The DOI matches its Crossref record; 129 of the 129 references it cites were found in a registry or an index.
TREM2 ectodomain and its soluble form in Alzheimer’s disease
Open accessAbstract
Triggering receptor expressed on myeloid cells 2 (TREM2) is a receptor mainly expressed on the surface of microglia. It mediates multiple pathophysiological processes in various diseases. Recently, TREM2 has been found to play a role in the development of Alzheimer's disease (AD). TREM2 is a transmembrane protein that is specifically expressed on microglia in the brain. It contains a long ectodomain that directly interacts with the extracellular environment to regulate microglial function. The ectodomain of TREM2 is processed by a disintegrin and metalloprotease, resulting in the release of a soluble form of TREM2 (sTREM2). Recent studies have demonstrated that sTREM2 is a bioactive molecule capable of binding ligands, activating microglia, and regulating immune responses during the AD continuum. Clinical studies revealed that sTREM2 level is elevated in cerebrospinal fluid (CSF) of AD patients, and the sTREM2 level is positively correlated with the levels of classical CSF biomarkers, namely t-tau and p-tau, indicating that it is a reliable predictor of the early stages of AD. Herein, we summarize the key results on the generation, structure, and function of sTREM2 to provide new insights into TREM2-related mechanisms underlying AD pathogenesis and to promote the development of TREM2-based therapeutic strategy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Figures
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In the healthy aging human brain, amyloid-β plaques have the ability to cause persistent inflammation in microglia, which are the brain’s resident immune cells.”
From Recent Advances in Therapeutics for the Treatment of Alzheimer’s Disease (2024) · cites this paper as [202]
Experimental — accuracy not yet measuredIn the citing paper
“TREM2 receptor interaction plays a key role in identifying microglia for the build-up of debris and damage during the regulation of microglial activation.”
From Recent Advances in Therapeutics for the Treatment of Alzheimer’s Disease (2024) · cites this paper as [202]
In the citing paper
“TREM2 agonists are being investigated as potential therapeutic agents since they reduce inflammation and encourage amyloid-beta microglial phagocytosis [202,203,204,205].”
From Recent Advances in Therapeutics for the Treatment of Alzheimer’s Disease (2024) · cites this paper as [202]
In the citing paper
“Inflammation, or neuroinflammation, is a crucial factor in the mechanisms behind AD.”
From Recent Advances in Therapeutics for the Treatment of Alzheimer’s Disease (2024) · cites this paper as [202]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Neuroinflammation in Alzheimer's disease
Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226
2016 Alzheimer's disease facts and figures
Alzheimer's Association (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.03.001 · Cited by 5,069
Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
Schafer, D. P., Lehrman, E. K., Kautzman, A. G., Koyama, R., Mardinly, A. R., Yamasaki, R., Ransohoff, R. M., Greenberg, M. E., Barres, B. A., & Stevens, B. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.026 · Cited by 4,089 · cited 1×
“Moreover, TREM2 combined with complement proteins, in particular C1q and C3 [93], promoting synaptic elimination of inappropriate connections during mature neural circuit refinement [94].”
