Early low-dose ghrelin intervention via miniosmotic pumps could protect against the progressive dopaminergic neuron loss in Parkinson's disease mice
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Abstract
Ghrelin has been identified as a multifunctional peptide that has a potential application for treating Parkinson's disease (PD). The objective of this study was to assess the effects of subcutaneous administration of low-dose ghrelin via miniosmotic pumps on PD progression. The decreased levels of total and active ghrelin in plasma were rescued by ghrelin administration in PD mice. Interestingly, ghrelin did not affect weight gain in wild-type mice but improved weight loss in PD mice. We observed the attenuation of dopaminergic neuron loss in substantia nigra and a low level of dopamine content in the striatum in PD mice with ghrelin treatment. Ghrelin administration could improve the microenvironment of dopaminergic neurons by inhibiting microglial proliferation and proinflammatory cytokine expression and could enhance cell survival by upregulating Bcl-2/Bax ratio and superoxide dismutase1 protein level in the substantia nigra of PD mice. Subcutaneous administration of low-dose ghrelin could prevent the onset of the progression of PD and also provide a possible method for ghrelin application to cure PD.
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Ghrelin has neuroprotective effects in multiple rodent models of PD, including MPTP-induced PD mice, 6-OHDA-induced PD rats, and A53T α-synuclein transgenic mice.
“accumulating evidence has demonstrated the neuroprotective effects of ghrelin in multiple rodent models of PD, including MPTP-induced PD mice”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [571]
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- Authors
- Jiao, L., Du, X., Jia, F., Li, Y., Zhu, D., Tang, T., Jiao, Q., & Jiang, H.
- Affiliations
- Qingdao University (CN)
- Corresponding author
- Tang, Tinging
- Jiao, Qian
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2021-05
- Volume
- 101
- Pages
- 70-78
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W3121781949
- Cited by
- 19
- References
- 42
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 7 · 2023: 2 · 2022: 5 · 2021: 1
- FWCI
- 1.79
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- Locations
- Neurobiology of Aging (publishedVersion)
- Research Square (acceptedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Keywords
- ghrelin, Parkinson's disease, subcutaneous administration, dopaminergic neuron loss, substantia nigra, dopamine, microglial proliferation, inflammatory cytokines, Bcl-2/Bax ratio, superoxide dismutase 1, neuroprotection, weight loss
- MeSH terms
- Animals, Cell Survival, Disease Models, Animal, Inflammation, Injections, Subcutaneous, Mice, Transgenic, Osmotic Pressure, Parkinson Disease, Cytokines, Microglia, Oxidative Stress, Disease Progression, Inflammation Mediators, Cell Proliferation, Ghrelin, Dopaminergic Neurons, Cellular Microenvironment
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