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The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles

Li, Jian-Guo, Chiu, Jin, Ramanjulu, Mercy, Blass, Benjamin E., Praticò, Domenico·2020·Molecular Neurodegeneration
DOI 10.1186/s13024-019-0350-4PMC PMC6975032
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Abstract

Background: The vacuolar protein sorting 35 (VPS35) is a major component of the retromer complex system, an ubiquitous multiprotein assembly responsible for sorting and trafficking protein cargos out of the endosomes. VPS35 can regulate APP metabolism and Aβ formation, and its levels are reduced in Alzheimer’s disease (AD) brains. We and others demonstrated that VPS35 genetic manipulation modulates the phenotype of mouse models of AD. However, the translational value of this observation remains to be investigated. Methods: Triple transgenic mice were randomized to receive a pharmacological chaperone, which stabilizes the retromer complex, and the effect on their AD-like phenotype assessed. Results: Compared with controls, treated mice had a significant improvement in learning and memory, an elevation of VPS35 levels, and improved synaptic integrity. Additionally, the same animals had a significant decrease in Aβ levels and deposition, reduced tau phosphorylation and less astrocytes activation. Conclusions: Our study demonstrates that the enhancement of retromer function by pharmacological chaperones is a potentially novel and viable therapy against AD.

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Research works printed but not linked: 27

