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Cited by 75Gastrointestinal motility and disordersMicrobial Metabolites in Food BiotechnologyGut microbiota and health

Randomized clinical study: Partially hydrolyzed guar gum (PHGG) versus placebo in the treatment of patients with irritable bowel syndrome

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Niv, E., Halak, A., Tiommny, E., Yanai, H., Strul, H., Naftali, T., Vaisman, N.·2016·Nutrition & Metabolism
DOI 10.1186/s12986-016-0070-5PMC PMC4744437
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Abstract

BACKGROUND: The treatment of Irritable bowel syndrome (IBS) is still challenging. Partially hydrolyzed guar gum (PHGG) is a known prebiotic fiber. To assess the effects of PHGG on clinical symptoms of IBS patients in a prospective randomized double blind placebo-controlled study. METHODS: Suitable IBS patients were recruited into an 18-week-long study (2 weeks of run-in, 12 weeks of treatment and 4 weeks of follow-up). They were blindly randomized to receive 6 gr of PHGG or placebo. Treatment efficacy was evaluated by the Francis Severity IBS score, the IBS quality-of-life scores and scored parameters of weekly journal of symptoms. Deltas of changes between the final and baseline scores were compared between two groups. RESULTS: Of 121 patients who underwent randomization, 108 patients (49 in the PHGG group and 59 in the placebo group) had all the data needed for intention-to-treat analysis. A 12-week administration of PHGG led to a significant improvement of journal bloating score in the PHGG group versus placebo (-4.1±13.4 versus -1.2±11.9, P=0.03), as well as in bloating+gasses score (-4.3±10.4 versus -1.12±10.5, P = 0.035). The effect lasted for at least 4 weeks after the last PHGG administration. PHGG had no effect on other journal reported IBS symptoms or on Severity and Quality of life scores. There were no significant side effects associated with PHGG ingestion. The rate of dropouts was significantly higher among patients in the placebo group compared with the PHGG group (49.15% versus 22.45%, respectively, P = 0.01). CONCLUSIONS: The results of this study support the administration of 6 g/day PHGG for IBS patients with bloating. TRIAL REGISTRATION: NCT01779765.

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Authors
Niv, E., Halak, A., Tiommny, E., Yanai, H., Strul, H., Naftali, T., & Vaisman, N.
Affiliations
Tel Aviv University (IL)
Corresponding author
Niv, E.
ORCID
Venue
Nutrition & Metabolism
Publisher
Springer Science and Business Media LLC
Published
2016-02-06
Volume
13
Issue
1
Pages
10-10
ISSN
1743-7075 (ISSN-L)
DOI
10.1186/s12986-016-0070-5
PMC
PMC4744437
OpenAlex
W2272464073
Cited by
75
References
2
Citations by year
2026: 7 · 2025: 2 · 2024: 10 · 2023: 16 · 2022: 7 · 2021: 5 · 2020: 10 · 2019: 4 · 2018: 7 · 2017: 4 · 2016: 2 · 2015: 1
FWCI
5.31
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Nutrition & Metabolism (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
irritable bowel syndrome, partially hydrolyzed guar gum, prebiotic fiber, bloating, IBS symptom severity, quality of life, symptom diary, medication adherence, placebo effect

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