Quality of life and psychological distress in women with recurrent miscarriage: a comparative study
Open accessAbstract
BACKGROUND: This study aimed to evaluate quality of life and psychological distress in Iranian women with recurrent miscarriage and to compare it in women without miscarriage. METHODS: This was a comparative study of quality of life among women with and without recurrent miscarriage. Cases were selected from patients with complain of recurrent miscarriage and comparison group were selected from women attending to two teaching hospitals for annual screening. Quality of life (QOL) was measured using the 36-Item Short Form Survey (SF-36). In addition the Hospital Anxiety and Depression Scale (HADS) were used to measure anxiety and depression. Comparison was made between two groups using the independent samples t-test and chi-square. RESULTS: In all 105 women with recurrent miscarriage and 105 healthy women were studied. The socio-demographic status for both groups was similar. Women with recurrent miscarriage showed a significant higher degree of psychological distress [mean (SD) anxiety score was: 10.6 (2.3) vs. 9.1 (2.2), P < 0.0001; and mean (SD) depression score was: 11.0 (2.3) vs. 9.5 (1.9), P < 0.0001]. In addition women with recurrent miscarriage reported significantly lower level of quality of life in all domains (role physical, general health, vitality, social functioning, role emotional, and mental health, all P values < 0.0001), except for physical functioning (P = 0.06) and bodily pain (P = 0.17). CONCLUSION: The findings demonstrated that women with recurrent miscarriage reported extensive functional disability, and lower level of well-being compared to women without recurrent miscarriage. The findings have some implications for prenatal care and suggest that appropriate treatment of recurrent miscarriage is essential.
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Results suggest a notable level of consistency in estimates of depression and anxiety across Low and Middle resource settings, contradicting outcomes from previous studies.
“Our results suggest a notable level of consistency in estimates of depression and anxiety across Low and Middle resource settings, contradicting outcomes from previous studies (Isguder et al., 2017; Adeyemi et al., 2008; Tavoli et al., 2018).”
From The mental health impact of perinatal loss: A systematic review and meta-analysis (2022) · cites this paper as Tavoli et al., 2018
The Abstract Results report anxiety and depression scores for women with recurrent miscarriage and a comparison group, so Tavoli et al. provide earlier estimates on those outcomes. The Methods (Study population and data collection) describe participants recruited at two Tehran hospitals; the paper does not compare estimates across low- and middle-resource settings or establish that its findings contradict the citing authors’ cross-setting result. (LLM, conf=0.78)
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Previous prenatal loss as a predictor of perinatal depression and anxiety
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The mental health impact of perinatal loss: A systematic review and meta-analysis
Herbert, D., Young, K., Pietrusińska, M., & MacBeth, A. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.10.026 · Cited by 146 · see citing works
Kent-Nye, F. E., Sheen, K. S., Burgess, K., Oza, M., Magee, L. A., Jurković, D., & Silverio, S. A. (2025) · BMC Public Health · doi:10.1186/s12889-024-20882-2 · Cited by 4 · see citing works
“These responses may be persistent, with long-term implications for mental health in subsequent pregnancies [20], particularly if a woman has no living children [21] or if EPL is recurrent [22, 23].”
- Authors
- Tavoli, Z., Mohammadi, M., Tavoli, A., Moini, A., Effatpanah, M., Khedmat, L., & Montazeri, A.
- Affiliations
- University of Tehran (IR)
- Tehran University of Medical Sciences (IR)
- Alzahra University (IR)
- Baqiyatallah University of Medical Sciences (IR)
- Academic Center for Education, Culture and Research (IR)
- Corresponding author
- Montazeri, Ali
- ORCID
- Venue
- Health and Quality of Life Outcomes
- Published
- 2018-07-28
- Volume
- 16
- Issue
- 1
- Pages
- 150-150
- ISSN
- 1477-7525 (ISSN-L)
- PMC
- PMC6064101
- OpenAlex
- W2884099467
- Cited by
- 119
- References
- 2
- Citations by year
- 2026: 12 · 2025: 12 · 2024: 21 · 2023: 32 · 2022: 15 · 2021: 15 · 2020: 11 · 2019: 1
- FWCI
- 7.24
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Health and Quality of Life Outcomes (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Tehran University of Medical Sciences and Health Services
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Keywords
- recurrent pregnancy loss, quality of life, psychological distress, anxiety, depression, women's health, functional disability, prenatal care
- MeSH terms
- Abortion, Habitual, Adult, Anxiety, Cross-Sectional Studies, Depression, Female, Humans, Iran, Pregnancy, Quality of Life, Surveys and Questionnaires, Stress, Psychological, Case-Control Studies
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