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Developing natural products as potential anti-biofilm agents
Open accessAbstract
Biofilm is a natural form of bacterial growth ubiquitously in environmental niches. The biofilm formation results in increased resistance to negative environmental influences including resistance to antibiotics and antimicrobial agents. Quorum sensing (QS) is cell-to-cell communication mechanism, which plays an important role in biofilm development and balances the environment when the bacteria density becomes high. Due to the prominent points of biofilms implicated in infectious disease and the spread of multi-drug resistance, it is urgent to discover new antibacterial agents that can regulate biofilm formation and development. Accumulated evidences demonstrated that natural products from plants had antimicrobial and chemo-preventive properties in modulation of biofilm formation in the last two decades. This review will summarize recent studies on the discovery of natural anti-biofilm agents from plants with clear-cut mechanisms or identified molecular addresses, as well as some herbs with unknown mechanisms or unidentified bioactive ingredients. We also focus on the progression of techniques on the extraction and identification of natural anti-biofilm substances. Besides, anti-biofilm therapeutics undergoing clinical trials are discussed. These newly discovered natural anti-biofilm agents are promising candidates which could provide novel strategies for biofilm-associated infections.
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Cited by
Sharma, S., Mohler, J., Mahajan, S. D., Schwartz, S. A., Bruggemann, L., & Aalinkeel, R. (2023) · Microorganisms · doi:10.3390/microorganisms11061614 · Cited by 993
Melo, R. S., Albuquerque Azevedo, Á. M., Gomes Pereira, A. M., Rocha, R. R., Bastos Cavalcante, R. M., Carneiro Matos, M. N., Ribeiro Lopes, P. H., Gomes, G. A., Soares Rodrigues, T. H., Santos, H. S. D., et al. (2019) · Molecules · doi:10.3390/molecules24213864 · Cited by 106
Recent advances of tanshinone in regulating autophagy for medicinal research
Wu, S., Zhao, K., Wang, J., Liu, N., Nie, K., Qi, L., & Xia, L. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1059360 · Cited by 32
Zeineldin, M., Esmael, A., Al-Hindi, R. R., Alharbi, M. G., Ashenafi Bekele, D., & Teklemariam, A. D. (2023) · Life · doi:10.3390/life13020503 · Cited by 27
Siderophores: A Case Study in Translational Chemical Biology
LeBlanc, A. R., & Wuest, W. M. (2024) · Biochemistry · doi:10.1021/acs.biochem.4c00276 · Cited by 20
Metadata
- Authors
- Lu, L., Hu, W., Tian, Z., Yuan, D., Yi, G., Zhou, Y., Cheng, Q., Zhu, J., & Li, M.
- Venue
- Chinese Medicine
- Published
- 2019-03-20
- Volume
- 14
- Issue
- 1
- Pages
- 11-11
- ISSN
- 1749-8546 (ISSN-L)
- OpenAlex
- W2938373565
- Cited by
- 387
- References
- 4
- FWCI
- 11.60
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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