Basal cell carcinoma, squamous cell carcinoma and melanoma of the head and face
Open accessAbstract
Ultraviolet light (UV) is an important risk factor for cutaneous basal cell carcinoma, cutaneous squamous cell carcinoma and cutaneous melanoma of the skin. These cancers most commonly affect persons with fair skin and blue eyes who sunburn rather than suntan. However, each of these cancers appears to be associated with a different pattern of UV exposure and to be mediated by different intracellular molecular pathways.Some melanocortin 1 receptor (MC1R) gene variants play a direct role in the pathogenesis of cutaneous basal cell carcinoma, cutaneous squamous cell carcinoma and cutaneous melanoma apart from their role in determining a cancer-prone pigmentory phenotype (fair skin, red hair, blue eyes) through their interactions with other genes regulating immuno-inflammatory responses, DNA repair or apoptosis.In this short review we focus on the aetiological role of UV in cutaneous basal cell carcinoma, cutaneous squamous cell carcinoma and cutaneous melanoma of the skin, and on some associated biopathological events.
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Overexposure to sunlight is directly connected with the onset of skin cancers such as basal cell carcinoma (BSC), squamous cell carcinoma (SCC), and malignant melanoma (MM).
“Overexposure to sunlight is directly connected the with onset of skin cancers such as basal cell carcinoma (BSC) [165], squamous cell carcinoma (SCC) [166,167], and malignant melanoma (MM) [168,169].”
From Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies (2020) · cites this paper as [168]
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Research works printed but not linked: 3
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Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies
Kciuk, M., Marciniak, B., Mojzych, M., & Kontek, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197264 · Cited by 168 · see citing works
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- Authors
- Feller, L., Khammissa, R. A. G., Kramer, B., Altini, M., & Lemmer, J.
- Affiliations
- Sefako Makgatho Health Sciences University (ZA)
- University of the Witwatersrand (ZA)
- Corresponding author
- Feller, L.
- Venue
- Head & Face Medicine
- Published
- 2016-02-05
- Volume
- 12
- Issue
- 1
- Pages
- 11-11
- ISSN
- 1746-160X (ISSN-L)
- PMC
- PMC4744388
- OpenAlex
- W2265344969
- Cited by
- 105
- References
- 64
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 12 · 2023: 7 · 2022: 12 · 2021: 10 · 2020: 13 · 2019: 13 · 2018: 8 · 2017: 9 · 2014: 1
- FWCI
- 1.35
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Head & Face Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Keywords
- basal cell carcinoma, squamous cell carcinoma, melanoma, ultraviolet radiation, MC1R, DNA repair, apoptosis
- MeSH terms
- Basal Cell Carcinoma, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Humans, Melanoma, Risk Factors, Skin Neoplasms, Ultraviolet Rays
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