Cited by 424Chemokine receptors and signalingMosquito-borne diseases and controlinterferon and immune responses

Neuronal CXCL10 Directs CD8 + T-Cell Recruitment and Control of West Nile Virus Encephalitis

Open access
Klein, Robyn S., Lin, Eugene, Zhang, Bo, Luster, Andrew D., Tollett, Judy, Samuel, Melanie A., Engle, Michael, Diamond, Michael S.·2005·Journal of Virology

Abstract

The activation and entry of antigen-specific CD8 + T cells into the central nervous system is an essential step towards clearance of West Nile virus (WNV) from infected neurons. The molecular signals responsible for the directed migration of virus-specific T cells and their cellular sources are presently unknown. Here we demonstrate that in response to WNV infection, neurons secrete the chemokine CXCL10, which recruits effector T cells via the chemokine receptor CXCR3. Neutralization or a genetic deficiency of CXCL10 leads to a decrease in CXCR3 + CD8 + T-cell trafficking, an increase in viral burden in the brain, and enhanced morbidity and mortality. These data support a new paradigm in chemokine neurobiology, as neurons are not generally considered to generate antiviral immune responses, and CXCL10 may represent a novel neuroprotective agent in response to WNV infection in the central nervous system.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1128/jvi.79.17.11457-11466.2005

Cites

65 of 65 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Neuron-derived inflammatory signaling is a critical feature of the antiviral response to neurotropic viral infections.

    “However, work examining the immune response to neurotropic viral infections reveals neuron‐derived inflammatory signaling is a critical feature of the antiviral response (Klein et al, 2005; Chakraborty et al, 2010; Di Liberto et al, 2018).”

    From Mechanisms of DNA damage-mediated neurotoxicity in neurodegenerative disease (2022) · cites this paper as Klein et al, 2005

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Klein, R. S., Lin, E., Zhang, B., Luster, A. D., Tollett, J., Samuel, M. A., Engle, M., & Diamond, M. S.
Affiliations
  • Washington University in St. Louis (US)
  • Division of Infectious Diseases, Department of Medicine
  • Massachusetts General Hospital (US)
Corresponding author
Klein, Robyn S.
Venue
Journal of Virology
Published
2005-09
Volume
79
Issue
17
Pages
11457-11466
ISSN
  • 0022-538X (ISSN-L)
  • 1098-5514
OpenAlex
W2142913420
Cited by
424
References
65
Citations by year
2026: 12 · 2025: 19 · 2024: 22 · 2023: 17 · 2022: 13 · 2021: 18 · 2020: 19 · 2019: 24 · 2018: 15 · 2017: 21 · 2016: 14 · 2015: 24 · 2014: 30 · 2013: 31 · 2012: 18
FWCI
9.64
Type
journal article
Language
en
Open access
Locations
  • Journal of Virology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Howard Hughes Medical Institute
  • Edward Mallinckrodt, Jr. Foundation
  • National Institutes of Health (5r01ca069212-18)
  • National Cancer Institute (R01-CA069212)
  • National Institute of Neurological Disorders and Stroke (K02NS045607, R01NS052632)
Topics
  • Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
  • Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Keywords
West Nile virus, encephalitis, CXCL10, CXCR3, CD8+ T cells, T cell migration, chemokines, neuroinflammation, neuroprotection, viral encephalitis, antiviral immunity
MeSH terms
Animals, Cell Movement, Mice, Inbred C57BL, Neurons, T-Lymphocytes, West Nile Fever, West Nile virus, CD8 Antigens, Mice, Knockout, Receptors, Chemokine, Chemokines, CXC, Mice, Chemokine CXCL10, Receptors, CXCR3

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review