Cited by 389Genetics, Aging, and Longevity in Model OrganismsT-cell and B-cell ImmunologyTelomeres, Telomerase, and Senescence

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Immunosenescence in aging: between immune cells depletion and cytokines up-regulation

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Ventura, Maria Teresa, Casciaro, Marco, Gangemi, Sebastiano, Buquicchio, Rosalba·2017·Clinical and Molecular Allergy

DOI 10.1186/s12948-017-0077-0PMC PMC5731094

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Abstract

BACKGROUND: The immunosenescence is a relatively recent chapter, correlated with the linear extension of the average life began in the nineteenth century and still in progress. The most important feature of immunosenescence is the accumulation in the "immunological space" of memory and effector cells as a result of the stimulation caused by repeated clinical and subclinical infections and by continuous exposure to antigens (inhalant allergens, food, etc.). This state of chronic inflammation that characterizes senescence has a significant impact on survival and fragility. In fact, the condition of frail elderly occurs less frequently in situations characterized by poor contact with viral infections and parasitic diseases. Furthermore the immunosenescence is characterized by a particular "remodelling" of the immune system, induced by oxidative stress. Apoptosis plays a central role in old age, a period in which the ability of apoptosis can change. The remodelling of apoptosis, together with the Inflammaging and the up-regulation of the immune response with the consequent secretion of pro-inflammatory lymphokines represents the major determinant of the rate of aging and longevity, as well as of the most common diseases related with age and with tumors. Other changes occur in the innate immunity, the first line of defence providing rapid, but unspecific and incomplete protection, consisting mostly of monocytes, natural killer cells and dendritic cells, acting up to the establishment of a adaptive immune response, which is slower, but highly specific, which cellular substrate consists of T and B lymphocytes. The markers of "Inflammaging" in adaptive immunity in centenarians are characterized by a decrease in T cells "naive." The reduction of CD8 virgins may be related to the risk of morbidity and death, as well as the combination of the increase of CD8+ cells and reduction of CD4+ T cells and the reduction of CD19+ B cells. The immune function of the elderly is weakened to due to the exhaustion of T cell-virgin (CD95-), which are replaced with the clonal expansion of CD28-T cells. CONCLUSIONS: The increase of pro-inflammatory cytokines is associated with dementia, Parkinson's disease, atherosclerosis, diabetes type 2, sarcopenia and a high risk of morbidity and mortality. A correct modulation of immune responses and apoptotic phenomena can be useful to reduce age-related degenerative diseases, as well as inflammatory and neoplastic diseases.

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Additional file 2 of Increased Tc17 cell levels and imbalance of naïve/effector immune response in Parkinson’s disease patients in a two-year follow-up: a case control study
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Additional file 4 of Increased Tc17 cell levels and imbalance of naïve/effector immune response in Parkinson’s disease patients in a two-year follow-up: a case control study
Álvarez‐Luquín, D. D., Guevara‐Salinas, A., Arce-Sillas, A., Espinosa-Cárdenas, R., Leyva-Hernández, J., Montes-Moratilla, E. U., & Adalid-Peralta, L. V. (2021) · Figshare · doi:10.6084/m9.figshare.16575428
Additional file 3 of Increased Tc17 cell levels and imbalance of naïve/effector immune response in Parkinson’s disease patients in a two-year follow-up: a case control study
Álvarez‐Luquín, D. D., Guevara‐Salinas, A., Arce-Sillas, A., Espinosa-Cárdenas, R., Leyva-Hernández, J., Montes-Moratilla, E. U., & Adalid-Peralta, L. V. (2021) · Figshare · doi:10.6084/m9.figshare.16575422
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Additional file 5 of Increased Tc17 cell levels and imbalance of naïve/effector immune response in Parkinson’s disease patients in a two-year follow-up: a case control study
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Additional file 1 of Increased Tc17 cell levels and imbalance of naïve/effector immune response in Parkinson’s disease patients in a two-year follow-up: a case control study
Álvarez‐Luquín, D. D., Guevara‐Salinas, A., Arce-Sillas, A., Espinosa-Cárdenas, R., Leyva-Hernández, J., Montes-Moratilla, E. U., & Adalid-Peralta, L. V. (2021) · Figshare · doi:10.6084/m9.figshare.16575416
Additional file 7 of Increased Tc17 cell levels and imbalance of naïve/effector immune response in Parkinson’s disease patients in a two-year follow-up: a case control study
Álvarez‐Luquín, D. D., Guevara‐Salinas, A., Arce-Sillas, A., Espinosa-Cárdenas, R., Leyva-Hernández, J., Montes-Moratilla, E. U., & Adalid-Peralta, L. V. (2021) · Figshare · doi:10.6084/m9.figshare.16575437
Additional file 1 of Elevated free interleukin-18 associated with severity and mortality in prospective cohort study of 206 hospitalised COVID-19 patients
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Additional file 6 of Increased Tc17 cell levels and imbalance of naïve/effector immune response in Parkinson’s disease patients in a two-year follow-up: a case control study
Álvarez‐Luquín, D. D., Guevara‐Salinas, A., Arce-Sillas, A., Espinosa-Cárdenas, R., Leyva-Hernández, J., Montes-Moratilla, E. U., & Adalid-Peralta, L. V. (2021) · Figshare · doi:10.6084/m9.figshare.16575434
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Azzolino, D., Baldassari, I., Perna, S., Spolidoro, G. C. I., Moroni, A., Coelho-Junior, H. J., Cesari, M., & Lucchi, T. A. (2026) · World Allergy Organization Journal · doi:10.1016/j.waojou.2026.101428
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Park, J.-H., Bae, S., Jang, M., Kim, M. H., Park, H., & Shin, M.-J. (2026) · Journal of Functional Foods · doi:10.1016/j.jff.2026.107537

Authors: Ventura, M. T., Casciaro, M., Gangemi, S., & Buquicchio, R.
Affiliations: University of Bari Aldo Moro (IT)
University of Messina (IT)
Azienda Universitaria Ospedaliera Consorziale - Policlinico Bari (IT)
Corresponding author: Casciaro, Marco
ORCID: Ventura, Maria Teresa
Casciaro, Marco
Gangemi, Sebastiano
Buquicchio, Rosalba
Venue: Clinical and Molecular Allergy
Publisher: Springer Science and Business Media LLC
Published: 2017-12
Volume: 15
Issue: 1
Pages: 21-21
ISSN: 1476-7961 (ISSN-L)
DOI: 10.1186/s12948-017-0077-0
PMC: PMC5731094
OpenAlex: W2773578465
Cited by: 389
References: 70
Citations by year: 2026: 12 · 2025: 21 · 2024: 31 · 2023: 81 · 2022: 48 · 2021: 67 · 2020: 63 · 2019: 44 · 2018: 22
FWCI: 3.91
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
Locations: Clinical and Molecular Allergy (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion, cc-by)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Keywords: immunosenescence, aging, inflammaging, chronic inflammation, inflammatory cytokines, T cell exhaustion, naive T cells, CD8+ T cells, CD4+ T cells, B cells, apoptosis, oxidative stress, innate immunity, centenarians, frailty, age-related diseases, longevity

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Immunosenescence in aging: between immune cells depletion and cytokines up-regulation

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