.dc05-1593 · Cited by 8,676
Stone, N. J., Robinson, J. G., Lichtenstein, A. H., Bairey Merz, C. N., Blum, C. B., Eckel, R. H., Goldberg, A. C., Gordon, D., Levy, D., Lloyd-Jones, D. M., et al. (2014) · Circulation · doi:10.1161/01.cir.0000437738.63853.7a · Cited by 7,081
Standards of medical care in diabetes—2014
American Diabetes Association (2014) · Diabetes Care · doi:10.2337/dc14-s014 · Cited by 4,572
Stone, N. J., Robinson, J. G., Lichtenstein, A. H., Bairey Merz, C. N., Blum, C. B., Eckel, R. H., Goldberg, A. C., Gordon, D., Levy, D., Lloyd-Jones, D. M., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.11.002 · Cited by 3,845
Fish Consumption, Fish Oil, Omega-3 Fatty Acids, and Cardiovascular Disease
Kris-Etherton, P. M., Harris, W. S., & Appel, L. J. (2002) · Circulation · doi:10.1161/01.cir.0000038493.65177.94 · Cited by 3,707
ESC/EAS Guidelines for the management of dyslipidaemias
Reiner, Ž., Catapano, A. L., De Backer, G., Graham, I., Taskinen, M.-R., Wiklund, O., Agewall, S., Alegria, E., Chapman, M. J., Durrington, P., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr158 · Cited by 3,549
Complementary and Alternative Medicine Use Among Adults and Children: United States, 2007
Barnes, P. M., Bloom, B. E., & Nahin, R. L. (2008) · PsycEXTRA Dataset · doi:10.1037/e623942009-001 · Cited by 3,144
Kavey, R., Simons-Morton, D., & de Jesus, J. D. (2011) · Pediatrics · doi:10.1542/peds.2009-2107c · Cited by 2,131
Cited by
Sorted by citations
Items 101–200 of 201
Lipid profile in the aqueous humor of patients with myopia
Che, D., Lv, L., Cao, Y., Zhang, Y., Yu, Q., Li, F., & Zhou, J. (2024) · Experimental Eye Research · doi:10.1016/j.exer.2024.110023 · Cited by 6
The EPA oxylipin, 12-HEPE, directly regulates human platelet activity
Goerger, K., Stanger, L., Rickenberg, A., Nguyễn, A., Lee, T., Holman, T. R., & Holinstat, M. A. (2025) · Journal of Lipid Research · doi:10.1016/j.jlr.2025.100807 · Cited by 7
Ghini, V., Tenori, L., Capozzi, F., Luchinat, C., Bub, A., Malpuech‐Brugère, C., Orfila, C., Ricciardiello, L., & Bordoni, A. (2019) · Nutrients · doi:10.3390/nu12010086 · Cited by 7
Yokote, K., Niwa, K., Hakoda, T., Oh, F., Kajimoto, Y., Fukui, T., Kim, H., Noda, Y., Lundström, T., & Yajima, T. (2020) · Circulation Journal · doi:10.1253/circj.cj-19-0358 · Cited by 7
Wilson, D. P., Williams, L. H., & Kavey, R.-E. W. (2021) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2021.12.017 · Cited by 8
Sales, A. L. C. C., Primo, M. G. S., Neto, R. S. M., Mendes, A. V. D. S., Furtado, M. M., Rocha, J. É. L., de Almeida, J. O. C. S., França, J. V. D. S., de Alencar, S. R. M., Brito, A. K. D. S., et al. (2024) · Pharmaceuticals · doi:10.3390/ph17010072 · Cited by 6
Monte, M. G., Tonon, C. R., Fujimori, A. S. S., Ribeiro, A. P. D., Bazan, S. G. Z., Okoshi, K., Corrêa, C. R., Moretto, M. R., de Paiva, S. A. R., Zornoff, L. A. M., et al. (2024) · Food Science & Nutrition · doi:10.1002/fsn3.4492 · Cited by 6
Chang, Y., Xuan, Y., Zhang, R., Ding, X., Zeng, Q., Wang, J., Bai, S., Li, S., Liu, Y., Chen, Y., et al. (2024) · Animals · doi:10.3390/ani15010021 · Cited by 6
Miao, X., Li, B., Zhu, Z., & Yang, T. (2025) · PLoS ONE · doi:10.1371/journal.pone.0316130 · Cited by 6
Is There Something Fishy About Fish Oil?
