Fetuin-A Induces Cytokine Expression and Suppresses Adiponectin Production
Open accessAbstract
BACKGROUND: The secreted liver protein fetuin-A (AHSG) is up-regulated in hepatic steatosis and the metabolic syndrome. These states are strongly associated with low-grade inflammation and hypoadiponectinemia. We, therefore, hypothesized that fetuin-A may play a role in the regulation of cytokine expression, the modulation of adipose tissue expression and plasma concentration of the insulin-sensitizing and atheroprotective adipokine adiponectin. METHODOLOGY AND PRINCIPAL FINDINGS: Human monocytic THP1 cells and human in vitro differenttiated adipocytes as well as C57BL/6 mice were treated with fetuin-A. mRNA expression of the genes encoding inflammatory cytokines and the adipokine adiponectin (ADIPOQ) was assessed by real-time RT-PCR. In 122 subjects, plasma levels of fetuin-A, adiponectin and, in a subgroup, the multimeric forms of adiponectin were determined. Fetuin-A treatment induced TNF and IL1B mRNA expression in THP1 cells (p<0.05). Treatment of mice with fetuin-A, analogously, resulted in a marked increase in adipose tissue Tnf mRNA as well as Il6 expression (27- and 174-fold, respectively). These effects were accompanied by a decrease in adipose tissue Adipoq mRNA expression and lower circulating adiponectin levels (p<0.05, both). Furthermore, fetuin-A repressed ADIPOQ mRNA expression of human in vitro differentiated adipocytes (p<0.02) and induced inflammatory cytokine expression. In humans in plasma, fetuin-A correlated positively with high-sensitivity C-reactive protein, a marker of subclinical inflammation (r = 0.26, p = 0.01), and negatively with total- (r = -0.28, p = 0.02) and, particularly, high molecular weight adiponectin (r = -0.36, p = 0.01). CONCLUSIONS AND SIGNIFICANCE: We provide novel evidence that the secreted liver protein fetuin-A induces low-grade inflammation and represses adiponectin production in animals and in humans. These data suggest an important role of fatty liver in the pathophysiology of insulin resistance and atherosclerosis.
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Fetuin A suppresses production of adiponectin by adipocytes.
“Fetuin A has been shown to directly induce insulin resistance [189], suppress production of adiponectin by adipocytes [148], and induce pancreatic β-cell toxicity [152].”
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Cites
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502 · see citing works
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041 · see citing works
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760 · see citing works
Adipose Tissue as an Endocrine Organ
Kershaw, E. E., & Flier, J. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0395 · Cited by 5,522 · see citing works
Weyer, C., Funahashi, T., Tanaka, S., Hotta, K., Matsuzawa, Y., Pratley, R. E., & Tataranni, P. A. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.5.7463 · Cited by 3,541 · see citing works
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
Kadowaki, T. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29126 · Cited by 2,824 · see citing works
Plasma Adiponectin Levels and Risk of Myocardial Infarction in Men
Pischon, T. (2004) · JAMA · doi:10.1001/jama.291.14.1730 · Cited by 1,762 · see citing works
Schäfer, C., Heiss, A., Schwarz, A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17202 · Cited by 919 · see citing works
Ketteler, M., Bongartz, P., Westenfeld, R., Wildberger, J. E., Mahnken, A. H., Böhm, R. O. B., Metzger, T., Wanner, C., Jahnen‐Dechent, W., & Floege, J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12710-9 · Cited by 909 · see citing works
