GSDMD/Drp1 signaling pathway mediates hippocampal synaptic damage and neural oscillation abnormalities in a mouse model of sepsis-associated encephalopathy

Fu, Qun; Zhang, Yi-Bao; Shi, Chang-Xi; Jiang, Ming; Lu, Kai; Fu, Zi-Hui; Ruan, Jia-Ping; Wu, Jing; Gu, Xiao-Ping

doi:10.1186/s12974-024-03084-w

GSDMD/Drp1 signaling pathway mediates hippocampal synaptic damage and neural oscillation abnormalities in a mouse model of sepsis-associated encephalopathy

Background Gasdermin D (GSDMD)-mediated pyroptotic cell death is implicated in the pathogenesis of cognitive deficits in sepsis-associated encephalopathy (SAE), yet the underlying mechanisms remain largely unclear. Dynamin-related protein 1 (Drp1) facilitates mitochondrial fission and ensures qua…