The DOI matches its Crossref record; 55 of the 56 references it cites were found in a registry or an index.
Is bulk flow plausible in perivascular, paravascular and paravenous channels?
Open accessAbstract
BACKGROUND: Transport of solutes has been observed in the spaces surrounding cerebral arteries and veins. Indeed, transport has been found in opposite directions in two different spaces around arteries. These findings have motivated hypotheses of bulk flow within these spaces. The glymphatic circulation hypothesis involves flow of cerebrospinal fluid from the cortical subarachnoid space to the parenchyma along the paraarterial (extramural, Virchow-Robin) space around arteries, and return flow to the cerebrospinal fluid (CSF) space via paravenous channels. The second hypothesis involves flow of interstitial fluid from the parenchyma to lymphatic vessels along basement membranes between arterial smooth muscle cells. METHODS: This article evaluates the plausibility of steady, pressure-driven flow in these channels with one-dimensional branching models. RESULTS: According to the models, the hydraulic resistance of arterial basement membranes is too large to accommodate estimated interstitial perfusion of the brain, unless the flow empties to lymphatic ducts after only several generations (still within the parenchyma). The estimated pressure drops required to drive paraarterial and paravenous flows of the same magnitude are not large, but paravenous flow back to the CSF space means that the total pressure difference driving both flows is limited to local pressure differences among the different CSF compartments, which are estimated to be small. CONCLUSIONS: Periarterial flow and glymphatic circulation driven by steady pressure are both found to be implausible, given current estimates of anatomical and fluid dynamic parameters.
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“based on estimates of anatomical and fluid dynamic parameters, the plausibility of periarterial flow and glymphatic circulation is controversial”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [289]
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Iliff, J. J., Wang, M., Liao, Y., Plogg, B. A., Peng, W., Gundersen, G. A., Benveniste, H., Vates, G. E., Deane, R., Goldman, S. A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003748 · Cited by 5,824
The blood-brain barrier: Bottleneck in brain drug development
Pardridge, W. M. (2005) · NeuroRX · doi:10.1602/neurorx.2.1.3 · Cited by 2,798
The Physiological Principle of Minimum Work
Murray, C. D. (1926) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.12.3.207 · Cited by 2,105
The glymphatic system: a beginner's guide
Jessen, N. A., Munk, A. S. F., Lundgaard, I., & Nedergaard, M. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1581-6 · Cited by 2,075
Cerebral Arterial Pulsation Drives Paravascular CSF–Interstitial Fluid Exchange in the Murine Brain
Iliff, J. J., Wang, M., Zeppenfeld, D. M., Venkataraman, A., Plog, B. A., Liao, Y., Deane, R., & Nedergaard, M. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1592-13.2013 · Cited by 1,319
Basement Membranes: Cell Scaffoldings and Signaling PlatformsPreprint
Yurchenco, P. D. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a004911 · Cited by 960
Mitchell, G. F., van Buchem, M. A., Sigurdsson, S. O., Gotal, J. D., Jónsdóttir, M. K., Kjartansson, Ó., García, M., Aspelund, T., Harris, T. B., Gudnason, V. G., et al. (2011) · Brain · doi:10.1093/brain/awr253 · Cited by 891
Cortical blood vessels of the human brain
Duvernoy, H. M., Delon, S., & Vannson, J. L. (1981) · Brain Research Bulletin · doi:10.1016/0361-9230(81)90007-1 · Cited by 849
Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathology
Abbott, N. J. (2004) · Neurochemistry International · doi:10.1016/j.neuint.2003.11.006 · Cited by 786
Duvernoy, H. M. (1999) · Springer eBooks · doi:10.1007/978-3-7091-6792-2 · Cited by 759
Research works printed but not linked: 3
- Robin C. Recherches sur quelques particularites de la structure des capillaires de l’encephale. J Physiol Homme Animaux. 1859;2:537–48.
- Sharp MK, Darcy-Brinkman model of shearaugmented dispersion in cerebrovascular basement membranes and the spinal subarachnoid space. 2017 Cerebrospinal Fluid Dynamics Symposium, Atlanta, GA, 19–20 June 2017.
- Cieslicki K. Experimental and numerical modeling in cerebral arteries. J Med Informat Technol. 2004;7:17–26.
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Items 101–101 of 101
Modeling glioma-induced impairments on the glymphatic system
Poulain, A., Riseth, J. N., Emblem, K. E., & Mardal, K.-A. (2026) · Fluids and Barriers of the CNS · doi:10.1186/s12987-025-00736-8
Metadata
- Authors
- Faghih, M. M., & Sharp, M. K.
- Affiliations
- University of Louisville (US)
- Corresponding author
- Sharp, M. Keith
- ORCID
- Sharp, M. Keith
- Venue
- Fluids and Barriers of the CNS
- Published
- 2018-06-15
- Volume
- 15
- Issue
- 1
- Pages
- 17-17
- ISSN
- 2045-8118 (ISSN-L)
- PMC
- PMC6003203
- OpenAlex
- W2807029080
- Cited by
- 101
- References
- 56
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 24 · 2023: 10 · 2022: 15 · 2021: 12 · 2020: 17 · 2019: 11 · 2018: 5
- FWCI
- 5.13
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Fluids and Barriers of the CNS (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Cerebrospinal fluid and hydrocephalus
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Keywords
- bulk flow, perivascular spaces, cerebrospinal fluid transport, interstitial fluid, lymphatic drainage, pressure-driven flow, brain parenchyma
- MeSH terms
- Basement Membrane, Blood Vessels, Brain, Cerebrospinal Fluid, Humans, Models, Biological, Viscosity, Extracellular Fluid
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