Bruun, J. M., Lihn, A. S., Verdich, C., Pedersen, S. B., Toubro, S., Astrup, A. V., & Richelsen, B. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00110.2003 · Cited by 779 · see citing works
Vionnet, N., Hani, E. H., Dupont, S., Gallina, S., Francke, S., Dotte, S., de Matos, F., Durand, E., Leprêtre, F., Lecœur, C., et al. (2000) · The American Journal of Human Genetics · doi:10.1086/316887 · Cited by 679 · see citing works
Hormonal regulation of adiponectin gene expression in 3T3-L1 adipocytes
Fasshauer, M., Klein, J., Neumann, S., Eszlinger, M., & Paschke, R. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.6307 · Cited by 655 · see citing works
Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome
Kissebah, A. H., Sonnenberg, G. E., Myklebust, J. B., Goldstein, M., Broman, K. W., James, R. G., Marks, J., Krakower, G. R., Jacob, H. J., Weber, J. L., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.26.14478 · Cited by 629 · see citing works
Adipose Tissue-Derived Factors: Impact on Health and Disease
Trujillo, M. E., & Scherer, P. E. (2006) · Endocrine Reviews · doi:10.1210/er.2006-0033 · Cited by 611 · see citing works
Plasma Adiponectin Concentrations Predict Insulin Sensitivity of Both Glucose and Lipid Metabolism
Tschritter, O., Fritsche, A., Thamer, C., Haap, M. M., Shirkavand, F., Rahe, S., Staiger, H., Maerker, E., Häring, H. U., & Stümvoll, M. (2003) · Diabetes · doi:10.2337/diabetes.52.2.239 · Cited by 585 · see citing works
Self-citationHara, K., Horikoshi, M., Yamauchi, T., Yago, H., Miyazaki, O., Ebinuma, H., Imai, Y., Nagai, R., & Kadowaki, T. (2006) · Diabetes Care · doi:10.2337/dc05-1801 · Cited by 574 · see citing works
Stefan, N., Vozarova, B., Funahashi, T., Matsuzawa, Y., Weyer, C., Lindsay, R. S., YOUNGREN, J. F., Havel, P. J., Pratley, R. E., Bogardus, C., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.6.1884 · Cited by 557 · see citing works
Self-citationAdiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes
Faßhauer, M., Kralisch, S., Klier, M., Lössner, U., Blüher, M., Klein, J. C., & Paschke, R. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00090-1 · Cited by 534 · see citing works
Adiponectin Multimeric Complexes and the Metabolic Syndrome Trait Cluster
Lara‐Castro, C., Luo, N., Wallace, P., Klein, R. L., & Garvey, W. T. (2006) · Diabetes · doi:10.2337/diabetes.55.01.06.db05-1105 · Cited by 480 · see citing works
Stefan, N., Hennige, A. M., Staiger, H., Machann, J., Schick, F., Kröber, S. M., Machicao, F. E., Fritsche, A., & Häring, H. (2006) · Diabetes Care · doi:10.2337/diacare.29.04.06.dc05-1938 · Cited by 475 · see citing works
Self-citationMechanisms of Disease: hepatic steatosis in type 2 diabetes—pathogenesis and clinical relevance
Roden, M. (2006) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0190 · Cited by 404 · see citing works
Adiponectin and Future Coronary Heart Disease Events Among Men With Type 2 Diabetes
Schulze, M. B., Shai, I., Rimm, E. B., Li, T., Rifai, N., & Hu, F. B. (2005) · Diabetes · doi:10.2337/diabetes.54.2.534 · Cited by 365 · see citing works
Tsao, T., Murrey, H. E., Hug, C., Lee, D. H., & Lodish, H. F. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200312200 · Cited by 352 · see citing works
Improved Insulin Sensitivity and Resistance to Weight Gain in Mice Null for the Ahsg Gene
Mathews, S. T., Singh, G. P., Ranalletta, M., Cintrón, V. J., Qiang, X., Goustin, A. S., Jen, K. C., Charron, M. J., Jahnen‐Dechent, W., & Grunberger, G. (2002) · Diabetes · doi:10.2337/diabetes.51.8.2450 · Cited by 343 · see citing works