Šunderić, M., Robajac, D., Gligorijević, N., Miljuš, G., Nedić, O., Smilkov, K., Ackova, D. G., Rudić-Grujić, V., & Penezić, A. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190705185800 · Cited by 5
Assefa, M., Zhao, Y., Zhou, C., Song, Y., & Zhao, X. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26083462 · Cited by 5
Musazadeh, V., Mahmoudinezhad, M., Pam, P., Brazandeh, S., Faramarzi, F., Mohammadpour, Y., Faghfouri, A. H., & Gheibi, S. (2025) · Nutrition & Metabolism · doi:10.1186/s12986-025-00952-x · Cited by 7
Bashmakov, Y. K., Petyaev, I. M., Chalyk, N. E., Klochkov, V. A., Pristensky, D. V., Chernyshova, M. P., & Kyle, N. (2018) · International Journal of Applied and Basic Medical Research · doi:10.4103/ijabmr.ijabmr_367_17 · Cited by 5
Takada, N., Hosomi, R., & Fukunaga, K. (2022) · Foods · doi:10.3390/foods11213434 · Cited by 5
Xu, K., Shimizu, M., Murai, C., Fujisawa, M., Ito, D., Saitoh, N., Nakagome, Y., Yamashita, M., Murata, A., Oikawa, S., et al. (2022) · Pharmacology Research & Perspectives · doi:10.1002/prp2.952 · Cited by 5
Caldas, B. V., Guimarães, V. H. D., Ribeiro, G. H. M., Santos, T., Nobre, D. A., de Castro, R. J. S., da Costa, D. V., de Paula, A. M. B., Guimarães, A. L. S., Mafra, V., et al. (2022) · Journal of Insects as Food and Feed · doi:10.3920/jiff2022.0070 · Cited by 5
Aguilera, E. C., Vachon, A., & Plourde, M. (2022) · Nutrients · doi:10.3390/nu14245347 · Cited by 5
Effect of Sacha Inchi Oil on Human Blood Pressure and Lipid Profile: A Preliminary Study in Malaysia
En, C. Y., Udin, N. A. B., Vanoh, D., & Leng, S. K. (2024) · Jurnal Gizi dan Pangan · doi:10.25182/jgp.2024.19.1.61-68 · Cited by 6
Dobre, M.-Z., Vîrgolici, B., Doicin, I.-C., Vîrgolici, H., & Stănescu-Spînu, I.-I. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262010183 · Cited by 6
Indications for omega-3 fatty acid supplementation in prevention of cardiovascular disease
Bosomworth, N. J. (2023) · Canadian Family Physician · doi:10.46747/cfp.6907459 · Cited by 4
Effects of gut microbiota and metabolites on pancreatitis: a 2-sample Mendelian randomization study
Zhao, Z., Li, H., Tuerxunbieke, B., Ming, L., Ji, J., Chen, Y., Sun, R., Tian, W., Yang, F., & Huang, Q. (2024) · Journal of Gastrointestinal Surgery · doi:10.1016/j.gassur.2024.101885 · Cited by 4
Acute Pancreatitis in the Transgender Population
Chaudhry, A., Yelisetti, R., Millet, C., Biggiani, C., & Upadhyay, S. (2021) · Cureus · doi:10.7759/cureus.16140 · Cited by 4
Fatty Acids - From Biosynthesis to Human Health
Froyen, E. (2022) · Biochemistry · doi:10.5772/intechopen.100947 · Cited by 4
Zhang, M., Yang, F., Qiu, F., Yang-hong, O., Zhang, J., Wan, H., Cao, H., & Ning, P. (2024) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-024-01266-3 · Cited by 7
Zhao, Q., Wang, F., Xiong, A., Li, S., Wang, Y., Lei, X., Deyholos, M. K., Wang, Y., Zhuang, J., Yu, H., et al. (2025) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2025.2529591 · Cited by 4
Qi, L., Zhang, Q., Zheng, Z., Pei, Z., Hong, M., Jiang, T., Kazei, D., Kahler, E., & Huo, Y. (2021) · Vascular Health and Risk Management · doi:10.2147/vhrm.s325217 · Cited by 3
Xu, K., Shimizu, M., Yamashita, T., Fujiwara, M., Oikawa, S., Ou, G., Takazakura, N., Kusakabe, T., Takahashi, K., Kato, K., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-62578-y · Cited by 4
