The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.
Lessons learned from the blockade of immune checkpoints in cancer immunotherapy
Open accessAbstract
The advent of immunotherapy, especially checkpoint inhibitor-based immunotherapy, has provided novel and powerful weapons against cancer. Because only a subset of cancer patients exhibit durable responses, further exploration of the mechanisms underlying the resistance to immunotherapy in the bulk of cancer patients is merited. Such efforts may help to identify which patients could benefit from immune checkpoint blockade. Given the existence of a great number of pathways by which cancer can escape immune surveillance, and the complexity of tumor-immune system interaction, development of various combination therapies, including those that combine with conventional therapies, would be necessary. In this review, we summarize the current understanding of the mechanisms by which resistance to checkpoint blockade immunotherapy occurs, and outline how actionable combination strategies may be derived to improve clinical outcomes for patients.
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Roles of IFN-γ in tumor progression and regression: A review
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Regulation of PD-L1 expression in the tumor microenvironment
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Metadata
- Authors
- Li, X., Shao, C., Shi, Y., & Han, W.
- Venue
- Journal of Hematology & Oncology
- Published
- 2018-02-27
- Volume
- 11
- Issue
- 1
- Pages
- 31-31
- ISSN
- 1756-8722 (ISSN-L)
- OpenAlex
- W2797580541
- Cited by
- 381
- References
- 77
- FWCI
- 10.87
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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