The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
New insights into the function and regulation of mitochondrial fission
Open accessAbstract
Mitochondrial morphology changes dynamically by coordinated fusion and fission and cytoskeleton-based transport. Cycles of outer and inner membrane fusion and fission are required for the exchange of damaged mitochondrial genome DNA, proteins, and lipids with those of healthy mitochondria to maintain robust mitochondrial structure and function. These dynamics are crucial for cellular life and death, because they are essential for cellular development and homeostasis, as well as apoptosis. Disruption of these functions leads to cellular dysfunction, resulting in neurologic disorders and metabolic diseases. The cytoplasmic dynamin-related GTPase Drp1 plays a key role in mitochondrial fission, while Mfn1, Mfn2 and Opa1 are involved in fusion reaction. Here, we review current knowledge regarding the regulation and physiologic relevance of Drp1-dependent mitochondrial fission: the initial recruitment and assembly of Drp1 on the mitochondrial fission foci, regulation of Drp1 activity by post-translational modifications, and the role of mitochondrial fission in cell pathophysiology.
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Citations
Cites
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Cited by
Mitochondrial dynamics: overview of molecular mechanisms
Tilokani, L., Nagashima, S., Paupe, V., & Prudent, J. (2018) · Essays in Biochemistry · doi:10.1042/ebc20170104 · Cited by 1,397
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Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD
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The endoplasmic reticulum–mitochondria connection: One touch, multiple functions
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Metadata
- Authors
- Otera, H., Ishihara, N., & Mihara, K.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Publisher
- Elsevier BV
- Published
- 2013-05
- Volume
- 1833
- Issue
- 5
- Pages
- 1256-1268
- ISSN
- 0167-4889 (ISSN-L)
- OpenAlex
- W2074341964
- Cited by
- 479
- References
- 40
- FWCI
- 16.94
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Otera, H., Ishihara, N., & Mihara, K. (2013). New insights into the function and regulation of mitochondrial fission. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. https://doi.org/10.1016/j.bbamcr.2013.02.002
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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