BackgroundTREM2 Variants in Alzheimer's Disease
Guerreiro, R., Wojtas, A., Bras, J., Carrasquillo, M., Rogaeva, E., Majounie, E., Cruchaga, C., Sassi, C., Kauwe, J. S. K., Younkin, S., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211851 · Cited by 3,020
Krasemann, S., Madore, C., Cialic, R., Baufeld, C., Calcagno, N., El Fatimy, R., Beckers, L., O’Loughlin, E., Xu, Y., Fanek, Z., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.08.008 · Cited by 2,979
Lane, C. A., Hardy, J., & Schott, J. M. (2018) · European Journal of Neurology · doi:10.1111/ene.13439 · Cited by 2,616
Variant of TREM2 Associated with the Risk of Alzheimer's Disease
Jonsson, T., Stefansson, H., Steinberg, S., Jonsdottir, I., Jonsson, P. V., Snaedal, J., Bjornsson, S., Huttenlocher, J., Levey, A. I., Lah, J. J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211103 · Cited by 2,558
Bloom (2014) · doi:10.1001/jamaneurol.2013.5847 · Cited by 2,194
Immune attack: the role of inflammation in Alzheimer disease
Heppner, F. L., Ransohoff, R. M., & Becher, B. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3880 · Cited by 2,134
TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model
Wang, Y., Cella, M., Mallinson, K., Ulrich, J. D., Young, K. L., Robinette, M. L., Gilfillan, S., Krishnan, G. M., Sudhakar, S., Zinselmeyer, B. H., et al. (2015) · Cell · doi:10.1016/j.cell.2015.01.049 · Cited by 1,736
Cited by
Sorted by citations
Glial Cell-Mediated Neuroinflammation in Alzheimer’s Disease
Al-Ghraiybah, N. F., Wang, J., Alkhalifa, A. E., Roberts, A. B., Raj, R., Yang, E., & Kaddoumi, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810572 · Cited by 217
Haure-Mirande, J.-V., Audrain, M., Ehrlich, M. E., & Gandy, S. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00552-w · Cited by 159
Zhang, S., Zhu, L., Peng, Y., Zhang, L., Chao, F., Jiang, L. H., Xiao, Q., Liang, X., Tang, J., Yang, H., et al. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02401-5 · Cited by 143
Soluble TREM2: Innocent bystander or active player in neurological diseases?
Filipello, F., Goldsbury, C., You, S. F., Locca, A., Karch, C. M., & Piccio, L. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105630 · Cited by 134
Gong, S., Zhai, M., Shi, J., Yu, G., Lei, Z., Shi, Y., Zeng, Y., Ju, P., Yang, N., Zhang, Z., et al. (2024) · Cell Death and Differentiation · doi:10.1038/s41418-023-01252-8 · Cited by 129
The role of the immune system in Alzheimer’s disease
Wu, K., Zhang, Y.-R., Huang, Y., Dong, Q., Tan, L., & Yu, J. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101409 · Cited by 119
Insights Into the Role of CSF1R in the Central Nervous System and Neurological Disorders
Hu, B., Duan, S., Wang, Z., Li, X., Zhou, Y., Zhang, X., Zhang, Y., Xu, H., & Zheng, H. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.789834 · Cited by 112
Neuroinflammation as a Potential Therapeutic Target in Alzheimer’s Disease
Liu, P., Wang, Y., Sun, Y., & Peng, G. (2022) · Clinical Interventions in Aging · doi:10.2147/cia.s357558 · Cited by 94
Magno, L., Bunney, T. D., Mead, E., Svensson, F., & Bictash, M. N. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00436-5 · Cited by 64
Microglial Function and Regulation during Development, Homeostasis and Alzheimer’s Disease
Casali, B. T., & Reed-Geaghan, E. G. (2021) · Cells · doi:10.3390/cells10040957 · Cited by 70
Reprogramming of Hepatic Metabolism and Microenvironment in Nonalcoholic Steatohepatitis
Rui, L., & Lin, J. D. (2022) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-062220-105200 · Cited by 59
Wang, L., Nykänen, N.-P., Western, D., Gorijala, P., Timsina, J., Li, F., Wang, Z., Ali, M., Yang, C., Liu, M., et al. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00687-4 · Cited by 58
Recent Advances in Therapeutics for the Treatment of Alzheimer’s Disease
Thawabteh, A. M., Ghanem, A. W., AbuMadi, S., Thaher, D., Jaghama, W., Karaman, D., & Karaman, R. (2024) · Molecules · doi:10.3390/molecules29215131 · Cited by 56
“TREM2 agonists are being investigated as potential therapeutic agents since they reduce inflammation and encourage amyloid-beta microglial phagocytosis [202–205].”