  1. Giannopoulos FP, Pratico D. Alzheimer’s disease. In: Martin CR, Reddy V, editors. Diet and nutrition in dementia and cognitive decline. London: Elsevier Publisher; 2015. p. 3–21.
  2. Vardarajan BN, Bruesegem SY, Harbour ME, George-Hyslop PS, Seaman MN, Farrer LA. Identification of Alzheimer disease-associated variants in genes that regulate retromer function. Neurobiol Aging. 2012;33(9):2231–e15. · DOI · Paper page
  3. Vagnozzi AN, Praticò D. Endosomal sorting and trafficking, the retromer complex and neurodegeneration. Mol Psychiatry. 2018. https://doi.org/10.1038/s41380-018-0221-3. · DOI · Paper page
  4. Small SA, Kent K, Pierce A, Leung C, Kang MS, Okada H, Honig L, Vonsattel JP, Kim TW. Model-guided microarray implicates the retromer complex in Alzheimer's disease. Ann Neurol. 2005;58(6):909–19. · DOI · Paper page
  5. Chu J, Praticò D. The retromer complex system in a transgenic mouse model of AD: influence of age. Neurobiol Aging. 2017;52:32–8. · DOI
  6. Li JG, Chiu J, Praticò D. Full recovery of the Alzheimer's disease phenotype by gain of function of vacuolar protein sorting 35. Mol Psychiatry. 2019. https://doi.org/10.1038/s41380-019-0364. · DOI
  7. Mecozzi VJ, Berman DE, Simoes S, Vetanovetz C, Awal MR, Patel VM, Schneider RT, Petsko GA, Ringe D, Small SA. Pharmacological chaperones stabilize retromer to limit APP processing. Nat Chem Biol. 2014;10(6):443. · DOI · Paper page
  8. Lauretti E, Iuliano L, Praticò D. Extra-virgin olive oil ameliorates cognition and neuropathology of the 3xTg mice: role of autophagy. Ann Clin Transl Neurol. 2017;4(8):564–74. · DOI
  9. Li J-G, Barrero C, Merali S, Praticò D. Genetic absence of ALOX5 protects from homocysteine-induced memory impairment, tau phosphorylation and synaptic pathology. Hum Mol Genet. 2017;26(10):1855–62. · DOI
  10. Giannopoulos PF, Chu J, Sperow M, Li JG, Yu WH, Kirby LG, Abood M, Praticò D. Pharmacologic inhibition of 5-Lipoxygenase improves memory, rescues synaptic dysfunction, and ameliorates tau pathology in a transgenic model of tauopathy. Biol Psychiatry. 2015;78:693–701. · DOI · Paper page
  11. Di Meco A, Joshi YB, Lauretti E, Praticò D. Maternal dexamethasone exposure ameliorates cognition and tau pathology in the offspring of triple transgenic AD mice. Mol Psychiatry. 2016;21(3):403–10. · DOI
  12. Vagnozzi AN, Giannopoulos PF, Praticò D. The direct role of 5-lipoxygenase on tau pathology, synaptic integrity and cognition in a mouse model of tauopathy. Transl Psychiatry. 2017;7(12):1288. · DOI
  13. Small SA, Gandy S. Sorting through the cell biology of Alzheimer’ disease: intracellular pathways to pathogenesis. Neuron. 2006;52:15–31. · DOI
  14. Liu JJ. Retromer-mediated protein sorting and vesicular trafficking. J Genet Genomics. 2016;43:165–77. · DOI
  15. Choy RW-Y, Cheng Z, Schekman R. Amyloid precursor protein (APP) traffics from the cell surface via endosomes for Aβ production in the trans-Golgi. Proc Natl Acad Sci U S A. 2012;109(30):E2077–82. · DOI
  16. Range D, Pesko GA. What are pharmacological chaperones and why are they interesting? J Biol. 2009;8:80. · DOI
  17. Puzzo D, Lee L, Palmeri A, Calabrese G, Arancio O. Behavioral assays with mouse models of Alzheimer’s disease: practical considerations and guidelines. Biochem Pharmacol. 2014;88(4):450–67. · DOI
  18. Yau JOY, McNally GP. Brain mechanisms controlling Pavlovian fear conditioning. J Exp Psychol Anim Learn Cogn. 2018;44(4):341–57. · DOI
  19. Arighi CN, Hartnell EM, Aguilar RC, Haft CR, Bonifacino JS. Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor. J Cell Biol. 2004;165:123–33. · DOI · Paper page
  20. Bhalla A, Vetanovetz CP, Morel E, Chamoun Z, Di Paolo G, Small SA. The location and trafficking routes of the neuronal retromer and its role in amyloid precursor protein transport. Neurobiol Dis. 2012;47:126–34. · DOI · Paper page
  21. Sullivan CP, Jay AG, Stack EC, Pakaluk M, Wadlinger E, Fine RE, Wells JM, Morin PJ. Retromer disruption promotes amyloidogenic APP processing. Neurobiol Dis. 2011;43(2):338–45. · DOI
  22. Nielsen MS, Gustafsen C, Madsen P, Nyengaard JR, Hermey G, Bakke O, Mari M, Schu P, Pohlmann R, Dennes A, et al. Sorting by the cytoplasmic domain of the amyloid precursor protein b9nding receptor SorLA. Mol Cell Biol. 2007;27:6842–51. · DOI · Paper page
  23. Fjorback AW, Seaman M, Gustafsen C, Mehmedbasic A, Gokool S, Wu C, Militz D, Scmidt V, Madsen P, Nyengaard JR, et al. Retromer binds the FANSHY sorting motif in SorLA to regulate amyloid precursor protein sorting and processing. J Neurosci. 2012;32:1467–80. · DOI · Paper page
  24. Herskowitz JH, Offe K, Deshpande A, Kahn RA, Levey AI, Lah JJ. GGAI-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution of amyloid beta production. Mol Biol Cell. 2012;23:2645–57. · DOI
  25. Bain HDC, Davidson YS, Robinson AC, Ryan S, Rollinson S, Richardson A, Jones M, Snowden JS, Pickering-Brown S, Mann DMA. The role of lysosomes and autophagosomes in frontotemporal lobar degeneration. Neuropathol Appl Neurobiol. 2019;45(3):244–61. · DOI · Paper page
  26. Qureshi YH, Patel VM, Berman DE, Kothiya MJ, Neufeld JL, Vardarajan B, Tang M, Reyes-Dumeyer D, Lantigua R, Medrano M, Jiménez-Velázquez IJ, Small SA, Reitz C. An Alzheimer's disease-linked loss-of-function CLN5 variant impairs cathepsin D maturation, consistent with a retromer trafficking defect. Mol Cell Biol. 2018;38(20). https://doi.org/10.1128/MCB.00011-18. · DOI
  27. Henstridge CM, Pickett E, Spire-Jones TL. Synaptic pathology: a shared mechanism in neurological disease. Ageing Res Rev. 2016;28:72–84. · DOI

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Metadata

Authors
Li, J.-G., Chiu, J., Ramanjulu, M., Blass, B. E., & Praticò, D.
ORCID
Praticò, Domenico
Venue
Molecular Neurodegeneration
Publisher
Springer Science and Business Media LLC
Published
2020-01-22
Volume
15
Issue
1
ISSN
1750-1326
DOI
10.1186/s13024-019-0350-4
PMC
PMC6975032
Cited by
74
References
5
Language
en
Update notices
correction (2021-06-28)
Licence
Funders
National Institute on Aging (AG55707, AG56689)

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