Auberger, P., Falquerho, L., Contreres, J. O., Pagès, G., Cam, G. L., Rossi, B., & Cam, A. L. (1989) · Cell · doi:10.1016/0092-8674(89)90098-6 · Cited by 321 · see citing works
Association Between Human Fetuin-A and the Metabolic Syndrome
Ix, J. H., Shlipak, M. G., Brandenburg, V. M., Ali, S., Ketteler, M., & Whooley, M. A. (2006) · Circulation · doi:10.1161/circulationaha.105.588723 · Cited by 316 · see citing works
Fetuin, a New Globulin Isolated from Serum
Pedersen, K. O. (1944) · Nature · doi:10.1038/154575a0 · Cited by 289 · see citing works
Denecke, B., Gräber, S., Schäfer, C., Heiss, A., Wöltje, M., & Jahnen‐Dechent, W. (2003) · Biochemical Journal · doi:10.1042/bj20030676 · Cited by 287 · see citing works
Bacha, F. F., Saad, R. J., Gungor, N., & Arslanian, S. A. (2004) · Diabetes Care · doi:10.2337/diacare.27.2.547 · Cited by 278 · see citing works
Fisher, F., Trujillo, M. E., Hanif, W., Barnett, A. H., McTernan, P. G., Scherer, P. E., & Kumar, S. (2005) · Diabetologia · doi:10.1007/s00125-005-1758-7 · Cited by 262 · see citing works
Sopasakis, V. R., Sandqvist, M., Gustafson, B., Hammarstedt, A., Schmelz, M., Yang, X., Jansson, P., & Smith, U. (2004) · Obesity Research · doi:10.1038/oby.2004.51 · Cited by 243 · see citing works
Srinivas, P. R., Wagner, A. S., Reddy, L. V. K., Deutsch, D. D., Leon, M. A., Goustin, A. S., & Grunberger, G. (1993) · Molecular Endocrinology · doi:10.1210/mend.7.11.7906861 · Cited by 243 · see citing works
Association of Serum Fetuin-A With Insulin Resistance in Type 2 Diabetic and Nondiabetic Subjects
Mori, K., Emoto, M., Yokoyama, H., Araki, T., Teramura, M., Koyama, H., Shoji, T., Inaba, M., & Nishizawà, Y. (2006) · Diabetes Care · doi:10.2337/diacare.29.02.06.dc05-1484 · Cited by 213 · see citing works
Kappes, A., & Löffler, G. (2000) · Hormone and Metabolic Research · doi:10.1055/s-2007-978684 · Cited by 193 · see citing works
Mathews, S. T. (2000) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(00)00237-9 · Cited by 179 · see citing works
Adiponectin, risk of coronary heart disease and correlations with cardiovascular risk markers
Rothenbacher, D., Brenner, H., März, W., & Köenig, W. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi340 · Cited by 175 · see citing works
Lihn, A. S., Richelsen, B., Pedersen, S. B., Haugaard, S. B., Rathje, G. S., Madsbad, S., & Andersen, O. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00206.2003 · Cited by 173 · see citing works
Evidence for a local renin angiotensin system in primary cultured human preadipocytes
Schling, P., Mallow, H., Trindl, A., & Löffler, G. (1999) · International Journal of Obesity · doi:10.1038/sj.ijo.0800821 · Cited by 158 · see citing works
Dzięgielewska, K. M., Brown, W. M., Casey, S. J., et al. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39571-7 · Cited by 137 · see citing works
The nucleotide and partial amino acid sequences of rat fetuin
Rauth, G., Poeschke, O., Fink, E., Eulitz, M., Tippmer, S., Kellerer, M., Häring, H.-U., Nawratil, P., Haasemann, M., Jahnen‐Dechent, W., et al. (1992) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1992.tb16663.x · Cited by 134 · see citing works
Self-citationSchmidt, W. E., Pöll-Jordan, G., & Löffler, G. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55422-3 · Cited by 122 · see citing works
Pollin, T. I., Tanner, K., O’Connell, J. R., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.1.268 · Cited by 106 · see citing works
Plasma Adiponectin Levels and Sonographic Phenotypes of Subclinical Carotid Artery Atherosclerosis
Iglseder, B., Mackēvičs, V., Stadlmayer, A., Tasch, G., Ladurner, G., & Paulweber, B. (2005) · Stroke · doi:10.1161/01.str.0000190834.00284.fd · Cited by 97 · see citing works
