The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Genetic alterations of m6A regulators predict poorer survival in acute myeloid leukemia
Open accessAbstract
Methylation of N 6 adenosine (m 6 A) is known to be important for diverse biological processes including gene expression control, translation of protein, and messenger RNA (mRNA) splicing. However, its role in the development of human cancers is poorly understood. By analyzing datasets from the Cancer Genome Atlas Research Network (TCGA) acute myeloid leukemia (AML) study, we discover that mutations and/or copy number variations of m 6 A regulatory genes are strongly associated with the presence of TP53 mutations in AML patients. Further, our analyses reveal that alterations in m 6 A regulatory genes confer a worse survival in AML. Our work indicates that genetic alterations of m 6 A regulatory genes may cooperate with TP53 and/or its regulator/downstream targets in the pathogenesis and/or maintenance of AML.
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Cerami, E., Gao, J., Dogrusoz, U., Gross, B. E., Sumer, S. O., Aksoy, B. A., Jacobsen, A., Byrne, C. J., Heuer, M. L., Larsson, E., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0095 · Cited by 17,455
Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia
The Cancer Genome Atlas Research Network (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1301689 · Cited by 5,078
Genomic classification and prognosis in acute myeloid leukemia
Papaemmanuil, E., Gerstung, M., Bullinger, L., Gaidzik, V. I., Paschka, P., Roberts, N. D., Potter, N. E., Heuser, M., Thol, F., Bolli, N., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1516192 · Cited by 4,350
Cited by
The role of m6A modification in the biological functions and diseases
Jiang, X., Liu, B., Nie, Z., Duan, L., Xiong, Q., Jin, Z., Yang, C., & Chen, Y. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00450-x · Cited by 2,335
The role of m6A RNA methylation in cancer
Sun, T., Wu, R., & Ming, L. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108613 · Cited by 963
The interplay between m6A RNA methylation and noncoding RNA in cancer
Ma, S., Chen, C., Ji, X., Liu, J., Zhou, Q., Wang, G., Yuan, W., Kan, Q., & Sun, Z. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0805-7 · Cited by 632
Knuckles, P., Lence, T., Haussmann, I. U., Jacob, D., Kreim, N., Carl, S. H., Masiello, I., Hares, T., Villaseñor, R., Hess, D., et al. (2018) · Genes & Development · doi:10.1101/gad.309146.117 · Cited by 580
m 6 A in mRNA: An Ancient Mechanism for Fine-Tuning Gene Expression
Roignant, J.-Y., & Soller, M. (2017) · Trends in Genetics · doi:10.1016/j.tig.2017.04.003 · Cited by 426
Metadata
- Authors
- Kwok, C.-T., Marshall, A. D., Rasko, J. E. J., & Wong, J. J. L.
- Venue
- Journal of Hematology & Oncology
- Published
- 2017-02-02
- Volume
- 10
- Issue
- 1
- Pages
- 39-39
- ISSN
- 1756-8722 (ISSN-L)
- OpenAlex
- W2584920615
- Cited by
- 199
- References
- 3
- FWCI
- 10.00
- Type
- journal article
- Language
- en
- Open access
- gold
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- Kwok, C.-T., Marshall, A. D., Rasko, J. E. J., & Wong, J. J. L. (2017). Genetic alterations of m6A regulators predict poorer survival in acute myeloid leukemia. Journal of Hematology & Oncology. https://doi.org/10.1186/s13045-017-0410-6
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