Cited by 161Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and AdiposityRegulation of Appetite and Obesity

Fetuin-A: A novel link between obesity and related complications

Trepanowski, J F, Mey, J, Varady, K A·2015·International Journal of Obesity

Abstract

Fetuin-A (FetA) is a 64-kDa glycoprotein that is secreted from both the liver and adipose tissue. Circulating FetA is elevated in obesity and related disorders including type 2 diabetes mellitus, nonalcoholic fatty liver disease and the metabolic syndrome; and a FetA-related parameter, caliciprotein particle, is highly relevant to vascular calcification in overweight/obese patients with chronic kidney disease. FetA level is also associated with impaired insulin sensitivity and glucose tolerance. Accumulating evidence suggests that elevated FetA level causes impaired glycemic control, as FetA has been implicated in impairment of insulin receptor signaling, toll-like receptor 4 activation, macrophage migration and polarization, adipocyte dysfunction, hepatocyte triacylglycerol accumulation and liver inflammation and fibrosis. Weight loss, aerobic exercise, metformin and pioglitazone have each been shown to be effective for reducing FetA level.

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Crossref · 10.1038/ijo.2014.203

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Authors
Trepanowski, J. F., Mey, J., & Varady, K. A.
Affiliations
University of Illinois Chicago (US)
Corresponding author
Trepanowski, J F
Venue
International Journal of Obesity
Published
2014-12-03
Volume
39
Issue
5
Pages
734-741
ISSN
  • 0307-0565 (ISSN-L)
  • 1476-5497
OpenAlex
W2036987566
Cited by
161
References
87
Citations by year
2026: 2 · 2025: 16 · 2024: 17 · 2023: 13 · 2022: 21 · 2021: 20 · 2020: 18 · 2019: 14 · 2018: 15 · 2017: 8 · 2016: 13 · 2015: 4
FWCI
1.11
Type
journal article
Language
en
Open access
closed
Locations
  • International Journal of Obesity (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
fetuin-A, obesity, type 2 diabetes, non-alcoholic fatty liver disease, metabolic syndrome, vascular calcification, chronic kidney disease, insulin resistance, glucose tolerance, insulin receptor signaling, TLR4, macrophage polarization, adipocyte dysfunction, hepatic steatosis, liver fibrosis, weight loss, aerobic exercise, metformin, pioglitazone
MeSH terms
Adipose Tissue, Blood Glucose, Gene Expression Regulation, Humans, Inflammation, Insulin Resistance, Liver, Obesity, Signal Transduction, Metabolic Syndrome, Toll-Like Receptor 4, Renal Insufficiency, Chronic, alpha-2-HS-Glycoprotein, Non-alcoholic Fatty Liver Disease

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