Cited by 290Grief, Bereavement, and Mental HealthMaternal Mental Health During Pregnancy and PostpartumFamily Support in Illness

Previous prenatal loss as a predictor of perinatal depression and anxiety

Open access
Blackmore, Emma Robertson, Côté-Arsenault, Denise, Tang, Wan, Glover, Vivette, Evans, Jonathan, Golding, Jean, O'Connor, Thomas G.·2011·British Journal of Psychiatry

Abstract

BACKGROUND: Prenatal loss, the death of a fetus/child through miscarriage or stillbirth, is associated with significant depression and anxiety, particularly in a subsequent pregnancy. AIMS: This study examined the degree to which symptoms of depression and anxiety associated with a previous loss persisted following a subsequent successful pregnancy. METHOD: Data were derived from the Avon Longitudinal Study of Parents and Children cohort, a longitudinal cohort study in the west of England that has followed mothers from pregnancy into the postnatal period. A total of 13,133 mothers reported on the number and conditions of previous perinatal losses and provided self-report measures of depression and anxiety at 18 and 32 weeks' gestation and at 8 weeks and 8, 21 and 33 months postnatally. Controls for pregnancy outcome and obstetric and psychosocial factors were included. RESULTS: Generalised estimating equations indicated that the number of previous miscarriages/stillbirths significantly predicted symptoms of depression (β = 0.18, s.e. = 0.07, P<0.01) and anxiety (β = 0.14, s.e. = 0.05, P<0.01) in a subsequent pregnancy, independent of key psychosocial and obstetric factors. This association remained constant across the pre- and postnatal period, indicating that the impact of a previous prenatal loss did not diminish significantly following the birth of a healthy child. CONCLUSIONS: Depression and anxiety associated with a previous prenatal loss shows a persisting pattern that continues after the birth of a subsequent (healthy) child. Interventions targeting women with previous prenatal loss may improve the health outcomes of women and their children.

Integrity signals

Registry

Crossref · 10.1192/bjp.bp.110.083105

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Nothing to recompute.

Claims the paper makes

3 of 21 cited sources checked · 0 supported · 0 flagged · accuracy not yet measured

  • Premisecitation

    Previous prenatal loss (miscarriage or stillbirth) is associated with elevated depression and anxiety, particularly during a subsequent pregnancy.

    “Prenatal loss, the death of a fetus/child through miscarriage or stillbirth, is associated with significant depression and anxiety, particularly in a subsequent pregnancy.”
    • Also stated in: § Conclusions · plain
      “Women exhibit significantly elevated levels of depression and anxiety in the weeks and months following the loss, compared with samples of pregnant, community or postpartum women.5–10”
    • Also stated in: § Conclusions · boosted
      “women with a history of prenatal loss are consistently reported to exhibit significantly elevated rates of anxiety and depressive symptoms during a subsequent pregnancy.14–18”
    Quote in the paperSubstantial claim1 of 10 sources checked
    • cites [5]

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

    • cites [6] source
    • cites [7] source

      The Introduction says the cohort included women with a previous stillbirth or late miscarriage, and the Discussion reports significantly higher depression and state anxiety in the third trimester of their subsequent pregnancy. The claim is broader than the study: participants’ losses occurred after 18 weeks’ gestation, so it does not establish the association for earlier miscarriages. The Discussion also says the elevation was concentrated among women who conceived within 12 months of the loss. (LLM, conf=0.88)

      Experimental — accuracy not yet measured
    • cites [8]
    • cites [9] source
    • cites [10]

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

    • cites [14] source
    • cites [15] source
    • cites [16] source
    • cites [17] source
  • Findingown data

    The association between previous prenatal loss and depressive and anxiety symptoms did not differ significantly across pre- and postnatal assessments.

    “This association remained constant across the pre- and postnatal period”
    • Also stated in: § Results · plain
      “For neither depressive nor anxiety symptoms was there an interaction between time of assessment and prenatal loss; that is, the association between prenatal loss and depressive and anxiety symptoms was not significantly different across the pre- and postnatal assessments”
    Quote in the paperSubstantial claim
  • Findingown data

    The difference between previous stillbirth and previous miscarriage in predicting depression and anxiety symptoms was not significant (P = 0.27).

    “Results indicated that the difference between stillbirth and miscarriage was not significant (P = 0.27).”
    Quote in the paperSubstantial claim
  • Findingown data

    A greater number of previous miscarriages/stillbirths was significantly associated with more depressive symptoms in a subsequent pregnancy, after adjustment for key psychosocial and obstetric factors (β = 0.18, s.e. = 0.07, P < 0.01).

