Chemokine-mediated inflammation in the degenerating retina is coordinated by Müller cells, activated microglia, and retinal pigment epithelium
Open accessAbstract
BACKGROUND: Monocyte infiltration is involved in the pathogenesis of many retinal degenerative conditions. This process traditionally depends on local expression of chemokines, though the roles of many of these in the degenerating retina are unclear. Here, we investigate expression and in situ localization of the broad chemokine response in a light-induced model of retinal degeneration. METHODS: Sprague-Dawley (SD) rats were exposed to 1,000 lux light damage (LD) for up to 24 hrs. At time points during (1 to 24 hrs) and following (3 and 7 days) exposure, animals were euthanized and retinas processed. Microarray analysis assessed differential expression of chemokines. Some genes were further investigated using polymerase chain reaction (PCR) and in situ hybridization and contrasted with photoreceptor apoptosis using terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL). Recruitment of retinal CD45 (+) leukocytes was determined via fluorescence activated cell sorting (FACS), and expression of chemokine receptors determined using PCR. RESULTS: Exposure to 24 hrs of LD resulted in differential expression of chemokines including Ccl3, Ccl4, Ccl7, Cxcl1, and Cxcl10. Their upregulation correlated strongly with peak photoreceptor death, at 24 hrs exposure. In situ hybridization revealed that the modulated chemokines were expressed by a combination of Müller cells, activated microglia, and retinal pigment epithelium (RPE). This preceded large increases in the number of CD45(+) cells at 3- and 7-days post exposure, which expressed a corresponding repertoire of chemokine receptors. CONCLUSIONS: Our data indicate that retinal degeneration induces upregulation of a broad chemokine response whose expression is coordinated by Müller cells, microglia, and RPE. The findings inform our understanding of the processes govern the trafficking of leukocytes, which are contributors in the pathology of retinal degenerations.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Retinal degeneration induces upregulation of a cytokine and chemokine production whose expression is coordinated by Müller cells, microglia, and RPE.
“Retinal degeneration induces upregulation of a cytokine and chemokine production whose expression is coordinated by Müller cells, microglia, and RPE [102].”
From Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain (2022) · cites this paper as [102]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Gene Ontology: tool for the unification of biology
Ashburner, M., Ball, C. A., Blake, J. A., Botstein, D., Butler, H., Cherry, J. M., Davis, A. P., Dolinski, K., Dwight, S. S., Eppig, J. T., et al. (2000) · Nature Genetics · doi:10.1038/75556 · Cited by 43,206 · see citing works
Primer3 on the WWW for General Users and for Biologist Programmers
Rozen, S., & Skaletsky, H. (2003) · Humana Press eBooks · doi:10.1385/1-59259-192-2:365 · Cited by 14,952 · see citing works
Mizgerd, J. P., Kubo, H., Kutkoski, G. J., Bhagwan, S. D., Scharffetter-Kochanek, K., Beaudet, A. L., & Doerschuk, C. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.8.1357 · Cited by 7,332 · see citing works
Zlotnik, A., & Yoshie, O. (2000) · Immunity · doi:10.1016/s1074-7613(00)80165-x · Cited by 3,859 · see citing works
Chemokines — Chemotactic Cytokines That Mediate Inflammation
Luster, A. D. (1998) · New England Journal of Medicine · doi:10.1056/nejm199802123380706 · Cited by 3,634 · see citing works
Boring, L., Gosling, J., Cleary, M., & Charo, I. F. (1998) · Nature · doi:10.1038/29788 · Cited by 1,965 · see citing works
Properties Of The Novel Proinflammatory Supergene Intercrine Cytokine Family
Oppenheim, J. J., Zachariae, C. O. C., Mukaida, N., & Matsushima, K. (1991) · Annual Review of Immunology · doi:10.1146/annurev.iy.09.040191.003153 · Cited by 1,878 · see citing works
