Cited by 23

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

MiR-100-5p-rich small extracellular vesicles from activated neuron to aggravate microglial activation and neuronal activity after stroke

Xin, Danqing, Li, Tingting, Zhao, Yijing, Guo, Xiaofan, Gai, Chengcheng, Jiang, Zige, Yu, Shuwen, Cheng, Jiao, Song, Yan, Cheng, Yahong, Luo, Qian, Gu, Bing, Liu, Dexiang, Wang, Zhen·2024·Journal of Nanobiotechnology

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1186/s12951-024-02782-0

Cites

5 of 5 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Show all 5 references

Research works printed but not linked: 73

  1. George PM, Steinberg GK. Novel stroke therapeutics: unraveling stroke pathophysiology and its impact on clinical treatments. Neuron. 2015;87:297–309. · DOI
  2. Hartings JA, Rolli ML, Lu X-CM, Tortella FC. Delayed secondary phase of peri-infarct depolarizations after focal cerebral ischemia: relation to infarct growth and neuroprotection. J Neurosci. 2003;23:11602–10. · DOI
  3. Chamorro Á, Dirnagl U, Urra X, Planas AM. Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation. Lancet Neurol. 2016;15:869–81. · DOI · Paper page
  4. von Bornstädt D, Houben T, Seidel JL, Zheng Y, Dilekoz E, Qin T, et al. Supply-demand mismatch transients in susceptible peri-infarct hot zones explain the origins of spreading injury depolarizations. Neuron. 2015;85:1117–31. · DOI
  5. Hossmann KA. Periinfarct depolarizations. Cerebrovasc Brain Metab Rev. 1996;8:195–208.
  6. Xia X, Chen J, Ren H, Zhou C, Zhang Q, Cheng H, et al. Gypenoside pretreatment alleviates the cerebral ischemia injury via inhibiting the microglia-mediated neuroinflammation. Mol Neurobiol. 2023. https://doi.org/10.1007/s12035-023-03624-0. · DOI
  7. Wang Y-C, Galeffi F, Wang W, Li X, Lu L, Sheng H, et al. Chemogenetics-mediated acute inhibition of excitatory neuronal activity improves stroke outcome. Exp Neurol. 2020;326: 113206. · DOI
  8. Caracciolo L, Marosi M, Mazzitelli J, Latifi S, Sano Y, Galvan L, et al. CREB controls cortical circuit plasticity and functional recovery after stroke. Nat Commun. 2018;9:2250. · DOI
  9. Carmichael ST. Emergent properties of neural repair: elemental biology to therapeutic concepts. Ann Neurol. 2016;79:895–906. · DOI
  10. Di Pino G, Pellegrino G, Assenza G, Capone F, Ferreri F, Formica D, et al. Modulation of brain plasticity in stroke: a novel model for neurorehabilitation. Nat Rev Neurol. 2014;10:597–608. · DOI
  11. Rivera-Urbina GN, Batsikadze G, Molero-Chamizo A, Paulus W, Kuo M-F, Nitsche MA. Parietal transcranial direct current stimulation modulates primary motor cortex excitability. Eur J Neurosci. 2015;41:845–55. · DOI
  12. Hu K-H, Li Y-A, Jia W, Wu G-Y, Sun L, Wang S-R, et al. Chemogenetic activation of glutamatergic neurons in the motor cortex promotes functional recovery after ischemic stroke in rats. Behav Brain Res. 2019;359:81–8. · DOI
  13. Cheng MY, Wang EH, Woodson WJ, Wang S, Sun G, Lee AG, et al. Optogenetic neuronal stimulation promotes functional recovery after stroke. Proc Natl Acad Sci U S A. 2014;111:12913–8. · DOI