    “Generalised estimating equations indicated that the number of previous miscarriages/stillbirths significantly predicted symptoms of depression (β = 0.18, s.e. = 0.07, P < 0.01) and anxiety (β = 0.14, s.e. = 0.05, P < 0.01) in a subsequent pregnancy, independent of key psychosocial and obstetric factors.”
    Quote in the paperSubstantial claim
    • Rests on an assumption: The set of covariates included in the models adequately controls for confounding of the association between previous prenatal loss and depressive/anxiety symptoms.
  • Findingown data

    A greater number of previous miscarriages/stillbirths was significantly associated with more anxiety symptoms in a subsequent pregnancy, after adjustment for key psychosocial and obstetric factors (β = 0.14, s.e. = 0.05, P < 0.01).

    “Generalised estimating equations indicated that the number of previous miscarriages/stillbirths significantly predicted symptoms of depression (β = 0.18, s.e. = 0.07, P < 0.01) and anxiety (β = 0.14, s.e. = 0.05, P < 0.01) in a subsequent pregnancy, independent of key psychosocial and obstetric factors.”
    Quote in the paperSubstantial claim
    • Rests on an assumption: The set of covariates included in the models adequately controls for confounding of the association between previous prenatal loss and depressive/anxiety symptoms.
  • Classified as probably not a substantial claim. 11
  • May combine two claims. 7
  • The quote only partly states this claim. 1
  • Classified as probably not a substantial claim. May combine two claims.

    Premisecitation

    Postpartum depression has deleterious effects on maternal-child attachment, child behaviour, and cognitive and neuroendocrine outcomes that persist into adolescence.

    “which in turn has deleterious effects on maternal–child attachment, child behaviour, and cognitive and neuroendocrine outcomes that persist into adolescence.36–40”
    Quote in the paperSubstantial claim2 of 5 sources checked
    • cites [36] source
    • cites [37] source

      The section on antenatal anxiety and behavioural/emotional problems identifies postnatal depression as a known risk factor for children's behavioural/emotional problems. It does not establish effects on maternal–child attachment or cognitive and neuroendocrine outcomes, nor persistence into adolescence; this study assessed child outcomes at 47 months (Method). (LLM, conf=0.88)

      Experimental — accuracy not yet measured
    • cites [38] source

      The Interviews and Interview data sections (page not available) examine grief after stillbirth and report that the women did not develop debilitating depression. A search for maternal–child attachment, child behaviour, cognitive or neuroendocrine outcomes, and effects persisting into adolescence found no passage addressing those effects of postpartum depression. (LLM, conf=0.78)

      Experimental — accuracy not yet measured
    • cites [39] source
    • cites [40] source
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingown data

    Analyses using categorical cut-off scores for depression and anxiety produced substantively comparable results to continuous scale analyses.

    “We found substantively comparable results using this alternate scaling.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Findingown data

    The effect of prenatal loss on anxious symptoms was not distinguishable from its effect on depressive symptoms; the association with anxious symptoms was confounded by the association with depressive symptoms and high covariation (>r = 0.70).

    “It was not. The association between prenatal loss and anxious symptoms was confounded by the association between prenatal loss and depressive symptoms and the high degree of covariation between anxious and depressive symptoms (>r = 0.70 at each assessment).”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingown data

    Many psychosocial and sociodemographic covariates were associated with depressive and anxiety symptom scores.

    “Results indicate that, as expected, many of the psychosocial and sociodemographic covariates were associated with depressive and anxiety symptom scores.”
    Quote in the paperNot a substantial claim
  • Classified as probably not a substantial claim.

    Study design and conductnone given

    Controls for pregnancy outcome and obstetric and psychosocial factors were included in the analyses.

    “Controls for pregnancy outcome and obstetric and psychosocial factors were included.”
    Quote in the paperSubstantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing), S4 (based).

    Study design and conductnone given

    The study was unable to assess the impact of time since previous loss as a predictor of postpartum mood because reliable information on timing was not available.

    “Finally, as noted, we were unable to assess the impact of time since loss as a potential predictor of postpartum mood.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Study design and conductnone given

    Ethical approval for all measures was obtained from the ALSPAC Ethics and Law Committee and local research ethics committees.

    “Ethical approval for all measures was obtained from the ALSPAC Ethics and Law Committee and from local research ethics committees.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Study design and conductcitation

    Anxiety was measured using the Crown-Crisp Experiential Index (CCEI), a validated self-rating inventory that correlates with the State and Trait subscales of the Spielberger State-Trait Anxiety Inventory.

    “Maternal anxiety at each occasion was measured using the anxiety items from the Crown–Crisp Experiential Index (CCEI), a validated self-rating inventory.21 It has been shown to correlate with the State (0.70) and Trait (0.76) subscales of the Spielberger State–Trait Anxiety Inventory.22”
    Quote in the paperNot a substantial claim0 of 2 sources checked
    • cites [21] source
    • cites [22] source
  • Classified as probably not a substantial claim. May combine two claims.

