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Cited by 31T-cell and Retrovirus StudiesHIV Research and TreatmentViral-associated cancers and disorders

HTLV-1 infection of myeloid cells: from transmission to immune alterations

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Rocamonde, Brenda, Carcone, Auriane, Mahieux, Renaud, Dutartre, Hélène·2019·Retrovirology
DOI 10.1186/s12977-019-0506-xPMC PMC6929313
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Abstract

Human T cell leukemia virus type 1 (HTLV-1), the etiological agent of adult T-cell leukemia/lymphoma (ATLL) and the demyelinating neuroinflammatory disease known as HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP), was the first human retrovirus to be discovered. T-cells, which represent the main reservoir for HTLV-1, have been the main focus of studies aimed at understanding viral transmission and disease progression. However, other cell types such as myeloid cells are also target of HTLV-1 infection and display functional alterations as a consequence. In this work, we review the current investigations that shed light on infection, transmission and functional alterations subsequent to HTLV-1 infection of the different myeloid cells types, and we highlight the lack of knowledge in this regard.

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  • APCs, such as DCs and macrophages, are the first targets of HIV-1 and HTLV-1 during transmission via sexual routes and breastfeeding.

    “APCs, such as DCs and macrophages, are the first targets of HIV-1 and HTLV-1 during transmission via sexual routes and breastfeeding [56,57,58,59].”

    From HIV-1 and HTLV-1 Transmission Modes: Mechanisms and Importance for Virus Spread (2022) · cites this paper as [59]

    In “Mechanisms/route of viral transmission” (page unavailable), the paper proposes that mucosal dendritic cells are the first newly infected cells in HTLV-1 transmission through breastfeeding or sex. The “In vivo” section reports infected macrophages in breast milk, but does not identify macrophages as first targets; nor does this paper establish the claimed first-target role for HIV-1. The citing sentence also states as fact what the paper presents as a model for HTLV-1. (LLM, conf=0.88)

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Cited by

Sorted by citations

Authors
Rocamonde, B., Carcone, A., Mahieux, R., & Dutartre, H.
Affiliations
Lyon 1 Université (FR)
Corresponding author
Dutartre, Hélène
ORCID
Venue
Retrovirology
Publisher
Springer Science and Business Media LLC
Published
2019-12
Volume
16
Issue
1
Pages
45-45
ISSN
1742-4690 (ISSN-L)
DOI
10.1186/s12977-019-0506-x
PMC
PMC6929313
OpenAlex
W2996528181
Cited by
31
References
4
Citations by year
2026: 2 · 2025: 3 · 2024: 7 · 2023: 4 · 2022: 5 · 2021: 5 · 2020: 2 · 2019: 1 · 2018: 2
FWCI
0.28
Type
journal article
Language
en
Open access
Licence
Locations
  • Retrovirology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • Fondation pour la Recherche Médicale (DEQ20180339200)
  • Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation (PhD grant)
  • Agence Nationale de la Recherche (ANR-11-LABX-0048)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
  • Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
Keywords
HTLV-1, myeloid cells, adult T-cell leukemia/lymphoma, HAM/TSP, virus transmission, immunological changes, retroviruses
MeSH terms
Animals, Humans, Macrophages, T-Lymphocytes, Human T-lymphotropic virus 1, Leukemia-Lymphoma, Adult T-Cell, HTLV-I Infections, Myeloid Cells

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