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Cited by 16Cardiovascular Health and Disease PreventionLipoproteins and Cardiovascular HealthParaoxonase enzyme and polymorphisms

High-density lipoprotein 3 cholesterol is a predictive factor for arterial stiffness: a community-based 4.8-year prospective study

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Wang, Fan, Wang, Xiaona, Ye, Ping, Cao, Ruihua, Zhang, Yun, Qi, Yue, Zhao, Dong·2018·Lipids in Health and Disease
DOI 10.1186/s12944-017-0650-zPMC PMC5756332
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Abstract

BACKGROUND: Although drug trials with niacin and cholesteryl ester transfer protein inhibitors that substantially increase high-density lipoprotein-cholesterol (HDL-C) failed to reduce the risk of coronary heart disease, HDL protection of the cardiovascular system cannot be easily denied. Hence, it may be HDL subfractions that are responsible for the long-held and consistent cardioprotective association of HDL. Arterial stiffness has been increasingly recognized as a strong predictor of subclinical vascular disease, atherosclerotic disease, and cardiovascular mortality. As the association of HDL subfractions and arterial stiffness is not well characterized, we aimed to determine the relations between these two entities in a community-based longitudinal Chinese population sample. METHODS: We evaluated the associations of plasma HDL2-C and HDL3-C subfractions with arterial stiffness measured using carotid-femoral pulse wave velocity (cf-PWV) and then multivariate logistic regression in 1447 subjects (mean age 61.3 years) from a community-based population in Beijing, China. RESULTS: After a median follow-up of 4.8 years, Pearson's correlation analysis revealed that HDL3-C was negatively associated with follow-up cf-PWV (r = -0.114; P = 0.001), and there was no correlation between HDL2-C and follow-up cf-PWV (r = -0.045; P = 0.181). In the multivariate logistic regression analysis, each standard deviation (SD) increase in HDL3-C was associated with a 1.490-increased likelihood of the presence of follow-up cf-PWV [odds ratio (per SD increase in HDL3-C) 1.490; 95% confidence interval 1.021-1.470; P = 0.039), whereas there was no relation between HDL2-C and follow-up cf-PWV. CONCLUSIONS: HDL3-C subfractions were significantly and inversely associated with arterial stiffness, suggesting that HDL subfractions are likely more important than HDL-C in preventing cardiovascular disease.

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Research works printed but not linked: 31

