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Cited by 327

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Current status and perspectives in translational biomarker research for PD-1/PD-L1 immune checkpoint blockade therapy

Open access
Ma, Weijie, Gilligan, Barbara M., Yuan, Jianda, Li, Tianhong·2016·Journal of Hematology & Oncology
DOI 10.1186/s13045-016-0277-y
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Abstract

Modulating immune inhibitory pathways has been a major recent breakthrough in cancer treatment. Checkpoint blockade antibodies targeting cytotoxic T-lymphocyte antigen 4 (CTLA-4) and programed cell-death protein 1 (PD-1) have demonstrated acceptable toxicity, promising clinical responses, durable disease control, and improved survival in some patients with advanced melanoma, non-small cell lung cancer (NSCLC), and other tumor types. About 20 % of advanced NSCLC patients and 30 % of advanced melanoma patients experience tumor responses from checkpoint blockade monotherapy, with better clinical responses seen with the combination of anti-PD-1 and anti-CTLA-4 antibodies. Given the power of these new therapies, it is important to understand the complex and dynamic nature of host immune responses and the regulation of additional molecules in the tumor microenvironment and normal organs in response to the checkpoint blockade therapies. In this era of precision oncology, there remains a largely unmet need to identify the patients who are most likely to benefit from immunotherapy, to optimize the monitoring assays for tumor-specific immune responses, to develop strategies to improve clinical efficacy, and to identify biomarkers so that immune-related adverse events can be avoided. At this time, PD-L1 immunohistochemistry (IHC) staining using 22C3 antibody is the only FDA-approved companion diagnostic for patients with NSCLC-treated pembrolizumab, but more are expected to come to market. We here summarize the current knowledge, clinical efficacy, potential immune biomarkers, and associated assays for immune checkpoint blockade therapies in advanced solid tumors.

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Metadata

Authors
Ma, W., Gilligan, B. M., Yuan, J., & Li, T.
Venue
Journal of Hematology & Oncology
Publisher
Springer Science and Business Media LLC
Published
2016-05-27
Volume
9
Issue
1
Pages
47-47
ISSN
1756-8722 (ISSN-L)
DOI
10.1186/s13045-016-0277-y
OpenAlex
W2400328547
Cited by
327
References
37
FWCI
27.35
Type
journal article
Language
en
Open access
gold

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