Ruminy, P., Gangneux, C., Claeyssens, S., Scotté, M., Daveau, M., & Salier, J. (2001) · Inflammation Research · doi:10.1007/pl00000260 · Cited by 97 · see citing works
Adiponectin: Protection of the endothelium
Lam, K. S. L., & Xu, A. (2005) · Current Diabetes Reports · doi:10.1007/s11892-005-0019-y · Cited by 94 · see citing works
Association of serum fetuin‐A with carotid arterial stiffness
Mori, K., Emoto, M., Araki, T., et al. (2006) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2006.02716.x · Cited by 83 · see citing works
Lin, X., Braymer, H. D., Bray, G. A., & York, D. A. (1998) · Life Sciences · doi:10.1016/s0024-3205(98)00250-1 · Cited by 79 · see citing works
Siddiq, A., Leprêtre, F., Herçberg, S., Froguel, P., & Gibson, F. (2005) · Diabetes · doi:10.2337/diabetes.54.8.2477 · Cited by 75 · see citing works
Dyslipidemia in Visceral Obesity
Chan, D., Barrett, H., & Watts, G. (2004) · American Journal of Cardiovascular Drugs · doi:10.2165/00129784-200404040-00004 · Cited by 69 · see citing works
Bovine fetuin is an inhibitor of insulin receptor tyrosine kinase
Mathews, S. T., Srinivas, P. R., Leon, M. A., & Grunberger, G. (1997) · Life Sciences · doi:10.1016/s0024-3205(97)00737-6 · Cited by 68 · see citing works
Jahnen‐Dechent, W., Schäfer, C., Heiss, A., et al. (2001) · PubMed · doi:10.1007/pl00022849 · Cited by 67 · see citing works
?2-Heremans?Schmid glycoprotein gene polymorphisms are associated with adipocyte insulin action
Dahlman, I. A., Eriksson, P. O., Kaaman, M., Jiao, H., Lindgren, C. M., Kere, J., & Arner, P. (2004) · Diabetologia · doi:10.1007/s00125-004-1556-7 · Cited by 63 · see citing works
Hepatic steatosis and vascular disease.
Santoliquido, A., Campli, C. D., Miele, L., Gabrieli, M. L., Forgione, A., Zocco, M. A., Lupascu, A., Giorgio, A. D., Flore, R. A., Pola, P., et al. (2005) · PubMed · Cited by 37 · see citing works
Regulation of NCAM by growth factors in serum‐free myotube cultures
Lyles, J. M., Amin, W., Bock, E., et al. (1993) · Journal of Neuroscience Research · doi:10.1002/jnr.490340304 · Cited by 28 · see citing works
Systemic inhibition of spontaneous calcification by the serum protein α 2 -HS glycoprotein/fetuin
Jahnen‐Dechent, W., Schäfer, C., Heiss, A., et al. (2001) · Zeitschrift für Kardiologie · doi:10.1007/s003920170042 · Cited by 24 · see citing works
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Sorted by citations
Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance
Pal, D., Dasgupta, S., Kundu, R., Maitra, S., Das, G., Mukhopadhyay, S., Ray, S., Majumdar, S. S., & Bhattacharya, S. (2012) · Nature Medicine · doi:10.1038/nm.2851 · Cited by 922 · see citing works
The role of hepatokines in metabolism
Stefan, N., & Häring, H.-U. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.258 · Cited by 500 · see citing works
Plasma fetuin-A levels and the risk of type 2 diabetes
Stefan, N., Fritsche, A., Weikert, C., Boeing, H., Joost, H.-G., Häring, H.-U., & Schulze, M. B. (2008) · Diabetes · doi:10.2337/db08-0538 · Cited by 379 · see citing works
Self-citationGonzalez-Gil, A. M., & Elizondo-Montemayor, L. (2020) · Nutrients · doi:10.3390/nu12061899 · Cited by 278 · see citing works
Hepatokines and metabolism: Deciphering communication from the liver
Jensen-Cody, S. O., & Potthoff, M. J. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101138 · Cited by 252 · see citing works
Metabolic adaptation in obesity and type ii diabetes: myokines, adipokines and hepatokines
Oh, K.-J., Lee, D., Kim, W., Han, B., Lee, S., & Bae, K.-H. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms18010008 · Cited by 210 · see citing works