BackgroundPocock, J., Vasilopoulou, F., Svensson, E., & Cosker, K. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110020 · Cited by 54
The role of TREM2 in Alzheimer’s disease: from the perspective of Tau
Huang, W., Huang, J., Huang, N., & Luo, Y. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1280257 · Cited by 49
The relationship of soluble TREM2 to other biomarkers of sporadic Alzheimer’s disease
Park, S., Lee, E.-H., Kim, H., Jo, S., Lee, S., Seo, S. W., Park, H.-H., Koh, S., & Lee, J. (2021) · Scientific Reports · doi:10.1038/s41598-021-92101-6 · Cited by 53
Aβ and Tau Regulate Microglia Metabolism via Exosomes in Alzheimer’s Disease
Zhao, Y., Liu, B., Wang, J., Xu, L., Yu, S., Fu, J., Yan, X., & Su, J. (2022) · Biomedicines · doi:10.3390/biomedicines10081800 · Cited by 48
Plasma soluble TREM2 is associated with white matter lesions independent of amyloid and tau
Tsai, H.-H. C., Chen, Y., Yen, R., Lo, Y.-L., Yang, K., Jeng, J., Tsai, L., & Chang, C.-F. (2021) · Brain · doi:10.1093/brain/awab332 · Cited by 47
Does soluble TREM2 protect against Alzheimer's disease?
Brown, G. C., & St George-Hyslop, P. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.834697 · Cited by 39
Hok‐A‐Hin, Y. S., del Campo, M., Boiten, W. A., Stoops, E., Vanhooren, M., Lemstra, A. W., van der Flier, W. M., & Teunissen, C. E. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02796-9 · Cited by 40
Roles of TREM2 in the Pathological Mechanism and the Therapeutic Strategies of Alzheimer's Disease
Lin, M., Yu, J., Zhang, W., Lao, F., & Huang, H. (2024) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2024.164 · Cited by 46
Abbas, K., Mustafa, M., Alam, M., Habib, S., Ahmad, W., Adnan, M., Hassan, M. I., & Usmani, N. (2025) · Neurogenetics · doi:10.1007/s10048-025-00821-y · Cited by 48
Targeting TREM2 for Parkinson’s Disease: Where to Go?
Li, X., & Zhang, F. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.795036 · Cited by 38
TREM2: Keeping Pace With Immune Checkpoint Inhibitors in Cancer Immunotherapy
Qiu, H., Shao, Z., Wen, X., Jiang, J., Ma, Q., Wang, Y., Huang, L., Ding, X., & Zhang, L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.716710 · Cited by 32
TREM2 in Alzheimer's disease: Structure, function, therapeutic prospects, and activation challenges
Zgórzyńska, E. (2024) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2024.103917 · Cited by 29
Zhao, Y., Guo, Q., Tian, J., Liu, W., & Wang, X. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102596 · Cited by 23
Small molecule therapeutics for neuroinflammation-mediated neurodegenerative disorders
Miller, S., & Blanco, M.-J. (2021) · RSC Medicinal Chemistry · doi:10.1039/d1md00036e · Cited by 21
Španić, E., Leko, M. B., Horvat, L. L., Brgić, K., Vogrinc, Ž., Boban, M., Klepac, N., Borovečki, F., & Šimić, G. (2023) · Neurology International · doi:10.3390/neurolint15030053 · Cited by 21
Current understanding on TREM-2 molecular biology and physiopathological functions
Bharadwaj, S., Groza, Y., Mierzwicka, J. M., & Malý, P. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112042 · Cited by 23
TREM2 in Neurodegenerative Diseases: Mechanisms and Therapeutic Potential
Li, L., Zheng, X., Ma, H., Zhu, M., Li, X., Sun, X., & Feng, X. (2025) · Cells · doi:10.3390/cells14171387 · Cited by 22
The versatile role of TREM2 in regulating of microglia fate in the ischemic stroke
Ma, W.-Y., Wang, S., Wu, Q.-L., Zhou, X., Chu, S., & Chen, N. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108733 · Cited by 20