Tsou, C.-L., Peters, W., Si, Y., Slaymaker, S., Aslanian, A. M., Weisberg, S. P., Mack, M., & Charo, I. F. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29919 · Cited by 1,152 · see citing works
CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow
Eash, K. J., Greenbaum, A. M., Gopalan, P. K., & Link, D. C. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41649 · Cited by 794 · see citing works
Roach, D. R., Bean, A. G. D., Demangel, C., France, M. P., Briscoe, H., & Britton, W. J. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.9.4620 · Cited by 782 · see citing works
TNF-α mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity
Ramesh, G., & Reeves, W. B. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15606 · Cited by 749 · see citing works
TNF-α mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity
Ramesh, G., & Reeves, W. B. (2002) · Journal of Clinical Investigation · doi:10.1172/jci200215606 · Cited by 707 · see citing works
Izikson, L., Klein, R. S., Charo, I. F., Weiner, H. L., & Luster, A. D. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.7.1075 · Cited by 584 · see citing works
Gupta, N., Brown, K. E., & Milam, A. H. (2003) · Experimental Eye Research · doi:10.1016/s0014-4835(02)00332-9 · Cited by 582 · see citing works
Krady, J. K., Basu, A., Allen, C. M., Xu, Y., LaNoue, K. F., Gardner, T. W., & Levison, S. W. (2005) · Diabetes · doi:10.2337/diabetes.54.5.1559 · Cited by 529 · see citing works
Chen, C. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28075 · Cited by 475 · see citing works
Expression and Characterization of the Chemokine Receptors CCR2 and CCR5 in Mice
Mack, M., Cihak, J., Simonis, C., Luckow, B., Proudfoot, A. E. I., Plachý, J., Brühl, H., Frink, M., Anders, H., Vielhauer, V., et al. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.7.4697 · Cited by 459 · see citing works
Klein, R. S., Lin, E., Zhang, B., Luster, A. D., Tollett, J., Samuel, M. A., Engle, M., & Diamond, M. S. (2005) · Journal of Virology · doi:10.1128/jvi.79.17.11457-11466.2005 · Cited by 424 · see citing works
Microglial Activation in Human Diabetic Retinopathy
Zeng, H.-Y. (2008) · Archives of Ophthalmology · doi:10.1001/archophthalmol.2007.65 · Cited by 401 · see citing works
Chemokines and Chemokine Receptors: Standing at the Crossroads of Immunobiology and Neurobiology
Ransohoff, R. M. (2009) · Immunity · doi:10.1016/j.immuni.2009.09.010 · Cited by 372 · see citing works
Activated microglia in the human glaucomatous optic nerve head
Yuan, L., & Neufeld, A. H. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.1104 · Cited by 348 · see citing works
Chou, R. C., Kim, N. D., Sadik, C. D., Seung, E., Lan, Y., Byrne, M. H., Haribabu, B., Iwakura, Y., & Luster, A. D. (2010) · Immunity · doi:10.1016/j.immuni.2010.07.018 · Cited by 342 · see citing works
Critical role of endothelial CXCR2 in LPS-induced neutrophil migration into the lung
Reutershan, J. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27009 · Cited by 324 · see citing works
Bosco, A., Inman, D. M., Steele, M. R., Wu, G., Soto, I., Marsh‐Armstrong, N., Hubbard, W. C., Calkins, D. J., Horner, P. J., & Vetter, M. L. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-1337 · Cited by 322 · see citing works
Bajetto, A., Bonavia, R., Barbero, S., & Schettini, G. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01091.x · Cited by 318 · see citing works
Sennlaub, F., Auvynet, C., Calippe, B., Lavalette, S., Poupel, L., Hu, S. J., Dominguez, E., Camelo, S., Levy, O., Guyon, E., et al. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201302692 · Cited by 313 · see citing works
Ccr5 But Not Ccr1 Deficiency Reduces Development of Diet-Induced Atherosclerosis in Mice
