The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Obesity as disruptor of the female fertility
Open accessAbstract
Both obesity and overweight are increasing worldwide and have detrimental influences on several human body functions including the reproductive health. In particular, obese women undergo perturbations of the 'hypothalamic pituitary ovarian axis', and frequently suffer of menstrual dysfunction leading to anovulation and infertility. Besides the hormone disorders and subfertility that are common in the polycystic ovary syndrome (PCOS), in obesity the adipocytes act as endocrine organ. The adipose tissue indeed, releases a number of bioactive molecules, namely adipokines, that variably interact with multiple molecular pathways of insulin resistance, inflammation, hypertension, cardiovascular risk, coagulation, and oocyte differentiation and maturation. Moreover, endometrial implantation and other reproductive functions are affected in obese women with complications including delayed conceptions, increased miscarriage rate, reduced outcomes in assisted conception treatments.On the contrary, weight loss programs through lifestyle modification in obese women, have been proven to restore menstrual cyclicity and ovulation and improve the likelihood of conception.
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1 retracted
Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin
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RetractedInitial and cyclic recruitment of ovarian follicles
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Molecular mechanism of action of metformin: old or new insights?
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Human resistin: found in translation from mouse to man
Schwartz, D. R., & Lazar, M. A. (2011) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2011.03.005 · Cited by 297
Cited by
Sermondade, N., Huberlant, S., Bourhis-Lefebvre, V., Arbo, E., Gallot, V., Colombani, M., & Fréour, T. (2019) · Human Reproduction Update · doi:10.1093/humupd/dmz011 · Cited by 397
Environment, lifestyle, and female infertility
Bala, R., Singh, V., Rajender, S., & Singh, K. (2021) · Reproductive Sciences · doi:10.1007/s43032-020-00279-3 · Cited by 242
Calcaterra, V., Verduci, E., Cena, H., Magenes, V. C., Todisco, C. F., Tenuta, E., Gregorio, C., De Giuseppe, R., Bosetti, A., Di Profio, E., et al. (2021) · Nutrients · doi:10.3390/nu13061848 · Cited by 183
Yang, J., Song, Y., Gaskins, A. J., Li, L.-J., Huang, Z., Eriksson, J. G., Hu, F. B., Chong, Y. S., & Zhang, C. (2023) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2023.05.030 · Cited by 56
Obesity and female infertility
Ennab, F., & Atiomo, W. (2023) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2023.102336 · Cited by 47
Phycocyanin Improves Reproductive Ability in Obese Female Mice by Restoring Ovary and Oocyte Quality
Wen, X., Han, Z., Liu, S.-J., Hao, X., Zhang, X.-J., Wang, X.-Y., Zhou, C.-J., Ma, Y.-Z., & Liang, C.-G. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.595373 · Cited by 43
Mączka, K., Stasiak, O., Przybysz, P., Grymowicz, M., & Smolarczyk, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25179391 · Cited by 38
Pirotta, S., Joham, A., Grieger, J. A., Tay, C. T., Bahri-Khomami, M., Lujan, M., Lim, S. S., & Moran, L. J. (2020) · Seminars in Reproductive Medicine · doi:10.1055/s-0041-1726866 · Cited by 29
Foetal Sonographic Anogenital Distance Is Longer in Polycystic Ovary Syndrome Mothers
Perlman, S., Toledano, Y., Kivilevitch, Z., Halevy, N., Rubin, E., & Gilboa, Y. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9092863 · Cited by 20
The effect of obesity on human reproductive health and foetal life
Incedal Irgat, S., & Bakirhan, H. (2022) · Human Fertility · doi:10.1080/14647273.2021.1928774 · Cited by 19
Tatarchuk, T., Todurov, I., Anagnostis, P., Tutchenko, T., Pedachenko, N., Glamazda, M., Koseii, N., & Regeda, S. (2022) · Obesity Surgery · doi:10.1007/s11695-021-05820-0 · Cited by 13
Metadata
- Authors
- Silvestris, E., de Pergola, G., Rosania, R., & Loverro, G.
- Venue
- Reproductive Biology and Endocrinology
- Published
- 2018-03-09
- Volume
- 16
- Issue
- 1
- Pages
- 22-22
- ISSN
- 1477-7827 (ISSN-L)
- OpenAlex
- W2800554476
- Cited by
- 664
- References
- 6
- FWCI
- 33.23
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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