  14. Théry C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, Andriantsitohaina R, et al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the international society for extracellular vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles. 2018;7:1535750. · DOI · Paper page
  15. Jia Y, Yu L, Ma T, Xu W, Qian H, Sun Y, et al. Small extracellular vesicles isolation and separation: current techniques, pending questions and clinical applications. Theranostics. 2022;12:6548–75. · DOI
  16. Mathieu M, Martin-Jaular L, Lavieu G, Théry C. Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication. Nat Cell Biol. 2019;21:9–17. · DOI
  17. Deng Z, Wang J, Xiao Y, Li F, Niu L, Liu X, et al. Ultrasound-mediated augmented exosome release from astrocytes alleviates amyloid-β-induced neurotoxicity. Theranostics. 2021;11:4351–62. · DOI
  18. Chiang C-S, Fu S-J, Hsu C-L, Jeng C-J, Tang C-Y, Huang Y-S, et al. Neuronal exosomes secreted under oxygen-glucose deprivation/reperfusion presenting differentially expressed mirnas and affecting neuronal survival and neurite outgrowth. Neuromolecular Med. 2021;23:404–15. · DOI
  19. Wilton DK, Dissing-Olesen L, Stevens B. Neuron-glia signaling in synapse elimination. Annu Rev Neurosci. 2019;42:107–27. · DOI · Paper page
  20. Frühbeis C, Fröhlich D, Kuo WP, Amphornrat J, Thilemann S, Saab AS, et al. Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication. PLoS Biol. 2013;11: e1001604. · DOI · Paper page
  21. Yin Z, Han Z, Hu T, Zhang S, Ge X, Huang S, et al. Neuron-derived exosomes with high miR-21-5p expression promoted polarization of M1 microglia in culture. Brain Behav Immun. 2020;83:270–82. · DOI · Paper page
  22. Jiang D, Gong F, Ge X, Lv C, Huang C, Feng S, et al. Neuron-derived exosomes-transmitted miR-124-3p protect traumatically injured spinal cord by suppressing the activation of neurotoxic microglia and astrocytes. J Nanobiotechnology. 2020;18:105. · DOI · Paper page
  23. Peng H, Harvey BT, Richards CI, Nixon K. Neuron-derived extracellular vesicles modulate microglia activation and function. Biology (Basel). 2021;10:948.
  24. Han M, Cao Y, Xue H, Chu X, Li T, Xin D, et al. Neuroprotective effect of mesenchymal stromal cell-derived extracellular vesicles against cerebral ischemia-reperfusion-induced neural functional injury: a pivotal role for AMPK and JAK2/STAT3/NF-κB Signaling pathway modulation. Drug Des Devel Ther. 2020;14:2865–76. · DOI
  25. Kim H, Seo JS, Lee S-Y, Ha K-T, Choi BT, Shin Y-I, et al. AIM2 inflammasome contributes to brain injury and chronic post-stroke cognitive impairment in mice. Brain Behav Immun. 2020;87:765–76. · DOI
  26. Chen J, Sanberg PR, Li Y, Wang L, Lu M, Willing AE, et al. Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats. Stroke. 2001;32:2682–8. · DOI
  27. Ridder K, Sevko A, Heide J, Dams M, Rupp A-K, Macas J, et al. Extracellular vesicle-mediated transfer of functional RNA in the tumor microenvironment. Oncoimmunology. 2015;4: e1008371. · DOI
  28. Tian Y, Gong M, Hu Y, Liu H, Zhang W, Zhang M, et al. Quality and efficiency assessment of six extracellular vesicle isolation methods by nano-flow cytometry. J Extracell Vesicles. 2020;9:1697028. · DOI · Paper page
  29. Xin D, Li T, Chu X, Ke H, Liu D, Wang Z. MSCs-extracellular vesicles attenuated neuroinflammation, synapse damage and microglial phagocytosis after hypoxia-ischemia injury by preventing osteopontin expression. Pharmacol Res. 2021;164: 105322. · DOI