Basha, S. C., Ramaiah, M. J., & Rao, K. S. J. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221070 · Cited by 23
Bonomi, C. G., Assogna, M., Donna, M. G. D., Bernocchi, F., Lucia, V. D., Nuccetelli, M., Fiorelli, D., Loizzo, S., Mercuri, N. B., Koch, G., et al. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221010 · Cited by 20
Microglia Biomarkers in Alzheimer’s Disease
Zhang, P., Hu, H., Tan, L., & Yu, J. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02348-3 · Cited by 19
Hypoxia/ischemia impairs CD33 (Siglec-3)/TREM2 signaling: Potential role in Alzheimer's pathogenesis
Salminen, A., Kaarniranta, K., & Kauppinen, A. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105186 · Cited by 20
Placental DNA methylation changes in gestational diabetes mellitus
Chen, F., Fei, X., Zhu, W., Zhang, Z., Shen, Y., Mao, Y., Zhu, Q., Xu, J., Zhou, W., Li, M., et al. (2022) · Epigenetics · doi:10.1080/15592294.2022.2110193 · Cited by 19
Liu, W., Zhang, Y.-R., Ge, Y., Wang, H.-F., Cheng, W., & Yu, J. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03648-6 · Cited by 18
Regulation of TREM2 on BV2 inflammation through PI3K/AKT/mTOR pathway
Li, L., Chen, Q., Qin, Y., Yu, G., Qi, T., Sui, H., Qi, X., & Huang, L. (2023) · Biotechnology and Genetic Engineering Reviews · doi:10.1080/02648725.2023.2204719 · Cited by 18
Microglia Process α‐Synuclein Fibrils and Enhance their Pathogenicity in a TREM2‐Dependent Manner
Xiong, M., Xia, D., Yu, H., Meng, L., Zhang, X., Chen, J., Tian, Y., Yuan, X., Niu, X., Nie, S., et al. (2024) · Advanced Science · doi:10.1002/advs.202413451 · Cited by 21
A Review of APOE Genotype-Dependent Autophagic Flux Regulation in Alzheimer’s Disease
Chen, H., Chen, F., Zhang, M., Chen, Y., Cui, L., & Liang, C. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210602 · Cited by 15
Menéndez‐González, M., Tamba, B.-I., Leclere, M., Mabrouk, M., Schreiner, T. G., Ciobanu, R. C., & Tomás‐Zapico, C. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15030768 · Cited by 15
VEGF controls microglial phagocytic response to amyloid-β
Gea, P. D., Benkeder, S., Bouvet, P., Aimard, M., Chounlamountri, N., Honnorat, J., Do, L.-D., & Meissirel, C. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1264402 · Cited by 19
Inflammation in the CNS: Understanding Various Aspects of the Pathogenesis of Alzheimer's Disease
Doroszkiewicz, J., Mroczko, P., & Kulczyńska‐Przybik, A. (2021) · Current Alzheimer Research · doi:10.2174/1567205018666211202143935 · Cited by 14
TREM-2: friend or foe in infectious diseases?
Matos, A. D. O., Dantas, P. H. D. S., Queiroz, H. A. G. D. B., Silva‐Sales, M., & Sales‐Campos, H. (2022) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2022.2146481 · Cited by 12
Farzan, M., Rounkian, M. S., Rizi, A. A., Heidari, Z., Farzan, M., Fathi, M., Aghaei, A., Azadegan‐Dehkordi, F., & Bagheri, N. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.115071 · Cited by 15
Dehydroervatamine as a promising novel TREM2 agonist, attenuates neuroinflammation
Li, L., Xu, N., He, Y., Tang, M., Yang, B., Du, J., Liang, C., Mao, X., Song, B., Zhou, H., et al. (2024) · Neurotherapeutics · doi:10.1016/j.neurot.2024.e00479 · Cited by 14
Bubak, A. N., Merle, L., Niemeyer, C. S., Baxter, B. D., Polese, A. G., Ramakrishnan, V. R., Gómez, J., Madrigal, L., Villegas‐Lanau, A., Lopera, F. J., et al. (2022) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2022.12.004 · Cited by 13
The Pathogenesis in Alzheimer's Disease: TREM2 as a Potential Target