  1. [1]Di Angelantonio E Sarwar N Perry P Kaptoge S Ray KK Thompson A Emerging risk factors collaboration. Major lipids, apolipoproteins, and risk of vascular disease JAMA 2009 302 1993 2000 10.1001/jama.2009.1619 19903920 PMC3284229 · DOI · Paper page
  2. [3]Voight BF Peloso GM Orho-Melander M Frikke-Schmidt R Barbalic M Jensen MK Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study Lancet 2012 380 572 580 10.1016/S0140-6736(12)60312-2 22607825 PMC3419820 · DOI · Paper page
  3. [4]Garcia-Rios A Nikolic D Perez-Martinez P Lopez-Miranda J Rizzo M Hoogeveen RC LDL and HDL subfractions, dysfunctional HDL: treatment options Curr Pharm Des 2014 20 6249 6255 10.2174/1381612820666140620154014 24953394 · DOI
  4. [5]Vickers KC Remaley AT Thematic review series: high density lipoprotein structure, function, and metabolism HDL and cholesterol: life after the divorce? J Lipid Res 2014 55 4 12 10.1194/jlr.R035964 23515282 PMC3927467 · DOI
  5. [6]Superko HR Pendyala L Williams PT Momary KM King SB 3rd Garrett BC High-density lipoprotein subclasses and their relationship to cardiovascular disease J Clin Lipidol 2012 6 496 523 10.1016/j.jacl.2012.03.001 23312047 · DOI
  6. [7]Ito Y, Satoh N, Ishii T, Kumakura J, Hirano T. Development of a homogeneous assay for measurement of high-density lipoprotein-subclass cholesterol. Clin Chim Acta. 2014;427:86-93. 24055774
  7. [8]Ashmaig ME Gupta S McConnell JP Warnick GR Validation of a novel homogeneous assay for of HDL3-C measurement Clin Chim Acta 2013 21 37 41 10.1016/j.cca.2013.07.007 23891742 · DOI
  8. [9]Anagnostis P Stevenson JC Crook D Johnston DG Godsland IF Effects of menopause, gender and age on lipids and high-density lipoprotein cholesterol subfractions Maturitas 2015 81 62 68 10.1016/j.maturitas.2015.02.262 25804951 · DOI
  9. [10]Lamarche B Moorjani S Cantin B Dagenais GR Lupien PJ Després JP Associations of HDL2 and HDL3 subfractions with ischemic heart disease in men: prospective results from the Quebec cardiovascular study, Arterioscler Thromb Vasc Biol 1997 17 1098 1105 10.1161/01.ATV.17.6.1098 9194760 · DOI
  10. [11]López-Olmos V, Carreón-Torres E, Luna-Luna M, Flores-Castillo C, Martínez-Ramírez M, Bautista-Pérez R, et al. Increased HDL Size and Enhanced Apo A-I Catabolic Rates Are Associated With Doxorubicin-Induced Proteinuria in New Zealand White Rabbits. Lipids. 2016;51:311-20. 26781765
  11. [12]Ambrosino P Lupoli R Tortora A Cacciapuoti M Lupoli GA Tarantino P Cardiovascular risk markers in patients with primary aldosteronism: a systematic review and meta-analysis of literature studies Int J Cardiol 2016 208 46 55 10.1016/j.ijcard.2016.01.200 26826789 · DOI
  12. [13]Vlachopoulos C Aznaouridis K Stefanadis C Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis J Am Coll Cardiol 2010 55 1318 1327 10.1016/j.jacc.2009.10.061 20338492 · DOI · Paper page
  13. [14]Hirano T Nohtomi K Koba S Muroi A Ito YA Simple and precise method for measuring HDL-cholesterol subfractions by a single precipitation followed by homogenous HDL-cholesterol assay J Lipid Res 2008 49 1130 1136 10.1194/jlr.D700027-JLR200 18223297 · DOI
  14. [15]McEniery C Cockcroft JR Does arterial stiffness predict atherosclerotic coronary events? Adv Cardiol 2007 44 160 172 10.1159/000096728 17075206 · DOI
  15. [16]Zhao F Zhang L Lu J Guo K Wu M Yu H The chronic kidney disease epidemiology collaboration equation improves the detection of hyperfiltration in Chinese diabetic patients Int J Clin Exp Med 2015 8 22084 22097 26885183 PMC4729969
  16. [17]Bai Y Ye P Luo L Xiao W Xu R Wu H Bai J Arterial stiffness is associated with minimally elevated high-sensitivity cardiac, troponin T levels in a community-dwelling population Atherosclerosis 2011 218 493 498 10.1016/j.atherosclerosis.2011.06.035 21784424 · DOI
  17. [18]Wang XN Ye P Cao RH Yang X Xiao WK Zhang Y Plasma Homocysteine is a predictive factor for arterial stiffness: a community-based 4.8-year prospective study J Clin Hypertens (Greenwich) 2015 17 594 600 10.1111/jch.12555 25894449 PMC8032057 · DOI
  18. [19]Ershova AI Meshkov AN Rozhkova TA Kalinina MV Deev AD Rogoza AN Carotid and aortic stiffness in patients with heterozygous familial hypercholesterolemia PLoS One 2016 11 e0158964 10.1371/journal.pone.0158964 27434535 PMC4951005 · DOI
  19. [20]Hirano T Abnormal lipoprotein metabolism in diabetic nephropathy Clin Exp Nephrol 2014 18 206 209 10.1007/s10157-013-0880-y 24132562 · DOI
  20. [21]de la Llera-Moya de M Drazul-Schrader D Asztalos BF Cuchel M Rader DJ The ability to promote efflux via ABCA1 determines the capacity of serum specimens with similar high-density lipoprotein cholesterol to remove cholesterol from macrophages Arterioscler Thromb Vasc Biol 2010 30 796 801 10.1161/ATVBAHA.109.199158 20075420 PMC2866499 · DOI
  21. [22]Martin SS Khokhar AA May HT Kulkarni KR Blaha MJ Joshi PH HDL cholesterol subclasses, myocardial infarction, and mortality in secondary prevention: the lipoprotein investigators collaborative Eur Heart J 2015 36 22 30 10.1093/eurheartj/ehu264 24980493 PMC4286318 · DOI
  22. [23]Joshi PH Toth PP Lirette ST Griswold ME Massaro JM Martin SS Lipoprotein investigators collaborative (LIC) study group. Association of high-density lipoprotein subclasses and incident coronary heart disease: the Jackson heart and Framingham offspring cohort studies Eur J Prev Cardiol 2016 23 41 49 10.1177/2047487314543890 25062744 PMC4312248 · DOI
  23. [24]Ditah C Otvos J Nassar H Shaham D Sinnreich R Kark JD Small and medium sized HDL particles are protectively associated with coronary calcification in a cross-sectional population-based sample Atherosclerosis 2016 251 124 131 10.1016/j.atherosclerosis.2016.06.010 27318832 · DOI
  24. [25]Kim DS Li YK Bell GA Burt AA Vaisar T Hutchins PM Concentration of smaller high-density lipoprotein particle (HDL-P) is inversely correlated with carotid intima media thickening after confounder adjustment: the multi ethnic study of atherosclerosis (MESA) J Am Heart Assoc 2016 5 e002977 10.1161/JAHA.115.002977 27207961 PMC4889175 · DOI
  25. [26]Kontush A1 Chapman MJ Antiatherogenic small, dense HDL--guardian angel of the arterial wall? Nat Clin Pract Cardiovasc Med 2006 3 144 153 10.1038/ncpcardio0500 16505860 · DOI
  26. [27]Yassine HN Belopolskaya A Schall C Stump CS Lau SS Reaven PD Enhanced cholesterol efflux to HDL through the ABCA1 transporter in hypertriglyceridemia of type 2 diabetes Metabolism 2014 63 727 734 10.1016/j.metabol.2014.03.001 24636347 PMC4014062 · DOI
  27. [28]Kontush A Chapman MJ Antiatherogenic function of HDL particle subpopulations: focus on antioxidative activities Curr Opin Lipidol 2010 21 312 318 10.1097/MOL.0b013e32833bcdc1 20581677 · DOI
  28. [29]Duprez DA Otvos J Tracy RP Feingold KR Greenland P Gross MD High density lipoprotein subclasses and noncardiovascular, noncancer chronic inflammatory related events versus cardiovascular events: the multi ethnic study of atherosclerosis J Am Heart Assoc 2015 4 9 e002295 10.1161/JAHA.115.002295 26370448 PMC4599511 · DOI
  29. [30]Tsai HC Han MH Sphingosine-1-phosphate (S1P) and S1P signaling pathway: therapeutic targets in autoimmunity and inflammation Drugs 2016 76 1067 1079 10.1007/s40265-016-0603-2 27318702 · DOI
  30. [31]Kontush A Therond P Zerrad A Couturier M Negre-Salvayre A de Souza JA Preferential sphingosine-1-phosphate enrichment and sphingomyelin depletion are key features of small dense HDL3 particles: relevance to antiapoptotic and antioxidative activities Arterioscler Thromb Vasc Biol 2007 27 1843 1849 10.1161/ATVBAHA.107.145672 17569880 · DOI
  31. [32]Kimura T Sato K Malchinkhuu E Tomura H Tamama K Kuwabara A High-density lipoprotein stimulates endothelial cell migration and survival through sphingosine 1-phosphate and its receptors Arterioscler Thromb Vasc Biol 2003 23 1283 1288 10.1161/01.ATV.0000079011.67194.5A 12775579 · DOI

