Synergy of hypoxia relief and heat shock protein inhibition for phototherapy enhancement
Open accessAbstract
Background: Phototherapy is a promising strategy for cancer therapy by reactive oxygen species (ROS) of photodynamic therapy (PDT) and hyperthermia of photothermal therapy (PTT). However, the therapeutic efficacy was restricted by tumor hypoxia and thermal resistance of increased expression of heat shock protein (Hsp). In this study, we developed albumin nanoparticles to combine hypoxia relief and heat shock protein inhibition to overcome these limitations for phototherapy enhancement. Results: Near-infrared photosensitizer (IR780) and gambogic acid (GA, Hsp90 inhibitor) were encapsulated into albumin nanoparticles via hydrophobic interaction, which was further deposited MnO 2 on the surface to form IGM nanoparticles. Both in vitro and in vivo studies demonstrated that IGM could catalyze overexpress of hydrogen peroxide to relive hypoxic tumor microenvironment. With near infrared irradiation, the ROS generation was significantly increase for PDT enhancement. In addition, the release of GA was promoted by irradiation to bind with Hsp90, which could reduce cell tolerance to heat for PTT enhancement. As a result, IGM could achieve better antitumor efficacy with enhanced PDT and PTT. Conclusion: This study develops a facile approach to co-deliver IR780 and GA with self-assembled albumin nanoparticles, which could relive hypoxia and suppress Hsp for clinical application of cancer phototherapy.
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Organic small-molecule NIR-II fluorophores for tumor phototheranostics
Xiang, D., Wang, Z., Zheng, H., Tang, Y., & Li, Q. (2026) · Light: Science & Applications · doi:10.1038/s41377-026-02212-w · Cited by 22 · see citing works
“…of 4T1 tumor-bearing mice revealed ef fi cient accumulation of TPEB NPs at tumor sites, with a distinct NIR-II fl uorescence signal observable 12 h Most reported photosensitizers are con fi ned to either PDT or PTT, fundamentally limited by hypoxic TME and heat shock response, respectively 229 .”
- Authors
- Zhang, G., Cheng, W., Du, L., Xu, C., & Li, J.
- Affiliations
- Nanjing Drum Tower Hospital (CN)
- Nanjing University of Chinese Medicine (CN)
- Corresponding author
- Zhang, Gutian
- Li, Jinlong
- Venue
- Journal of Nanobiotechnology
- Published
- 2021-01-06
- Volume
- 19
- Issue
- 1
- Pages
- 9-9
- ISSN
- 1477-3155 (ISSN-L)
- PMC
- PMC7789325
- OpenAlex
- W3120574651
- Cited by
- 95
- References
- 61
- Citations by year
- 2026: 6 · 2025: 24 · 2024: 21 · 2023: 18 · 2022: 14 · 2021: 12
- FWCI
- 5.01
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Nanobiotechnology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (81703088, 11774167)
- Medical Science and Technology Development Foundation, Nanjing Department of Health (YKK19110)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- phototherapy, photodynamic therapy, photothermal therapy, tumor hypoxia, HSP90, albumin nanoparticles, hydrogen peroxide catalysis, reactive oxygen species, IR780, geldanamycin, near-infrared irradiation, thermal resistance, cancer therapy
- MeSH terms
- Animals, Hypoxia, Antineoplastic Agents, Cell Survival, Heat-Shock Proteins, Infrared Rays, Male, Mice, Inbred BALB C, Oxides, Phototherapy, Photosensitizing Agents, Manganese Compounds, HSP90 Heat-Shock Proteins, Xanthones, Mice, Nanoparticles, Hydrophobic and Hydrophilic Interactions, Tumor Microenvironment
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