The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
T cell senescence and CAR-T cell exhaustion in hematological malignancies
Open accessAbstract
T cell senescence has been recognized to play an immunosuppressive role in the aging population and cancer patients. Strategies dedicated to preventing or reversing replicative and premature T cell senescence are required to increase the lifespan of human beings and to reduce the morbidity from cancer. In addition, overcoming the T cell terminal differentiation or senescence from lymphoma and leukemia patients is a promising approach to enhance the effectiveness of adoptive cellular immunotherapy (ACT). Chimeric antigen receptor T (CAR-T) cell and T cell receptor-engineered T (TCR-T) cell therapy highly rely on functionally active T cells. However, the mechanisms which drive T cell senescence remain unclear and controversial. In this review, we describe recent progress for restoration of T cell homeostasis from age-related senescence as well as recovery of T cell activation in hematological malignancies.
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Cites
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Cited by
Clinical implications of T cell exhaustion for cancer immunotherapy
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Immunosenescence: a key player in cancer development
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Age related human T cell subset evolution and senescence
Li, M., Yao, D., Zeng, X., Kasakovski, D., Zhang, Y., Chen, S., Zha, X., Li, Y., & Xu, L. (2019) · Immunity & Ageing · doi:10.1186/s12979-019-0165-8 · Cited by 230
Self-citationThe Evolving Role of CD8+CD28− Immunosenescent T Cells in Cancer Immunology
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Metadata
- Authors
- Kasakovski, D., Xu, L., & Li, Y.
- Venue
- Journal of Hematology & Oncology
- Published
- 2018-07-04
- Volume
- 11
- Issue
- 1
- Pages
- 91-91
- ISSN
- 1756-8722 (ISSN-L)
- OpenAlex
- W2810308581
- Cited by
- 272
- References
- 15
- FWCI
- 15.74
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