Hegde, P. S., Agni, M. B., Rai, P., Upadhyay, S. S., Aravind, A., Prasad, T. S. K., & M, D. G. K. (2024) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174424000345 · Cited by 3
Prabhakar, A. P., Vedamurthy, D., & Kalra, D. K. (2025) · Current Cardiovascular Risk Reports · doi:10.1007/s12170-025-00764-x · Cited by 3
Manubolu, V. S., Budoff, M. J., & Lakshmanan, S. (2022) · Heart International · doi:10.17925/hi.2022.16.1.2 · Cited by 4
Huang, N. H., Wang, F., Li, S., Zhai, X., Ma, W., Liu, K., Sheerah, H. A., Cao, J., & Eshak, E. S. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.1031168 · Cited by 3
Meneses, R. R. C., Damasceno, N. R. T., Cartolano, F. D. C., Verde, S. M. M. L., Lira, L. G., Dantas, M. B., Viana, G. D. A., da Silva, M. E., de Sousa, E. L. H., Meneses, G. C., et al. (2022) · Brazilian Journal of Pharmaceutical Sciences · doi:10.1590/s2175-97902022e20488 · Cited by 5
Bosomworth, N. J. (2023) · Canadian Family Physician · doi:10.46747/cfp.6907e134 · Cited by 2
Role of Dietary Nutrition, Vitamins, Nutrients, and Supplements in Cardiovascular Health
Moran, R. J., Davis, M. G., & Maletz, A. (2021) · Contemporary cardiology · doi:10.1007/978-3-030-78177-4_1 · Cited by 3
Omega-3 Polyunsaturated Fatty Acids Added to Yogurt
Olson, D. W., & Aryana, K. J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805134-4.00007-9 · Cited by 3
Almutairi, M. S., Almutleb, E. S., Bajsair, A. A., El-Hiti, G. A.-R., Altoaimi, B. H., Alghamdi, M., Alanazi, S. A., & Masmali, A. M. (2025) · Medicine · doi:10.1097/md.0000000000046566 · Cited by 2
Efficacy of DHA and EPA on Serum Triglyceride Levels of Healthy Participants: Systematic Review
Kawasaki, Y., Iwahori, Y., Chiba, Y., Hiroyuki, M., Kawasaki, T., Fujita, S., & Takahashi, Y. (2019) · International Journal Of Nutrition · doi:10.14302/issn.2379-7835.ijn-18-2469 · Cited by 2
Polyunsaturated Fatty Acid-Loaded Nanomedicine for Solid Tumor
Saad, S., Beg, S., & Ahmad, F. J. (2020) · Springer eBooks · doi:10.1007/978-981-15-1664-1_6 · Cited by 2
Designer Microbes for Nutraceutical Application
Dhar, H., Chaudhary, A., & Rana, V. (2020) · Springer eBooks · doi:10.1007/978-981-15-2874-3_11 · Cited by 2
Three different oils improve HFD‐induced lipid metabolism disorders via driving gut microbiota
Lai, M., Liu, Y., Han, X., Chen, Y., Liu, B., & Zeng, F. (2023) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.202300129 · Cited by 2
Parekh, N., Merota, V., Joshi, R., Kaur, G., Tuli, H. S., & Buttar, H. S. (2023) · Scripta Medica · doi:10.5937/scriptamed54-46932 · Cited by 3
Management of Dyslipidemia in Chronic Kidney Disease
Vedamurthy, D., Sagheer, U., Patel, A., Singh, G., & Kalra, D. K. (2025) · Current Cardiovascular Risk Reports · doi:10.1007/s12170-025-00763-y · Cited by 2
Safety Considerations of Pharmacological Treatment
Kim, K., & Choi, S. H. (2021) · Stroke revisited · doi:10.1007/978-981-16-3923-4_17 · Cited by 2
Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Madasamy, S., Liu, D., Lundry, J., Alderete, B. E., Kong, R., Robinson, J. P., Wu, A. H. B., & Amento, E. P. (2017) · Journal of Visualized Experiments · doi:10.3791/56596 · Cited by 2
Marine Derived Bioactives to Combat Obesity: Potential Mechanisms of Action
Phadtare, I., Vaidya, H. B., & Cheema, S. K. (2021) · Advances in biochemistry in health and disease · doi:10.1007/978-3-030-84763-0_20 · Cited by 2