Braunersreuther, V., Zernecke, A., Arnaud, C., Liehn, E. A., Steffens, S., Shagdarsuren, E., Bidzhekov, K., Burger, F., Pelli, G., Luckow, B., et al. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000253886.44609.ae · Cited by 287 · see citing works
Davatelis, G., Tekamp-Olson, P., Wolpe, S. D., Hermsen, K. M., Luedke, C. E., Gallegos, C., Coit, D., Merryweather, J. P., & Cerami, A. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.167.6.1939 · Cited by 277 · see citing works
Tsutsumi, C., Sonoda, K.-H., Egashira, K., Qiao, H., Hisatomi, T., Nakao, S., Ishibashi, M., Charo, I. F., Sakamoto, T., Murata, T., et al. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0902436 · Cited by 277 · see citing works
Monocyte chemoattractant protein 1 mediates retinal detachment-induced photoreceptor apoptosis
Nakazawa, T., Hisatomi, T., Nakazawa, C., Noda, K., Maruyama, K., She, H., Matsubara, A., Miyahara, S., Nakao, S., Yin, Y., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608167104 · Cited by 272 · see citing works
Newman, A. M., Gallo, N., Hancox, L. S., Miller, N. J., Radeke, C. M., Maloney, M. A., Cooper, J. B., Hageman, G. S., Anderson, D. H., Johnson, L. V., et al. (2012) · Genome Medicine · doi:10.1186/gm315 · Cited by 269 · see citing works
Broxmeyer, H. E., Sherry, B. A., Cooper, S., et al. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.8.3448 · Cited by 268 · see citing works
Weber, C., Weber, K. S. C., Klier, C. M., Gu, S., Wank, R., Horuk, R., & Nelson, P. J. (2001) · Blood · doi:10.1182/blood.v97.4.1144 · Cited by 262 · see citing works
Jia, T., Serbina, N. V., Brandl, K., Zhong, M., Leiner, I. M., Charo, I. F., & Pamer, E. G. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.10.6846 · Cited by 256 · see citing works
Microglia in the Optic Nerve Head and the Region of Parapapillary Chorioretinal Atrophy in Glaucoma
Neufeld, A. H. (1999) · Archives of Ophthalmology · doi:10.1001/archopht.117.8.1050 · Cited by 248 · see citing works
Chemokines and their receptors in rheumatoid arthritis: Future targets?
Koch, A. E. (2005) · Arthritis & Rheumatism · doi:10.1002/art.20932 · Cited by 247 · see citing works
Bruch's membrane and choroidal macrophages in early and advanced age-related macular degeneration
Cherepanoff, S., McMenamin, P. G., Gillies, M. C., Kettle, E., & Sarks, S. H. (2009) · British Journal of Ophthalmology · doi:10.1136/bjo.2009.165563 · Cited by 234 · see citing works
Regulation of chemokine receptor expression in human microglia and astrocytes
Flynn, G., Maru, S., Loughlin, J., Romero, I. A., & Male, D. K. (2003) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(03)00009-2 · Cited by 229 · see citing works
Wang, M., Ma, W., Zhao, L., Fariss, R. N., & Wong, W. T. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-173 · Cited by 228 · see citing works
Ma, W., Zhao, L., Fontainhas, A. M., Fariss, R. N., & Wong, W. T. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007945 · Cited by 213 · see citing works
Soehnlein, O., Drechsler, M. D., Döring, Y., Lievens, D., Hartwig, H., Kemmerich, K., Ortega‐Gómez, A., Mandl, M., Vijayan, S., Projahn, D., et al. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201201717 · Cited by 205 · see citing works
Luhmann, U. F. O., Robbie, S. J., Munro, P., Barker, S. E., Durán, Y., Luong, V., Fitzke, F. W., Bainbridge, J. W., Ali, R. R., & MacLaren, R. E. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-3462 · Cited by 205 · see citing works
Boisvert, W. A., Rose, D. M., Johnson, K. A., Fuentes, M. E., Lira, S. A., Curtiss, L. K., & Terkeltaub, R. A. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.040748 · Cited by 189 · see citing works
Zhang, B., Chan, Y., Lu, B., Diamond, M. S., & Klein, R. S. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.4.2641 · Cited by 169 · see citing works
Cytokine regulation of CC and CXC chemokine expression by human astrocytes
Oh, J., Schwiebert, L. M., & Benveniste, E. N. (1999) · Journal of NeuroVirology · doi:10.3109/13550289909029749 · Cited by 169 · see citing works