Cited by

Sorted by citations

Authors
Wang, F., Wang, X., Ye, P., Cao, R., Zhang, Y., Qi, Y., & Zhao, D.
Affiliations
  • Chinese PLA General Hospital (CN)
  • Beijing Anzhen Hospital (CN)
Corresponding author
Ye, Ping
ORCID
Venue
Lipids in Health and Disease
Publisher
Springer Science and Business Media LLC
Published
2018-01-05
Volume
17
Issue
1
Pages
5-5
ISSN
1476-511X (ISSN-L)
DOI
10.1186/s12944-017-0650-z
PMC
PMC5756332
OpenAlex
W2782513687
Cited by
16
References
1
Citations by year
2024: 4 · 2023: 4 · 2022: 3 · 2021: 3 · 2018: 2
FWCI
0.95
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Lipids in Health and Disease (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • the National Nature Science Foundation of China (81500316)
  • the Open Project Program of the State Key Laboratory of Proteomics (SKLP-O201508)
  • the Key National Basic Research Program of China (2012CB517503, 2013CB530804)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
Keywords
HDL3 cholesterol, HDL2, HDL subfractions, arterial stiffness, carotid-femoral pulse wave velocity, cardiovascular risk prediction, subclinical vascular disease, cardiovascular disease prevention, Chinese population
MeSH terms
Aged, China, Coronary Disease, Cross-Sectional Studies, Female, Humans, Cholesterol, HDL, Male, Middle Aged, Prospective Studies, Risk Factors, Multivariate Analysis, Odds Ratio, Protein Isoforms, Atherosclerosis, Vascular Stiffness, Pulse Wave Analysis, Protective Factors

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