Dasgupta, S., Bhattacharya, S., Biswas, A., Majumdar, S. S., Mukhopadhyay, S., Ray, S., & Bhattacharya, S. (2010) · Biochemical Journal · doi:10.1042/bj20100330 · Cited by 168 · see citing works
Fetuin-A: A novel link between obesity and related complications
Trepanowski, J. F., Mey, J., & Varady, K. A. (2015) · International Journal of Obesity · doi:10.1038/ijo.2014.203 · Cited by 161 · see citing works
Circulating fetuin-A and free fatty acids interact to predict insulin resistance in humans
Stefan, N., & Häring, H.-U. (2013) · Nature Medicine · doi:10.1038/nm.3116 · Cited by 160 · see citing works
Self-citationChoi, H. Y., Hwang, S. Y., Lee, C. H., Hong, H. C., Yang, S. J., Yoo, H. J., Seo, J. A., Kim, S. G., Kim, N. H., Baik, S. H., et al. (2013) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2013.37.1.63 · Cited by 111 · see citing works
Exercise-induced lowering of fetuin-A may increase hepatic insulin sensitivity
Malin, S. K., del Rincon, J. P., Huang, H., & Kirwan, J. P. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000338 · Cited by 85 · see citing works
Implication of hepatokines in metabolic disorders and cardiovascular diseases
Jung, T. W., Yoo, H. J., & Choi, K. M. (2016) · BBA Clinical · doi:10.1016/j.bbacli.2016.03.002 · Cited by 71 · see citing works
Reinehr, T., Karges, B., Meissner, T., Wiegand, S., Stoffel-Wagner, B., Holl, R. W., & Woelfle, J. (2016) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2016.02.055 · Cited by 51 · see citing works
Fetuin-A and change in body composition in older persons
Ix, J. H., Wassel, C. L., Chertow, G. M., Koster, A., Johnson, K. C., Tylavsky, F. A., Cauley, J. A., Cummings, S. R., Harris, T. B., Shlipak, M. G., et al. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0916 · Cited by 51 · see citing works
(2020) · Advances in clinical chemistry · doi:10.1016/bs.acc.2019.07.012 · Cited by 46 · see citing works
Ramírez-Vélez, R., García-Hermoso, A., Hackney, A. C., & Izquierdo, M. (2019) · Lipids in Health and Disease · doi:10.1186/s12944-019-0962-2 · Cited by 37 · see citing works
Fetuin-a expression profile in mouse and human adipose tissue
Khadir, A., Kavalakatt, S., Madhu, D., & Tiss, A. (2020) · Lipids in Health and Disease · doi:10.1186/s12944-020-01225-7 · Cited by 4 · see citing works
- Authors
- Hennige, A. M., Staiger, H., Wicke, C., Machicao, F., Fritsche, A., Häring, H.-U., & Stefan, N.
- Affiliations
- University of Tübingen (DE)
- Corresponding author
- Stefan, Norbert
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2008-03-12
- Volume
- 3
- Issue
- 3
- Pages
- e1765
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC2258416
- OpenAlex
- W2060405968
- Cited by
- 282
- References
- 55
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 6 · 2023: 11 · 2022: 13 · 2021: 6 · 2020: 20 · 2019: 17 · 2018: 9 · 2017: 17 · 2016: 21 · 2015: 31 · 2014: 15 · 2013: 25 · 2012: 28
- FWCI
- 12.21
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Deutsche Forschungsgemeinschaft (HE 3653/3-1, KFO 114)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- fetuin-A, adiponectin, adiponectin multimers, low-grade inflammation, hepatic steatosis, metabolic syndrome, TNF-α, IL-1β, interleukin-6, adipose tissue, insulin resistance, atherosclerosis, C-reactive protein, adipokines, THP-1 macrophages, adipocytes
- MeSH terms
- alpha-Fetoproteins, Animals, Blood Glucose, Cell Line, Enzyme-Linked Immunosorbent Assay, Humans, Male, Mice, Inbred C57BL, RNA, Messenger, Cytokines, Reverse Transcriptase Polymerase Chain Reaction, Mice, Adiponectin
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