Babalola, F., Ng, D. S., Bulic, A., & Curtis, J. (2022) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem-2021-0718 · Cited by 2
Richardson, C. E., Krishnan, S., Gray, I. J., Keim, N. L., & Newman, J. W. I. (2021) · medRxiv · doi:10.1101/2021.09.22.21263899 · Cited by 2
Pediatric Hypertriglyceridemia: Lipoprotein Metabolism, Etiology, and Management
Moriyama, H., & Ham, J. N. (2025) · Current Pediatrics Reports · doi:10.1007/s40124-025-00349-7 · Cited by 2
Dias, K. C., Pretto, A., Pedron, F. D. A., Bergamin, G. T., Gralha, T. S., Stefanello, C. M., Xavier, A. C. H., Wagner, R. C., Kuradomi, R. Y., Ferrigolo, F. R. G., et al. (2025) · Aquaculture International · doi:10.1007/s10499-025-02199-y · Cited by 2
Shao, C., Lin, H., Yu, J., Chen, H., Ren, Y., Ren, J., Zeng, Y., Wu, Y., Zhang, Q., & Xiao, X. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1745358 · Cited by 1
Arora, A. V., Singh, N. R., & Sharma, R. (2019) · International Journal of Basic & Clinical Pharmacology · doi:10.18203/2319-2003.ijbcp20192176 · Cited by 1
Effects of omega-3 supplementation on endothelial dysfunction in humans: a systematic review
Sales, A. L. D. C. C., Primo, M. G. S., Severo, J. S., Oliveira, A. S. D. S. S., Silva, T. M., Mendes, V. R., & Martins, M. D. C. D. C. E. (2021) · Revista Eletrônica Acervo Saúde · doi:10.25248/reas.e7826.2021 · Cited by 1
Vlasova, O. S., Bichkaeva, F. A., Васильевна, Н. Е., Shengof, B. А., Bichkaev, A., & Baranova, N. F. (2022) · American Journal of Human Biology · doi:10.1002/ajhb.23841 · Cited by 1
Vuković, M., Jovičić-Bata, J., Todorović, N., Puača, G., Vesković, D., Panić, J. Č., Dugandžija, T., & Lalic-Popovic, M. N. (2023) · Current Medical Research and Opinion · doi:10.1080/03007995.2023.2296963 · Cited by 1
Liang, X., Han, H., Shen, X., Williams, P. L., James-Todd, T. M., Allan, Y., Keshet, R. P., Ford, J. B., Rexrode, K. M., Chavarro, J. E., et al. (2025) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaf594
Guennec, J. L., Céline, F., Laureen, M., Camille, S., Ivette, C., Simon, L., Pessiot-Royer, S., Guennec, J. L., & Demion, M. (2020) · Journal of Integrative Cardiology Open Access · doi:10.31487/j.jicoa.2020.04.04
Sun, Y., LIU, Y., Xue, B.-H., Wang, X., & Yu, W. (2021) · Biocell · doi:10.32604/biocell.2021.013275 · Cited by 1
Çimen, H., & Öztürk, Y. E. (2015) · AYDIN SAĞLIK DERGİSİ · doi:10.17932/iau.asd.2015.007/asd_v08i1001 · Cited by 1
Maio, A., & Dowd, F. J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.64176-4 · Cited by 1
Teramoto, T., Ogawa, H., Ueshima, H., Okada, Y., Haze, K., Matsui, S., Fujikawa, K., Hashimoto, T., Sakui, S., Nishimura, K., et al. (2022) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2022.2094914 · Cited by 1
N-3 Polyunsaturated Fatty Acids and Their Role on Cardiovascular System
Nodari, S., & Fioretti, F. (2023) · Biochemistry · doi:10.5772/intechopen.110145 · Cited by 1
Targeting triglycerides for cardiovascular risk reduction
Maiorca, C., Tramontano, D., Di Costanzo, A., & D’Erasmo, L. (2026) · Internal and Emergency Medicine · doi:10.1007/s11739-026-04383-1
Курята, О. В., & Гречаник, М. М. (2018) · Family Medicine · doi:10.30841/2307-5112.3.2018.146288
The Potential Effect of Alpha-Linolenic Acid on Prostate Specific Antigen
Xu, J. (2016) · TSpace (University of Toronto)
