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Cited by 215Botanical Research and ApplicationsNatural Antidiabetic Agents StudiesFood Science and Nutritional Studies

Functional properties of beetroot (Beta vulgaris) in management of cardio-metabolic diseases

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Mirmiran, Parvin, Houshialsadat, Zeinab, Gaeini, Zahra, Bahadoran, Zahra, Azizi, Fereidoun·2020·Nutrition & Metabolism
DOI 10.1186/s12986-019-0421-0PMC PMC6947971
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Abstract

Red beetroot ( Beta vulgaris ), as a naturally occurring root vegetable and a rich source of phytochemicals and bioactive compounds, is known for its beneficial roles in the improvement of several clinical and pathologic outcome. Chronic and acute beetroot juice supplementation, as a cost-effective strategy, is proposed to hold promises in controlling diabetes and insulin hemostasis, blood pressure and vascular function, renal health and the possible effect on microbiome abundance. The secondary outcome and physiological response of microbiome abundance modulation included the non- significant fluctuation of systolic and diastolic blood pressures. Also, some studies have suggested a reno-protective property of beetroot juice that is associated with the reduction of mortality rate and favorable changes in kidney’s functional parameters among patients with renal disorders. Similarly, it is shown that the persistent consumption of beetroot juice effectively postpones the postprandial glycemic response and decreases the blood glucose peak. The significant blood pressure lowering effect has been seen among normotensive subjects, which tend to be more considerable among hypertensive individuals and progressive among overweight adults. Within this context, this review aims to provide a comprehensive overview on the therapeutic applications of beetroot juice in metabolic disorders and theirs underlying mechanisms. Despite the inconsistencies in the set of results from the reviewed studies, there is no doubt that further contributing factors must be investigated more deeply in future studies.

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  • Beetroot juice and extracts have been shown to improve antioxidant status, vascular function, and exercise performance, partly through enhanced mitochondrial efficiency.

    “The most extensively studied forms are beetroot juice and extracts, which have been shown to improve antioxidant status, vascular function, and exercise performance, partly through enhanced mitochondrial efficiency [101,103].”

    From Dietary Nitrate-Rich Vegetables as Natural Modulators of Health: Mechanisms and Benefits in Ageing Populations (2026) · cites this paper as [103]

    The sections on kidney function and blood pressure and vascular function (pages not supplied) report improved antioxidant markers and vascular measures after beetroot juice supplementation. The paper mentions possible ergogenic effects, but the retrieved text does not establish improved exercise performance or attribute it to enhanced mitochondrial efficiency. Its introduction also describes the reviewed vascular findings as mostly inconsistent. (LLM, conf=0.86)

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References 80 · Cited by 215

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Authors
Mirmiran, P., Houshialsadat, Z., Gaeini, Z., Bahadoran, Z., & Azizi, F.
Affiliations
Research Institute for Endocrine Sciences (IR)
Corresponding author
Bahadoran, Zahra
ORCID
Venue
Nutrition & Metabolism
Publisher
Springer Science and Business Media LLC
Published
2020-01-07
Volume
17
Issue
1
Pages
3-3
ISSN
1743-7075 (ISSN-L)
DOI
10.1186/s12986-019-0421-0
PMC
PMC6947971
OpenAlex
W3001961439
Cited by
215
References
80
Citations by year
2026: 26 · 2025: 33 · 2024: 35 · 2023: 37 · 2022: 45 · 2021: 25 · 2020: 13 · 2019: 1
FWCI
2.54
Type
journal article
Language
en
Open access
Licence
Locations
  • Nutrition & Metabolism (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Botanical Research and Applications
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
  • Health Sciences › Nursing › Nutrition and Dietetics › Food Science and Nutritional Studies
Keywords
beetroot juice, Beta vulgaris, cardiometabolic disease, diabetes mellitus, insulin sensitivity, blood pressure, vascular function, renal protection, gut microbiota, postprandial glycemic response, phytochemicals, hypertension

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