Fetuin-a expression profile in mouse and human adipose tissue
Open accessAbstract
Fetuin-A (Fet-A) was one of the first hepatokines to be reportedly linked to metabolic diseases. Fet-A was also suggested to be an adipokine, but its expression in the adipose tissue remains debatable. Here we compared the expression of Fet-A between human and mice adipose tissue biopsies as well as among human subcutaneous tissue and visceral adipose tissue primary cells, and mouse 3 T3-L1 cells at various stages of differentiation. Fet-A was expressed in mice biopsies and cells but not in human biopsies and cells, except in visceral adipose tissue primary cells following differentiation. Although the marginal expression of Fet-A in human visceral adipose tissue, a major contribution of Fet-A expression in human adipose tissue to systemic Fet-A levels is discounted, but it could indicate specific local Fet-A action in the visceral adipose tissue.
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Fet-A levels are increased in obese individuals with diabetes.
“Fet-A levels are increased in obese individuals with diabetes [35].”
From Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions (2021) · cites this paper as [35]
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Fetuin-A Induces Cytokine Expression and Suppresses Adiponectin Production
Hennige, A. M., Staiger, H., Wicke, C., Machicao, F., Fritsche, A., Häring, H.-U., & Stefan, N. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001765 · Cited by 282 · see citing works
Fetuin-A: A novel link between obesity and related complications
Trepanowski, J. F., Mey, J., & Varady, K. A. (2015) · International Journal of Obesity · doi:10.1038/ijo.2014.203 · Cited by 161 · see citing works
Fetuin-null mice are protected against obesity and insulin resistance associated with aging
Mathews, S. T., Rakhade, S. N., Zhou, X., Parker, G. C., Coscina, D. V., & Grunberger, G. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.09.071 · Cited by 129 · see citing works
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Fetuin-A levels are increased in the adipose tissue of diabetic obese humans but not in circulation
Khadir, A., Kavalakatt, S., Madhu, D., Hammad, M. M., Devarajan, S., Tuomilehto, J., & Tiss, A. (2018) · Lipids in Health and Disease · doi:10.1186/s12944-018-0919-x · Cited by 48 · see citing works
Self-citationJialal, I., & Pahwa, R. (2019) · Lipids in Health and Disease · doi:10.1186/s12944-019-1021-8 · Cited by 30 · see citing works
Circulating Fetuin-A and Risk of Type 2 Diabetes: A Mendelian Randomization Analysis
Kröger, J., Meidtner, K., Stefan, N., Guevara, M., Kerrison, N. D., Ardanáz, E., Aune, D., Boeing, H., Dorronsoro, M., Dow, C., et al. (2018) · Diabetes · doi:10.2337/db17-1268 · Cited by 23 · see citing works
Expression of osteoprotegerin in human fat tissue; implications for chronic kidney disease
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Letter to the Editor, concerning: “FGF23-regulated production of fetuin-A (AHSG) in osteocytes”
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Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions
de Oliveira dos Santos, A. R., de Oliveira Zanuso, B., Miola, V. F. B., Barbalho, S. M., Santos Bueno, P. C., Flato, U. A. P., Detregiachi, C. R. P., Buchaim, D. V., Buchaim, R. L., Tofano, R. J., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052639 · Cited by 189 · see citing works
- Authors
- Khadir, A., Kavalakatt, S., Madhu, D., & Tiss, A.
- Affiliations
- Dasman Diabetes Institute (KW)
- Corresponding author
- Tiss, Ali
- Venue
- Lipids in Health and Disease
- Published
- 2020-03-12
- Volume
- 19
- Issue
- 1
- Pages
- 38-38
- ISSN
- 1476-511X (ISSN-L)
- PMC
- PMC7068996
- OpenAlex
- W3011267026
- Cited by
- 4
- References
- 10
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2021: 1
- FWCI
- 0.36
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Lipids in Health and Disease (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Kuwait Foundation for the Advancement of Sciences (RA2010-003)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- fetuin-A, adipose tissue, adipokines, visceral adipose tissue, subcutaneous adipose tissue, 3T3-L1 adipocytes, adipogenesis, species differences, human-mouse comparison, metabolic disorders
- MeSH terms
- Adipose Tissue, Animals, Cells, Cultured, Humans, Subcutaneous Tissue, Intra-Abdominal Fat, Mice, alpha-2-HS-Glycoprotein
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