Liu, G., Zhang, L., Fan, Y., & Ji, W. (2023) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2206150 · Cited by 13
Maass, F., Canaslan, S., van Riesen, C., Hermann, P., Schmitz, M., Schulte, C., Brockmann, K., Synofzik, M., Bähr, M., & Zerr, I. (2024) · Journal of Neurology · doi:10.1007/s00415-024-12747-w · Cited by 14
Tanaka, M., Yamakage, H., Muranaka, K., Yamada, T., Araki, R., Ogo, A., Matoba, Y., Watanabe, T., Saito, M. H., Kurita, S., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.880148 · Cited by 13
Variants in the MS4A cluster interact with soluble TREM2 expression on biomarkers of neuropathology
Winfree, R. L., Nolan, E., Dumitrescu, L. C., Blennow, K., Zetterberg, H., Gifford, K. A., Pechman, K. R., Seto, M., Petyuk, V., Wang, Y., et al. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-024-00727-7 · Cited by 12
Biofluid biomarkers for Alzheimer’s disease: past, present, and future
An, C., Cai, H., Ren, Z., Fu, X., Quan, S., & Jia, L. (2024) · Medical Review · doi:10.1515/mr-2023-0071 · Cited by 14
Xiao, Z., Wang, Y., Chen, Y., Jin, L., Shi, Y., Liu, C., Fu, C., & Cao, Y. (2024) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00219.2024 · Cited by 13
Milos, T., Vuić, B., Balic, N., Farkaš, V., Erjavec, G. N., Štrac, D. Š., Perković, M. N., & Pivac, N. (2024) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2024.2400683 · Cited by 11
Leng, F., Initiative, O. B. O. A. D. N., Zhan, Z., Sun, Y., Liu, F., Edison, P., Sun, Y., & Wang, Z. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220102 · Cited by 11
Zhong, Z., Ulmschneider, M. B., & Lorenz, C. D. (2024) · ACS Omega · doi:10.1021/acsomega.4c03060 · Cited by 8
Yong, Y., Cai, Y., Lin, J., Ma, L., Han, H., & Li, F. (2024) · Med-X · doi:10.1007/s44258-024-00021-7 · Cited by 10
Jiang, J. H., Liu, H., Wang, Z., Tian, H., Wang, S., Yang, J., & Li, Z. (2022) · Acupuncture in Medicine · doi:10.1177/09645284221077103 · Cited by 8
Wu, C., Initiative, A. D. N., Ma, Y., Hu, H., Zhao, B. T., & Tan, L. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-220731 · Cited by 8
Wang, Z., Tan, L., Zong, Y., Ma, Y.-H., Wang, Z.-B., Wang, H.-F., & Tan, L. (2023) · Journal of Alzheimer's Disease · doi:10.3233/jad-220725 · Cited by 5
Soluble TREM2 in body fluid in Alzheimer’s disease and Parkinson’s disease
Gu, L., Shu, H., & Wang, Y. (2023) · Neurological Sciences · doi:10.1007/s10072-023-06729-5 · Cited by 7
Balan, I. S., Grusca, A., Chéry, S. L., Materia, B. R., O’Buckley, T. K., & Morrow, A. L. (2024) · Life · doi:10.3390/life14070860 · Cited by 6
Sun, Y., Zhang, H., Liu, R., Huang, R., Zhang, X., Zhou, S., Wu, L., Zhu, B., & Wu, H. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117214 · Cited by 6
do Nascimento, E. F., Batista, P. V. C., Cunha, C. S., Lacerda, L. R. A., de Moura, V. C., Oliveira, T. D. Q., Filho, A. J. M. C., de Rezende, P. H. F., Macêdo, D. S., & Vasconcelos, S. M. M. (2025) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5c00221 · Cited by 7
Liu, J., Zhang, Z., Zhou, M., Ling, S., Zhou, X., Yuan, B., Zhao, X., Qi, M., Han, Y., Qin, F., et al. (2024) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2902050 · Cited by 6
Patil, V., Sharma, A., Parekh, B. K., Jyothi.S, R., Priyadarshini‐Nayak, P., Janney-J, B., Singh, G., Al-Hasnaawei, S., & Kumar-Mishra, M. (2026) · Molecular Neurobiology · doi:10.1007/s12035-025-05634-6 · Cited by 5
Barragán-Álvarez, C. P., Flores-Fernández, J. M., Hernández‐Pérez, O. R., Ávila‐González, D., Díaz, N. F., Padilla‐Camberos, E., Dublán‐García, O., Gómez‐Oliván, L. M., & Diaz-Martinez, N. E. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.947769 · Cited by 5