Silva, L. M. D. L., Bloise, A. M. N. D. L. G., Fontes, D. A. F., de Araújo, K. S., Barbosa, M. O., & Costa‐Silva, J. H. (2019) · Revista de Nutrição · doi:10.1590/1678-9865201932e180292 · Cited by 1
The Effect of Omega-3 Fatty Acids on Hypertriglyceridemia: A Review
Patrikios, I. S. (2020) · Biomedical Journal of Scientific & Technical Research · doi:10.26717/bjstr.2020.26.004382
Caramantin, W. A. M. R. V., & Malca, A. I. J. (2020) · Universidad Peruana de Ciencias Aplicadas (UPC) · doi:10.19083/tesis/652708
Novotny, K., Fritz, K., & Parmar, M. S. (2021) · StatPearls
Oshima, M., Suzuki, É., Ihara, H., Nagai, K., & Kishida, K. (2021) · Nippon Eiyo Shokuryo Gakkaishi · doi:10.4327/jsnfs.74.155
Anthropometric and Biochemical Effects of Consuming Omega-3 Fatty Acids Enriched Eggs
Iorio, A. B. D., Javier, F. Á. B., & Esteban, V. D. R. (2021) · Acta Scientifci Nutritional Health · doi:10.31080/asnh.2020.05.0932
Fette runter mit Omega-3? – Der Einfluss von Omega-3-Fettsäuren auf den Lipidstoffwechsel
Schmiedel, V. (2021) · Erfahrungsheilkunde · doi:10.1055/a-1606-8928
Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Madasamy, S., Liu, D., Lundry, J., Alderete, B. E., Kong, R., Robinson, J. P., Wu, A. H. B., & Amento, E. P. (2017) · Journal of Visualized Experiments · doi:10.3791/56596-v
Kim, J.-M., & Park, M.-S. (2021) · Stroke revisited · doi:10.1007/978-981-16-3923-4_10
Was It a Case of “Flatbush Diabetes” with Severe Hypertriglyceridemia?
Alnuaimi, M., Ismail, M. M., & El-Houni, A. (2022) · Ibnosina Journal of Medicine and Biomedical Sciences · doi:10.1055/s-0042-1756686
Schmiedel, V. (2023) · Deutsche Heilpraktiker-Zeitschrift · doi:10.1055/a-2073-1214
Ganda, O. P., Busch, R. S., Nelson, J. R., & Philip, S. (2023) · Contemporary diabetes · doi:10.1007/978-3-031-26681-2_25
Николаевна, С. М., Константинович, И. Л., Синьков, М. А., & Plotnikova, E. Y. (2023) · Bulletin of Medical Science · doi:10.31684/25418475-2023-2-15 · Cited by 1
Wang, W., Yang, L., Zhang, J., & Xiang, H. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1328087
Lu, W., Luo, M., Fang, X., Zhang, R., Li, S., Tang, M., Yu, X., & Hu, C. (2021) · Figshare · doi:10.6084/m9.figshare.16305508
Lu, W., Luo, M., Fang, X., Zhang, R., Li, S., Tang, M., Yu, X., & Hu, C. (2021) · Figshare · doi:10.6084/m9.figshare.16305511
Lu, W., Luo, M., Fang, X., Zhang, R., Li, S., Tang, M., Yu, X., & Hu, C. (2021) · Figshare · doi:10.6084/m9.figshare.16305505
Lu, W., Luo, M., Fang, X., Zhang, R., Li, S., Tang, M., Yu, X., & Hu, C. (2021) · Figshare · doi:10.6084/m9.figshare.16305517
Lu, W., Luo, M., Fang, X., Zhang, R., Li, S., Tang, M., Yu, X., & Hu, C. (2021) · Figshare · doi:10.6084/m9.figshare.16305514
Lu, W., Luo, M., Fang, X., Zhang, R., Li, S., Tang, M., Yu, X., & Hu, C. (2021) · Figshare · doi:10.6084/m9.figshare.16305520
Lu, W., Luo, M., Fang, X., Zhang, R., Li, S., Tang, M., Yu, X., & Hu, C. (2021) · Figshare · doi:10.6084/m9.figshare.16305487
Moderne Strategien zur Lipidsenkung – die frühe Kombinationstherapie
Geiling, J. A., Schulze, P. C., & Weingärtner, O. (2024) · Zeitschrift für Herz- Thorax- und Gefäßchirurgie · doi:10.1007/s00398-024-00650-5
Mambaya, H. D., Muniroh, M., Sulchan, M., & Afifah, D. N. (2024) · Jurnal Penelitian Pendidikan IPA · doi:10.29303/jppipa.v10ispecialissue.7440
Singh, A. K., Tripathi, P., Saini, R., & Singh, S. (2025) · Springer eBooks · doi:10.1007/978-3-031-84200-9_20
