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Cited by 344

The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.

Bat origin of human coronaviruses

Hu, Ben, Ge, Xingyi, Wang, Lin-Fa, Shi, Zhengli·2015·Virology Journal

Abstract

Bats have been recognized as the natural reservoirs of a large variety of viruses. Special attention has been paid to bat coronaviruses as the two emerging coronaviruses which have caused unexpected human disease outbreaks in the 21st century, Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV), are suggested to be originated from bats. Various species of horseshoe bats in China have been found to harbor genetically diverse SARS-like coronaviruses. Some strains are highly similar to SARS-CoV even in the spike protein and are able to use the same receptor as SARS-CoV for cell entry. On the other hand, diverse coronaviruses phylogenetically related to MERS-CoV have been discovered worldwide in a wide range of bat species, some of which can be classified to the same coronavirus species as MERS-CoV. Coronaviruses genetically related to human coronavirus 229E and NL63 have been detected in bats as well. Moreover, intermediate hosts are believed to play an important role in the transmission and emergence of these coronaviruses from bats to humans. Understanding the bat origin of human coronaviruses is helpful for the prediction and prevention of another pandemic emergence in the future.

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Research works printed but not linked: 1

  1. de Groot R, Baker S, Baric R, Enjuanes L, Gorbalenya A, Holmes K, et al. Family Coronaviridae. In: King A, Adams M, Cartens E, Lefkowitz E, editors. Virus Taxonomy; Ninth Report of the International Committee on Taxonomy of Viruses. San Diego: Academic; 2012. p. 806–28.

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Metadata

Authors
Hu, B., Ge, X., Wang, L.-F., & Shi, Z.
Venue
Virology Journal
Published
2015-12
Volume
12
Issue
1
ISSN
1743-422X
Cited by
344
References
110
Language
en
Licence
Funders
  • National Natural Science Foundation of China (81290341)
  • Scientific and technological basis specialrom the Minister of Science and Technology of the People’s Republic of China project (2013FY113500)
  • National Institutes of Health (NIAID R01AI110964)

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CoChat. (2026). Citation check: Bat origin of human coronaviruses. https://app.cochat.ai/papers/10.1186/s12985-015-0422-1
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Hu, B., Ge, X., Wang, L.-F., & Shi, Z. (2015). Bat origin of human coronaviruses. Virology Journal. https://doi.org/10.1186/s12985-015-0422-1

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