Wang, Y., Ye, M., Ji, Q., Liu, Q., Xu, X., & Zhan, Y. (2024) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2024.70 · Cited by 5
Yang, D., Chen, F., Ren, J., Wang, L., Zhu, Z., Wu, Z., Jin, Q., Luo, Y., Huang, H., Zhu, B., et al. (2024) · Journal of Neurology · doi:10.1007/s00415-024-12779-2 · Cited by 5
Li, Y., Wang, Y., Li, H., Gao, R., Zhang, W., & Yang, X. (2026) · Cellular Signalling · doi:10.1016/j.cellsig.2026.112509 · Cited by 4
Khaled, M., Al-Jamal, H., Tajer, L., & El-Mir, R. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-231432 · Cited by 4
Guo, F., Tan, M., Hu, H., Ou, Y., Zhang, M., Sheng, Z.-H., Chi, H., Tan, L., & Initiative, A. D. N. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-240372 · Cited by 4
Bonomi, C. G., Chiaravalloti, A., Camedda, R., Ricci, F., Mercuri, N. B., Schillaci, O., Koch, G., Martorana, A., & Motta, C. (2023) · Biomedicines · doi:10.3390/biomedicines11030725 · Cited by 5
Shen, H., He, J., & Lin, F. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1546292 · Cited by 4
Wang, M., Long, J., Yuan, K., Cao, M., Peng, Y., Xu, T., He, J., Zhang, Y., Zhong, C., & Zhai, G. (2025) · Journal of the American Heart Association · doi:10.1161/jaha.124.040555 · Cited by 3
Yu, J., Bao, X., Shan, C., Yu, Z., Yu, Y., Wang, H., & Zhang, Y. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1691253 · Cited by 3
Research progress on humoral biomarkers of Alzheimer’s disease: A review
Zhang, H., Fu, X., Yang, M., Song, X., Li, M., & Wang, X. (2024) · Medicine · doi:10.1097/md.0000000000038978 · Cited by 4
Exploring the orphan immune receptor TREM2 and its non-protein ligands: In silico characterization
Dantas, P. H. D. S., Costa, V. A. F., Felice, A. G., Sousa, E. G., Matos, A. D. O., Soares, S. D. C., Silva‐Sales, M., Neves, B. J., & Sales‐Campos, H. (2024) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2024.105449 · Cited by 3
Sun, M., Yang, L., Zong, Q., Ying, L., Liu, X., & Lin, R. (2023) · Frontiers in Pediatrics · doi:10.3389/fped.2023.1185151 · Cited by 3
sTREM2 in the prognostic evaluation of acute lung injury after cardiac surgery in infants
Yang, L., Sun, M., Ying, L., Liu, X., Zhao, W., Lin, R., & Shu, Q. (2023) · Pediatric Research · doi:10.1038/s41390-023-02915-5 · Cited by 3
Huber, C. C., Callegari, E. A., Paez, M., Li, X., Dwamena, A., & Wang, H. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.09.579699 · Cited by 3
Nada, H., Yuan, S., Gaamouch, F. E., Cho, S., & Gabr, M. T. (2026) · European Journal of Medicinal Chemistry Reports · doi:10.1016/j.ejmcr.2026.100354 · Cited by 3
Loss of Y is associated with multi-omic changes in immune cells from Alzheimer’s disease patientsPreprint
Jąkalski, M., Rychlicka-Buniowska, E., Davies, H., Sarkisyan, D., Siedlar, M., Baran, J., Węglarczyk, K., Jaszczyński, J., Ryś, J., Gedraitis, V., et al. (2023) · medRxiv · doi:10.1101/2023.02.07.23285520 · Cited by 2
Buthut, M., Reber, P., Siebert, E., Eisenhut, K., Thaler, F., Finck, J., Soekadar, S. R., & Prüß, H. (2023) · Neurological Sciences · doi:10.1007/s10072-023-06726-8 · Cited by 2
Wang, S., Yuan, Y., Guo, X., Qin, M., Chen, J., Jiang, D., Feng, Y., & Mao, L. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.106101 · Cited by 1
Pottorf, T. S., Lane, E. L., & Álvarez, F. J. (2025) · Cells · doi:10.3390/cells14191520 · Cited by 1
CellSP enables module discovery and visualization for subcellular spatial transcriptomics data
