Cited by 19Parkinson's Disease Mechanisms and TreatmentsRegulation of Appetite and ObesityNuclear Receptors and Signaling

Early low-dose ghrelin intervention via miniosmotic pumps could protect against the progressive dopaminergic neuron loss in Parkinson's disease mice

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Jiao, Lingling, Du, Xixun, Jia, Fengju, Li, Yong, Zhu, Dexiao, Tang, Tinging, Jiao, Qian, Jiang, Hong·2021·Neurobiology of Aging

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Abstract

Ghrelin has been identified as a multifunctional peptide that has a potential application for treating Parkinson's disease (PD). The objective of this study was to assess the effects of subcutaneous administration of low-dose ghrelin via miniosmotic pumps on PD progression. The decreased levels of total and active ghrelin in plasma were rescued by ghrelin administration in PD mice. Interestingly, ghrelin did not affect weight gain in wild-type mice but improved weight loss in PD mice. We observed the attenuation of dopaminergic neuron loss in substantia nigra and a low level of dopamine content in the striatum in PD mice with ghrelin treatment. Ghrelin administration could improve the microenvironment of dopaminergic neurons by inhibiting microglial proliferation and proinflammatory cytokine expression and could enhance cell survival by upregulating Bcl-2/Bax ratio and superoxide dismutase1 protein level in the substantia nigra of PD mice. Subcutaneous administration of low-dose ghrelin could prevent the onset of the progression of PD and also provide a possible method for ghrelin application to cure PD.

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Crossref · 10.1016/j.neurobiolaging.2021.01.011

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  1. [26]26. Jang H, Boltz D, Sturm-Ramirez K, Shepherd KR, Jiao Y, Webster R, Smeyne RJ: Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration. Proc Natl Acad Sci U S A 2009, 106:14063-14068.

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Authors
Jiao, L., Du, X., Jia, F., Li, Y., Zhu, D., Tang, T., Jiao, Q., & Jiang, H.
Affiliations
Qingdao University (CN)
Corresponding author
  • Tang, Tinging
  • Jiao, Qian
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
2021-05
Volume
101
Pages
70-78
ISSN
0197-4580 (ISSN-L)
OpenAlex
W3121781949
Cited by
19
References
42
Citations by year
2026: 1 · 2025: 3 · 2024: 7 · 2023: 2 · 2022: 5 · 2021: 1
FWCI
1.79
Type
journal article
Language
en
Open access
Locations
  • Neurobiology of Aging (publishedVersion)
  • Research Square (acceptedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China
  • Natural Science Foundation of Shandong Province
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
Keywords
ghrelin, Parkinson's disease, subcutaneous administration, dopaminergic neuron loss, substantia nigra, dopamine, microglial proliferation, inflammatory cytokines, Bcl-2/Bax ratio, superoxide dismutase 1, neuroprotection, weight loss
MeSH terms
Animals, Cell Survival, Disease Models, Animal, Inflammation, Injections, Subcutaneous, Mice, Transgenic, Osmotic Pressure, Parkinson Disease, Cytokines, Microglia, Oxidative Stress, Disease Progression, Inflammation Mediators, Cell Proliferation, Ghrelin, Dopaminergic Neurons, Cellular Microenvironment

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