Light damage induced changes in mouse retinal gene expression
Chen, L., Wu, W., Dentchev, T., Zeng, Y., Wang, J., Tsui, I., Tobias, J. W., Bennett, J., Baldwin, D. A., & Dunaief, J. L. (2004) · Experimental Eye Research · doi:10.1016/j.exer.2004.05.002 · Cited by 162 · see citing works
The molecular basis of leukocytosis
Opdenakker, G., Fibbe, W. E., & Damme, J. V. (1998) · Immunology Today · doi:10.1016/s0167-5699(97)01243-7 · Cited by 153 · see citing works
Joly, S., Francke, M., Ulbricht, E., Beck, S. C., Seeliger, M. W., Hirrlinger, P. G., Hirrlinger, J., Lang, K. S., Zinkernagel, M. S., Odermatt, B., et al. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.090023 · Cited by 149 · see citing works
Growth-related gene product α. A chemotactic cytokine for neutrophils in rheumatoid arthritis
Koch, A. E., Kunkel, S. L., Shah, M. R., Hosaka, S., Halloran, M. M., Haines, G. K., Burdick, M. D., Pope, R. M., & Strieter, R. M. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.7.3660 · Cited by 146 · see citing works
Chemokines in immune-mediated inflammation of the central nervous system
Ransohoff, R. M. (1996) · Cytokine & Growth Factor Reviews · doi:10.1016/1359-6101(96)00003-2 · Cited by 144 · see citing works
Maslim, J., Valter, K., Egensperger, R., et al. (1997) · PubMed · Cited by 134 · see citing works
Self-citationNatoli, R., Zhu, Y. O., Valter, K., Bisti, S., Eells, J., & Stone, J. (2010) · PubMed Central · Cited by 123 · see citing works
Self-citationRutar, M., Natoli, R., & Provis, J. M. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-221 · Cited by 121 · see citing works
Self-citationThe clinical potential of chemokine receptor antagonists
Ribeiro, S., & Horuk, R. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.01.004 · Cited by 115 · see citing works
Dual targeting of CCR2 and CCR5: therapeutic potential for immunologic and cardiovascular diseases
Zhao, Q. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.1009671 · Cited by 114 · see citing works
Ma, W., Cojocaru, R. I., Gotoh, N., Gieser, L. M., Villasmil, R., Cogliati, T., Swaroop, A., & Wong, W. T. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.03.022 · Cited by 107 · see citing works
Activation of microglia and chemokines in light-induced retinal degeneration.
Zhang, C., Shen, J. K., Lam, T. T., Zeng, H., Chiang, S. K. S., Yang, F. W., & Tso, M. O. M. (2005) · PubMed · Cited by 105 · see citing works
Dominant Myelopoietic Effector Functions Mediated by Chemokine Receptor CCR1
Broxmeyer, H. E., Cooper, S. H., Hangoc, G., Gao, J., & Murphy, P. M. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.12.1987 · Cited by 103 · see citing works
Penfold, P. L., Killingsworth, M. C., & Sarks, S. H. (1986) · PubMed · Cited by 100 · see citing works
Rutar, M., Natoli, R., Kozulin, P., Valter, K., Gatenby, P. A., & Provis, J. M. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-7119 · Cited by 100 · see citing works
Self-citationIbrahim, A. S., El‐Shishtawy, M. M., Peña, A., & Liou, G. I. (2010) · Europe PMC (PubMed Central) · Cited by 97 · see citing works
Rutar, M., Natoli, R., Valter, K., & Provis, J. (2011) · Investigative Ophthalmology and Visual Science · doi:10.1167/iovs.10-6010 · Cited by 94 · see citing works
Self-citationBroxmeyer, H. E., Sherry, B. A., Cooper, S., et al. (1993) · Cited by 92 · see citing works
Eliminating Complement Factor D Reduces Photoreceptor Susceptibility to Light-Induced Damage
Rohrer, B., Guo, Y., Kunchithapautham, K., & Gilkeson, G. S. (2007) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-0282 · Cited by 90 · see citing works
Microglial cell activation following retinal detachment: a comparison between species.
Lewis, G. P., Sethi, C. S., Carter, K. M., Charteris, D. G., & Fisher, S. K. (2005) · PubMed · Cited by 89 · see citing works
Neutrophils promote experimental choroidal neovascularization.