Aggarwal, B., & Sinha, S. (2025) · Communications Biology · doi:10.1038/s42003-025-08891-2 · Cited by 1
Pashaei, S., Mirzaei, S. Z., Mohammadi, S., Shabani, S., & Khodarahmi, R. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.150648 · Cited by 1
TREM2 as a possible link between Alzheimer's disease and diabetes mellitus
Chen, W., Huang, N., Huang, W., Wang, M., Luo, Y., & Huang, J. (2026) · Experimental Neurology · doi:10.1016/j.expneurol.2026.115739 · Cited by 3
Wang, H.-Y., Pei, Z., Lee, K.-C., Rojas, Y. G., Doehner, T., Puente, J., Sciara, P., Beck, B., Lopez‐Brignoni, E., Nikolov, B., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-249858/v1 · Cited by 1
Placental DNA methylation changes in the development of gestational diabetes mellitusPreprint
Chen, F., Li, M., Fei, X., Zhu, W., Zhang, Z., Shen, Y., Mao, Y., Zhu, Q., Xu, J., Zhou, W., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1375478/v1 · Cited by 1
TREM2 Recognition of Candidalysin Orchestrates Mucosal Immunity in Oropharyngeal CandidiasisPreprint
Deng, W., Chen, Y., Liu, S., Lin, K., Zhang, K., Wang, D., Yu, Z., Zhao, W., Xu, Y., Wang, X., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-4137807/v1 · Cited by 1
Jadhav, V. (2021) · IUScholarWorks (Indiana University) · doi:10.7912/c2/2086
Microglia, TREM2, and Therapeutic Methods of Alzheimer’s Disease
Xu, S., Ji, Y., Sha, T., & Li, H. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.100203
Placental DNA methylation changes in the development of gestational diabetes mellitusPreprint
Chen, F., Li, M., Fei, X., Zhu, W., Zhang, Z., Shen, Y., Mao, Y., Zhu, Q., Xu, J., Zhou, W., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1375478/v2
Emerging Roles of TREM2 in Neurodegenerative Diseases
Kabir, M. T. (2022) · Springer eBooks · doi:10.1007/978-981-16-7606-2_7
Huang, T., Zhu, Y., Lu, Y., Zhang, Q., Fang, C., Ju, Z., He, J., Zhang, Y., Xu, T., & Zhong, C. (2023) · medRxiv · doi:10.1101/2023.04.25.23289122
Alzheimer’s Disease Mechanism in Neuroimmunology Perspective
Hao, J. (2023) · Theoretical and Natural Science · doi:10.54254/2753-8818/4/20220540
Andrejić, N., Pešić, M., Marjanović, A., Branković, M., Janković, M. Z., Mandić, G., Novaković, I. V., Stojković, T., & Stefanova, E. D. (2023) · Medicinska istrazivanja · doi:10.5937/medi56-46143
Hsp60 and nervous system development and diseases
Scalia, F., Cappello, F., de Macario, E. C., & Macario, A. J. L. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23996-0.00012-2
Metadata
- Authors
- Yang, J., Fu, Z., Zhang, X., Xiong, M., Meng, L., & Zhang, Z.
- Affiliations
- Renmin Hospital of Wuhan University (CN)
- Corresponding author
- Zhang, Zhentao
- Venue
- Journal of Neuroinflammation
- Published
- 2020-07-07
- Volume
- 17
- Issue
- 1
- Pages
- 204-204
- ISSN
- 1742-2094 (ISSN-L)
- PMC
- PMC7341574
- OpenAlex
- W3039674883
- Cited by
- 113
- References
- 129
- Citations by year
- 2026: 12 · 2025: 11 · 2024: 32 · 2023: 23 · 2022: 19 · 2021: 16
- FWCI
- 1.44
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Neuroinflammation (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (No.81822016,81771382, and 81571249)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- TREM2, soluble TREM2, Alzheimer's disease, microglia, extracellular domain, cerebrospinal fluid biomarkers, tau protein, early diagnosis, neuroinflammation
- MeSH terms
- Alzheimer Disease, Animals, Humans, Membrane Glycoproteins, Receptors, Immunologic, Solubility, Biomarkers, tau Proteins, Microglia, Protein Isoforms
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
