Fetuin-A: A novel link between obesity and related complications
Abstract
Fetuin-A (FetA) is a 64-kDa glycoprotein that is secreted from both the liver and adipose tissue. Circulating FetA is elevated in obesity and related disorders including type 2 diabetes mellitus, nonalcoholic fatty liver disease and the metabolic syndrome; and a FetA-related parameter, caliciprotein particle, is highly relevant to vascular calcification in overweight/obese patients with chronic kidney disease. FetA level is also associated with impaired insulin sensitivity and glucose tolerance. Accumulating evidence suggests that elevated FetA level causes impaired glycemic control, as FetA has been implicated in impairment of insulin receptor signaling, toll-like receptor 4 activation, macrophage migration and polarization, adipocyte dysfunction, hepatocyte triacylglycerol accumulation and liver inflammation and fibrosis. Weight loss, aerobic exercise, metformin and pioglitazone have each been shown to be effective for reducing FetA level.
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Fetuin A levels are increased in obesity, especially associated with NAFLD.
“Notably, its levels have been found increased in obesity, especially associated with NAFLD [137], and are predictive for the development of T2DM [190].”
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Gonzalez-Gil, A. M., & Elizondo-Montemayor, L. (2020) · Nutrients · doi:10.3390/nu12061899 · Cited by 278 · see citing works
Ganesan, K., Chung, S. K., Vanamala, J., & Xu, B. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123720 · Cited by 221 · see citing works
Ezpeleta, M., Gabel, K., Cienfuegos, S., Kalam, F., Lin, S., Pavlou, V., Song, Z., Haus, J. M., Koppe, S., Alexandria, S. J., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2022.12.001 · Cited by 181 · see citing works
Self-citationImplication of hepatokines in metabolic disorders and cardiovascular diseases
Jung, T. W., Yoo, H. J., & Choi, K. M. (2016) · BBA Clinical · doi:10.1016/j.bbacli.2016.03.002 · Cited by 71 · see citing works
Sargeant, J. A., Aithal, G. P., Takamura, T., Misu, H., Takayama, H., Douglas, J. A., Turner, M. C., Stensel, D. J., Nimmo, M. A., Webb, D. R., et al. (2018) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2017-0639 · Cited by 56 · see citing works
Role of exercise-induced hepatokines in metabolic disorders
Ennequin, G., Sirvent, P., & Whitham, M. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00433.2018 · Cited by 54 · see citing works
(2020) · Advances in clinical chemistry · doi:10.1016/bs.acc.2019.07.012 · Cited by 46 · see citing works
Ramírez-Vélez, R., García-Hermoso, A., Hackney, A. C., & Izquierdo, M. (2019) · Lipids in Health and Disease · doi:10.1186/s12944-019-0962-2 · Cited by 37 · see citing works
Willis, S. A., Sargeant, J. A., Yates, T., Takamura, T., Takayama, H., Gupta, V., Brittain, E., Crawford, J., Parry, S. A., Thackray, A. E., et al. (2020) · The Journal of Nutrition · doi:10.1093/jn/nxz333 · Cited by 34 · see citing works
Telgenkamp, I., Kusters, Y. H. A. M., Schalkwijk, C. G., Houben, A. J. H. M., Kooi, M. E., Lindeboom, L., Bons, J. A. P., Schaper, N. C., Joris, P. J., Plat, J., et al. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-02378 · Cited by 18 · see citing works
Fetuin-a expression profile in mouse and human adipose tissue
Khadir, A., Kavalakatt, S., Madhu, D., & Tiss, A. (2020) · Lipids in Health and Disease · doi:10.1186/s12944-020-01225-7 · Cited by 4 · see citing works
- Authors
- Trepanowski, J. F., Mey, J., & Varady, K. A.
- Affiliations
- University of Illinois Chicago (US)
- Corresponding author
- Trepanowski, J F
- ORCID
- Venue
- International Journal of Obesity
- Published
- 2014-12-03
- Volume
- 39
- Issue
- 5
- Pages
- 734-741
- ISSN
- 0307-0565 (ISSN-L)
- 1476-5497
- OpenAlex
- W2036987566
- Cited by
- 161
- References
- 87
- Citations by year
- 2026: 2 · 2025: 16 · 2024: 17 · 2023: 13 · 2022: 21 · 2021: 20 · 2020: 18 · 2019: 14 · 2018: 15 · 2017: 8 · 2016: 13 · 2015: 4
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Obesity (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- fetuin-A, obesity, type 2 diabetes, non-alcoholic fatty liver disease, metabolic syndrome, vascular calcification, chronic kidney disease, insulin resistance, glucose tolerance, insulin receptor signaling, TLR4, macrophage polarization, adipocyte dysfunction, hepatic steatosis, liver fibrosis, weight loss, aerobic exercise, metformin, pioglitazone
- MeSH terms
- Adipose Tissue, Blood Glucose, Gene Expression Regulation, Humans, Inflammation, Insulin Resistance, Liver, Obesity, Signal Transduction, Metabolic Syndrome, Toll-Like Receptor 4, Renal Insufficiency, Chronic, alpha-2-HS-Glycoprotein, Non-alcoholic Fatty Liver Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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