  30. Brewer HB, Ronan R, Meng M, Bishop C. Isolation and characterization of apolipoproteins A-I, A-II, and A-IV. Methods Enzymol. 1986;128:223–46. · DOI
  31. Rubio FJ, Li X, Liu Q-R, Cimbro R, Hope BT. Fluorescence activated cell sorting (FACS) and gene expression analysis of Fos-expressing neurons from fresh and frozen rat brain tissue. J Vis Exp. 2016. https://doi.org/10.3791/54358-v. · DOI
  32. Rubio FJ, Liu Q-R, Li X, Cruz FC, Leão RM, Warren BL, et al. Context-induced reinstatement of methamphetamine seeking is associated with unique molecular alterations in Fos-expressing dorsolateral striatum neurons. J Neurosci. 2015;35:5625–39. · DOI
  33. Slepko N, Levi G. Progressive activation of adult microglial cells in vitro. Glia. 1996;16:241–6. · DOI
  34. Wallach T, Mossmann ZJ, Szczepek M, Wetzel M, Machado R, Raden M, et al. MicroRNA-100-5p and microRNA-298-5p released from apoptotic cortical neurons are endogenous Toll-like receptor 7/8 ligands that contribute to neurodegeneration. Mol Neurodegener. 2021;16:80. · DOI · Paper page
  35. Lehmann SM, Krüger C, Park B, Derkow K, Rosenberger K, Baumgart J, et al. An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration. Nat Neurosci. 2012;15:827–35. · DOI · Paper page
  36. Zhang Z, Ohto U, Shibata T, Taoka M, Yamauchi Y, Sato R, et al. Structural analyses of toll-like receptor 7 reveal detailed rna sequence specificity and recognition mechanism of agonistic ligands. Cell Rep. 2018;25:3371-3381.e5. · DOI
  37. Nazmi A, Mukherjee S, Kundu K, Dutta K, Mahadevan A, Shankar SK, et al. TLR7 is a key regulator of innate immunity against Japanese encephalitis virus infection. Neurobiol Dis. 2014;69:235–47. · DOI
  38. Eng H-L, Hsu Y-Y, Lin T-M. Differences in TLR7/8 activation between monocytes and macrophages. Biochem Biophys Res Commun. 2018;497:319–25. · DOI
  39. Ahn JH, Song M, Kim H, Lee T-K, Park CW, Park YE, et al. Differential regional infarction, neuronal loss and gliosis in the gerbil cerebral hemisphere following 30 min of unilateral common carotid artery occlusion. Metab Brain Dis. 2019;34:223–33. · DOI
  40. Park JH, Cho JH, Ahn JH, Choi SY, Lee T-K, Lee J-C, et al. Neuronal loss and gliosis in the rat striatum subjected to 15 and 30 minutes of middle cerebral artery occlusion. Metab Brain Dis. 2018;33:775–84. · DOI
  41. Lefaucheur J-P, André-Obadia N, Antal A, Ayache SS, Baeken C, Benninger DH, et al. Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS). Clin Neurophysiol. 2014;125:2150–206. · DOI · Paper page
  42. Levy RM, Harvey RL, Kissela BM, Winstein CJ, Lutsep HL, Parrish TB, et al. Epidural electrical stimulation for stroke rehabilitation: results of the prospective, multicenter, randomized single-blinded everest trial. Neurorehabil Neural Repair. 2016;30:107–19. · DOI
  43. Roque C, Pinto N, Vaz Patto M, Baltazar G. Astrocytes contribute to the neuronal recovery promoted by high-frequency repetitive magnetic stimulation in in vitro models of ischemia. J Neurosci Res. 2021;99:1414–32. · DOI