    Study design and conductcitation

    Depression was assessed using the Edinburgh Postnatal Depression Scale (EPDS), a 10-item self-report questionnaire shown to be valid in and outside the postnatal period.

    “Depression was assessed using the Edinburgh Postnatal Depression Scale (EPDS), a 10-item self-report questionnaire that has been extensively used and shown to be valid in and outside the postnatal period.23”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites [23] source
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Study design and conductreasoning

    The study is able to assess the psychological impact of prenatal loss but is not positioned to examine biological hypotheses about shared risk underlying both prenatal loss and depressive/anxiety symptoms.

    “Accordingly, the current study is able to assess the psychological impact of prenatal loss, but is not positioned to examine biological hypotheses that there may be risk underlying both prenatal loss and the experience of depressive and anxiety symptoms.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Study design and conductown data

    The study used a large community sample (ALSPAC) with detailed and repeated assessments of depressive and anxiety symptoms in the prenatal and postnatal period, and follow-up well past the postnatal period.

    “Strengths of the study include the large community sample and detailed and repeated assessments of depressive and anxiety symptoms in the prenatal and postnatal period; the follow-up well past the postnatal period is a particular novelty in this area of study.”
    Quote in the paperSubstantial claim
  • Probably not a substantial claim: may not pass S2 (checkable), S3 (load-bearing). The quote only partly states this claim.

    Interpretationcitation

    The current findings underscore the view that pregnancy and childbirth are major life events that can trigger affective illness episodes.

    “The current findings underscore the view that pregnancy and childbirth are major life events, a careful assessment of which may reveal information of value in understanding psychiatric morbidity.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Premisecitation

    Both prenatal depression and anxiety are among the biggest predictors of postpartum depression.

    “Both prenatal depression and anxiety are among the biggest predictors of postpartum depression,34,35”
    Quote in the paperNot a substantial claim0 of 2 sources checked
    • cites [34] source
    • cites [35] source
13 of 13
  • The paper relies on this without support.

    The set of covariates included in the models adequately controls for confounding of the association between previous prenatal loss and depressive/anxiety symptoms.

    “Controls for pregnancy outcome and obstetric and psychosocial factors were included.”
  • The authors state this as an assumption.

    The missing data are missing at random.

    “The impact of missing data was characterised by model estimates through two well-established missing data mechanisms: the missing completely at random assumption and the missing at random assumption.26”
  • The authors state this as an assumption.

    Birth weight and gestational age adequately index the birth of a healthy child.

    “The current study extends this work by showing that the impact persists well past the subsequent pregnancy and despite the birth of a healthy child (indexed here by birth weight and gestational age of the subsequent child).”
3 of 3

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

Each contradiction between two passages listed here was confirmed by an independent check.

  • Depression cut-off differs between methods and results

    Minor

    The methods define probable major depression using an EPDS score of 12 or higher, but the results describe Table 2 as counting only scores greater than 12. These rules classify women scoring exactly 12 differently.

1 of 1

Cites

Flagged first, then by citations

4 of the 46 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. 1998, Birth Statistics 1996, England and Wales

Cited by

Sorted by citations

Authors
Blackmore, E. R., Côté-Arsenault, D., Tang, W., Glover, V., Evans, J., Golding, J., & O'Connor, T. G.
Affiliations
  • University of Rochester Medicine (US)
  • Imperial College London (GB)
  • University of Bristol (GB)
Corresponding author
Blackmore, Emma Robertson
Venue
British Journal of Psychiatry
Published
2011-05
Volume
198
Issue
5
Pages
373-378
ISSN
  • 0007-1250 (ISSN-L)
  • 1472-1465
OpenAlex
W2117946497
Cited by
290
References
46
Citations by year
2026: 19 · 2025: 20 · 2024: 24 · 2023: 43 · 2022: 19 · 2021: 16 · 2020: 14 · 2019: 17 · 2018: 16 · 2017: 16 · 2016: 17 · 2015: 19 · 2014: 20 · 2013: 13 · 2012: 10
FWCI
15.46
Type
journal article
Language
en
Open access
Locations
  • The British Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (submittedVersion)
  • PubMed Central (submittedVersion)
  • Explore Bristol Research (submittedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Grief, Bereavement, and Mental Health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
  • Social Sciences › Sociology and Political Science › Family Support in Illness
Keywords
miscarriage, stillbirth, perinatal depression, perinatal anxiety, subsequent pregnancy, maternal mental health, Avon Longitudinal Study of Parents and Children
MeSH terms
Abortion, Spontaneous, Adolescent, Adult, Alcohol Drinking

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Claims read under definition version 3 (extract-v3) on 2026-09-28.

Classified by jev-1.13-20260917 (gold-guideline-v0.2) on 2026-09-28.

Cited sources are checked by gpt-6-sol.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review