Zhou, J., Pham, L. N., Zhang, N., He, S., Gamulescu, M., Spee, C. K., Ryan, S. J., & Hinton, D. R. (2005) · PubMed · Cited by 87 · see citing works
Chintakuntlawar, A. V., & Chodosh, J. (2009) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2009.0006 · Cited by 82 · see citing works
Mini-review series: focus on chemokines
Comerford, I., & McColl, S. R. (2011) · Immunology & Cell Biology · doi:10.1038/icb.2010.164 · Cited by 81 · see citing works
Kochan, T. J., Singla, A., Tosi, J., & Kumar, A. (2012) · Infection and Immunity · doi:10.1128/iai.00149-12 · Cited by 81 · see citing works
Pharmacological blockade of CCR1 ameliorates murine arthritis and alters cytokine networksin vivo
Amat, M., Benjamim, C. F., Williams, L., et al. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706912 · Cited by 81 · see citing works
IL-1 regulates in vivo C—X—C chemokine induction and neutrophil sequestration following endotoxemia
Calkins, C. M., Bensard, D. D., Shames, B. D., Pulido, E. J., Abraham, E. H., Fernandez, N., Meng, X., Dinarello, C. A., & McIntyre, R. C. (2002) · Journal of Endotoxin Research · doi:10.1177/09680519020080010601 · Cited by 80 · see citing works
Wood, L. D., & Richmond, A. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.51.30619 · Cited by 80 · see citing works
Kohno, H., Maeda, T., Perusek, L., Pearlman, E. M., & Maeda, A. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1301738 · Cited by 80 · see citing works
Jia, T., Leiner, I. M., Dorothée, G., Brandl, K., & Pamer, E. G. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900460 · Cited by 78 · see citing works
The Roles of Vitreal Macrophages and Circulating Leukocytes in Retinal Neovascularization
Kataoka, K., Nishiguchi, K. M., Kaneko, H., et al. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-5798 · Cited by 78 · see citing works
Neufeld, A. H. (2003) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2003.07.005 · Cited by 73 · see citing works
Norose, K., Kikumura, A., Luster, A. D., Hunter, C. A., & Harris, T. H. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-5819 · Cited by 70 · see citing works
Immune cells in the human choroid
Ezzat, M.-K., Hann, C. R., Vuk‐Pavlović, S., & Pulido, J. S. (2008) · British Journal of Ophthalmology · doi:10.1136/bjo.2007.129742 · Cited by 68 · see citing works
Ni, Y., Xu, G., Hu, W., Shi, L., Qin, Y., & Da, C. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-1173 · Cited by 67 · see citing works
Burdon, P. C. E., Martin, C., & Rankin, S. M. (2008) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07018.x · Cited by 64 · see citing works
CXCL10 Production by Human Monocytes in Response to Leishmania braziliensis Infection
Vargas‐Inchaustegui, D. A., Hogg, A. E., Tulliano, G., Llanos‐Cuentas, A., Arévalo, J., Endsley, J. J., & Soong, L. (2009) · Infection and Immunity · doi:10.1128/iai.00959-09 · Cited by 64 · see citing works
Expression of CXCL8, CXCR1, and CXCR2 in Neurons and Glial Cells of the Human and Rabbit Retina
Goczalik, I., Ulbricht, E., Hollborn, M., Raap, M., Uhlmann, S., Weick, M., Pannicke, T., Wiedemann, P., Bringmann, A., Reichenbach, A., et al. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-1887 · Cited by 61 · see citing works
Cornish, E. E., Madigan, M. C., Natoli, R., et al. (2005) · Visual Neuroscience · doi:10.1017/s0952523805224069 · Cited by 58 · see citing works
Self-citationTLR‐2‐mediated cytokine and chemokine secretion in human keratinocytes
Niebuhr, M., Baumert, K., & Werfel, T. (2010) · Experimental Dermatology · doi:10.1111/j.1600-0625.2010.01140.x · Cited by 49 · see citing works
Selective Loss of Chemokine Receptor Expression on Leukocytes after Cell Isolation
Nieto, J. C., Cantó, E., Zamora, C., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031297 · Cited by 45 · see citing works
Ishikawa, K., Yoshida, S., Nakao, S., Sassa, Y., Asato, R., Kohno, R.-I., Arima, M., Kita, T., Yoshida, A., Ohuchida, K., et al. (2011) · Laboratory Investigation · doi:10.1038/labinvest.2011.141 · Cited by 43 · see citing works
CD40 Mediates Retinal Inflammation and Neurovascular Degeneration
Portillo, J. C., Grol, J. V., Zheng, L., Okenka, G., Gentil, K., Garland, A., Carlson, E. C., Kern, T. S., & Subauste, C. S. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.12.8719 · Cited by 43 · see citing works
Lindner, M., Trebst, C., Heine, S., Skripuletz, T., Koutsoudaki, P. N., & Stangel, M. (2008) · Glia · doi:10.1002/glia.20682 · Cited by 40 · see citing works
Singh, P. K., Shiha, M. J., & Kumar, A. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-33 · Cited by 39 · see citing works
A possible mechanism of microglia-photoreceptor crosstalk.