Ácidos grasos poliinsaturados omega-3 en pacientes pediátricos con leucemia linfoblástica aguda
Morales-Montes, S. B., Atilano-Miguel, S., & Barbosa-Cortés, L. (2024) · PubMed Central · doi:10.5281/zenodo.14199882
徐, 瑾. (2025) · Advances in Clinical Medicine · doi:10.12677/acm.2025.1582278
Current advances and controversies in the therapeutic use of fish oil: Theme revisited
Télessy, I. G., Buttar, H. S., & Wilson, D. W. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-33122-0.00015-5
Lu, W., Luo, M., Fang, X., Zhang, R., Li, S., Tang, M., Yu, X., & Hu, C. (2021) · Figshare · doi:10.6084/m9.figshare.16305490
Lu, W., Luo, M., Fang, X., Zhang, R., Li, S., Tang, M., Yu, X., & Hu, C. (2021) · Figshare · doi:10.6084/m9.figshare.16305499
Lu, W., Luo, M., Fang, X., Zhang, R., Li, S., Tang, M., Yu, X., & Hu, C. (2021) · Figshare · doi:10.6084/m9.figshare.16305493
Functional Components of Foods: Health Effects and Therapeutic Mechanisms in Metabolic Syndrome
Estefes-Duarte, J. A., Hernández-Peña, N., Hernández-Soto, I., Cabrera, G. B., Muñoz‐Pérez, V. M., & Fernández‐Martínez, E. (2026) · Current Nutrition & Food Science · doi:10.2174/0115734013441158251212074509
Таранушенко, Т. Е., & Zakharova, I. N. (2026) · Meditsinskiy sovet = Medical Council · doi:10.21518/ms2026-008
Yeasmin, R., Abuhussein, E., Tubbs, A. R., Lee, M., Fujiwara, T., Bumgardner, J. D., Cho, H., & Jennings, J. A. (2026) · Frontiers in Medical Engineering · doi:10.3389/fmede.2026.1897565
Olezarsen for the Treatment of Hypertriglyceridemia
Rodriguez, A. S. H., & Yokota, T. (2026) · Methods in molecular biology · doi:10.1007/978-1-0716-5476-7_6
Darwish, A., Kiryowa, I., Boulkrane, M. S., & El-Messery, T. M. (2026) · Food Bioscience · doi:10.1016/j.fbio.2026.110215
Metadata
- Authors
- Backes, J., Anzalone, D., Hilleman, D., & Catini, J.
- Affiliations
- University of Kansas (US)
- AstraZeneca (United States) (US)
- Creighton University (US)
- Corresponding author
- Backes, James
- Venue
- Lipids in Health and Disease
- Published
- 2016-07-22
- Volume
- 15
- Issue
- 1
- Pages
- 118-118
- ISSN
- 1476-511X (ISSN-L)
- PMC
- PMC4957330
- OpenAlex
- W2487890137
- Cited by
- 195
- References
- 97
- Citations by year
- 2026: 8 · 2025: 20 · 2024: 20 · 2023: 20 · 2022: 26 · 2021: 29 · 2020: 25 · 2019: 15 · 2018: 9 · 2017: 20 · 2016: 1
- FWCI
- 2.01
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Lipids in Health and Disease (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Creighton Digital Repository (CDR) (submittedVersion)
- KU ScholarWorks (The University of Kansas) (submittedVersion, cc-by)
- Funders
- AstraZeneca
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Keywords
- omega-3 fatty acids, severe hypertriglyceridemia, triglyceride-lowering therapy, icosapent ethyl, eicosapentaenoic acid, docosahexaenoic acid, docosapentaenoic acid, VLDL, non-HDL cholesterol, lipoprotein lipase, hepatic lipogenesis, fatty acid beta-oxidation, bioavailability, drug-drug interactions, cardiovascular risk, pancreatitis
- MeSH terms
- Adult, Hypolipidemic Agents, Biological Availability, Docosahexaenoic Acids, Drug Combinations, Esters, Humans, Lipoprotein Lipase, Cholesterol, LDL, Lipoproteins, VLDL, Liver, Oxidation-Reduction, Triglycerides, Eicosapentaenoic Acid, Hypertriglyceridemia, Fatty Acids, Omega-3, Lipogenesis, Diacylglycerol O-Acyltransferase
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