  44. Gava-Junior G, Ferreira SA, Roque C, Mendes-Oliveira J, Serrenho I, Pinto N, et al. High-frequency repetitive magnetic stimulation rescues ischemia-injured neurons through modulation of glial-derived neurotrophic factor present in the astrocyte’s secretome. J Neurochem. 2023;164:813–28. · DOI
  45. Lee S, Toda T, Kiyama H, Yamashita T. Weakened rate-dependent depression of Hoffmann’s reflex and increased motoneuron hyperactivity after motor cortical infarction in mice. Cell Death Dis. 2014;5: e1007. · DOI
  46. Zhang H, Li L, Xu G-Y, Mei Y-W, Zhang J-J, Murong S-X, et al. Changes of c-fos, malondialdehyde and lactate in brain tissue after global cerebral ischemia under different brain temperatures. J Huazhong Univ Sci Technolog Med Sci. 2014;34:354–8. · DOI
  47. Uemura Y, Kowall NW, Moskowitz MA. Focal ischemia in rats causes time-dependent expression of c-fos protein immunoreactivity in widespread regions of ipsilateral cortex. Brain Res. 1991;552:99–105. · DOI
  48. Estus S, Zaks WJ, Freeman RS, Gruda M, Bravo R, Johnson EM. Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis. J Cell Biol. 1994;127:1717–27. · DOI
  49. Estus S, Tucker HM, van Rooyen C, Wright S, Brigham EF, Wogulis M, et al. Aggregated amyloid-beta protein induces cortical neuronal apoptosis and concomitant “apoptotic” pattern of gene induction. J Neurosci. 1997;17:7736–45. · DOI
  50. Hoffman GE, Smith MS, Verbalis JG. c-Fos and related immediate early gene products as markers of activity in neuroendocrine systems. Front Neuroendocrinol. 1993;14:173–213. · DOI · Paper page
  51. Kovács KJ. Measurement of immediate-early gene activation- c-fos and beyond. J Neuroendocrinol. 2008;20:665–72. · DOI · Paper page
  52. Cho J, Ryu S, Lee S, Kim J, Park J-Y, Kwon H-S, et al. Clozapine-induced chemogenetic neuromodulation rescues post-stroke deficits after chronic capsular infarct. Transl Stroke Res. 2023;14:499–512. · DOI
  53. Norris GT, Smirnov I, Filiano AJ, Shadowen HM, Cody KR, Thompson JA, et al. Neuronal integrity and complement control synaptic material clearance by microglia after CNS injury. J Exp Med. 2018;215:1789–801. · DOI · Paper page
  54. Frühbeis C, Fröhlich D, Kuo WP, Krämer-Albers E-M. Extracellular vesicles as mediators of neuron-glia communication. Front Cell Neurosci. 2013;7:182. · DOI
  55. Antonucci F, Turola E, Riganti L, Caleo M, Gabrielli M, Perrotta C, et al. Microvesicles released from microglia stimulate synaptic activity via enhanced sphingolipid metabolism. EMBO J. 2012;31:1231–40. · DOI · Paper page
  56. Mueller AC, Sun D, Dutta A. The miR-99 family regulates the DNA damage response through its target SNF2H. Oncogene. 2013;32:1164–72. · DOI
  57. Ye X, Luo H, Chen Y, Wu Q, Xiong Y, Zhu J, et al. MicroRNAs 99b–5p/100-5p regulated by endoplasmic reticulum stress are involved in abeta-induced pathologies. Front Aging Neurosci. 2015;7:210. · DOI
  58. Gao H, Yu Z, Li Y, Wang X. miR-100-5p in human umbilical cord mesenchymal stem cell-derived exosomes mediates eosinophilic inflammation to alleviate atherosclerosis via the FZD5/Wnt/β-catenin pathway. Acta Biochim Biophys Sin (Shanghai). 2021;53:1166–76. · DOI
  59. Li N, Gao Z, Zhao L, Du B, Ma B, Nian H, et al. MSC-derived small extracellular vesicles attenuate autoimmune dacryoadenitis by promoting M2 macrophage polarization and inducing tregs via miR-100-5p. Front Immunol. 2022;13: 888949. · DOI