Yang, L., Zhu, X. A., & Tso, M. O. M. (2007) · PubMed · Cited by 39 · see citing works
Neutrophils Compromise Retinal Pigment Epithelial Barrier Integrity
Zhou, J., He, S., Zhang, N., et al. (2010) · BioMed Research International · doi:10.1155/2010/289360 · Cited by 29 · see citing works
Chang, C.-J., Cherng, C., Liou, W., & Liao, C. (2005) · Ophthalmic Research · doi:10.1159/000086610 · Cited by 27 · see citing works
Gene regulation induced in the C57BL/6J mouse retina by hyperoxia: a temporal microarray study.
Natoli, R., Provis, J. M., Valter, K., & Stone, J. (2008) · PubMed Central · Cited by 23 · see citing works
Self-citationDifferential expression of retinal pigment epithelium (RPE) IP-10 and interleukin-8
Elner, S. G., DelMonte, D., Bian, Z.-M., et al. (2006) · Experimental Eye Research · doi:10.1016/j.exer.2006.01.013 · Cited by 20 · see citing works
Activated human retinal microglia under pathological conditions
Vrabec, F. (1975) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/bf00410026 · Cited by 19 · see citing works
von Toerne, C., Menzler, J., Ly, A., Senninger, N., Ueffing, M., & Hauck, S. M. (2014) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m113.033613 · Cited by 19 · see citing works
Didier, P. J., Paradis, T. J., & Gladue, R. P. (1999) · Inflammation · doi:10.1023/a:1020243701890 · Cited by 12 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Parker, A., Romano, S., Ansorge, R., Aboelnour, A., Le Gall, G., Savva, G. M., Pontifex, M. G., Telatin, A., Baker, D., Jones, E., et al. (2022) · Microbiome · doi:10.1186/s40168-022-01243-w · Cited by 368 · see citing works
- Authors
- Rutar, M., Natoli, R., Chia, R., Valter, K., & Provis, J. M.
- Affiliations
- Australian National University (AU)
- Corresponding author
- Rutar, Matt
- Venue
- Journal of Neuroinflammation
- Published
- 2015
- Volume
- 12
- Issue
- 1
- Pages
- 8
- ISSN
- 1742-2094 (ISSN-L)
- PMC
- PMC4308937
- OpenAlex
- W2000919900
- Cited by
- 127
- References
- 97
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 9 · 2023: 9 · 2022: 11 · 2021: 13 · 2020: 16 · 2019: 9 · 2018: 13 · 2017: 13 · 2016: 11 · 2015: 3 · 2014: 2
- FWCI
- 5.79
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Neuroinflammation (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by)
- ANU Open Research (Australian National University) (submittedVersion, cc-by)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- chemokines, retinal degeneration, Müller cells, microglia, retinal pigment epithelium, photoreceptor apoptosis, light-induced retinal damage, monocyte infiltration, chemokine receptors, neuroinflammation, leukocyte migration, CCL3, carbon tetrachloride, CCL7, CXCL1, CXCL10
- MeSH terms
- Animals, Disease Models, Animal, Flow Cytometry, Gene Expression Regulation, Inflammation, Light, Photoreceptor Cells, Retina, Retinal Degeneration, RNA, Messenger, Time Factors, Cell Death, Rats, Sprague-Dawley, Microglia, Statistics, Nonparametric, Chemokines, Microarray Analysis, Rats, Retinal Pigment Epithelium, Ependymoglial Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