  60. Luo P, Jiang C, Ji P, Wang M, Xu J. Exosomes of stem cells from human exfoliated deciduous teeth as an anti-inflammatory agent in temporomandibular joint chondrocytes via miR-100-5p/mTOR. Stem Cell Res Ther. 2019;10:216. · DOI
  61. Li K, Yan G, Huang H, Zheng M, Ma K, Cui X, et al. Anti-inflammatory and immunomodulatory effects of the extracellular vesicles derived from human umbilical cord mesenchymal stem cells on osteoarthritis via M2 macrophages. J Nanobiotechnology. 2022;20:38. · DOI
  62. Otero-Ortega L, Alonso-López E, Pérez-Mato M, Laso-García F, Gómez-de Frutos MC, Diekhorst L, et al. Circulating extracellular vesicle proteins and microrna profiles in subcortical and cortical-subcortical ischaemic stroke. Biomedicines. 2021;9:786. · DOI
  63. Heil F, Hemmi H, Hochrein H, Ampenberger F, Kirschning C, Akira S, et al. Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science. 2004;303:1526–9. · DOI · Paper page
  64. Wang S, Yang Y, Suen A, Zhu J, Williams B, Hu J, et al. Role of extracellular microRNA-146a-5p in host innate immunity and bacterial sepsis. Iscience. 2021;24:103441. · DOI
  65. Fabbri M, Paone A, Calore F, Galli R, Gaudio E, Santhanam R, et al. MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response. Proc Natl Acad Sci U S A. 2012;109:E2110-2116. · DOI · Paper page
  66. Liu H-Y, Hong Y-F, Huang C-M, Chen C-Y, Huang T-N, Hsueh Y-P. TLR7 negatively regulates dendrite outgrowth through the Myd88-c-Fos-IL-6 pathway. J Neurosci. 2013;33:11479–93. · DOI · Paper page
  67. Sun S, Rao NL, Venable J, Thurmond R, Karlsson L. TLR7/9 antagonists as therapeutics for immune-mediated inflammatory disorders. Inflamm Allergy Drug Targets. 2007;6:223–35. · DOI
  68. Dixit V, Mak TW. NF-kappaB signaling Many roads lead to madrid. Cell. 2002;111:615–9. · DOI
  69. Tang J, Cheng X, Yi S, Zhang Y, Tang Z, Zhong Y, et al. Euphorbia factor L2 ameliorates the progression of K/BxN serum-induced arthritis by blocking TLR7 mediated IRAK4/IKKβ/IRF5 and NF-kB signaling pathways. Front Pharmacol. 2021;12: 773592. · DOI
  70. Wang J, Zhang J, Ye Y, Xu Q, Li Y, Feng S, et al. Peripheral organ injury after stroke. Front Immunol. 2022;13: 901209. · DOI
  71. Kerr N, de Rivero Vaccari JP, Dietrich WD, Keane RW. Neural-respiratory inflammasome axis in traumatic brain injury. Exp Neurol. 2020;323: 113080. · DOI
  72. Kerr NA, de Rivero Vaccari JP, Abbassi S, Kaur H, Zambrano R, Wu S, et al. Traumatic brain injury-induced acute lung injury: evidence for activation and inhibition of a neural-respiratory-inflammasome axis. J Neurotrauma. 2018;35:2067–76. · DOI
  73. Xu Q, Ye Y, Wang Z, Zhu H, Li Y, Wang J, et al. NLRP3 knockout protects against lung injury induced by cerebral ischemia-reperfusion. Oxid Med Cell Longev. 2022;2022:6260102.

Cited by

Sorted by citations

See all 23

Metadata

Authors
Xin, D., Li, T., Zhao, Y., Guo, X., Gai, C., Jiang, Z., Yu, S., Cheng, J., Song, Y., Cheng, Y., Luo, Q., Gu, B., Liu, D., & Wang, Z.
Venue
Journal of Nanobiotechnology
Published
2024-09-03
Volume
22
Issue
1
ISSN
1477-3155
Cited by
23
References
5
Language
en
Funders
National Natural Science Foundation of China (82271327)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review